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Literature for peptidase M41.004: i-AAA peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fremlen,H. and Burmann,B.M.
    Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases
    Chembiocheme202500048-e202500048. PubMed  Europe PubMed DOI  V
  2. Gaur,D., Acquaviva,B. and Wohlever,M.L.
    An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors
    bioRxiv PubMed  Europe PubMed DOI
  3. Ludwig,K. and Heidorn-Czarna,M.
    Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast
    Plant Cell Physiol PubMed  Europe PubMed DOI  V
    4. 2024
  4. Ganesan,I., Pfanner,N. and Wiedemann,N.
    Screen for temperature-sensitive mutants of non-essential yeast genes
    Methods Enzymol707, 611-634. PubMed  Europe PubMed DOI
  5. Kan,K.T., Wilcock,J. and Lu,H.
    Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics
    Biochem Soc Trans52, 1539-1548. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Kumar,A., Waingankar,T.P. and D'Silva,P.
    Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity
    J Cell Sci136, PubMed  Europe PubMed DOI
  7. Matsushima,Y.
    Mitochondrial AAA+ proteases
    Enzymes54, 205-220. PubMed  Europe PubMed DOI
    8. 2022
  8. Heidorn-Czarna,M., Maziak,A. and Janska,H.
    Protein Processing in Plant Mitochondria Compared to Yeast and Mammals
    Front Plant Sci13, 824080-824080. PubMed  Europe PubMed DOI  V
  9. Kan,K.T., Nelson,M.G., Grant,C.M., Hubbard,S.J. and Lu,H.
    Understanding the Role of Yeast Yme1 in Mitochondrial Function Using Biochemical and Proteomics Analyses
    Int J Mol Sci23, PubMed  Europe PubMed DOI
    10. 2021
  10. Loser,T., Joppe,A., Hamann,A. and Osiewacz,H.D.
    Mitochondrial Phospholipid Homeostasis Is Regulated by the i-AAA Protease PaIAP and Affects Organismic Aging
    Cells10, 2775-2775. PubMed  Europe PubMed DOI
    11. 2018
  11. Opalinska,M. and Janska,H.
    AAA Proteases: guardians of mitochondrial function and homeostasis
    Cells7, 163-163. PubMed  Europe PubMed DOI
  12. Wu,X., Li,L. and Jiang,H.
    Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45
    J Cell Biol217, 139-149. PubMed  Europe PubMed DOI
    13. 2017
  13. Opalinska,M., Parys,K., Murcha,M.W. and Janska,H.
    Plant i - AAA protease controls the turnover of the essential mitochondrial protein import component
    J Cell Sci131, jcs200733-jcs200733. PubMed  Europe PubMed DOI
  14. Puchades,C., Rampello,A.J., Shin,M., Giuliano,C.J., Wiseman,R.L., Glynn,S.E. and Lander,G.C.
    Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing
    Science358, eaao0464-eaao0464. PubMed  Europe PubMed DOI  S
  15. Rampello,A.J. and Glynn,S.E.
    Identification of a degradation signal sequence within substrates of the mitochondrial i-AAA protease
    J Mol Biol429, 873-885. PubMed  Europe PubMed DOI  P
    16. 2016
  16. Dasari,S. and Kolling,R.
    Role of mitochondrial processing peptidase and AAA proteases in processing of the yeast acetohydroxyacid synthase precursor
    FEBS Open Bio6, 765-773. PubMed  Europe PubMed DOI  M
    17. 2015
  17. Gaspard,G.J. and McMaster,C.R.
    The mitochondrial quality control protein Yme1 is necessary to prevent defective mitophagy in a yeast model of Barth Syndrome
    J Biol Chem290, 9284-9298. PubMed  Europe PubMed DOI
  18. Spiller,M.P., Guo,L., Wang,Q., Tran,P. and Lu,H.
    Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1
    Biosci Rep35, e00193-e00193. PubMed  Europe PubMed DOI
    19. 2013
  19. Wang,K., Jin,M., Liu,X. and Klionsky,D.J.
    Proteolytic processing of Atg32 by the mitochondrial i-AAA protease Yme1 regulates mitophagy
