Literature for peptidase M48.003: farnesylated-protein converting enzyme 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2023

Kaufmann,L., Pilic,J., Auinger,L., Mayer,A.L., Blatterer,J., Semmler-Bruckner,J., Abbas,S., Rehman,K., Ayaz,M., Graier,W.F., Malli,R., Petek,E., Wagner,K., Al Kaissi,A., Khan,M.A. and Windpassinger,C. Analysis of a non-lethal biallelic frameshift mutation in ZMPSTE24 reveals utilization of alternative translation initiation codons Clin Genet (2023) 104, 491-496. PubMed Europe PubMed DOI
Ververi,A., Babatseva,E., Mitsiakos,G., Karagiannopoulou,G., Malakozi,M., Patsatsi,A., Diamanti,E. and Garg,A. Restrictive dermopathy due to ZMPSTE24 deficiency Clin Dysmorphol (2023) 32, 92-94. PubMed Europe PubMed DOI PMC EPMC
Worman,H.J. and Michaelis,S. Prelamin A and ZMPSTE24 in premature and physiological aging Nucleus (2023) 14, 2270345-2270345. PubMed Europe PubMed DOI PMC EPMC V

2022

Hsu,T.C., Yu,P.H., Chang,Y.H., Guevara,B.E.K., Tsai,M.C., Yang,M.H., Tsai,P.Y., Lee,J.Y., Chao,S.C. and Hsu,C.K. Novel compound heterozygous indel ZMPSTE24 mutations in a Taiwanese male infant with restrictive dermopathy J Dermatol (2022) 49, e280-e280. PubMed Europe PubMed DOI
Schaflinger,E., Blatterer,J., Khan,A.S., Kaufmann,L., Auinger,L., Tatrai,B., Abbasi,S.W., Zeeshan Ali,M., Abbasi,A.A., Al Kaissi,A., Petek,E., Wagner,K., Ahmad Khan,M. and Windpassinger,C. An exceptional biallelic N-terminal frame shift mutation in ZMPSTE24 leads to non-lethal progeria due to possible utilization of a downstream alternative start codon Gene (2022) 833, 146582-146582. PubMed Europe PubMed DOI
Shilagardi,K., Spear,E.D., Abraham,R., Griffin,D.E. and Michaelis,S. The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation MBio (2022) 13, e0254322-e0254322. PubMed Europe PubMed DOI PMC EPMC K
Wang,Y., Shilagardi,K., Hsu,T., Odinammadu,K.O., Maruyama,T., Wu,W., Lin,C.S., Damoci,C.B., Spear,E.D., Shin,J.Y., Hsu,W., Michaelis,S. and Worman,H.J. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice Proc Natl Acad Sci U S A (2022) 119 PubMed Europe PubMed DOI PMC EPMC
Wu,D.D., Li,R., Li,X.N., Liu,Q.Q. and Dou,L.H. Diagnosis and genetic analysis of a case with mandibuloacral dysplasia type B due to compound heterozygous mutations of the ZMPSTE24 gene Yi Chuan (2022) 44, 1167-1174. PubMed Europe PubMed DOI

2020

Babatz,T.D., Spear,E.D., Xu,W., Sun,O.L., Nie,L., Carpenter,E.P. and Michaelis,S. Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24 J Biol Chem (2020) PubMed Europe PubMed DOI
Goblirsch,B.R., Pryor EE Jr and Wiener,M.C. The tripartite architecture of the eukaryotic integral membrane protein zinc metalloprotease Ste24 Proteins (2020) 88, 604-615. PubMed Europe PubMed DOI
Goblirsch,B.R. and Wiener,M.C. Ste24: An integral membrane protein zinc metalloprotease with provocative structure and emergent biology J Mol Biol (2020) PubMed Europe PubMed DOI V
Wood,K.M., Spear,E.D., Mossberg,O.W., Odinammadu,K.O., Xu,W. and Michaelis,S. Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24 PLoS ONE (2020) 15, e0239269-e0239269. PubMed Europe PubMed DOI PMC EPMC

