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Literature for peptidase M41.005: AtFtsH2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Chai,X., Chen,J., Fu,C., Zhang,J., Zhao,X., Lyu,H.N., Xia,S., Li,X., Suo,Y., Shi,Q., Wang,J. and Xu,C.
    Exploring leaf variegation in Arabidopsis yellow variegated2 by single-cell RNA sequencing
    Plant J (2026) 125, e70659-e70659. PubMed  Europe PubMed DOI
    2. 2025
  2. Wang,P., Zhu,L., Wang,X., Zhai,Y., Zhong,J., Zhang,H., Shao,J., Liu,X., Yu,F. and Qi,Y.
    Balance of chlorophyll synthesis and thylakoid protein quality control influences chloroplast development in var2
    J Exp Bot (2025) PubMed  Europe PubMed DOI
  3. Wu,W., Guo,W., Zhu,H., Li,D., Zhang,Z., Lin,D., Qu,M., Yu,Z. and Huang,J.
    Arabidopsis Leaf variegation is caused by simultaneous defects in chloroplast development and division
    Plant Commun (2025) , 101564-101564. PubMed  Europe PubMed DOI
    4. 2024
  4. Liu,D., Luo,S., Li,Z., Liang,G., Guo,Y., Xu,Y. and Chong,K.
    COG3 confers the chilling tolerance to mediate OsFtsH2-D1 module in rice
    New Phytol (2024) 241, 2143-2157. PubMed  Europe PubMed DOI
    5. 2022
  5. Wang,X., Li,Q., Zhang,Y., Pan,M., Wang,R., Sun,Y., An,L., Liu,X., Yu,F. and Qi,Y.
    VAR2/AtFtsH2 and EVR2/BCM1/CBD1 synergistically regulate the accumulation of PSII reaction centre D1 protein during de-etiolation in Arabidopsis
    Plant Cell Environ (2022) 45, 2395-2409. PubMed  Europe PubMed DOI
    6. 2021
  6. Luo,S. and Kim,C.
    Current Understanding of Temperature Stress-Responsive Chloroplast FtsH Metalloproteases
    Int J Mol Sci (2021) 22, 12106-12106. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2020
  7. Qi,Y., Wang,X., Lei,P., Li,H., Yan,L., Zhao,J., Meng,J., Shao,J., An,L., Yu,F. and Liu,X.
    The chloroplast metalloproteases VAR2 and EGY1 act synergistically to regulate chloroplast development in Arabidopsis
    J Biol Chem (2020) 295, 1036-1046. PubMed  Europe PubMed DOI
    8. 2019
  8. Kato,Y. and Sakamoto,W.
    Phosphorylation of the chloroplastic metalloprotease FtsH in Arabidopsis characterized by Phos-Tag SDS-PAGE
    Front Plant Sci (2019) 10, 1080-1080. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2018
  9. Kato,Y. and Sakamoto,W.
    FtsH protease in the thylakoid membrane: physiological functions and the regulation of protease activity
    Front Plant Sci (2018) 9, 855-855. PubMed  Europe PubMed DOI  PMC  EPMC  V
    10. 2017
  10. Dogra,V., Duan,J., Lee,K.P., Lv,S., Liu,R. and Kim,C.
    FtsH2-Dependent proteolysis of EXECUTER1 is essential in mediating singlet oxygen-triggered retrograde signaling in Arabidopsis thaliana
    Front Plant Sci (2017) 8, 1145-1145. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Wang,F., Qi,Y., Malnoe,A., Choquet,Y., Wollman,F.A. and de Vitry,C.
    The high light response and redox control of thylakoid FtsH protease in Chlamydomonas reinhardtii
