Literature for peptidase M20.001: glutamate carboxypeptidase

(Topics flags: S Structure, A Assay, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Gupta,S., Kaunfer,S.A., Chen,K.L., Dias,J.A., Vijayan,A., Rajasekaran,A., Prosek,J., Truong,H.L., Wood,A., Bassil,C., Renaghan,A.D., Shah,C.V., Zhang,J., Glezerman,I., Carlos,C., Kelly,K., Passero,C.J., Drappatz,J., Abudayyeh,A., Shin,D., Sperati,C.J., Yelvington,B.J., Kanduri,S.R., Neyra,J.A., Edmonston,D., Shirali,A.C., Bansal,A., Geara,A., Mithani,Z., Ziolkowski,S.L., Rashidi,A., Jakubowski,J., Pujari,A., Bond,D.A., Dotson,E.K., Wall,S.A., Patton,J.T., Barreto,J.N., Herrmann,S.M., Sheikh,M.S., Baz,R.C., Lee,J.H., Lucchesi,N., Kolman,M., Rasheed,M.A., Afzal,A., Kang,D., Mahesh,A., Hsu,R., Nicolaysen,A., Tefera,K., Schretlen,C., Miller,R.M., Velez,J.C.Q., Flannery,A.H., Aklilu,A.M., Anand,S., Chandrasekhara,S., Donley,V., Patel,A., Ni,J., Krishnamurthy,S., Ali,R., Yilmam,O.A., Wells,S.L., Ortega,J.L., Green-Lingren,O.L., Leaf,R.K., Sise,M.E., Nayak,L., LaCasce,A.S., Leung,N. and Leaf,D.E.
   Glucarpidase for Treatment of High-Dose Methotrexate Toxicity
   Blood PubMed  Europe PubMed DOI
2024
2. Ogawa,A., Kawamoto,H., Hara,J., Kikuta,A., Ogawa,C., Hiraga,H., Yoshimura,K., Miyairi,K., Omori,R., Ro,T., Kamei,Y. and Kimura,T.
   Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy
   Cancer Chemother Pharmacol PubMed  Europe PubMed DOI
2023
3. Ahmad,R., Tyryshkin,A.M., Xie,L., Hansen,W.A., Yachnin,B.J., Emge,T.J., Mashrai,A., Khare,S.D. and Knapp,S.
   A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly
   J Inorg Biochem244, 112206-112206. PubMed  Europe PubMed DOI
4. Moradbeygi,F., Ghasemi,Y., Farmani,A.R. and Hemmati,S.
   Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy
   Biomed Pharmacother166, 115292-115292. PubMed  Europe PubMed DOI  V
2022
5. Yachnin,B.J., Azouz,L.R., White,R.E., III, Minetti,C.A.S.A., Remeta,D.P., Tan,V.M., Drake,J.M. and Khare,S.D.
   Massively parallel, computationally guided design of a proenzyme
   Proc Natl Acad Sci U S A119, e2116097119-e2116097119. PubMed  Europe PubMed DOI
6. You,Y., Doi,Y., Maeda,N., Masuo,S., Takeshita,N. and Takaya,N.
   Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1
   BMC Microbiol22, 225-225. PubMed  Europe PubMed DOI
2021
7. Aldughaim,M.S., Alsaffar,F. and Barker,M.D.
   Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site
   Molecules26, 625-625. PubMed  Europe PubMed DOI
8. Khodakarami,A., Dabirmanesh,B., Asad,S. and Khaledi,M.
   Enhanced Solubility and One-Step Purification of Functional Dimeric Carboxypeptidase G2
   Biochemistry (Mosc)86, 190-196. PubMed  Europe PubMed DOI
9. Truong,H. and Leung,N.
   Fixed-Dose Glucarpidase for Toxic Methotrexate Levels and Acute Kidney Injury in Adult Lymphoma Patients: Case Series
   Clin Lymphoma Myeloma Leuk21, e497-e502. PubMed  Europe PubMed DOI
10. Zobeck,M.C., Bernhardt,M.B., Kamdar,K.Y., Rabin,K.R., Lupo,P.J. and Scheurer,M.E.
    Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene
    Pediatr Blood Cancere29036-e29036. PubMed  Europe PubMed DOI  V
2020
11. Domingo-Gonzalez,A., Osorio,S., Landete,E., Monsalvo,S. and Diez-Martin,J.L.
    A second administration of glucarpidase in a different cycle of high-dose methotrexate: Is it safe and effective in adults?