2019

Spear,E.D., Alford,R.F., Babatz,T.D., Wood,K.M., Mossberg,O.W., Odinammadu,K., Shilagardi,K., Gray,J.J. and Michaelis,S. A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24 Methods (2019) 157, 47-55. PubMed Europe PubMed DOI

2018

Goblirsch,B.R., Arachea,B.T., Councell,D.J. and Wiener,M.C. Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24 Acta Crystallogr D Struct Biol (2018) 74, 739-747. PubMed Europe PubMed DOI PMC EPMC A S
Kayatekin,C., Amasino,A., Gaglia,G., Flannick,J., Bonner,J.M., Fanning,S., Narayan,P., Barrasa,M.I., Pincus,D., Landgraf,D., Nelson,J., Hesse,W.R., Costanzo,M., Myers,C.L., Boone,C., Florez,J.C. and Lindquist,S. Translocon declogger Ste24 protects against IAPP oligomer-induced proteotoxicity Cell (2018) 173, 62-73. PubMed Europe PubMed DOI

2017

Clark,K.M., Jenkins,J.L., Fedoriw,N. and Dumont,M.E. Human CaaX protease ZMPSTE24 expressed in yeast: structure and inhibition by HIV protease inhibitors Protein Sci (2017) 26, 242-257. PubMed Europe PubMed DOI E S I
Fu,B., Wang,L., Li,S. and Dorf,M.E. ZMPSTE24 defends against influenza and other pathogenic viruses J Exp Med (2017) 214, 919-929. PubMed Europe PubMed DOI

2016

Afonso,P., Auclair,M., Boccara,F., Vantyghem,M.C., Katlama,C., Capeau,J., Vigouroux,C. and Caron-Debarle,M. LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: role of ZMPSTE24 downregulation Atherosclerosis (2016) 245, 200-211. PubMed Europe PubMed DOI
Casasola,A., Scalzo,D., Nandakumar,V., Halow,J., Recillas-Targa,F., Groudine,M. and Rincon-Arano,H. Prelamin A Processing, Accumulation and Distribution in Normal Cells and Laminopathy Disorders Nucleus (2016) 7, 84-102. PubMed Europe PubMed DOI
Mehmood,S., Marcoux,J., Gault,J., Quigley,A., Michaelis,S., Young,S.G., Carpenter,E.P. and Robinson,C.V. Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24 Nat Chem (2016) 8, 1152-1158. PubMed Europe PubMed DOI PMC EPMC

2013

Michaelis,S. and Hrycyna,C.A. Biochemistry. A protease for the ages Science (2013) 339, 1529-1530. PubMed Europe PubMed DOI
Quigley,A., Dong,Y.Y., Pike,A.C., Dong,L., Shrestha,L., Berridge,G., Stansfeld,P.J., Sansom,M.S., Edwards,A.M., Bountra,C., von Delft,F., Bullock,A.N., Burgess-Brown,N.A. and Carpenter,E.P. The structural basis of ZMPSTE24-dependent laminopathies Science (2013) 339, 1604-1607. PubMed Europe PubMed DOI M S

2012

Adolphsen,K., Amell,A., Havko,N., Kevorkian,S., Mears,K., Neher,H., Schwarz,D. and Schulze,S.R. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster G3 (Bethesda) (2012) 2, 629-642. PubMed Europe PubMed DOI PMC EPMC K
Barrowman,J., Wiley,P.A., Hudon-Miller,S.E., Hrycyna,C.A. and Michaelis,S. Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity Hum Mol Genet (2012) 21, 4084-4093. PubMed Europe PubMed DOI M
Barrowman,J., Hamblet,C., Kane,M.S. and Michaelis,S. Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24 PLoS ONE (2012) 7, e32120-e32120. PubMed Europe PubMed DOI PMC EPMC P
Young,S.G., Coffinier,C., Jung,H.J. and Fong,L.G. Mammalian farnesylated protein-converting enzyme 1 [ISSN:978-0-12-407744-7] (2012) 3, 677-682. DOI