    Mol Plant (2017) 10, 99-114. PubMed  Europe PubMed DOI
    12. 2016
  12. Jarvi,S., Suorsa,M., Tadini,L., Ivanauskaite,A., Rantala,S., Allahverdiyeva,Y., Leister,D. and Aro,E.M.
    Thylakoid-bound FtsH proteins facilitate proper biosynthesis of photosystem I
    Plant Physiol (2016) 171, 1333-1343. PubMed  Europe PubMed DOI  M
  13. Wang,L., Kim,C., Xu,X., Piskurewicz,U., Dogra,V., Singh,S., Mahler,H. and Apel,K.
    Singlet oxygen- and EXECUTER1-mediated signaling is initiated in grana margins and depends on the protease FtsH2
    Proc Natl Acad Sci U S A (2016) 113, E3792-E3800. PubMed  Europe PubMed DOI
    14. 2015
  14. Sacharz,J., Bryan,S.J., Yu,J., Burroughs,N.J., Spence,E.M., Nixon,P.J. and Mullineaux,C.W.
    Sub-cellular location of FtsH proteases in the cyanobacterium Synechocystis sp. PCC 6803 suggests localised PSII repair zones in the thylakoid membranes
    Mol Microbiol (2015) 96, 448-462. PubMed  Europe PubMed DOI
    15. 2014
  15. Krynicka,V., Tichy,M., Krafl,J., Yu,J., Kana,R., Boehm,M., Nixon,P.J. and Komenda,J.
    Two essential FtsH proteases control the level of the Fur repressor during iron deficiency in the cyanobacterium Synechocystis sp. PCC 6803
    Mol Microbiol (2014) 94, 609-624. PubMed  Europe PubMed DOI
  16. Malnoe,A., Wang,F., Girard-Bascou,J., Wollman,F.A. and de Vitry,C.
    Thylakoid FtsH protease contributes to photosystem II and cytochrome b6f remodeling in Chlamydomonas reinhardtii under stress conditions
    Plant Cell (2014) 26, 373-390. PubMed  Europe PubMed DOI
  17. Yoshioka-Nishimura,M. and Yamamoto,Y.
    Quality control of photosystem II: the molecular basis for the action of FtsH protease and the dynamics of the thylakoid membranes
    J Photochem Photobiol B (2014) 137, 100-106. PubMed  Europe PubMed DOI
    18. 2013
  18. Kato,Y. and Sakamoto,W.
    Possible compensatory role among chloroplast proteases under excess-light stress condition
    Plant Signal Behav (2013) 8, e23198-e23198. PubMed  Europe PubMed DOI
  19. Lucinski,R. and Jackowski,G.
    AtFtsH heterocomplex-mediated degradation of apoproteins of the major light harvesting complex of photosystem II (LHCII) in response to stresses
    J Plant Physiol (2013) 170, 1082-1089. PubMed  Europe PubMed DOI
    20. 2012
  20. Adam,Z.
    FtsH homolog in chloroplasts
    [ISSN:978-0-12-407744-7] (2012) 3, 710-713. DOI
  21. Boehm,M., Yu,J., Krynicka,V., Barker,M., Tichy,M., Komenda,J., Nixon,P.J. and Nield,J.
    Subunit organization of a Synechocystis hetero-oligomeric thylakoid FtsH complex involved in photosystem II repair
    Plant Cell (2012) 24, 3669-3683. PubMed  Europe PubMed DOI
  22. Chi,W., Sun,X. and Zhang,L.
    The roles of chloroplast proteases in the biogenesis and maintenance of photosystem II
    Biochim Biophys Acta (2012) 1817, 239-246. PubMed  Europe PubMed DOI
  23. Kato,Y., Kouso,T. and Sakamoto,W.
    Variegated tobacco leaves generated by chloroplast FtsH suppression: implication of FtsH function in the maintenance of thylakoid membranes
    Plant Cell Physiol (2012) 53, 391-404. PubMed  Europe PubMed DOI  K
  24. Kato,Y., Sun,X., Zhang,L. and Sakamoto,W.
    Cooperative D1 degradation in the photosystem II repair mediated by chloroplastic proteases in Arabidopsis
    Plant Physiol (2012) 159, 1428-1439. PubMed  Europe PubMed DOI
  25. Moldavski,O., Levin-Kravets,O., Ziv,T., Adam,Z. and Prag,G.
    The Hetero-Hexameric Nature of a Chloroplast AAA+ FtsH Protease Contributes to Its Thermodynamic Stability
    PLoS ONE (2012) 7, e36008-e36008. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Wagner,R., Aigner,H. and Funk,C.