    J Oncol Pharm Pract27, 734-738. PubMed  Europe PubMed DOI
12. Medrano,C., Oberic,L., Puisset,F., Recher,C., Larrieu-Ciron,D., Ysebaert,L., Protin,C., Picard,M., Perriat,S., Chatelut,E., Bertoli,S., Huguet,F., Tavitian,S. and Faguer,S.
    Life-threatening complications after high-dose methotrexate and the benefits of glucarpidase as salvage therapy: a cohort study of 468 patients
    Leuk Lymphoma62, 1-8. PubMed  Europe PubMed DOI
2019
13. AlQahtani,A.D., Al-Mansoori,L., Bashraheel,S.S., Rashidi,F.B., Al-Yafei,A., Elsinga,P., Domling,A. and Goda,S.K.
    Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment
    Eur J Pharm Sci127, 79-91. PubMed  Europe PubMed DOI  U
2018
14. Boelens,A.D., Mathot,R.A.A., Vlaar,A.P.J. and Bouman,C.S.C.
    Glucarpidase treatment for methotrexate intoxication: a case report and review of the literature
    Neth J Med76, 36-39. PubMed  Europe PubMed
15. Jeyaharan,D., Brackstone,C., Schouten,J., Davis,P. and Dixon,A.M.
    Characterisation of the carboxypeptidase G2 catalytic site and design of new inhibitors for cancer therapy
    Chembiochem19, 1959-1968. PubMed  Europe PubMed DOI  I
16. Ramsey,L.B., Balis,F.M., O'Brien,M.M., Schmiegelow,K., Pauley,J.L., Bleyer,A., Widemann,B.C., Askenazi,D., Bergeron,S., Shirali,A., Schwartz,S., Vinks,A.A. and Heldrup,J.
    Consensus guideline for use of glucarpidase in patients with high-dose methotrexate induced acute kidney injury and delayed methotrexate clearance
    Oncologist23, 52-61. PubMed  Europe PubMed DOI
17. Rashidi,F.B., AlQhatani,A.D., Bashraheel,S.S., Shaabani,S., Groves,M.R., Domling,A. and Goda,S.K.
    Isolation and molecular characterization of novel glucarpidases: enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment
    PLoS ONE13, e0196254-e0196254. PubMed  Europe PubMed DOI
18. Sadeghian,I., Khalvati,B., Ghasemi,Y. and Hemmati,S.
    TAT-mediated intracellular delivery of carboxypeptidase G2 protects against methotrexate-induced cell death in HepG2 cells
    Toxicol Appl Pharmacol346, 9-18. PubMed  Europe PubMed DOI
2017
19. Yachnin,B.J. and Khare,S.D.
    Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme
    Protein Eng Des Sel30, 321-331. PubMed  Europe PubMed DOI
2016
20. Jeyaharan,D., Aston,P., Garcia-Perez,A., Schouten,J., Davis,P. and Dixon,A.M.
    Soluble expression, purification and functional characterisation of carboxypeptidase G2 and its individual domains
    Protein Expr Purif127, 44-52. PubMed  Europe PubMed DOI  E
2015
21. Yu,T. and Fu,X.
    Nanosecond electric pulses deprive zinc ions of carboxypeptidase G2
    Bioelectrochemistry101C, 42-45. PubMed  Europe PubMed DOI
2014
22. Cavone,J.L., Yang,D. and Wang,A.
    Glucarpidase intervention for delayed methotrexate clearance
    Ann Pharmacother48, 897-907. PubMed  Europe PubMed DOI  V
23. Fermiano,M., Bergsbaken,J. and Kolesar,J.M.
    Glucarpidase for the management of elevated methotrexate levels in patients with impaired renal function
    Am J Health Syst Pharm71, 793-798. PubMed  Europe PubMed DOI
24. Jamin,Y., Eykyn,T.R., Poon,E., Springer,C.J. and Robinson,S.P.
    Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance
    Mol Imaging Biol16, 152-157. PubMed  Europe PubMed DOI  A
25. Widemann,B.C., Schwartz,S., Jayaprakash,N., Christensen,R., Pui,C.H., Chauhan,N., Daugherty,C., King,T.R., Rush,J.E. and Howard,S.C.