2010

Osorio,F.G., Varela,I., Lara,E., Puente,X.S., Espada,J., Santoro,R., Freije,J.M., Fraga,M.F. and Lopez-Otin,C. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease Aging Cell (2010) 9, 947-957. PubMed Europe PubMed DOI K

2009

Barrowman,J. and Michaelis,S. ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders Biol Chem (2009) 390, 761-773. PubMed Europe PubMed DOI
Rivas,D., Li,W., Akter,R., Henderson,J.E. and Duque,G. Accelerated features of age-related bone loss in Zmpste24 metalloproteinase-deficient mice J Gerontol A Biol Sci Med Sci (2009) 64, 1015-1024. PubMed Europe PubMed DOI K

2008

Barrowman,J., Hamblet,C., George,C.M. and Michaelis,S. Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment Mol Biol Cell (2008) 19, 5398-5408. PubMed Europe PubMed DOI PMC EPMC
Bracha-Drori,K., Shichrur,K., Lubetzky,T.C. and Yalovsky,S. Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting Plant Physiol (2008) 148, 119-131. PubMed Europe PubMed DOI PMC EPMC
Coffinier,C., Hudon,S.E., Lee,R., Farber,E.A., Nobumori,C., Miner,J.H., Andres,D.A., Spielmann,H.P., Hrycyna,C.A., Fong,L.G. and Young,S.G. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells J Biol Chem (2008) 283, 9797-9804. PubMed Europe PubMed DOI PMC EPMC I
de Carlos,F., Varela,I., Germana,A., Montalbano,G., Freije,J.M., Vega,J.A., Lopez-Otin,C. and Cobo,J.M. Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice J Anat (2008) 213, 509-519. PubMed Europe PubMed DOI K
Espada,J., Varela,I., Flores,I., Ugalde,A.P., Cadinanos,J., Pendas,A.M., Stewart,C.L., Tryggvason,K., Blasco,M.A., Freije,J.M. and Lopez-Otin,C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice J Cell Biol (2008) 181, 27-35. PubMed Europe PubMed DOI PMC EPMC K
Marino,G., Ugalde,A.P., Salvador-Montoliu,N., Varela,I., Quiros,P.M., Cadinanos,J., van der Pluijm,I., Freije,J.M. and Lopez-Otin,C. Premature aging in mice activates a systemic metabolic response involving autophagy induction Hum Mol Genet (2008) 17, 2196-2211. PubMed Europe PubMed DOI K
Miyoshi,Y., Akagi,M., Agarwal,A.K., Namba,N., Kato-Nishimura,K., Mohri,I., Yamagata,M., Nakajima,S., Mushiake,S., Shima,M., Auchus,R.J., Taniike,M., Garg,A. and Ozono,K. Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings Clin Genet (2008) 73, 535-544. PubMed Europe PubMed DOI PMC EPMC M
Sander,C.S., Salman,N., van Geel,M., Broers,J.L., Al-Rahmani,A., Chedid,F., Hausser,I., Oji,V., Al Nuaimi,K., Berger,T.G. and Verstraeten,V.L. A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East Br J Dermatol (2008) 159, 961-967. PubMed Europe PubMed DOI

2007

Coffinier,C., Hudon,S.E., Farber,E.A., Chang,S.Y., Hrycyna,C.A., Young,S.G. and Fong,L.G. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells Proc Natl Acad Sci U S A (2007) 104, 13432-13437. PubMed Europe PubMed DOI PMC EPMC I

2006

Agarwal,A.K., Zhou,X.J., Hall,R.K., Nicholls,K., Bankier,A., Van Esch,H., Fryns,J.P. and Garg,A. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency J Investig Med (2006) 54, 208-213. PubMed Europe PubMed DOI M
[YEAR:27-4-2006]Cai,G.B., Bae,Y.A., Kim,S.H., Na,B.K., Kim,T.S., Jiang,M.S. and Kong,Y. A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family Int J Parasitol (27-4-2006) 36, 925-935. PubMed Europe PubMed DOI
Denecke,J., Brune,T., Feldhaus,T., Robenek,H., Kranz,C., Auchus,R.J., Agarwal,A.K. and Marquardt,T. A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS Hum Mutat (2006) 27, 524-531. PubMed Europe PubMed DOI K M

