Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M19.001: membrane dipeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hoyt,L.R., Liu,E., Olson,E.C., Jacobsen,D.R., Siniscalco,E.R., Krier-Burris,R.A., Greenfield,K.G., McBride,C.D., Alfajaro,M.M., Amat,J.A.R., Zhao,Z., Xu,L., Philip,V., Verma,A., Fourati,S., Senger,D.L., Zhang,L., Bunyavanich,S., Glass,S.E., Coffey,R.J., Wilen,C.B., Williams,A. and Eisenbarth,S.C.<br>Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice<br>Science (2025) 389, eadp0240-eadp0240. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Kim,J.T., Park,E.S., Hwang,Y.S., Yoon,H.R., Yoon,S.R., Cho,H.J. and Lee,H.G.<br>Attenuation of natural killer cell cytotoxicity by interaction between NKp30 of NK cells and dipeptidase 1 of colon cancer cells<br>Sci Rep (2025) 15, 34777-34777. PubMed  Europe PubMed DOI  PMC  EPMC  K
    3. 2021
  3. Guan,Y., Liang,X., Ma,Z., Hu,H., Liu,H., Miao,Z., Linkermann,A., Hellwege,J.N., Voight,B.F. and Susztak,K.<br>A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis<br>Nat Commun (2021) 12, 5078-5078. PubMed  Europe PubMed DOI
    4. 2015
  4. Moulton,R.D., Ruterbories,K.J., Bedwell,D.W. and Mohutsky,M.A.<br>In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug<br>Drug Metab Dispos (2015) 43, 756-761. PubMed  Europe PubMed DOI  I
    5. 2012
  5. Hooper,N.M.<br>Membrane dipeptidase<br>[ISSN:978-0-12-407743-0] (2012) 3, 1670-1673. DOI
    6. 2004
  6. [YEAR:5-7-2004]Gurulingappa,H., Buckhalts,P., Kinzler,K.W., Vogelstein,B. and Khan,S.R.<br>Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase<br>Bioorg Med Chem Lett (5-7-2004) 14, 3531-3533. PubMed  Europe PubMed DOI  I
  7. Hooper,N.M.<br>Membrane dipeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 994-997.  V
  8. [YEAR:8-6-2004]McIver,C.M., Lloyd,J.M., Hewett,P.J. and Hardingham,J.E.<br>Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma<br>Cancer Lett (8-6-2004) 209, 67-74. PubMed  Europe PubMed DOI
    9. 2003
  9. Ikeda,H., Ueda,M., Kobayashi,H. and Honda,Y.<br>Localization and activity of membrane dipeptidase in bovine ciliary epithelium<br>Invest Ophthalmol Vis Sci (2003) 44, 37-43. PubMed  Europe PubMed DOI
    10. 2002
  10. [YEAR:9-8-2002]Nitanai,Y., Satow,Y., Adachi,H. and Tsujimoto,M.<br>Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis<br>J Mol Biol (9-8-2002) 321, 177-184. PubMed  Europe PubMed DOI  S  I
    11. 2001
  11. [YEAR:15-8-2001]Parkin,E.T., Turner,A.J. and Hooper,N.M.<br>Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase<br>Biochem J (15-8-2001) 358, 209-216. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2000
  12. Choi,K., Park,S.W., Lee,K.J., Lee,H.B., Han,H.J., Park,S.K. and Park,H.S.<br>Grass carp (Ctenopharyngodon idellus) bile may inhibit the release of renal dipeptidase from the proximal tubules by nitric oxide generation<br>Kidney Blood Press Res (2000) 23, 113-118. PubMed  Europe PubMed
    13. 1999
  13. Grondin,G., Hooper,N.M. and LeBel,D.<br>Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells<br>J Histochem Cytochem (1999) 47, 489-498. PubMed  Europe PubMed
  14. Kera,Y., Liu,Z., Matsumoto,T., Sorimachi,Y., Nagasaki,H. and Yamada,R.H.<br>Rat and human membrane dipeptidase: tissue distribution and developmental changes<br>Comp Biochem Physiol B Biochem Mol Biol (1999) 123, 53-58. PubMed  Europe PubMed DOI  I
