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Literature for peptidase M41.004: i-AAA peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fremlen,H. and Burmann,B.M.
    Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases
    Chembiochem (2025) , e202500048-e202500048. PubMed  Europe PubMed DOI  V
  2. Gaur,D., Acquaviva,B. and Wohlever,M.L.
    An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  3. Ludwig,K. and Heidorn-Czarna,M.
    Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast
    Plant Cell Physiol (2025) PubMed  Europe PubMed DOI  V
  4. Tiku,V., Fakih,Z., Tatsuta,T., Jung,M., Rapaport,D. and Dimmer,K.S.
    Characterization of the putative yeast mitochondrial triacylglycerol lipase Tgl2
    J Biol Chem (2025) , 108217-108217. PubMed  Europe PubMed DOI
    5. 2024
  5. Ganesan,I., Pfanner,N. and Wiedemann,N.
    Screen for temperature-sensitive mutants of non-essential yeast genes
    Methods Enzymol (2024) 707, 611-634. PubMed  Europe PubMed DOI
  6. Kan,K.T., Wilcock,J. and Lu,H.
    Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics
    Biochem Soc Trans (2024) 52, 1539-1548. PubMed  Europe PubMed DOI  V
    7. 2023
  7. Kumar,A., Waingankar,T.P. and D'Silva,P.
    Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity
    J Cell Sci (2023) 136 PubMed  Europe PubMed DOI
  8. Matsushima,Y.
    Mitochondrial AAA+ proteases
    Enzymes (2023) 54, 205-220. PubMed  Europe PubMed DOI
    9. 2022
  9. Heidorn-Czarna,M., Maziak,A. and Janska,H.
    Protein Processing in Plant Mitochondria Compared to Yeast and Mammals
    Front Plant Sci (2022) 13, 824080-824080. PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Kan,K.T., Nelson,M.G., Grant,C.M., Hubbard,S.J. and Lu,H.
    Understanding the Role of Yeast Yme1 in Mitochondrial Function Using Biochemical and Proteomics Analyses
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Loser,T., Joppe,A., Hamann,A. and Osiewacz,H.D.
    Mitochondrial Phospholipid Homeostasis Is Regulated by the i-AAA Protease PaIAP and Affects Organismic Aging
    Cells (2021) 10, 2775-2775. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2018
  12. Opalinska,M. and Janska,H.
    AAA Proteases: guardians of mitochondrial function and homeostasis
    Cells (2018) 7, 163-163. PubMed  Europe PubMed DOI
  13. Wu,X., Li,L. and Jiang,H.
    Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45
    J Cell Biol (2018) 217, 139-149. PubMed  Europe PubMed DOI
    14. 2017
  14. Opalinska,M., Parys,K., Murcha,M.W. and Janska,H.
    Plant i - AAA protease controls the turnover of the essential mitochondrial protein import component
    J Cell Sci (2017) 131, jcs200733-jcs200733. PubMed  Europe PubMed DOI
  15. Puchades,C., Rampello,A.J., Shin,M., Giuliano,C.J., Wiseman,R.L., Glynn,S.E. and Lander,G.C.
    Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing
    Science (2017) 358, eaao0464-eaao0464. PubMed  Europe PubMed DOI  S
  16. Rampello,A.J. and Glynn,S.E.
    Identification of a degradation signal sequence within substrates of the mitochondrial i-AAA protease
    J Mol Biol (2017) 429, 873-885. PubMed  Europe PubMed DOI  P
    17. 2016
  17. Dasari,S. and Kolling,R.
    Role of mitochondrial processing peptidase and AAA proteases in processing of the yeast acetohydroxyacid synthase precursor
    FEBS Open Bio (2016) 6, 765-773. PubMed  Europe PubMed DOI  PMC  EPMC  M
    18. 2015
  18. Gaspard,G.J. and McMaster,C.R.
    The mitochondrial quality control protein Yme1 is necessary to prevent defective mitophagy in a yeast model of Barth Syndrome