2005

[YEAR:1-4-2005]Corrigan,D.P., Kuszczak,D., Rusinol,A.E., Thewke,D.P., Hrycyna,C.A., Michaelis,S. and Sinensky,M.S. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24 Biochem J (1-4-2005) 387, 129-138. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-2-2005]Gruber,J., Lampe,T., Osborn,M. and Weber,K. RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome J Cell Sci (15-2-2005) 118, 689-696. PubMed Europe PubMed DOI
Liu,B., Wang,J., Chan,K.M., Tjia,W.M., Deng,W., Guan,X., Huang,J.D., Li,K.M., Chau,P.Y., Chen,D.J., Pei,D., Pendas,A.M., Cadinanos,J., Lopez-Otin,C., Tse,H.F., Hutchison,C., Chen,J., Cao,Y., Cheah,K.S., Tryggvason,K. and Zhou,Z. Genomic instability in laminopathy-based premature aging Nat Med (2005) 11, 780-785. PubMed Europe PubMed DOI K
Moulson,C.L., Go,G., Gardner,J.M., van der Wal,A.C., Smitt,J.H., van Hagen,J.M. and Miner,J.H. Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy J Invest Dermatol (2005) 125, 913-919. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:20-4-2005]Navarro,C.L., Cadinanos,J., De Sandre-Giovannoli,A., Bernard,R., Courrier,S., Boccaccio,I., Boyer,A., Kleijer,W.J., Wagner,A., Giuliano,F., Beemer,F.A., Freije,J.M., Cau,P., Hennekam,R.C., Lopez-Otin,C., Badens,C. and Levy,N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of lamin A precursors Hum Mol Genet (20-4-2005) 14, 1503-1513. PubMed Europe PubMed DOI M
Shackleton,S., Smallwood,D.T., Clayton,P., Wilson,L.C., Agarwal,A.K., Garg,A. and Trembath,R.C. Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype J Med Genet (2005) 42, e36-e36. PubMed Europe PubMed DOI PMC EPMC M
Toth,J.I., Yang,S.H., Qiao,X., Beigneux,A.P., Gelb,M.H., Moulson,C.L., Miner,J.H., Young,S.G. and Fong,L.G. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes Proc Natl Acad Sci U S A (2005) 102, 12873-12878. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:3-8-2005]Varela,I., Cadinanos,J., Pendas,A.M., Gutierrez-Fernandez,A., Folgueras,A.R., Sanchez,L.M., Zhou,Z., Rodriguez,F.J., Stewart,C.L., Vega,J.A., Tryggvason,K., Freije,J.M. and Lopez-Otin,C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation Nature (3-8-2005) 437, 564-568. PubMed Europe PubMed DOI
[YEAR:5-10-2005]Young,S.G., Fong,L.G. and Michaelis,S. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria - New evidence suggesting that protein farnesylation could be important for disease pathogenesis J Lipid Res (5-10-2005) 46, 2531-2558. PubMed Europe PubMed DOI

2004

Bergo,M.O. and Young,S.G. Mammalian farnesylated protein-converting enzyme 1 [ISSN:0-12-079610-4] (2004) 2, 466-468. V
Fong,L.G., Ng,J.K., Meta,M., Cote,N., Yang,S.H., Stewart,C.L., Sullivan,T., Burghardt,A., Majumdar,S., Reue,K., Bergo,M.O. and Young,S.G. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice Proc Natl Acad Sci U S A (2004) 101, 18111-18116. PubMed Europe PubMed DOI PMC EPMC K

