Literature for peptidase M48.018: Oma1 peptidase

(Topics flags: A Assay, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Ludwig,K. and Heidorn-Czarna,M.
   Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast
   Plant Cell Physiol PubMed  Europe PubMed DOI  V
2024
2. Chen,L., Chen,D., Pan,Y., Mo,Y., Lai,B., Chen,H., Zhang,D.W. and Xia,X.D.
   Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis
   Cell Death Dis15, 786-786. PubMed  Europe PubMed DOI
3. Krakowczyk,M., Lenkiewicz,A.M., Sitarz,T., Malinska,D., Borrero,M., Mussulini,B.H.M., Linke,V., Szczepankiewicz,A.A., Biazik,J.M., Wydrych,A., Nieznanska,H., Serwa,R.A., Chacinska,A. and Bragoszewski,P.
   OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization
   J Cell Biol223, PubMed  Europe PubMed DOI
4. Purohit,G., Ghosh,P. and Khalimonchuk,O.
   Mitochondrial metallopeptidase OMA1 in cancer
   Adv Cancer Res162, 75-97. PubMed  Europe PubMed DOI  V
2023
5. Qiu,J., Yue,F., Zhu,P., Chen,J., Xu,F., Zhang,L., Kim,K.H., Snyder,M.M., Luo,N., Xu,H.W., Huang,F., Tao,W.A. and Kuang,S.
   FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
   Nat Commun14, 6344-6344. PubMed  Europe PubMed DOI
2022
6. Alavi,M.V.
   Recent advances in, and challenges of, designing OMA1 drug screens
   Pharmacol Res176, 106063-106063. PubMed  Europe PubMed DOI
7. Heidorn-Czarna,M., Maziak,A. and Janska,H.
   Protein Processing in Plant Mitochondria Compared to Yeast and Mammals
   Front Plant Sci13, 824080-824080. PubMed  Europe PubMed DOI  V
8. Shammas,M.K., Huang,X., Wu,B.P., Fessler,E., Song,I.Y., Randolph,N.P., Li,Y., Bleck,C.K., Springer,D.A., Fratter,C., Barbosa,I.A., Powers,A.F., Quiros,P.M., Lopez-Otin,C., Jae,L.T., Poulton,J. and Narendra,D.P.
   OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy
   J Clin Invest132, PubMed  Europe PubMed DOI
2021
9. Gilkerson,R., de La Torre,P. and St Vallier,S.
   Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response
   Front Cell Dev Biol9, 626117-626117. PubMed  Europe PubMed DOI
10. Maziak,A., Heidorn-Czarna,M., Weremczuk,A. and Janska,H.
    FTSH4 and OMA1 mitochondrial proteases reduce moderate heat stress-induced protein aggregation
    Plant Physiol187, 769-786. PubMed  Europe PubMed DOI
11. Tobacyk,J. and MacMillan-Crow,L.A.
    Fluorescence-Based Assay For Measuring OMA1 Activity
    Methods Mol Biol2276, 325-332. PubMed  Europe PubMed DOI
12. Viana,M.P., Levytskyy,R.M., Anand,R., Reichert,A.S. and Khalimonchuk,O.
    Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex
    iScience24, 102119-102119. PubMed  Europe PubMed DOI
2020
13. Alavi,M.V.
    OMA1-An integral membrane protease?
    Biochim Biophys Acta Proteins Proteom140558-140558. PubMed  Europe PubMed DOI  V
14. Liu,Y.T., Huang,X., Nguyen,D., Shammas,M.K., Wu,B.P., Dombi,E., Springer,D.A., Poulton,J., Sekine,S. and Narendra,D.P.
    Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations
    Hum Mol Genet29, 1547-1567. PubMed  Europe PubMed DOI
15. Noh,S., Phorl,S., Naskar,R., Oeum,K., Seo,Y., Kim,E., Kweon,H.S. and Lee,J.Y.
    p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis
    Sci Rep10, 10618-10618. PubMed  Europe PubMed DOI
2019
16. Bohovych,I., Dietz,J.V., Swenson,S., Zahayko,N. and Khalimonchuk,O.
    Redox regulation of the mitochondrial quality control protease Oma1
    Antioxid Redox Signal31, 429-443. PubMed  Europe PubMed DOI
17. Daverey,A., Levytskyy,R.M., Stanke,K.M., Viana,M.P., Swenson,S., Hayward,S.L., Narasimhan,M., Khalimonchuk,O. and Kidambi,S.
    Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells
    Sci Rep9, 14746-14746. PubMed  Europe PubMed DOI  K
18. Tobacyk,J., Parajuli,N., Shrum,S., Crow,J.P. and MacMillan-Crow,L.A.
    The first direct activity assay for the mitochondrial protease OMA1
    Mitochondrion46, 1-5. PubMed  Europe PubMed DOI  A
2018
19. Acin-Perez,R., Lechuga-Vieco,A.V., Del Mar Munoz,M., Nieto-Arellano,R., Torroja,C., Sanchez-Cabo,F., Jimenez,C., Gonzalez-Guerra,A., Carrascoso,I., Beninca,C., Quiros,P.M., Lopez-Otin,C., Castellano,J.M., Ruiz-Cabello,J., Jimenez-Borreguero,L.J. and Enriquez,J.A.
    Ablation of the stress protease OMA1 protects against heart failure in mice
    Sci Transl Med10, PubMed  Europe PubMed DOI  K
20. Garcia,I., Innis-Whitehouse,W., Lopez,A., Keniry,M. and Gilkerson,R.
    Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells
    Redox Rep23, 160-167. PubMed  Europe PubMed DOI  K
2016
21. Bohovych,I., Kastora,S., Christianson,S., Topil,D., Kim,H., Fangman,T., Zhou,Y.J., Barrientos,A., Lee,J., Brown,A.J. and Khalimonchuk,O.
    Oma1 links mitochondrial protein quality control and TOR signaling to modulate physiological plasticity and cellular stress responses
    Mol Cell Biol36, 2300-2312. PubMed  Europe PubMed DOI
22. MacVicar,T. and Langer,T.
    OPA1 processing in cell death and disease - the long and short of it
    J Cell Sci129, 2297-2306. PubMed  Europe PubMed DOI
2015
23. Bohovych,I., Fernandez,M.R., Rahn,J.J., Stackley,K.D., Bestman,J.E., Anandhan,A., Franco,R., Claypool,S.M., Lewis,R.E., Chan,S.S. and Khalimonchuk,O.
    Metalloprotease OMA1 fine-tunes mitochondrial bioenergetic function and respiratory supercomplex stability
    Sci Rep5, 13989-13989. PubMed  Europe PubMed DOI
2014
24. Anand,R., Wai,T., Baker,M.J., Kladt,N., Schauss,A.C., Rugarli,E. and Langer,T.
    The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
    J Cell Biol204, 919-929. PubMed  Europe PubMed DOI
25. Baker,M.J., Lampe,P.A., Stojanovski,D., Korwitz,A., Anand,R., Tatsuta,T. and Langer,T.
    Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics
    EMBO J33, 578-593. PubMed  Europe PubMed DOI
26. Bohovych,I., Donaldson,G., Christianson,S., Zahayko,N. and Khalimonchuk,O.
    Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast
    J Biol Chem289, 13259-13272. PubMed  Europe PubMed DOI
27. Jiang,X., Jiang,H., Shen,Z. and Wang,X.
    Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
    Proc Natl Acad Sci U S A111, 14782-14787. PubMed  Europe PubMed DOI
28. Macvicar,T.D. and Lane,J.D.
    Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation
    J Cell Sci127, 2313-2325. PubMed  Europe PubMed DOI
29. Xiao,X., Hu,Y., Quiros,P.M., Wei,Q., Lopez-Otin,C. and Dong,Z.
    OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury
    Am J Physiol Renal Physiol306, F1318-F1326. PubMed  Europe PubMed DOI
30. Zhang,K., Li,H. and Song,Z.
    Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage
    EMBO Rep15, 576-585. PubMed  Europe PubMed DOI
2013
31. Quiros,P.M., Ramsay,A.J. and Lopez-Otin,C.
    New roles for OMA1 metalloprotease: from mitochondrial proteostasis to metabolic homeostasis
    Adipocyte2, 7-11. PubMed  Europe PubMed DOI  K
2012
32. Khalimonchuk,O., Jeong,M.Y., Watts,T., Ferris,E. and Winge,D.R.
    Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants
    J Biol Chem287, 7289-7300. PubMed  Europe PubMed DOI
33. Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E., Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A., Enriquez,J.A., Zorzano,A. and Lopez-Otin,C.
    Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
    EMBO J31, 2117-2133. PubMed  Europe PubMed DOI  K
2009
34. Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S., Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and Langer,T.
    Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
    J Cell Biol187, 1023-1036. PubMed  Europe PubMed DOI
35. Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der Bliek,A.M.
    Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
    J Cell Biol187, 959-966. PubMed  Europe PubMed DOI
36. Short,B.
    Mitochondrial proteases strike the right balance. Two studies reveal how proteases combine to regulate mitochondrial fusion
    J Cell Biol187, 937-937. DOI
2003
37. [YEAR:8-9-2003]Kaser,M., Kambacheld,M., Kisters-Woike,B. and Langer,T.
    Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease
    J Biol Chem278, 46414-46423. PubMed  Europe PubMed DOI