    J Biol Chem (2015) 290, 9284-9298. PubMed  Europe PubMed DOI
  19. Spiller,M.P., Guo,L., Wang,Q., Tran,P. and Lu,H.
    Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1
    Biosci Rep (2015) 35, e00193-e00193. PubMed  Europe PubMed DOI
    20. 2013
  20. Wang,K., Jin,M., Liu,X. and Klionsky,D.J.
    Proteolytic processing of Atg32 by the mitochondrial i-AAA protease Yme1 regulates mitophagy
    Autophagy (2013) 9, 1828-1836. PubMed  Europe PubMed DOI
    21. 2012
  21. Janska,H.
    Plant mitochondrial FtsH peptidases
    [ISSN:978-0-12-407744-7] (2012) 3, 702-705. DOI
  22. Schreiner,B., Westerburg,H., Forne,I., Imhof,A., Neupert,W. and Mokranjac,D.
    Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
    Mol Biol Cell (2012) 23, 4335-4346. PubMed  Europe PubMed DOI
  23. Wai,T. and Langer,T.
    The i-AAA protease
    [ISSN:978-0-12-407744-7] (2012) 3, 696-701. DOI
    24. 2010
  24. Potting,C., Wilmes,C., Engmann,T., Osman,C. and Langer,T.
    Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35
    EMBO J (2010) 29, 2888-2898. PubMed  Europe PubMed DOI
    25. 2009
  25. Fiumera,H.L., Dunham,M.J., Saracco,S.A., Butler,C.A., Kelly,J.A. and Fox,T.D.
    Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18
    Genetics (2009) 182, 519-528. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Karnataki,A., DeRocher,A.E., Feagin,J.E. and Parsons,M.
    Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking
    Mol Biochem Parasitol (2009) 166, 126-133. PubMed  Europe PubMed DOI
  27. Tatsuta,T. and Langer,T.
    AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines
    Res Microbiol (2009) 160, 711-717. PubMed  Europe PubMed DOI
    28. 2008
  28. Dunn,C.D., Tamura,Y., Sesaki,H. and Jensen,R.E.
    Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex
    Mol Biol Cell (2008) 19, 5387-5397. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2007
  29. Graef,M., Seewald,G. and Langer,T.
    Substrate recognition by AAA+ ATPases: distinct substrate binding modes in ATP-dependent protease Yme1 of the mitochondrial intermembrane space
    Mol Cell Biol (2007) 27, 2476-2485. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Griparic,L., Kanazawa,T. and van der Bliek,A.M.
    Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
    J Cell Biol (2007) 178, 757-764. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Hwang,D.K., Claypool,S.M., Leuenberger,D., Tienson,H.L. and Koehler,C.M.
    Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion
    J Cell Biol (2007) 178, 1161-1175. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Karnataki,A., DeRocher,A.E., Coppens,I., Feagin,J.E. and Parsons,M.
    A membrane protease is targeted to the relict plastid of Toxoplasma via an internal signal sequence
    Traffic (2007) 8, 1543-1553. PubMed  Europe PubMed DOI
  33. Kolodziejczak,M., GibalaM., Urantowka,A. and Janska,H.
    The significance of Arabidopsis AAA proteases for activity and assembly/stability of mitochondrial OXPHOS complexes
    Physiologia Plantarum (2007) 129, 135-142.
  34. Koppen,M. and Langer,T.
    Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases
    Crit Rev Biochem Mol Biol (2007) 42, 221-242. PubMed  Europe PubMed DOI  V
    35. 2006
  35. [YEAR:3-1-2006]Arnold,I., Wagner-Ecker,M., Ansorge,W. and Langer,T.
    Evidence for a novel mitochondria-to-nucleus signalling pathway in respiring cells lacking i-AAA protease and the ABC-transporter Mdl1
    Gene (3-1-2006) 367, 74-88. PubMed  Europe PubMed DOI
  36. [YEAR:21-2-2006]Graef,M. and Langer,T.
    Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement
    J Struct Biol (21-2-2006) 156, 101-108. PubMed  Europe PubMed DOI
  37. [YEAR:11-9-2006]Rainey,R.N., Glavin,J.D., Chen,H.W., French,S.W., Teitell,M.A. and Koehler,C.M.