    Efficacy of glucarpidase (carboxypeptidase G2) in patients with acute kidney injury after high-dose methotrexate therapy
    Pharmacotherapy34, 427-439. PubMed  Europe PubMed DOI  U
2013
26. Bradley,A.M., Buie,L.W., Kuykendal,A. and Voorhees,P.M.
    Successful use of intrathecal carboxypeptidase G2 for intrathecal methotrexate overdose: a case study and review of the literature
    Clin Lymphoma Myeloma Leuk13, 166-170. PubMed  Europe PubMed DOI  U
27. Iqbal,S., Armaghani,A., Aiyer,R. and Kazory,A.
    Methotrexate nephrotoxicity: Novel treatment, new approach
    J Oncol Pharm Pract19, 373-376. PubMed  Europe PubMed DOI  U
28. Rattu,M.A., Shah,N., Lee,J.M., Pham,A.Q. and Marzella,N.
    Glucarpidase (voraxaze), a carboxypeptidase enzyme for methotrexate toxicity
    P T38, 732-744. PubMed  Europe PubMed  U
2012
29. 
    Glucarpidase (Voraxaze) for methotrexate toxicity
    Med Lett Drugs Ther54, 19-20. PubMed  Europe PubMed  V
30. [YEAR:10-9-2012]Belavic,J.M.
    Voraxaze treats toxic methotrexate levels
    Nurse Pract37, 15-16. PubMed  Europe PubMed
31. Capucha,V., Mendes,E., Francisco,A.P. and Perry,M.J.
    Development of triazene prodrugs for ADEPT strategy: new insights into drug delivery system based on carboxypeptidase G2 activation
    Bioorg Med Chem Lett22, 6903-6908. PubMed  Europe PubMed DOI
32. Christensen,A.M., Pauley,J.L., Molinelli,A.R., Panetta,J.C., Ward,D.A., Stewart,C.F., Hoffman,J.M., Howard,S.C., Pui,C.H., Pappo,A.S., Relling,M.V. and Crews,K.R.
    Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients
    Cancer118, 4321-4330. PubMed  Europe PubMed DOI  U
33. Green,J.M.
    Glucarpidase to combat toxic levels of methotrexate in patients
    Ther Clin Risk Manag8, 403-413. PubMed  Europe PubMed DOI  U
34. Sherwood,R.F. and Melton,R.G.
    Glutamate carboxypeptidase
    [ISSN:978-0-12-407743-0]3, 1576-1581. DOI
35. Tuffaha,H.W. and Al Omar,S.
    Glucarpidase for the treatment of life-threatening methotrexate overdose
    Drugs Today (Barc)48, 705-711. PubMed  Europe PubMed DOI  U
36. Turra,K.M., Pasqualoto,K.F., Ferreira,E.I. and Rando,D.G.
    Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G2
    J Mol Model18, 1867-1875. PubMed  Europe PubMed DOI  U
2011
37. Chang,Y.C., Chao,P.W. and Tung,C.H.
    Sensitive luciferin derived probes for selective carboxypeptidase activity
    Bioorg Med Chem Lett21, 3931-3934. PubMed  Europe PubMed DOI  A
38. Jamin,Y., Smyth,L., Robinson,S.P., Poon,E.S., Eykyn,T.R., Springer,C.J., Leach,M.O. and Payne,G.S.
    Noninvasive detection of carboxypeptidase G2 activity in vivo
    NMR Biomed24, 343-350. PubMed  Europe PubMed DOI  A
2010
39. Widemann,B.C., Balis,F.M., Kim,A., Boron,M., Jayaprakash,N., Shalabi,A., O'Brien,M., Eby,M., Cole,D.E., Murphy,R.F., Fox,E., Ivy,P. and Adamson,P.C.
    Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome
    J Clin Oncol28, 3979-3986. PubMed  Europe PubMed DOI
2009
40. Goda,S.K., Rashidi,F.A., Fakharo,A.A. and Al-Obaidli,A.
    Functional overexpression and purification of a codon optimized synthetic glucarpidase (carboxypeptidase G2) in Escherichia coli
    Protein J28, 435-442. PubMed  Europe PubMed DOI  E
2007
41. Hedley,D., Ogilvie,L. and Springer,C.
    Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury
    Nat Rev Cancer7, 870-879. PubMed  Europe PubMed DOI
42. Schepelmann,S., Ogilvie,L.M., Hedley,D., Friedlos,F., Martin,J., Scanlon,I., Chen,P., Marais,R. and Springer,C.J.
    Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2
    Cancer Res67, 4949-4955. PubMed  Europe PubMed DOI
43. Schwartz,S., Borner,K., Muller,K., Martus,P., Fischer,L., Korfel,A., Auton,T. and Thiel,E.
    Glucarpidase (carboxypeptidase G2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy
    Oncologist12, 1299-1308. PubMed  Europe PubMed DOI
44. Sieniawski,M., Rimpler,M., Herrmann,R. and Josting,A.
    Successful carboxypeptidase G2 rescue of a high-risk elderly Hodgkin lymphoma patient with methotrexate intoxication and renal failure
    Leuk Lymphoma48, 1641-1643. PubMed  Europe PubMed DOI
2005
45. [YEAR:14-2-2005]Buchen,S., Ngampolo,D., Melton,R.G., Hasan,C., Zoubek,A., Henze,G., Bode,U. and Fleischhack,G.
    Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure
    Br J Cancer92, 480-487. PubMed  Europe PubMed DOI
46. Hempel,G., Lingg,R. and Boos,J.
    Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications
    Cancer Chemother Pharmacol55, 347-353. PubMed  Europe PubMed DOI
2004
47. Sherwood,R.F. and Melton,R.G.
    Glutamate carboxypeptidase
    [ISSN:0-12-079610-4]2, 941-946.  V
48. [YEAR:20-10-2004]Widemann,B.C., Balis,F.M., Shalabi,A., Boron,M., O'Brien,M., Cole,D.E., Jayaprakash,N., Ivy,P., Castle,V., Muraszko,K., Moertel,C.L., Trueworthy,R., Hermann,R.C., Moussa,A., Hinton,S., Reaman,G., Poplack,D. and Adamson,P.C.
    Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2
    J Natl Cancer Inst96, 1557-1559. PubMed  Europe PubMed DOI
2003
49. [YEAR:24-4-2003]Niculescu-Duvaz,D., Niculescu-Duvaz,I., Friedlos,F., Martin,J., Lehouritis,P., Marais,R. and Springer,C.J.
    Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT
    J Med Chem46, 1690-1705. PubMed  Europe PubMed DOI
2002
50. [YEAR:15-3-2002]Friedlos,F., Davies,L., Scanlon,I., Ogilvie,L.M., Martin,J., Stribbling,S.M., Spooner,R.A., Niculescu-Duvaz,I., Marais,R. and Springer,C.J.
    Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
    Cancer Res62, 1724-1729. PubMed  Europe PubMed
51. Krause,A.S., Weihrauch,M.R., Bode,U., Fleischhack,G., Elter,T., Heuer,T., Engert,A., Diehl,V. and Josting,A.
    Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy
    Leuk Lymphoma43, 2139-2143. PubMed  Europe PubMed DOI
2001
52. Lu,H. and Berkman,C.E.
    Stereoselective inhibition of glutamate carboxypeptidase by chiral phosphonothioic acids
    Bioorg Med Chem9, 395-402. PubMed  Europe PubMed DOI
2000
53. [YEAR:15-2-2000]Bhatia,J., Sharma,S.K., Chester,K.A., Pedley,R.B., Boden,R.W., Read,D.A., Boxer,G.M., Michael,N.P. and Begent,R.H.
