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Literature for peptidase M20.005: carnosine dipeptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, R Splicing, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Homma,T., Shinbara,K. and Osaki,T.<br>Identification of KKL-35 as a Novel Carnosine Dipeptidase 2 (CNDP2) Inhibitor by In Silico Screening<br>Molecules (2025) 30 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Toviwek,B., Koonawootrittriron,S., Suwanasopee,T., Jattawa,D. and Pongprayoon,P.<br>Why Bestatin Prefers Human Carnosinase 2 (CN2) to Human Carnosinase 1 (CN1)<br>J Phys Chem B (2024) PubMed  Europe PubMed DOI  I
    3. 2019
  3. Kim,J.T., Li,V.L., Terrell,S.M., Fischer,C.R. and Long,J.Z.<br>Family-wide annotation of enzymatic pathways by parallel in vivo metabolomics<br>Cell Chem Biol (2019) 26, 1623-1629. PubMed  Europe PubMed DOI
    4. 2017
  4. Guilherme,J.P.L.F. and Lancha AH Jr<br>Single nucleotide polymorphisms in carnosinase genes (CNDP1 and CNDP2) are associated with power athletic status<br>Int J Sport Nutr Exerc Metab (2017) 27, 533-542. PubMed  Europe PubMed DOI  M
    5. 2016
  5. Bedernjak,A.F., Zaytsev,A.V., Babolat,M., Cellier,M., James,A.L., Orenga,S., Perry,J.D., Groundwater,P.W. and Anderson,R.J.<br>Synthesis and evaluation of novel 7- and 8-aminophenoxazinones for the detection of beta-alanine aminopeptidase activity and the reliable identification of Pseudomonas aeruginosa in clinical samples<br>J Med Chem (2016) 59, 4476-4487. PubMed  Europe PubMed DOI  A
    6. 2015
  6. Jansen,R.S., Addie,R., Merkx,R., Fish,A., Mahakena,S., Bleijerveld,O.B., Altelaar,M., IJlst,L., Wanders,R.J., Borst,P. and van de Wetering,K.<br>N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids<br>Proc Natl Acad Sci U S A (2015) 112, 6601-6606. PubMed  Europe PubMed DOI
    7. 2012
  7. Kilis-Pstrusinska,K.<br>[Carnosine, carnosinase and kidney diseases]<br>Postepy Hig Med Dosw (Online) (2012) 66, 215-221. PubMed  Europe PubMed  V
  8. Okumura,N.<br>Carnosine dipeptidase II<br>[ISSN:978-0-12-407743-0] (2012) 3, 1596-1600. DOI
    9. 2011
  9. Oku,T., Ando,S., Hayakawa,T., Baba,K., Nishi,R., Shiozaki,K. and Yamada,S.<br>Purification and identification of a novel primitive secretory enzyme catalyzing the hydrolysis of imidazole-related dipeptides in the jawless vertebrate Lethenteron reissneri<br>Peptides (2011) 32, 648-655. PubMed  Europe PubMed DOI
    10. 2009
  10. McDonough,C.W., Hicks,P.J., Lu,L., Langefeld,C.D., Freedman,B.I. and Bowden,D.W.<br>The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans<br>Hum Genet (2009) 126, 265-275. PubMed  Europe PubMed DOI  M
  11. Uramatsu,S., Liu,G., Yang,Q., Uramatsu,M., Chi,H., Lu,J., Yamashita,K. and Kodama,H.<br>Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency<br>Amino Acids (2009) 37, 543-551. PubMed  Europe PubMed DOI
    12. 2008
  12. Otani,H., Okumura,A., Nagai,K. and Okumura,N.<br>Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus<br>Neurosci Lett (2008) 445, 166-169. PubMed  Europe PubMed DOI
  13. Unno,H., Yamashita,T., Ujita,S., Okumura,N., Otani,H., Okumura,A., Nagai,K. and Kusunoki,M.<br>Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2<br>J Biol Chem (2008) 283, 27289-27299. PubMed  Europe PubMed DOI  S  I
