Literature for peptidase M48.018: Oma1 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Ludwig,K. and Heidorn-Czarna,M. Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast Plant Cell Physiol (2025) PubMed Europe PubMed DOI V
Wu,L.Z., Huang,Y.Y., Hu,H.J., Hong,W.B., Yan,H., Ai,Y.L., Mi,X.Y., Feng,D.Y., Guo,J.Y., Ding,Y., Liu,Z.J., Zhou,B., Xiao,L., Lin,T., Li,F.N., Chen,X.Q., Chen,H.Z. and Wu,Q. Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage Signal Transduct Target Ther (2025) 10, 413-413. PubMed Europe PubMed DOI PMC EPMC

2024

Chen,L., Chen,D., Pan,Y., Mo,Y., Lai,B., Chen,H., Zhang,D.W. and Xia,X.D. Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis Cell Death Dis (2024) 15, 786-786. PubMed Europe PubMed DOI PMC EPMC
Krakowczyk,M., Lenkiewicz,A.M., Sitarz,T., Malinska,D., Borrero,M., Mussulini,B.H.M., Linke,V., Szczepankiewicz,A.A., Biazik,J.M., Wydrych,A., Nieznanska,H., Serwa,R.A., Chacinska,A. and Bragoszewski,P. OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization J Cell Biol (2024) 223 PubMed Europe PubMed DOI PMC EPMC
Purohit,G., Ghosh,P. and Khalimonchuk,O. Mitochondrial metallopeptidase OMA1 in cancer Adv Cancer Res (2024) 162, 75-97. PubMed Europe PubMed DOI V

2023

Qiu,J., Yue,F., Zhu,P., Chen,J., Xu,F., Zhang,L., Kim,K.H., Snyder,M.M., Luo,N., Xu,H.W., Huang,F., Tao,W.A. and Kuang,S. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes Nat Commun (2023) 14, 6344-6344. PubMed Europe PubMed DOI PMC EPMC

2022

Alavi,M.V. Recent advances in, and challenges of, designing OMA1 drug screens Pharmacol Res (2022) 176, 106063-106063. PubMed Europe PubMed DOI
Heidorn-Czarna,M., Maziak,A. and Janska,H. Protein Processing in Plant Mitochondria Compared to Yeast and Mammals Front Plant Sci (2022) 13, 824080-824080. PubMed Europe PubMed DOI PMC EPMC V
Shammas,M.K., Huang,X., Wu,B.P., Fessler,E., Song,I.Y., Randolph,N.P., Li,Y., Bleck,C.K., Springer,D.A., Fratter,C., Barbosa,I.A., Powers,A.F., Quiros,P.M., Lopez-Otin,C., Jae,L.T., Poulton,J. and Narendra,D.P. OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy J Clin Invest (2022) 132 PubMed Europe PubMed DOI PMC EPMC

2021

Gilkerson,R., de La Torre,P. and St Vallier,S. Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response Front Cell Dev Biol (2021) 9, 626117-626117. PubMed Europe PubMed DOI PMC EPMC
Maziak,A., Heidorn-Czarna,M., Weremczuk,A. and Janska,H. FTSH4 and OMA1 mitochondrial proteases reduce moderate heat stress-induced protein aggregation Plant Physiol (2021) 187, 769-786. PubMed Europe PubMed DOI PMC EPMC
Tobacyk,J. and MacMillan-Crow,L.A. Fluorescence-Based Assay For Measuring OMA1 Activity Methods Mol Biol (2021) 2276, 325-332. PubMed Europe PubMed DOI
Viana,M.P., Levytskyy,R.M., Anand,R., Reichert,A.S. and Khalimonchuk,O. Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex iScience (2021) 24, 102119-102119. PubMed Europe PubMed DOI PMC EPMC

2020

Alavi,M.V. OMA1-An integral membrane protease? Biochim Biophys Acta Proteins Proteom (2020) , 140558-140558. PubMed Europe PubMed DOI V
Liu,Y.T., Huang,X., Nguyen,D., Shammas,M.K., Wu,B.P., Dombi,E., Springer,D.A., Poulton,J., Sekine,S. and Narendra,D.P. Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations Hum Mol Genet (2020) 29, 1547-1567. PubMed Europe PubMed DOI
Noh,S., Phorl,S., Naskar,R., Oeum,K., Seo,Y., Kim,E., Kweon,H.S. and Lee,J.Y. p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis Sci Rep (2020) 10, 10618-10618. PubMed Europe PubMed DOI PMC EPMC

2019

Bohovych,I., Dietz,J.V., Swenson,S., Zahayko,N. and Khalimonchuk,O. Redox regulation of the mitochondrial quality control protease Oma1 Antioxid Redox Signal (2019) 31, 429-443. PubMed Europe PubMed DOI
Daverey,A., Levytskyy,R.M., Stanke,K.M., Viana,M.P., Swenson,S., Hayward,S.L., Narasimhan,M., Khalimonchuk,O. and Kidambi,S. Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells Sci Rep (2019) 9, 14746-14746. PubMed Europe PubMed DOI PMC EPMC K
Tobacyk,J., Parajuli,N., Shrum,S., Crow,J.P. and MacMillan-Crow,L.A. The first direct activity assay for the mitochondrial protease OMA1 Mitochondrion (2019) 46, 1-5. PubMed Europe PubMed DOI A