  15. [YEAR:23-4-1999]Rajotte,D. and Ruoslahti,E.<br>Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display<br>J Biol Chem (23-4-1999) 274, 11593-11598. PubMed  Europe PubMed DOI
  16. [YEAR:15-3-1999]White,I.J., Lawson,J., Williams,C.H. and Hooper,N.M.<br>A continuous fluorometric assay for leukotriene D4 hydrolase<br>Anal Biochem (15-3-1999) 268, 245-251. PubMed  Europe PubMed DOI  A  I
    17. 1998
  17. [YEAR:28-4-1998]Habib,G.M., Shi,Z.Z., Cuevas,A.A., Guo,Q., Matzuk,M.M. and Lieberman,M.W.<br>Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice<br>Proc Natl Acad Sci U S A (28-4-1998) 95, 4859-4863. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Hofken,T., Linder,D., Kleene,R., Goke,B. and Wagner,A.C.<br>Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules<br>Exp Cell Res (1998) 244, 481-490. PubMed  Europe PubMed DOI
    19. 1997
  19. Hooper,N.M., Cook,S., Laine,J. and LeBel,D.<br>Identification of membrane dipeptidase as a major glycosyl-phosphatidylinositol-anchored protein of the pancreatic zymogen granule membrane, and evidence for its release by phospholipase A<br>Biochem J (1997) 324, 151-157. PubMed  Europe PubMed  PMC  EPMC  I
  20. Keynan,S., Asipu,A., Hooper,N.M., Turner,A.J. and Blair,G.E.<br>Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase<br>Oncogene (1997) 15, 1241-1245. PubMed  Europe PubMed DOI
  21. Keynan,S., Hooper,N.M. and Turner,A.J.<br>Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase<br>Biochem J (1997) 326, 47-51. PubMed  Europe PubMed  PMC  EPMC  I
  22. We,J.S., Kang,B.Y., Lee,J.C., Lee,H.B. and Park,H.S.<br>Identification of urinary dipeptidase as the released form of renal dipeptidase<br>Kidney Blood Press Res (1997) 20, 411-415. PubMed  Europe PubMed
    23. 1996
  23. [YEAR:5-7-1996]Habib,G.M., Barrios,R., Shi,Z.Z. and Lieberman,M.W.<br>Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase<br>J Biol Chem (5-7-1996) 271, 16273-16280. PubMed  Europe PubMed DOI  K  R
  24. Keynan,S., Habgood,N.T., Hooper,N.M. and Turner,A.J.<br>Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization<br>Biochemistry (1996) 35, 12511-12517. PubMed  Europe PubMed DOI
  25. Watanabe,T., Kera,Y., Matsumoto,T. and Yamada,R.H.<br>Purification and kinetic properties of a D-amino-acid peptide hydrolyzing enzyme from pig kidney cortex and its tentative identification with renal membrane dipeptidase<br>Biochim Biophys Acta (1996) 1298, 109-118. PubMed  Europe PubMed DOI  I
    26. 1995
  26. Brewis,I.A., Ferguson,M.A., Mehlert,A., Turner,A.J. and Hooper,N.M.<br>Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures<br>J Biol Chem (1995) 270, 22946-22956. PubMed  Europe PubMed DOI
  27. Heywood,S.P. and Hooper,N.M.<br>Development and application of a fluorometric assay for mammalian membrane dipeptidase<br>Anal Biochem (1995) 226, 10-14. PubMed  Europe PubMed DOI  A
    28. 1994
  28. An,S., Schmidt,F.J. and Campbell,B.J.<br>Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4<br>Biochim Biophys Acta (1994) 1226, 337-340. PubMed  Europe PubMed DOI
  29. Keynan,S., Hooper,N.M. and Turner,A.J.<br>Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity<br>FEBS Lett (1994) 349, 50-54. PubMed  Europe PubMed DOI
    30. 1993
  30. [YEAR:21-4-1993]Adachi,H., Katayama,T., Nakazato,H. and Tsujimoto,M.<br>Importance of Glu-125 in the catalytic activity of human renal dipeptidase<br>Biochim Biophys Acta (21-4-1993) 1163, 42-48. PubMed  Europe PubMed DOI