    Autophagy9, 1828-1836. PubMed  Europe PubMed DOI
    20. 2012
  20. Janska,H.
    Plant mitochondrial FtsH peptidases
    [ISSN:978-0-12-407744-7]3, 702-705. DOI
  21. Schreiner,B., Westerburg,H., Forne,I., Imhof,A., Neupert,W. and Mokranjac,D.
    Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
    Mol Biol Cell23, 4335-4346. PubMed  Europe PubMed DOI
  22. Wai,T. and Langer,T.
    The i-AAA protease
    [ISSN:978-0-12-407744-7]3, 696-701. DOI
    23. 2010
  23. Potting,C., Wilmes,C., Engmann,T., Osman,C. and Langer,T.
    Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35
    EMBO J29, 2888-2898. PubMed  Europe PubMed DOI
    24. 2009
  24. Fiumera,H.L., Dunham,M.J., Saracco,S.A., Butler,C.A., Kelly,J.A. and Fox,T.D.
    Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18
    Genetics182, 519-528. PubMed  Europe PubMed DOI
  25. Karnataki,A., DeRocher,A.E., Feagin,J.E. and Parsons,M.
    Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking
    Mol Biochem Parasitol166, 126-133. PubMed  Europe PubMed DOI
  26. Tatsuta,T. and Langer,T.
    AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines
    Res Microbiol160, 711-717. PubMed  Europe PubMed DOI
    27. 2008
  27. Dunn,C.D., Tamura,Y., Sesaki,H. and Jensen,R.E.
    Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex
    Mol Biol Cell19, 5387-5397. PubMed  Europe PubMed DOI
    28. 2007
  28. Graef,M., Seewald,G. and Langer,T.
    Substrate recognition by AAA+ ATPases: distinct substrate binding modes in ATP-dependent protease Yme1 of the mitochondrial intermembrane space
    Mol Cell Biol27, 2476-2485. PubMed  Europe PubMed DOI
  29. Griparic,L., Kanazawa,T. and van der Bliek,A.M.
    Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
    J Cell Biol178, 757-764. PubMed  Europe PubMed DOI
  30. Hwang,D.K., Claypool,S.M., Leuenberger,D., Tienson,H.L. and Koehler,C.M.
    Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion
    J Cell Biol178, 1161-1175. PubMed  Europe PubMed DOI
  31. Karnataki,A., DeRocher,A.E., Coppens,I., Feagin,J.E. and Parsons,M.
    A membrane protease is targeted to the relict plastid of Toxoplasma via an internal signal sequence
    Traffic8, 1543-1553. PubMed  Europe PubMed DOI
  32. Kolodziejczak,M., GibalaM., Urantowka,A. and Janska,H.
    The significance of Arabidopsis AAA proteases for activity and assembly/stability of mitochondrial OXPHOS complexes
    Physiologia Plantarum129, 135-142.
  33. Koppen,M. and Langer,T.
    Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases
    Crit Rev Biochem Mol Biol42, 221-242. PubMed  Europe PubMed DOI  V
    34. 2006
  34. [YEAR:3-1-2006]Arnold,I., Wagner-Ecker,M., Ansorge,W. and Langer,T.
    Evidence for a novel mitochondria-to-nucleus signalling pathway in respiring cells lacking i-AAA protease and the ABC-transporter Mdl1
    Gene367, 74-88. PubMed  Europe PubMed DOI
  35. [YEAR:21-2-2006]Graef,M. and Langer,T.
    Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement
    J Struct Biol156, 101-108. PubMed  Europe PubMed DOI
  36. [YEAR:11-9-2006]Rainey,R.N., Glavin,J.D., Chen,H.W., French,S.W., Teitell,M.A. and Koehler,C.M.
    A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space
    Mol Cell Biol26, 8488-8497. PubMed  Europe PubMed DOI
    37. 2005
  37. Janska,H.
    ATP-dependent proteases in plant mitochondria: what do we know about them today?
    Physiologia Plantarum123, 399-405. DOI
    38. 2002
  38. [YEAR:2-9-2002]Arnold,I. and Langer,T.
    Membrane protein degradation by AAA proteases in mitochondria
    Biochim Biophys Acta1592, 89-96. PubMed  Europe PubMed DOI
    39. 2001
  39. Klanner,C., Prokisch,H. and Langer,T.
    MAP-1 and IAP-1, two novel AAA proteases with catalytic sites on opposite membrane surfaces in mitochondrial inner membrane of Neurospora crassa
    Mol Biol Cell12, 2858-2869. PubMed  Europe PubMed
  40. Langer,T., Kaser,M., Klanner,C. and Leonhard,K.
    AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis
    Biochem Soc Trans29, 431-436. PubMed  Europe PubMed DOI
    41. 2000
  41. [YEAR:15-9-2000]Juhola,M.K., Shah,Z.H., Grivell,L.A. and Jacobs,H.T.
    The mitochondrial inner membrane AAA metalloprotease family in metazoans
    FEBS Lett481, 91-95. PubMed  Europe PubMed DOI
  42. Kominsky,D.J. and Thorsness,P.E.
    Expression of the Saccharomyces cerevisiae gene YME1 in the petite-negative yeast Schizosaccharomyces pombe converts it to petite-positive
    Genetics154, 147-154. PubMed  Europe PubMed
  43. [YEAR:4-8-2000]Lemaire,C., Hamel,P., Velours,J. and Dujardin,G.
    Absence of the mitochondrial AAA protease Yme1p restores F0-ATPase subunit accumulation in an oxa1 deletion mutant of Saccharomyces cerevisiae
    J Biol Chem275, 23471-23475. PubMed  Europe PubMed DOI
  44. Leonhard,K., Guiard,B., Pellecchia,G., Tzagoloff,A., Neupert,W. and Langer,T.
    Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface
    Mol Cell5, 629-638. PubMed  Europe PubMed
    45. 1999
  45. [YEAR:25-3-1999]Leonhard,K., Stiegler,A., Neupert,W. and Langer,T.
    Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease
    Nature398, 348-351. PubMed  Europe PubMed DOI
    46. 1996
  46. Langer,T. and Neupert,W.
    Regulated protein degradation in mitochondria
    Experientia52, 1069-1076. PubMed  Europe PubMed DOI
  47. Leonhard,K., Herrmann,J.M., Stuart,R.A., Mannhaupt,G., Neupert,W. and Langer,T.
    AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria
    EMBO J15, 4218-4229. PubMed  Europe PubMed
  48. Weber,E.R., Hanekamp,T. and Thorsness,P.E.
    Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae
    Mol Biol Cell7, 307-317. PubMed  Europe PubMed
    49. 1995
  49. Nakai,T., Yasuhara,T., Fujiki,Y. and Ohashi,A.
    Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria
    Mol Cell Biol15, 4441-4452. PubMed  Europe PubMed
  50. Pearce,D.A. and Sherman,F.
    Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1
    J Biol Chem270, 20879-20882. PubMed  Europe PubMed DOI
    51. 1994
  51. Campbell,C.L., Tanaka,N., White,K.H. and Thorsness,P.E.
    Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue
    Mol Biol Cell5, 899-905. PubMed  Europe PubMed
    52. 1993
  52. Thorsness,P.E., White,K.H. and Fox,T.D.
    Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae
    Mol Cell Biol13, 5418-5426. PubMed  Europe PubMed

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