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Literature for peptidase M48.018: Oma1 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ludwig,K. and Heidorn-Czarna,M.
    Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast
    Plant Cell Physiol (2025) PubMed  Europe PubMed DOI  V
  2. Wu,L.Z., Huang,Y.Y., Hu,H.J., Hong,W.B., Yan,H., Ai,Y.L., Mi,X.Y., Feng,D.Y., Guo,J.Y., Ding,Y., Liu,Z.J., Zhou,B., Xiao,L., Lin,T., Li,F.N., Chen,X.Q., Chen,H.Z. and Wu,Q.
    Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage
    Signal Transduct Target Ther (2025) 10, 413-413. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Chen,L., Chen,D., Pan,Y., Mo,Y., Lai,B., Chen,H., Zhang,D.W. and Xia,X.D.
    Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis
    Cell Death Dis (2024) 15, 786-786. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Krakowczyk,M., Lenkiewicz,A.M., Sitarz,T., Malinska,D., Borrero,M., Mussulini,B.H.M., Linke,V., Szczepankiewicz,A.A., Biazik,J.M., Wydrych,A., Nieznanska,H., Serwa,R.A., Chacinska,A. and Bragoszewski,P.
    OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization
    J Cell Biol (2024) 223 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Purohit,G., Ghosh,P. and Khalimonchuk,O.
    Mitochondrial metallopeptidase OMA1 in cancer
    Adv Cancer Res (2024) 162, 75-97. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Qiu,J., Yue,F., Zhu,P., Chen,J., Xu,F., Zhang,L., Kim,K.H., Snyder,M.M., Luo,N., Xu,H.W., Huang,F., Tao,W.A. and Kuang,S.
    FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
    Nat Commun (2023) 14, 6344-6344. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Alavi,M.V.
    Recent advances in, and challenges of, designing OMA1 drug screens
    Pharmacol Res (2022) 176, 106063-106063. PubMed  Europe PubMed DOI
  8. Heidorn-Czarna,M., Maziak,A. and Janska,H.
    Protein Processing in Plant Mitochondria Compared to Yeast and Mammals
    Front Plant Sci (2022) 13, 824080-824080. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Shammas,M.K., Huang,X., Wu,B.P., Fessler,E., Song,I.Y., Randolph,N.P., Li,Y., Bleck,C.K., Springer,D.A., Fratter,C., Barbosa,I.A., Powers,A.F., Quiros,P.M., Lopez-Otin,C., Jae,L.T., Poulton,J. and Narendra,D.P.
    OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy
    J Clin Invest (2022) 132 PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Gilkerson,R., de La Torre,P. and St Vallier,S.
    Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response
    Front Cell Dev Biol (2021) 9, 626117-626117. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Maziak,A., Heidorn-Czarna,M., Weremczuk,A. and Janska,H.
    FTSH4 and OMA1 mitochondrial proteases reduce moderate heat stress-induced protein aggregation
    Plant Physiol (2021) 187, 769-786. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Tobacyk,J. and MacMillan-Crow,L.A.
    Fluorescence-Based Assay For Measuring OMA1 Activity
    Methods Mol Biol (2021) 2276, 325-332. PubMed  Europe PubMed DOI
  13. Viana,M.P., Levytskyy,R.M., Anand,R., Reichert,A.S. and Khalimonchuk,O.
    Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex
    iScience (2021) 24, 102119-102119. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2020
  14. Alavi,M.V.
    OMA1-An integral membrane protease?
    Biochim Biophys Acta Proteins Proteom (2020) , 140558-140558. PubMed  Europe PubMed DOI  V
  15. Liu,Y.T., Huang,X., Nguyen,D., Shammas,M.K., Wu,B.P., Dombi,E., Springer,D.A., Poulton,J., Sekine,S. and Narendra,D.P.
    Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations
    Hum Mol Genet (2020) 29, 1547-1567. PubMed  Europe PubMed DOI
  16. Noh,S., Phorl,S., Naskar,R., Oeum,K., Seo,Y., Kim,E., Kweon,H.S. and Lee,J.Y.
    p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis
    Sci Rep (2020) 10, 10618-10618. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2019
  17. Bohovych,I., Dietz,J.V., Swenson,S., Zahayko,N. and Khalimonchuk,O.
    Redox regulation of the mitochondrial quality control protease Oma1
    Antioxid Redox Signal (2019) 31, 429-443. PubMed  Europe PubMed DOI
  18. Daverey,A., Levytskyy,R.M., Stanke,K.M., Viana,M.P., Swenson,S., Hayward,S.L., Narasimhan,M., Khalimonchuk,O. and Kidambi,S.
    Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells
    Sci Rep (2019) 9, 14746-14746. PubMed  Europe PubMed DOI  PMC  EPMC  K
  19. Tobacyk,J., Parajuli,N., Shrum,S., Crow,J.P. and MacMillan-Crow,L.A.
    The first direct activity assay for the mitochondrial protease OMA1
    Mitochondrion (2019) 46, 1-5. PubMed  Europe PubMed DOI  A
    20. 2018
  20. Acin-Perez,R., Lechuga-Vieco,A.V., Del Mar Munoz,M., Nieto-Arellano,R., Torroja,C., Sanchez-Cabo,F., Jimenez,C., Gonzalez-Guerra,A., Carrascoso,I., Beninca,C., Quiros,P.M., Lopez-Otin,C., Castellano,J.M., Ruiz-Cabello,J., Jimenez-Borreguero,L.J. and Enriquez,J.A.
    Ablation of the stress protease OMA1 protects against heart failure in mice
    Sci Transl Med (2018) 10 PubMed  Europe PubMed DOI  K
  21. Garcia,I., Innis-Whitehouse,W., Lopez,A., Keniry,M. and Gilkerson,R.
    Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells
    Redox Rep (2018) 23, 160-167. PubMed  Europe PubMed DOI  K
    22. 2016
  22. Bohovych,I., Kastora,S., Christianson,S., Topil,D., Kim,H., Fangman,T., Zhou,Y.J., Barrientos,A., Lee,J., Brown,A.J. and Khalimonchuk,O.
    Oma1 links mitochondrial protein quality control and TOR signaling to modulate physiological plasticity and cellular stress responses
    Mol Cell Biol (2016) 36, 2300-2312. PubMed  Europe PubMed DOI
  23. MacVicar,T. and Langer,T.
    OPA1 processing in cell death and disease - the long and short of it
    J Cell Sci (2016) 129, 2297-2306. PubMed  Europe PubMed DOI
    24. 2015
  24. Bohovych,I., Fernandez,M.R., Rahn,J.J., Stackley,K.D., Bestman,J.E., Anandhan,A., Franco,R., Claypool,S.M., Lewis,R.E., Chan,S.S. and Khalimonchuk,O.
    Metalloprotease OMA1 fine-tunes mitochondrial bioenergetic function and respiratory supercomplex stability
    Sci Rep (2015) 5, 13989-13989. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2014
  25. Anand,R., Wai,T., Baker,M.J., Kladt,N., Schauss,A.C., Rugarli,E. and Langer,T.
    The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
    J Cell Biol (2014) 204, 919-929. PubMed  Europe PubMed DOI
  26. Baker,M.J., Lampe,P.A., Stojanovski,D., Korwitz,A., Anand,R., Tatsuta,T. and Langer,T.
    Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics
    EMBO J (2014) 33, 578-593. PubMed  Europe PubMed DOI
  27. Bohovych,I., Donaldson,G., Christianson,S., Zahayko,N. and Khalimonchuk,O.
    Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast
    J Biol Chem (2014) 289, 13259-13272. PubMed  Europe PubMed DOI
  28. Jiang,X., Jiang,H., Shen,Z. and Wang,X.
    Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
    Proc Natl Acad Sci U S A (2014) 111, 14782-14787. PubMed  Europe PubMed DOI
  29. Macvicar,T.D. and Lane,J.D.
    Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation
    J Cell Sci (2014) 127, 2313-2325. PubMed  Europe PubMed DOI
  30. Xiao,X., Hu,Y., Quiros,P.M., Wei,Q., Lopez-Otin,C. and Dong,Z.
    OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury
    Am J Physiol Renal Physiol (2014) 306, F1318-F1326. PubMed  Europe PubMed DOI
  31. Zhang,K., Li,H. and Song,Z.
    Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage
    EMBO Rep (2014) 15, 576-585. PubMed  Europe PubMed DOI
    32. 2013
  32. Quiros,P.M., Ramsay,A.J. and Lopez-Otin,C.
    New roles for OMA1 metalloprotease: from mitochondrial proteostasis to metabolic homeostasis
    Adipocyte (2013) 2, 7-11. PubMed  Europe PubMed DOI  PMC  EPMC  K
    33. 2012
  33. Khalimonchuk,O., Jeong,M.Y., Watts,T., Ferris,E. and Winge,D.R.
    Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants
    J Biol Chem (2012) 287, 7289-7300. PubMed  Europe PubMed DOI
  34. Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E., Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A., Enriquez,J.A., Zorzano,A. and Lopez-Otin,C.
    Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
    EMBO J (2012) 31, 2117-2133. PubMed  Europe PubMed DOI  K
    35. 2009
  35. Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S., Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and Langer,T.
    Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
    J Cell Biol (2009) 187, 1023-1036. PubMed  Europe PubMed DOI
  36. Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der Bliek,A.M.
    Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
    J Cell Biol (2009) 187, 959-966. PubMed  Europe PubMed DOI
  37. Short,B.
    Mitochondrial proteases strike the right balance. Two studies reveal how proteases combine to regulate mitochondrial fusion
    J Cell Biol (2009) 187, 937-937. DOI
    38. 2003
  38. [YEAR:8-9-2003]Kaser,M., Kambacheld,M., Kisters-Woike,B. and Langer,T.
    Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease
    J Biol Chem (8-9-2003) 278, 46414-46423. PubMed  Europe PubMed DOI

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