    Catalytic activity of an in vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein
    Int J Cancer85, 571-577. PubMed  Europe PubMed DOI
54. Burke,P.J.
    The potential use of carboxypeptidase G2 in the treatment of cancer
    Expert Opin Ther Pat10, 209-214.  V
55. Krackhardt,A., Schwartz,S. and Thiel,E.
    Targeting folates by carboxypeptidase G2: potential applications in anticancer therapy
    Onkologie23, 538-543. PubMed  Europe PubMed
56. Mohty,M., Peyriere,H., Guinet,C., Hillaire-Buys,D., Blayac,J.P. and Rossi,J.F.
    Carboxypeptidase G2 rescue in delayed methotrexate elimination in renal failure
    Leuk Lymphoma37, 441-443. PubMed  Europe PubMed DOI
1999
57. [YEAR:25-3-1999]Khan,T.H., Eno-Amooquaye,E.A., Searle,F., Browne,P.J., Osborn,H.M. and Burke,P.J.
    Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy
    J Med Chem42, 951-956. PubMed  Europe PubMed DOI  I
58. Krackhardt,A., Schwartz,S., Korfel,A. and Thiel,E.
    Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure
    Leuk Lymphoma35, 631-635. PubMed  Europe PubMed DOI
59. [YEAR:17-5-1999]Rodriguez,C.E., Lu,H., Dinh,T.T., Mlodnosky,K.L., Dastgah,A., Lam,V.Q., Nichols,C.B. and Berkman,C.E.
    Competitive inhibition of a glutamate carboxypeptidase by phosphonamidothionate derivatives of glutamic acid
    Bioorg Med Chem Lett9, 1415-1418. PubMed  Europe PubMed DOI  I
1997
60. Marais,R., Spooner,R.A., Stribbling,S.M., Light,Y., Martin,J. and Springer,C.J.
    A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
    Nat Biotechnol15, 1373-1377. PubMed  Europe PubMed DOI
61. Rowsell,S., Pauptit,R.A., Tucker,A.D., Melton,R.G., Blow,D.M. and Brick,P.
    Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy
    Structure5, 337-347. PubMed  Europe PubMed  S
1996
62. DeAngelis,L.M., Tong,W.P., Lin,S., Fleisher,M. and Bertino,J.R.
    Carboxypeptidase G2 rescue after high-dose methotrexate
    J Clin Oncol14, 2145-2149. PubMed  Europe PubMed
63. Marais,R., Spooner,R.A., Light,Y., Martin,J. and Springer,C.J.
    Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination
    Cancer Res56, 4735-4742. PubMed  Europe PubMed
64. Michael,N.P., Chester,K.A., Melton,R.G., Robson,L., Nicholas,W., Boden,J.A., Pedley,R.B., Begent,R.H., Sherwood,R.F. and Minton,N.P.
    In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein
    Immunotechnology2, 47-57. PubMed  Europe PubMed DOI
65. O'Marcaigh,A.S., Johnson,C.M., Smithson,W.A., Patterson,M.C., Widemann,B.C., Adamson,P.C. and McManus,M.J.
    Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2
    Mayo Clin Proc71, 161-165. PubMed  Europe PubMed DOI
66. Tucker,A.D., Roswell,S., Melton,R.G. and Paupitt,R.A.
    A new crystal form of carboxypeptidase G2 from Pseudomonas sp. strain RS-16 which is more amenable to structure determination
    Acta Crystallogr D Biol Crystallogr52, 890-892. PubMed  Europe PubMed DOI
1995
67. Blakey,D.C., Davies,D.H., Dowell,R.I., East,S.J., Burke,P.J., Sharma,S.K., Springer,C.J., Mauger,A.B. and Melton,R.G.
    Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
    Br J Cancer72, 1083-1088. PubMed  Europe PubMed
68. Widemann,B.C., Hetherington,M.L., Murphy,R.F., Balis,F.M. and Adamson,P.C.
    Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity
    Cancer76, 521-526. PubMed  Europe PubMed DOI
1994
69. Werlen,R.C., Lankinen,M., Rose,K., Blakey,D., Shuttleworth,H., Melton,R. and Offord,R.E.
    Site-specific conjugation of an enzyme and an antibody fragment
    Bioconjug Chem5, 411-417. PubMed  Europe PubMed
1992
70. Boyen,A., Charlier,D., Charlier,J., Sakanyan,V., Mett,I. and Glansdorff,N.
    Acetylornithine deacetylase, succinyldiaminopimelate desuccinylase and carboxypeptidase G2 are evolutionarily related
    Gene116, 1-6. PubMed  Europe PubMed DOI
1991
71. Adamson,P.C., Balis,F.M., McCully,C.L., Godwin,K.S., Bacher,J.D., Walsh,T.J. and Poplack,D.G.
    Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase-G2
    J Clin Oncol9, 670-674. PubMed  Europe PubMed
72. Lloyd,L.F., Collyer,C.A. and Sherwood,R.F.
    Crystallization and preliminary crystallographic analysis of carboxypeptidase G2 from Pseudomonas sp. strain RS- 16
    J Mol Biol220, 17-18. PubMed  Europe PubMed DOI  S
73. Springer,C.J., Bagshawe,K.D., Sharma,S.K., Searle,F., Boden,J.A., Antoniw,P., Burke,P.J., Rogers,G.T., Sherwood,R.F. and Melton,R.G.
    Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds
    Eur J Cancer27, 1361-1366. PubMed  Europe PubMed DOI
1990
74. Melton,R.G., Searle,F., Sherwood,R.F., Bagshawe,K.D. and Boden,J.A.
    The potential of carboxypeptidase G2:antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model
    Br J Cancer61, 420-424. PubMed  Europe PubMed
75. [YEAR:1-6-1990]Searle,F., Bagshawe,K.D., Pedley,R.B., Bradshaw,T., Melton,R.G., Sherwood,R.F. and Mellor,B.
    Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro
    Biochem Pharmacol39, 1787-1791. PubMed  Europe PubMed DOI
76. Springer,C.J., Antoniw,P., Bagshawe,K.D., Searle,F., Bisset,G.M. and Jarman,M.
    Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
    J Med Chem33, 677-681. PubMed  Europe PubMed
1989
77. [YEAR:1-11-1989]Romanini,A., Sobrero,A.F., Chou,T.C., Sherwood,R.F. and Bertino,J.R.
    Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2
    Cancer Res49, 6019-6023. PubMed  Europe PubMed
1988
78. Bagshawe,K.D., Springer,C.J., Searle,F., Antoniw,P., Sharma,S.K., Melton,R.G. and Sherwood,R.F.
    A cytotoxic agent can be generated selectively at cancer sites
    Br J Cancer58, 700-703. PubMed  Europe PubMed
1986
79. Searle,F., Bier,C., Buckley,R.G., Newman,S., Pedley,R.B., Bagshawe,K.D., Melton,R.G., Alwan,S.M. and Sherwood,R.F.
    The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro
    Br J Cancer53, 377-384. PubMed  Europe PubMed
1985
80. Clarke,L.E., Gibson,R.F., Sherwood,R.F. and Minton,N.P.
    Expression of the Pseudomonas gene coding for carboxypeptidase G2 in Saccharomyces cerevisiae
    J Gen Microbiol131, 897-903. PubMed  Europe PubMed  E
81. [YEAR:2-5-1985]Sherwood,R.F., Melton,R.G., Alwan,S.M. and Hughes,P.
    Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method
    Eur J Biochem148, 447-453. PubMed  Europe PubMed
1984
82. Minton,N.P., Atkinson,T., Bruton,C.J. and Sherwood,R.F.
    The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2
    Gene31, 31-38. PubMed  Europe PubMed
1983
83. Minton,N.P., Atkinson,T. and Sherwood,R.F.
    Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida
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