  31. Austruy,E., Jeanpierre,C., Antignac,C., Whitmore,S.A., Van Cong,N., Bernheim,A., Callen,D.F. and Junien,C.<br>Physical and genetic mapping of the dipeptidase gene DPEP1 to 16q24.3<br>Genomics (1993) 15, 684-687. PubMed  Europe PubMed DOI
  32. Brewis,I.A., Hooper,N.M. and Turner,A.J.<br>Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase<br>Biochem Soc Trans (1993) 21, 44S-44S. PubMed  Europe PubMed
  33. Brewis,I.A., Ferguson,M.A., Turner,A.J. and Hooper,N.M.<br>Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases<br>Biochem Soc Trans (1993) 21, 46S-46S. PubMed  Europe PubMed
  34. Satoh,S., Keida,Y., Konta,Y., Maeda,M., Matsumoto,Y., Niwa,M. and Kohsaka,M.<br>Purification and molecular cloning of mouse renal dipeptidase<br>Biochim Biophys Acta (1993) 1163, 234-242. PubMed  Europe PubMed DOI
    35. 1992
  35. [YEAR:20-10-1992]Adachi,H., Ishida,N. and Tsujimoto,M.<br>Primary structure of rat renal dipeptidase and expression of its mRNA in rat tissues and COS-1 cells<br>Biochim Biophys Acta (20-10-1992) 1132, 311-314. PubMed  Europe PubMed DOI
  36. Nakagawa,H., Inazawa,J., Inoue,K., Misawa,S., Kashima,K., Adachi,H., Nakazato,H. and Abe,T.<br>Assignment of the human renal dipeptidase gene (DPEP1) to band q24 of chromosome 16<br>Cytogenet Cell Genet (1992) 59, 258-260. PubMed  Europe PubMed
    37. 1991
  37. Igarashi,P. and Karniski,L.P.<br>Cloning of cDNAs encoding a rabbit renal brush border membrane protein immunologically related to band 3. Sequence similarity with microsomal dipeptidase<br>Biochem J (1991) 280, 71-78. PubMed  Europe PubMed  PMC  EPMC
    38. 1990
  38. Adachi,H., Tawaragi,Y., Inuzuka,C., Kubota,I., Tsujimoto,M., Nishihara,T. and Nakazato,H.<br>Primary structure of human microsomal dipeptidase deduced from molecular cloning<br>J Biol Chem (1990) 265, 3992-3995. PubMed  Europe PubMed
  39. [YEAR:16-1-1990]Campbell,B.J., Baker,S.F., Shukla,S.D., Forrester,L.J. and Zahler,W.L.<br>Bioconversion of leukotriene D4 by lung dipeptidase<br>Biochim Biophys Acta (16-1-1990) 1042, 107-112. PubMed  Europe PubMed DOI
  40. Hooper,N.M., Keen,J.N. and Turner,A.J.<br>Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme<br>Biochem J (1990) 265, 429-433. PubMed  Europe PubMed  PMC  EPMC
  41. Rached,E., Hooper,N.M., James,P., Semenza,G., Turner,A.J. and Mantei,N.<br>cDNA cloning and expression in Xenopus laevis oocytes of pig renal dipeptidase, a glycosyl-phosphatidylinositol-anchored ectoenzyme<br>Biochem J (1990) 271, 755-760. PubMed  Europe PubMed  PMC  EPMC
    42. 1989
  42. Adachi,H., Kubota,I., Okamura,N., Iwata,H., Tsujimoto,M., Nakazato,H., Nishihara,T. and Noguchi,T.<br>Purification and characterization of human microsomal dipeptidase<br>J Biochem (1989) 105, 957-961. PubMed  Europe PubMed
    43. 1985
  43. Basker,M.J., Coulton,S. and Southgate,R.<br>Mutual pro-drugs of the olivanic acids and renal dipeptidase inhibitors<br>J Antibiot (Tokyo) (1985) 38, 70-74. PubMed  Europe PubMed  I
    44. 1984
  44. [YEAR:10-12-1984]Campbell,B.J., Forrester,L.J., Zahler,W.L. and Burks,M.<br>Beta-lactamase activity of purified and partially characterized human renal dipeptidase<br>J Biol Chem (10-12-1984) 259, 14586-14590. PubMed  Europe PubMed  I
    45. 1983