    FtsH proteases located in the plant chloroplast
    Physiol Plant (2012) 145, 203-214. PubMed  Europe PubMed DOI
    27. 2011
  27. Adam,Z., Frottin,F., Espagne,C., Meinnel,T. and Giglione,C.
    Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis
    Plant Cell (2011) 23, 3745-3760. PubMed  Europe PubMed DOI
  28. Baranek,M., Grabsztunowicz,M., Sikora,B. and Jackowski,G.
    [ATP-dependent FtsH and Lon chloroplast proteases]
    Postepy Biochem (2011) 57, 101-108. PubMed  Europe PubMed
  29. Rodrigues,R.A., Silva-Filho,M.C. and Cline,K.
    FtsH2 and FtsH5: two homologous subunits use different integration mechanisms leading to the same thylakoid multimeric complex
    Plant J (2011) 65, 600-609. PubMed  Europe PubMed DOI
  30. Wagner,R., Aigner,H., Pruzinska,A., Jankanpaa,H.J., Jansson,S. and Funk,C.
    Fitness analyses of Arabidopsis thaliana mutants depleted of FtsH metalloproteases and characterization of three FtsH6 deletion mutants exposed to high light stress, senescence and chilling
    New Phytol (2011) 191, 449-458. PubMed  Europe PubMed DOI
  31. Yoshioka,M. and Yamamoto,Y.
    Quality control of photosystem II: where and how does the degradation of the D1 protein by FtsH proteases start under light stress? - Facts and hypotheses
    J Photochem Photobiol B (2011) 104, 229-235. PubMed  Europe PubMed DOI
  32. Yu,F., Park,S.S., Liu,X., Foudree,A., Fu,A., Powikrowska,M., Khrouchtchova,A., Jensen,P.E., Kriger,J.N., Gray,G.R. and Rodermel,S.R.
    SUPPRESSOR OF VARIEGATION4, a new var2 suppressor locus, encodes a pioneer protein that is required for chloroplast biogenesis
    Mol Plant (2011) 4, 229-240. PubMed  Europe PubMed
    33. 2010
  33. Nixon,P.J., Michoux,F., Yu,J., Boehm,M. and Komenda,J.
    Recent advances in understanding the assembly and repair of photosystem II
    Ann Bot (2010) 106, 1-16. PubMed  Europe PubMed DOI
  34. Yue,G., Hu,X., He,Y., Yang,A. and Zhang,J.
    Identification and characterization of two members of the FtsH gene family in maize (Zea mays L.)
    Mol Biol Rep (2010) 37, 855-863. PubMed  Europe PubMed DOI
    35. 2009
  35. Zhang,J. and Sun,A.
    Genome-wide comparative analysis of the metalloprotease FtsH gene families between Arabidopsis thaliana and rice
    Sheng Wu Gong Cheng Xue Bao (2009) 25, 1402-1408. PubMed  Europe PubMed
    36. 2008
  36. Yu,F., Liu,X., Alsheikh,M., Park,S. and Rodermel,S.
    Mutations in SUPPRESSOR OF VARIEGATION1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis
    Plant Cell (2008) 20, 1786-1804. PubMed  Europe PubMed DOI  PMC  EPMC
    37. 2007
  37. Komayama,K., Khatoon,M., Takenaka,D., Horie,J., Yamashita,A., Yoshioka,M., Nakayama,Y., Yoshida,M., Ohira,S., Morita,N., Velitchkova,M., Enami,I. and Yamamoto,Y.
    Quality control of photosystem II: cleavage and aggregation of heat-damaged D1 protein in spinach thylakoids
    Biochim Biophys Acta (2007) 1767, 838-846. PubMed  Europe PubMed DOI
    38. 2006
  38. [YEAR:5-4-2006]Adam,Z., Rudella,A. and van Wijk,K.J.
    Recent advances in the study of Clp, FtsH and other proteases located in chloroplasts
    Curr Opin Plant Biol (5-4-2006) 9, 234-240. PubMed  Europe PubMed DOI
  39. Aluru,M.R., Yu,F., Fu,A. and Rodermel,S.
    Arabidopsis variegation mutants: new insights into chloroplast biogenesis
    J Exp Bot (2006) 57, 1871-1881. PubMed  Europe PubMed DOI
    40. 2005
  40. Adam,Z., Zaltsman,A., Sinvany-Villalobo,G. and Sakamoto,W.
    FtsH proteases in chloroplasts and cyanobacteria
    Physiol Plant (2005) 123, 386-390.  V
  41. [YEAR:15-11-2005]Nixon,P.J., Barker,M., Boehm,M., de Vries,R. and Komenda,J.