  14. Wanic,K., Placha,G., Dunn,J., Smiles,A., Warram,J.H. and Krolewski,A.S.<br>Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies<br>Diabetes (2008) 57, 2547-2551. PubMed  Europe PubMed DOI  PMC  EPMC  M
    15. 2007
  15. Liu,G., Nakayama,K., Awata,S., Tang,S., Kitaoka,N., Manabe,M. and Kodama,H.<br>Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors<br>Pediatr Res (2007) 62, 54-59. PubMed  Europe PubMed DOI
  16. [YEAR:29-6-2007]Uramatsu,M., Liu,G., Uramatsu,S., Zhang,M., Wang,W., Nakayama,K., Manabe,M. and Kodama,H.<br>Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes<br>Clin Chim Acta (29-6-2007) 375, 129-135. PubMed  Europe PubMed DOI
    17. 2006
  17. [YEAR:1-10-2006]Yamashita,T., Unno,H., Ujita,S., Otani,H., Okumura,N., Hashida-Okumura,A., Nagai,K. and Kusunoki,M.<br>Crystallization and preliminary crystallographic study of carnosinase CN2 from mice<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (1-10-2006) 62, 996-998. PubMed  Europe PubMed DOI
  18. [YEAR:15-11-2006]Zhang,P., Chan,D.W., Zhu,Y., Li,J.J., Ng,I.O., Wan,D. and Gu,J.<br>Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma<br>Clin Cancer Res (15-11-2006) 12, 6617-6625. PubMed  Europe PubMed DOI  R
    19. 2005
  19. Liu,G., Nakayama,K., Sagara,Y., Awata,S., Yamashita,K., Manabe,M. and Kodama,H.<br>Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: Comparison with prolidase I and II purified from normal human erythrocytes<br>Clin Biochem (2005) 38, 625-631. PubMed  Europe PubMed DOI
    20. 2004
  20. Bauer,K.<br>Cytosol nonspecific dipeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 1020-1022.  V
  21. Bauer,K.<br>X-His dipeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 1022-1024.  V
    22. 2003
  22. [YEAR:15-4-2003]Leiting,B., Pryor,K.D., Wu,J.K., Marsilio,F., Patel,R.A., Craik,C.S., Ellman,J.A., Cummings,R.T. and Thornberry,N.A.<br>Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII<br>Biochem J (15-4-2003) 371, 525-532. PubMed  Europe PubMed DOI  PMC  EPMC  P
  23. Nakayama,K., Awata,S., Zhang,J., Kaba,H., Manabe,M. and Kodama,H.<br>Characteristics of prolidase from the erythrocytes of normal humans and patients with prolidase deficiency and their mother<br>Clin Chem Lab Med (2003) 41, 1323-1328. PubMed  Europe PubMed DOI
  24. [YEAR:21-2-2003]Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S., Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D., Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C. and Smirnova,T.<br>Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase<br>J Biol Chem (21-2-2003) 278, 6521-6531. PubMed  Europe PubMed DOI
    25. 1994
  25. Myara,I., Cosson,C., Moatti,N. and Lemonnier,A.<br>Human kidney prolidase - purification, preincubation properties and immunological reactivity<br>Int J Biochem (1994) 26, 207-214. PubMed  Europe PubMed DOI
    26. 1990
  26. Lenney,J.F.<br>Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)<br>Biol Chem Hoppe Seyler (1990) 371, 433-440. PubMed  Europe PubMed
  27. Lenney,J.F.<br>Human cytosolic carnosinase: evidence of identity with prolinase, a non-specific dipeptidase<br>Biol Chem Hoppe Seyler (1990) 371, 167-171. PubMed  Europe PubMed