2003

[YEAR:15-8-2003]Agarwal,A.K., Fryns,J.P., Auchus,R.J. and Garg,A. Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia Hum Mol Genet (15-8-2003) 12, 1995-2001. PubMed Europe PubMed DOI M
[YEAR:15-3-2003]Cadinanos,J., Schmidt,W.K., Fueyo,A., Varela,I., Lopez-Otin,C. and Freije,J.M. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans Biochem J (15-3-2003) 370, 1047-1054. PubMed Europe PubMed DOI PMC EPMC

2002

[YEAR:1-10-2002]Bergo,M.O., Gavino,B., Ross,J., Schmidt,W.K., Hong,C., Kendall,L.V., Mohr,A., Meta,M., Genant,H., Jiang,Y., Wisner,E.R., Van Bruggen,N., Carano,R.A., Michaelis,S., Griffey,S.M. and Young,S.G. Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect Proc Natl Acad Sci U S A (1-10-2002) 99, 13049-13054. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:16-8-2002]Bracha,K., Lavy,M. and Yalovsky,S. The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity J Biol Chem (16-8-2002) 277, 29856-29864. PubMed Europe PubMed DOI
Pendas,A.M., Zhou,Z., Cadinanos,J., Freije,J.M., Wang,J., Hultenby,K., Astudillo,A., Wernerson,A., Rodriguez,F., Tryggvason,K. and Lopez-Otin,C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice Nat Genet (2002) 31, 94-99. PubMed Europe PubMed DOI K

2001

[YEAR:3-8-2001]Leung,G.K., Schmidt,W.K., Bergo,M.O., Gavino,B., Wong,D.H., Tam,A., Ashby,M.N., Michaelis,S. and Young,S.G. Biochemical studies of Zmpste24-deficient mice J Biol Chem (3-8-2001) 276, 29051-29058. PubMed Europe PubMed DOI K

2000

[YEAR:3-3-2000]Schmidt,W.K., Tam,A. and Michaelis,S. Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis J Biol Chem (3-3-2000) 275, 6227-6233. PubMed Europe PubMed DOI
Young,S.G., Ambroziak,P., Kim,E. and Clarke,S. Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase (2000) , 155-213.

1999

[YEAR:15-6-1999]Freije,J.M., Blay,P., Pendas,A.M., Cadinanos,J., Crespo,P. and Lopez-Otin,C. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins Genomics (15-6-1999) 58, 270-280. PubMed Europe PubMed DOI
[YEAR:30-4-1999]Kilic,F., Johnson,D.A. and Sinensky,M. Subcellular localization and partial purification of prelamin A endoprotease: an enzyme which catalyzes the conversion of farnesylated prelamin A to mature lamin A FEBS Lett (30-4-1999) 450, 61-65. PubMed Europe PubMed DOI
[YEAR:2-2-1999]Kumagai,H., Kawamura,Y., Yanagisawa,K. and Komano,H. Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p Biochim Biophys Acta (2-2-1999) 1426, 468-474. PubMed Europe PubMed DOI

1998

[YEAR:25-9-1998]Chen,Y. Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease Cancer Lett (25-9-1998) 131, 191-200. PubMed Europe PubMed DOI I

1997

Kilic,F., Salas-Marco,J., Garland,J. and Sinensky,M. Regulation of prelamin A endoprotease activity by prelamin A FEBS Lett (1997) 414, 65-68. PubMed Europe PubMed DOI
Kilic,F., Dalton,M.B., Burrell,S.K., Mayer,J.P., Patterson,S.D. and Sinensky,M. In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease J Biol Chem (1997) 272, 5298-5304. PubMed Europe PubMed DOI A
Nishii,W., Muramatsu,T., Kuchino,Y., Yokoyama,S. and Takahashi,K. Partial purification and characterization of a CAAX-motif-specific protease from bovine brain using a novel fluorometric assay J Biochem (1997) 122, 402-408. PubMed Europe PubMed A

1996

Hitz,A.M. and Georgopapadakou,N.H. Mammalian microsomal and soluble Ras-processing peptidase activities are distinct FEBS Lett (1996) 391, 310-312. PubMed Europe PubMed DOI