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Literature for peptidase M41.026: YME1L1 g.p. (Homo sapiens) and similar

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: M Mutation, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Demetriadou,A., Grafakou,O., Georgiou,T., Burska,D., Malekkou,A., Krizova,J., Paramera,E., Mavrikiou,G., Dionysiou,M., Theodosiou,A., Sismani,C., Anastasiadou,V., Ioannou,I., Papakonstantinou,E., Hansikova,H., Drousiotou,A. and Petrou,P.P.
    YME1L1 Dysfunction Associated With 3-Methylglutaconic Aciduria
    J Inherit Metab Dis (2025) 48, e70029-e70029. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Eldeeb,M.A., Shahid,M. and Fon,E.A.
    Cell biology: Mitochondrial protease degrades unoccupied translocases upon import stress
    Curr Biol (2025) 35, R287-R287. PubMed  Europe PubMed DOI
  3. Hsu,M.C., Kinefuchi,H., Lei,L., Kikuchi,R., Yamano,K. and Youle,R.J.
    Mitochondrial YME1L1 governs unoccupied protein translocase channels
    Nat Cell Biol (2025) PubMed  Europe PubMed DOI
  4. Wu,M., Qian,W., Xu,M., Zhang,J., Gao,F., Chen,L. and Huang,S.
    YME1L facilitates the development of non-small cell lung cancer by promoting activation of mitochondria-Galphai1-Akt pathway
    Cancer Genet (2025) 298-299, 212-220. PubMed  Europe PubMed DOI  K
    5. 2024
  5. Baker,M.J., Blau,K.U., Anderson,A.J., Palmer,C.S., Fielden,L.F., Crameri,J.J., Milenkovic,D., Thorburn,D.R., Frazier,A.E., Langer,T. and Stojanovski,D.
    CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
    J Cell Biol (2024) 223 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Tan,S., Dengler,A.S., Darawsheh,R.Z. and Kory,N.
    The iAAA-mitochondrial protease YME1L1 regulates the degradation of the short-lived mitochondrial transporter SLC25A38
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  7. Xin,W., Zhou,J., Peng,Y., Gong,S., Liao,W., Wang,Y., Huang,X., Mao,Y., Yao,M., Qin,S., Xiong,J., Li,Y., Lan,Q., Huang,Y. and Zhao,J.
    SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells
    Adv Sci (Weinh) (2024) , e2412233-e2412233. PubMed  Europe PubMed DOI
    8. 2023
  8. Qiu,J., Yue,F., Zhu,P., Chen,J., Xu,F., Zhang,L., Kim,K.H., Snyder,M.M., Luo,N., Xu,H.W., Huang,F., Tao,W.A. and Kuang,S.
    FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
    Nat Commun (2023) 14, 6344-6344. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zhou,D., Sun,M.H., Jiang,W.J., Li,X.H., Lee,S.H., Heo,G., Choi,J., Kim,K.S. and Cui,X.S.
    Knock-down of YME1L1 induces mitochondrial dysfunction during early porcine embryonic development
    Front Cell Dev Biol (2023) 11, 1147095-1147095. PubMed  Europe PubMed DOI  PMC  EPMC  K
    10. 2022
  10. Purandare,N., Kunji,Y., Xi,Y., Romero,R., Gomez-Lopez,N., Fribley,A., Grossman,L.I. and Aras,S.
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
    iScience (2022) 25, 105342-105342. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Sprenger,H.G., MacVicar,T., Bahat,A., Fiedler,K.U., Hermans,S., Ehrentraut,D., Ried,K., Milenkovic,D., Bonekamp,N., Larsson,N.G., Nolte,H., Giavalisco,P. and Langer,T.
    Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
    Nat Metab (2021) 3, 636-650. PubMed  Europe PubMed DOI
    12. 2020
  12. Lee,Y.J., Kim,G.H., Park,S.I. and Lim,J.H.
    Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation
    J Cell Mol Med (2020) 24, 899-909. PubMed  Europe PubMed DOI  K
  13. Li,S., Wu,Z., Tantray,I., Li,Y., Chen,S., Dong,J., Glynn,S., Vogel,H., Snyder,M. and Lu,B.
    Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD
    Proc Natl Acad Sci U S A (2020) 117, 25104-25115. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Miller,J.M., Brambley,C.A. and Marsee,J.D.
    Examination of the Role of Mg(2+) in the Mechanism of Nucleotide Binding to the Monomeric YME1L AAA+ Domain
    Biochemistry (2020) 59, 4303-4320. PubMed  Europe PubMed DOI
  15. Moore,S., Pickens,A., Rodriguez,J.L., Marsee,J.D. and Miller,J.M.
    Fluorescence methods applied to the description of urea-dependent YME1L protease unfolding
    Biomolecules (2020) 10, 656-656. PubMed  Europe PubMed DOI
  16. Ohba,Y., MacVicar,T. and Langer,T.
    Regulation of mitochondrial plasticity by the i-AAA protease YME1L
    Biol Chem (2020) 401, 877-890. PubMed  Europe PubMed DOI
    17. 2019
  17. Ando,K., Yokochi,T., Mukai,A., Wei,G., Li,Y., Kramer,S., Ozaki,T., Maehara,Y. and Nakagawara,A.
    Tumor suppressor KIF1Bbeta regulates mitochondrial apoptosis in collaboration with YME1L1
    Mol Carcinog (2019) 58, 1134-1144. PubMed  Europe PubMed DOI
  18. Brambley,C.A., Marsee,J.D., Halper,N. and Miller,J.M.
    Characterization of mitochondrial YME1L protease oxidative stress-induced conformational state
    J Mol Biol (2019) 431, 1250-1266. PubMed  Europe PubMed DOI
  19. MacVicar,T., Ohba,Y., Nolte,H., Mayer,F.C., Tatsuta,T., Sprenger,H.G., Lindner,B., Zhao,Y., Li,J., Bruns,C., Kruger,M., Habich,M., Riemer,J., Schwarzer,R., Pasparakis,M., Henschke,S., Bruning,J.C., Zamboni,N. and Langer,T.
    Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
    Nature (2019) 575, 361-365. PubMed  Europe PubMed DOI
  20. Richter,F., Dennerlein,S., Nikolov,M., Jans,D.C., Naumenko,N., Aich,A., MacVicar,T., Linden,A., Jakobs,S., Urlaub,H., Langer,T. and Rehling,P.
    ROMO1 is a constituent of the human presequence translocase required for YME1L protease import
    J Cell Biol (2019) 218, 598-614. PubMed  Europe PubMed DOI
    21. 2018
  21. Cesnekova,J., Rodinova,M., Hansikova,H., Zeman,J. and Stiburek,L.
    Loss of mitochondrial AAA proteases AFG3L2 and YME1L impairs mitochondrial structure and respiratory chain biogenesis
    Int J Mol Sci (2018) 19, 3930-3930. PubMed  Europe PubMed DOI  K
  22. Sprenger,H.G., Wani,G., Hesseling,A., Konig,T., Patron,M., MacVicar,T., Ahola,S., Wai,T., Barth,E., Rugarli,E.I., Bergami,M. and Langer,T.
    Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy
    EMBO Mol Med (2018) 11, e9288-e9288. PubMed  Europe PubMed DOI  M
    23. 2017
  23. Srinivasainagendra,V., Sandel,M.W., Singh,B., Sundaresan,A., Mooga,V.P., Bajpai,P., Tiwari,H.K. and Singh,K.K.
    Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma
    Genome Med (2017) 9, 31-31. PubMed  Europe PubMed DOI  PMC  EPMC  M
    24. 2016
  24. [YEAR:15-3-2016]Cesnekova,J., Rodinova,M., Hansikova,H., Houstek,J., Zeman,J. and Stiburek,L.
    The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits
    Biochem J (15-3-2016) 473, 797-804. PubMed  Europe PubMed
  25. Hartmann,B., Wai,T., Hu,H., MacVicar,T., Musante,L., Fischer-Zirnsak,B., Stenzel,W., Graf,R., van den Heuvel,L., Ropers,H.H., Wienker,T.F., Hubner,C., Langer,T. and Kaindl,A.M.
    Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation
    elife (2016) 5, e16078-e16078. PubMed  Europe PubMed DOI  M
  26. MacVicar,T. and Langer,T.
    OPA1 processing in cell death and disease - the long and short of it
    J Cell Sci (2016) 129, 2297-2306. PubMed  Europe PubMed DOI
  27. Rainbolt,T.K., Saunders,J.M. and Wiseman,R.L.
    YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress
    EMBO Rep (2016) 16, 97-106. PubMed  Europe PubMed DOI
  28. Shi,H., Rampello,A.J. and Glynn,S.E.
    Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
    Nat Commun (2016) 7, 13301-13301. PubMed  Europe PubMed DOI
    29. 2014
  29. Anand,R., Wai,T., Baker,M.J., Kladt,N., Schauss,A.C., Rugarli,E. and Langer,T.
    The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
    J Cell Biol (2014) 204, 919-929. PubMed  Europe PubMed DOI
    30. 2013
  30. Ruan,Y., Li,H., Zhang,K., Jian,F., Tang,J. and Song,Z.
    Loss of Yme1L perturbates mitochondrial dynamics
    Cell Death Dis (2013) 4, e896-e896. PubMed  Europe PubMed DOI
    31. 2012
  31. Stiburek,L., Cesnekova,J., Kostkova,O., Fornuskova,D., Vinsova,K., Wenchich,L., Houstek,J. and Zeman,J.
    YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation
    Mol Biol Cell (2012) 23, 1010-1023. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2009
  32. Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der Bliek,A.M.
    Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
    J Cell Biol (2009) 187, 959-966. PubMed  Europe PubMed DOI
    33. 2007
  33. Song,Z., Chen,H., Fiket,M., Alexander,C. and Chan,D.C.
    OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
    J Cell Biol (2007) 178, 749-755. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2005
  34. Coenen,M.J., Smeitink,J.A., Smeets,R., Trijbels,F.J. and van den Heuvel,L.P.
    Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system
    J Inherit Metab Dis (2005) 28, 1091-1097. PubMed  Europe PubMed DOI  M
    35. 2000
  35. [YEAR:15-5-2000]Coppola,M., Pizzigoni,A., Banfi,S., Bassi,M.T., Casari,G. and Incerti,B.
    Identification and characterization of YME1L1, a novel paraplegin-related gene
    Genomics (15-5-2000) 66, 48-54. PubMed  Europe PubMed DOI
  36. [YEAR:4-8-2000]Shah,Z.H., Hakkaart,G.A., Arku,B., de Jong,L., van der Spek,H., Grivell,L.A. and Jacobs,H.T.
    The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant
    FEBS Lett (4-8-2000) 478, 267-270. PubMed  Europe PubMed DOI

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