  28. [YEAR:31-1-1990]Ohhashi,T., Ohno,T., Arata,J., Sugahara,K. and Kodama,H.<br>Characterization of prolidase I and II from erythrocytes of a control, a patient with prolidase deficiency and her mother<br>Clin Chim Acta (31-1-1990) 187, 1-9. PubMed  Europe PubMed DOI
  29. Oono,T., Yasutomi,H., Ohhashi,T., Kodama,H. and Arata,J.<br>Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase<br>J Dermatol Sci (1990) 1, 319-323. PubMed  Europe PubMed DOI
    30. 1988
  30. Kalra,J., Balion,C., Massey,K.L. and Laxdal,V.A.<br>Regulation of carnosine metabolism: the subcellular localization of carnosinase in liver<br>Clin Biochem (1988) 21, 315-318. PubMed  Europe PubMed
  31. Oono,T. and Arata,J.<br>Characteristics of prolidase and prolinase in prolidase- deficient patients with some preliminary studies of their role in skin<br>J Dermatol (1988) 15, 212-219. PubMed  Europe PubMed
  32. Peppers,S.C. and Lenney,J.F.<br>Bestatin inhibition of human tissue carnosinase, a non-specific cytosolic dipeptidase<br>Biol Chem Hoppe Seyler (1988) 369, 1281-1286. PubMed  Europe PubMed  I
    33. 1986
  33. [YEAR:3-11-1986]Kunze,N., Kleinkauf,H. and Bauer,K.<br>Characterization of two carnosine-degrading enzymes from rat brain. Partial purification and characterization of a carnosinase and a beta-alanyl-arginine hydrolase<br>Eur J Biochem (3-11-1986) 160, 605-613. PubMed  Europe PubMed
    34. 1985
  34. Lenney,J.F., Peppers,S.C., Kucera-Orallo,C.M. and George,R.P.<br>Characterization of human tissue carnosinase<br>Biochem J (1985) 228, 653-660. PubMed  Europe PubMed  PMC  EPMC
  35. [YEAR:1-11-1985]Priestman,D.A. and Butterworth,J.<br>Prolinase and non-specific dipeptidase of human kidney<br>Biochem J (1-11-1985) 231, 689-694. PubMed  Europe PubMed  PMC  EPMC
    36. 1983
  36. [YEAR:18-5-1983]Margolis,F.L., Grillo,M., Grannot-Reisfeld,N. and Farbman,A.I.<br>Purification, characterization and immunocytochemical localization of mouse kidney carnosinase<br>Biochim Biophys Acta (18-5-1983) 744, 237-248. PubMed  Europe PubMed DOI
    37. 1982
  37. [YEAR:18-8-1982]Lenney,J.F., George,R.P., Weiss,A.M., Kucera,C.M., Chan,P.W. and Rinzler,G.S.<br>Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium<br>Clin Chim Acta (18-8-1982) 123, 221-231. PubMed  Europe PubMed DOI
    38. 1979
  38. [YEAR:11-10-1979]Margolis,F.L., Grillo,M., Brown,C.E., Williams,T.H., Pitcher,R.G. and Elgar,G.J.<br>Enzymatic and immunological evidence for two forms of carnosinase in the mouse<br>Biochim Biophys Acta (11-10-1979) 570, 311-323. PubMed  Europe PubMed
    39. 1977
  39. Akrawi,A.F. and Bailey,G.S.<br>The separation of prolyl dipeptidase from other dipeptidases of bovine kidney<br>Biochem Soc Trans (1977) 5, 272-274. PubMed  Europe PubMed
    40. 1974
  40. Rohm,K.H.<br>Properties of a highly purified dipeptidase (EC 3.4.13.?) from brewer's yeast<br>Hoppe Seylers Z Physiol Chem (1974) 355, 675-686. PubMed  Europe PubMed
    41. 1973
  41. Das,M. and Radhakrishnan,A.N.<br>Glycyl-L-leucine hydrolase, a versatile 'master' dipeptidase from monkey small intestine<br>Biochem J (1973) 135, 609-615. PubMed  Europe PubMed  PMC  EPMC
  42. Mayer,H. and Nordwig,A.<br>The cleavage of prolyl peptides by kidney peptidases. Purification of iminodipeptidase (prolinase)<br>Hoppe Seylers Z Physiol Chem (1973) 354, 371-379. PubMed  Europe PubMed