    FtsH-mediated repair of the photosystem II complex in response to light stress
    J Exp Bot (15-11-2005) 56, 357-363. PubMed  Europe PubMed DOI
  42. Yu,F., Park,S. and Rodermel,S.R.
    Functional redundancy of AtFtsH metalloproteases in thylakoid membrane complexes
    Plant Physiol (2005) 138, 1957-1966. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Zaltsman,A., Feder,A. and Adam,Z.
    Developmental and light effects on the accumulation of FtsH protease in Arabidopsis chloroplasts - implications for thylakoid formation and photosystem II maintenance
    Plant J (2005) 42, 609-617. PubMed  Europe PubMed DOI
  44. [YEAR:26-8-2005]Zaltsman,A., Ori,N. and Adam,Z.
    Two types of FtsH protease subunits are required for chloroplast biogenesis and photosystem II repair in Arabidopsis
    Plant Cell (26-8-2005) 17, 2782-2790. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2004
  45. Adam,Z.
    Ftsh homologue in chloroplast
    [ISSN:0-12-079610-4] (2004) 2, 805-807.  V
  46. Sakamoto,W., Miura,E., Kaji,Y., Okuno,T., Nishizono,M. and Ogura,T.
    Allelic characterization of the leaf-variegated mutation var2 identifies the conserved amino acid residues of FtsH that are important for ATP hydrolysis and proteolysis
    Plant Mol Biol (2004) 56, 705-716. PubMed  Europe PubMed DOI
  47. Sinvany-Villalobo,G., Davydov,O., Ben-Ari,G., Zaltsman,A., Raskind,A. and Adam,Z.
    Expression in multigene families. Analysis of chloroplast and mitochondrial proteases
    Plant Physiol (2004) 135, 1336-1345. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Yu,F., Park,S. and Rodermel,S.R.
    The Arabidopsis FtsH metalloprotease gene family: interchangeability of subunits in chloroplast oligomeric complexes
    Plant J (2004) 37, 864-876. PubMed  Europe PubMed DOI
    49. 2003
  49. Sakamoto,W., Zaltsman,A., Adam,Z. and Takahashi,Y.
    Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes
    Plant Cell (2003) 15, 2843-2855. PubMed  Europe PubMed DOI  PMC  EPMC
    50. 2002
  50. [YEAR:18-1-2002]Bailey,S., Thompson,E., Nixon,P.J., Horton,P., Mullineaux,C.W., Robinson,C. and Mann,N.H.
    A critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivo
    J Biol Chem (18-1-2002) 277, 2006-2011. PubMed  Europe PubMed DOI
    51. 2001
  51. Adam,Z., Adamska,I., Nakabayashi,K., Ostersetzer,O., Haussuhl,K., Manuell,A., Zheng,B., Vallon,O., Rodermel,S.R., Shinozaki,K. and Clarke,A.K.
    Chloroplast and mitochondrial proteases in Arabidopsis. A proposed nomenclature
    Plant Physiol (2001) 125, 1912-1918. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2000
  52. Chen,M., Choi,Y., Voytas,D.F. and Rodermel,S.
    Mutations in the Arabidopsis VAR2 locus cause leaf variegation due to the loss of a chloroplast FtsH protease
    Plant J (2000) 22, 303-313. PubMed  Europe PubMed DOI
  53. Takechi,K., Sodmergen, Murata,M., Motoyoshi,F. and Sakamoto,W.
    The YELLOW VARIEGATED (VAR2) locus encodes a homologue of FtsH, an ATP-dependent protease in Arabidopsis
    Plant Cell Physiol (2000) 41, 1334-1346. PubMed  Europe PubMed
    54. 1999
  54. Itoh,R., Takano,H., Ohta,N., Miyagishima,S., Kuroiwa,H. and Kuroiwa,T.
    Two ftsH-family genes encoded in the nuclear and chloroplast genomes of the primitive red alga Cyanidioschyzon merolae
    Plant Mol Biol (1999) 41, 321-337. PubMed  Europe PubMed DOI

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