    A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space
    Mol Cell Biol (11-9-2006) 26, 8488-8497. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2005
  38. Janska,H.
    ATP-dependent proteases in plant mitochondria: what do we know about them today?
    Physiologia Plantarum (2005) 123, 399-405. DOI
    39. 2002
  39. [YEAR:2-9-2002]Arnold,I. and Langer,T.
    Membrane protein degradation by AAA proteases in mitochondria
    Biochim Biophys Acta (2-9-2002) 1592, 89-96. PubMed  Europe PubMed DOI
    40. 2001
  40. Klanner,C., Prokisch,H. and Langer,T.
    MAP-1 and IAP-1, two novel AAA proteases with catalytic sites on opposite membrane surfaces in mitochondrial inner membrane of Neurospora crassa
    Mol Biol Cell (2001) 12, 2858-2869. PubMed  Europe PubMed  PMC  EPMC
  41. Langer,T., Kaser,M., Klanner,C. and Leonhard,K.
    AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis
    Biochem Soc Trans (2001) 29, 431-436. PubMed  Europe PubMed DOI
    42. 2000
  42. [YEAR:15-9-2000]Juhola,M.K., Shah,Z.H., Grivell,L.A. and Jacobs,H.T.
    The mitochondrial inner membrane AAA metalloprotease family in metazoans
    FEBS Lett (15-9-2000) 481, 91-95. PubMed  Europe PubMed DOI
  43. Kominsky,D.J. and Thorsness,P.E.
    Expression of the Saccharomyces cerevisiae gene YME1 in the petite-negative yeast Schizosaccharomyces pombe converts it to petite-positive
    Genetics (2000) 154, 147-154. PubMed  Europe PubMed  PMC  EPMC
  44. [YEAR:4-8-2000]Lemaire,C., Hamel,P., Velours,J. and Dujardin,G.
    Absence of the mitochondrial AAA protease Yme1p restores F0-ATPase subunit accumulation in an oxa1 deletion mutant of Saccharomyces cerevisiae
    J Biol Chem (4-8-2000) 275, 23471-23475. PubMed  Europe PubMed DOI
  45. Leonhard,K., Guiard,B., Pellecchia,G., Tzagoloff,A., Neupert,W. and Langer,T.
    Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface
    Mol Cell (2000) 5, 629-638. PubMed  Europe PubMed
    46. 1999
  46. [YEAR:25-3-1999]Leonhard,K., Stiegler,A., Neupert,W. and Langer,T.
    Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease
    Nature (25-3-1999) 398, 348-351. PubMed  Europe PubMed DOI
    47. 1996
  47. Langer,T. and Neupert,W.
    Regulated protein degradation in mitochondria
    Experientia (1996) 52, 1069-1076. PubMed  Europe PubMed DOI
  48. Leonhard,K., Herrmann,J.M., Stuart,R.A., Mannhaupt,G., Neupert,W. and Langer,T.
    AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria
    EMBO J (1996) 15, 4218-4229. PubMed  Europe PubMed  PMC  EPMC
  49. Weber,E.R., Hanekamp,T. and Thorsness,P.E.
    Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae
    Mol Biol Cell (1996) 7, 307-317. PubMed  Europe PubMed  PMC  EPMC
    50. 1995
  50. Nakai,T., Yasuhara,T., Fujiki,Y. and Ohashi,A.
    Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria
    Mol Cell Biol (1995) 15, 4441-4452. PubMed  Europe PubMed  PMC  EPMC
  51. Pearce,D.A. and Sherman,F.
    Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1
    J Biol Chem (1995) 270, 20879-20882. PubMed  Europe PubMed DOI
    52. 1994
  52. Campbell,C.L., Tanaka,N., White,K.H. and Thorsness,P.E.
    Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue
    Mol Biol Cell (1994) 5, 899-905. PubMed  Europe PubMed  PMC  EPMC
    53. 1993
  53. Thorsness,P.E., White,K.H. and Fox,T.D.
    Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae
    Mol Cell Biol (1993) 13, 5418-5426. PubMed  Europe PubMed  PMC  EPMC

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