  43. Patterson,E.K., Gatmaitan,J.S. and Hayman,S.<br>Substrate specificity and pH dependence of dipeptidases purified from Escherichia coli B and from mouse ascites tumor cells<br>Biochemistry (1973) 12, 3701-3709. PubMed  Europe PubMed
    44. 1972
  44. Das,M. and Radhakrishnan,A.N.<br>Substrate specificity of a highly active dipeptidase purified from monkey small intestine<br>Biochem J (1972) 128, 463-465. PubMed  Europe PubMed  PMC  EPMC  P
  45. Plancot,M.T. and Han,K.K.<br>Purification and characterization of an intracellular dipeptidase from Mycobacterium phlei<br>Eur J Biochem (1972) 28, 327-333. PubMed  Europe PubMed
    46. 1971
  46. [YEAR:10-2-1971]Hayman,S. and Patterson,E.K.<br>Purification and properties of a mouse ascites tumor dipeptidase, a metalloenzyme<br>J Biol Chem (10-2-1971) 246, 660-669. PubMed  Europe PubMed
  47. Noren,O., Sjostrom,H. and Josefsson,L.<br>Preparation of a highly purified glycyl-L-leucine dipeptidase from pig intestinal mucosa<br>Acta Chem Scand (1971) 25, 1913-1915. PubMed  Europe PubMed
    48. 1968
  48. Bidlingmaier,F. and Schneider,F.<br>[On the glycyl-glycine dipeptidase (EC 3.4.3.1) from porcine erythrocytes]<br>Hoppe Seylers Z Physiol Chem (1968) 349, 1529-1536. PubMed  Europe PubMed
    49. 1964
  49. Traniello,S. and Vescia,A.<br>Properties of a dipeptidase from swine kidney<br>Arch Biochem Biophys (1964) 105, 465-469. PubMed  Europe PubMed
    50. 1963
  50. Haschen,R.J.<br>[Characterization and determination of imido- and iminopeptidase (prolidase and prolinase) in human erythrocytes]<br>Acta Biol Med Ger (1963) 11, 169-173. PubMed  Europe PubMed
    51. 1962
  51. Sarid,S., Berger,A. and Katchalski,E.<br>Proline iminopeptidase. II. Purification and comparison with iminodipeptidase (prolinase)<br>J Biol Chem (1962) 237, 2207-2212. PubMed  Europe PubMed
    52. 1957
  52. [YEAR:6-7-1957]Wood,T.<br>Carnosine and carnosinase in rat tissue<br>Nature (6-7-1957) 180, 39-40. PubMed  Europe PubMed DOI
    53. 1955
  53. Davis,N.C. and Adams,E.<br>Specificity of iminodipeptidase: effect of alterations in the pyrrolidine ring of L-prolylglycine<br>Arch Biochem Biophys (1955) 57, 301-305. PubMed  Europe PubMed
  54. Smith,E.L.<br>[10] Dipeptidases<br>Methods Enzymol (1955) 2, 93-109. DOI  V
    55. 1951
  55. Neuman,R.E. and Smith,E.L.<br>Synthesis of proline and hydroxyproline peptides; their cleavage by prolinase<br>J Biol Chem (1951) 193, 97-111. PubMed  Europe PubMed
  56. Smith,E.L.<br>The specificity of certain peptidases<br>Adv Enzymol Relat Subj Biochem (1951) 12, 191-257. PubMed  Europe PubMed
    57. 1949
  57. Hanson,H.T. and Smith,E.L.<br>Carnosinase: an enzyme of swine kidney<br>J Biol Chem (1949) 179, 789-801. PubMed  Europe PubMed
    58. 1948
  58. Smith,E.L.<br>Studies on dipeptidases. II. Some properties of the glycyl-L-leucine dipeptidases of animal tissues<br>J Biol Chem (1948) 176, 9-19. PubMed  Europe PubMed
  59. Smith,E.L.<br>Studies on dipeptidases. III. Hydrolysis of methylated peptides; the role of cobalt in the action of glycylglycine dipeptidase<br>J Biol Chem (1948) 176, 21-32. PubMed  Europe PubMed
  60. Smith,E.L.<br>The glycylglycine dipeptidases of skeletal muscle and human uterus<br>J Biol Chem (1948) 173, 571-584. PubMed  Europe PubMed

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