  45. Kahan,F.M., Kropp,H., Sundelof,J.G. and Birnbaum,J.<br>Thienamycin: development of imipenen-cilastatin<br>J Antimicrob Chemother (1983) 12 Suppl D, 1-35. PubMed  Europe PubMed  I
    46. 1982
  46. [YEAR:29-10-1982]Kim,H.S. and Campbell,B.J.<br>beta-Lactamase activity of renal dipeptidase against N-formimidoyl-thienamycin<br>Biochem Biophys Res Commun (29-10-1982) 108, 1638-1642. PubMed  Europe PubMed
  47. [YEAR:10-6-1982]Kozak,E.M. and Tate,S.S.<br>Glutathione-degrading enzymes of microvillus membranes<br>J Biol Chem (10-6-1982) 257, 6322-6327. PubMed  Europe PubMed
  48. Kropp,H., Sundelof,J.G., Hajdu,R. and Kahan,F.M.<br>Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase<br>Antimicrobial Agents Chemother (1982) 22, 62-70. PubMed  Europe PubMed  PMC  EPMC
  49. [YEAR:25-10-1982]McIntyre,T. and Curthoys,N.P.<br>Renal catabolism of glutathione. Characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine<br>J Biol Chem (25-10-1982) 257, 11915-11921. PubMed  Europe PubMed
    50. 1974
  50. [YEAR:9-4-1974]Armstrong,D.J., Mukhopadhyay,S.K. and Campbell,B.J.<br>Physicochemical characterization of renal dipeptidase<br>Biochemistry (9-4-1974) 13, 1745-1750. PubMed  Europe PubMed
    51. 1971
  51. [YEAR:20-8-1971]Harper,C., Rene,A. and Campbell,B.J.<br>Renal dipeptidase: localization and inhibition<br>Biochim Biophys Acta (20-8-1971) 242, 446-458. PubMed  Europe PubMed
    52. 1970
  52. Campbell,B.J.<br>Renal dipeptidase<br>Methods Enzymol (1970) 19, 722-729. DOI  V
    53. 1969
  53. [YEAR:25-3-1969]Rene,A.M. and Campbell,B.J.<br>Amino acid composition and effect of pH on the kinetic parameters of renal dipeptidase<br>J Biol Chem (25-3-1969) 244, 1445-1450. PubMed  Europe PubMed
    54. 1966
  54. Campbell,B.J., Lin,Y.C., Davis,R.V. and Ballew,E.<br>The purification and properties of a particulate renal dipeptidase<br>Biochim Biophys Acta (1966) 118, 371-386. PubMed  Europe PubMed
    55. 1963
  55. Campbell,B.J., Lin,Y.C. and Bird,M.E.<br>Renal aminopeptidase- and copper-activated peptide hydrolysis<br>J Biol Chem (1963) 238, 3632-3639. PubMed  Europe PubMed
    56. 1949
  56. Price,V.E. and Meister,A.<br>The separation of dehydropeptidase and analogous L- and D-peptidases<br>J Biol Chem (1949) 181, 535-547. PubMed  Europe PubMed
    57. 1948
  57. Greenstein,J.P.<br>Dehydropeptidases<br>Adv Enzymol Relat Subj Biochem (1948) 8, 117-169.
  58. Greenstein,J.P., Price,V.E. and Leuthardt,F.M.<br>Studies on the possible multiple nature of dehydropeptidase I<br>J Biol Chem (1948) 175, 953-962. PubMed  Europe PubMed
  59. Rice,V.E. and Greenstein,J.P.<br>Enzymatic hydrolysis of analogous saturated and unsaturated peptides<br>J Biol Chem (1948) 175, 969-974.
    60. 1947
  60. Yudkin,W.H. and Fruton,J.S.<br>The activation of dehydropeptidase by zinc<br>J Biol Chem (1947) 170, 421-422.
  61. Yudkin,W.H. and Fruton,J.S.<br>On the proteolytic enzymes of animal tissues. VI. Dehydropeptidase<br>J Biol Chem (1947) 169, 521-529. PubMed  Europe PubMed
    62. 1932
  62. Bergmann,M.<br>[Dehydrodipeptidase. Enzymic cleavage of compounds of pyruvic acid and amino acids]<br>Hoppe Seylers Z Physiol Chem (1932) 207, 235-240.
  63. Bergmann,M. and Schleich,H.<br>[On the enzymatic cleavage of dehydropeptides. Discovery of a dehydropeptidase]<br>Hoppe Seylers Z Physiol Chem (1932) 205, 65-82.

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use