2018

Acin-Perez,R., Lechuga-Vieco,A.V., Del Mar Munoz,M., Nieto-Arellano,R., Torroja,C., Sanchez-Cabo,F., Jimenez,C., Gonzalez-Guerra,A., Carrascoso,I., Beninca,C., Quiros,P.M., Lopez-Otin,C., Castellano,J.M., Ruiz-Cabello,J., Jimenez-Borreguero,L.J. and Enriquez,J.A. Ablation of the stress protease OMA1 protects against heart failure in mice Sci Transl Med (2018) 10 PubMed Europe PubMed DOI K
Garcia,I., Innis-Whitehouse,W., Lopez,A., Keniry,M. and Gilkerson,R. Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells Redox Rep (2018) 23, 160-167. PubMed Europe PubMed DOI K

2016

Bohovych,I., Kastora,S., Christianson,S., Topil,D., Kim,H., Fangman,T., Zhou,Y.J., Barrientos,A., Lee,J., Brown,A.J. and Khalimonchuk,O. Oma1 links mitochondrial protein quality control and TOR signaling to modulate physiological plasticity and cellular stress responses Mol Cell Biol (2016) 36, 2300-2312. PubMed Europe PubMed DOI
MacVicar,T. and Langer,T. OPA1 processing in cell death and disease - the long and short of it J Cell Sci (2016) 129, 2297-2306. PubMed Europe PubMed DOI

2015

Bohovych,I., Fernandez,M.R., Rahn,J.J., Stackley,K.D., Bestman,J.E., Anandhan,A., Franco,R., Claypool,S.M., Lewis,R.E., Chan,S.S. and Khalimonchuk,O. Metalloprotease OMA1 fine-tunes mitochondrial bioenergetic function and respiratory supercomplex stability Sci Rep (2015) 5, 13989-13989. PubMed Europe PubMed DOI PMC EPMC

2014

Anand,R., Wai,T., Baker,M.J., Kladt,N., Schauss,A.C., Rugarli,E. and Langer,T. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission J Cell Biol (2014) 204, 919-929. PubMed Europe PubMed DOI
Baker,M.J., Lampe,P.A., Stojanovski,D., Korwitz,A., Anand,R., Tatsuta,T. and Langer,T. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics EMBO J (2014) 33, 578-593. PubMed Europe PubMed DOI
Bohovych,I., Donaldson,G., Christianson,S., Zahayko,N. and Khalimonchuk,O. Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast J Biol Chem (2014) 289, 13259-13272. PubMed Europe PubMed DOI
Jiang,X., Jiang,H., Shen,Z. and Wang,X. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis Proc Natl Acad Sci U S A (2014) 111, 14782-14787. PubMed Europe PubMed DOI
Macvicar,T.D. and Lane,J.D. Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation J Cell Sci (2014) 127, 2313-2325. PubMed Europe PubMed DOI
Xiao,X., Hu,Y., Quiros,P.M., Wei,Q., Lopez-Otin,C. and Dong,Z. OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury Am J Physiol Renal Physiol (2014) 306, F1318-F1326. PubMed Europe PubMed DOI
Zhang,K., Li,H. and Song,Z. Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage EMBO Rep (2014) 15, 576-585. PubMed Europe PubMed DOI

2013

Quiros,P.M., Ramsay,A.J. and Lopez-Otin,C. New roles for OMA1 metalloprotease: from mitochondrial proteostasis to metabolic homeostasis Adipocyte (2013) 2, 7-11. PubMed Europe PubMed DOI PMC EPMC K

2012

Khalimonchuk,O., Jeong,M.Y., Watts,T., Ferris,E. and Winge,D.R. Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants J Biol Chem (2012) 287, 7289-7300. PubMed Europe PubMed DOI
Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E., Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A., Enriquez,J.A., Zorzano,A. and Lopez-Otin,C. Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice EMBO J (2012) 31, 2117-2133. PubMed Europe PubMed DOI K

2009

Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S., Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and Langer,T. Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1 J Cell Biol (2009) 187, 1023-1036. PubMed Europe PubMed DOI
Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der Bliek,A.M. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells J Cell Biol (2009) 187, 959-966. PubMed Europe PubMed DOI
Short,B. Mitochondrial proteases strike the right balance. Two studies reveal how proteases combine to regulate mitochondrial fusion J Cell Biol (2009) 187, 937-937. DOI

2003

[YEAR:8-9-2003]Kaser,M., Kambacheld,M., Kisters-Woike,B. and Langer,T. Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease J Biol Chem (8-9-2003) 278, 46414-46423. PubMed Europe PubMed DOI