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Literature for peptidase M19.001: membrane dipeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hoyt,L.R., Liu,E., Olson,E.C., Jacobsen,D.R., Siniscalco,E.R., Krier-Burris,R.A., Greenfield,K.G., McBride,C.D., Alfajaro,M.M., Amat,J.A.R., Zhao,Z., Xu,L., Philip,V., Verma,A., Fourati,S., Senger,D.L., Zhang,L., Bunyavanich,S., Glass,S.E., Coffey,R.J., Wilen,C.B., Williams,A. and Eisenbarth,S.C.
    Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
    Science (2025) 389, eadp0240-eadp0240. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Kim,J.T., Park,E.S., Hwang,Y.S., Yoon,H.R., Yoon,S.R., Cho,H.J. and Lee,H.G.
    Attenuation of natural killer cell cytotoxicity by interaction between NKp30 of NK cells and dipeptidase 1 of colon cancer cells
    Sci Rep (2025) 15, 34777-34777. PubMed  Europe PubMed DOI  PMC  EPMC  K
    3. 2021
  3. Guan,Y., Liang,X., Ma,Z., Hu,H., Liu,H., Miao,Z., Linkermann,A., Hellwege,J.N., Voight,B.F. and Susztak,K.
    A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
    Nat Commun (2021) 12, 5078-5078. PubMed  Europe PubMed DOI
    4. 2015
  4. Moulton,R.D., Ruterbories,K.J., Bedwell,D.W. and Mohutsky,M.A.
    In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug
    Drug Metab Dispos (2015) 43, 756-761. PubMed  Europe PubMed DOI  I
    5. 2012
  5. Hooper,N.M.
    Membrane dipeptidase
    [ISSN:978-0-12-407743-0] (2012) 3, 1670-1673. DOI
    6. 2004
  6. [YEAR:5-7-2004]Gurulingappa,H., Buckhalts,P., Kinzler,K.W., Vogelstein,B. and Khan,S.R.
    Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase
    Bioorg Med Chem Lett (5-7-2004) 14, 3531-3533. PubMed  Europe PubMed DOI  I
  7. Hooper,N.M.
    Membrane dipeptidase
    [ISSN:0-12-079610-4] (2004) 2, 994-997.  V
  8. [YEAR:8-6-2004]McIver,C.M., Lloyd,J.M., Hewett,P.J. and Hardingham,J.E.
    Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma
    Cancer Lett (8-6-2004) 209, 67-74. PubMed  Europe PubMed DOI
    9. 2003
  9. Ikeda,H., Ueda,M., Kobayashi,H. and Honda,Y.
    Localization and activity of membrane dipeptidase in bovine ciliary epithelium
    Invest Ophthalmol Vis Sci (2003) 44, 37-43. PubMed  Europe PubMed DOI
    10. 2002
  10. [YEAR:9-8-2002]Nitanai,Y., Satow,Y., Adachi,H. and Tsujimoto,M.
    Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis
    J Mol Biol (9-8-2002) 321, 177-184. PubMed  Europe PubMed DOI  S  I
    11. 2001
  11. [YEAR:15-8-2001]Parkin,E.T., Turner,A.J. and Hooper,N.M.
    Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase
    Biochem J (15-8-2001) 358, 209-216. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2000
  12. Choi,K., Park,S.W., Lee,K.J., Lee,H.B., Han,H.J., Park,S.K. and Park,H.S.
    Grass carp (Ctenopharyngodon idellus) bile may inhibit the release of renal dipeptidase from the proximal tubules by nitric oxide generation
    Kidney Blood Press Res (2000) 23, 113-118. PubMed  Europe PubMed
    13. 1999
  13. Grondin,G., Hooper,N.M. and LeBel,D.
    Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells
    J Histochem Cytochem (1999) 47, 489-498. PubMed  Europe PubMed
  14. Kera,Y., Liu,Z., Matsumoto,T., Sorimachi,Y., Nagasaki,H. and Yamada,R.H.
    Rat and human membrane dipeptidase: tissue distribution and developmental changes
    Comp Biochem Physiol B Biochem Mol Biol (1999) 123, 53-58. PubMed  Europe PubMed DOI  I
  15. [YEAR:23-4-1999]Rajotte,D. and Ruoslahti,E.
    Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display
    J Biol Chem (23-4-1999) 274, 11593-11598. PubMed  Europe PubMed DOI
  16. [YEAR:15-3-1999]White,I.J., Lawson,J., Williams,C.H. and Hooper,N.M.
    A continuous fluorometric assay for leukotriene D4 hydrolase
    Anal Biochem (15-3-1999) 268, 245-251. PubMed  Europe PubMed DOI  A  I
    17. 1998
  17. [YEAR:28-4-1998]Habib,G.M., Shi,Z.Z., Cuevas,A.A., Guo,Q., Matzuk,M.M. and Lieberman,M.W.
    Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice
    Proc Natl Acad Sci U S A (28-4-1998) 95, 4859-4863. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Hofken,T., Linder,D., Kleene,R., Goke,B. and Wagner,A.C.
    Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules
    Exp Cell Res (1998) 244, 481-490. PubMed  Europe PubMed DOI
    19. 1997
  19. Hooper,N.M., Cook,S., Laine,J. and LeBel,D.
    Identification of membrane dipeptidase as a major glycosyl-phosphatidylinositol-anchored protein of the pancreatic zymogen granule membrane, and evidence for its release by phospholipase A
    Biochem J (1997) 324, 151-157. PubMed  Europe PubMed  PMC  EPMC  I
  20. Keynan,S., Asipu,A., Hooper,N.M., Turner,A.J. and Blair,G.E.
    Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase
    Oncogene (1997) 15, 1241-1245. PubMed  Europe PubMed DOI
  21. Keynan,S., Hooper,N.M. and Turner,A.J.
    Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase
    Biochem J (1997) 326, 47-51. PubMed  Europe PubMed  PMC  EPMC  I
  22. We,J.S., Kang,B.Y., Lee,J.C., Lee,H.B. and Park,H.S.
    Identification of urinary dipeptidase as the released form of renal dipeptidase
    Kidney Blood Press Res (1997) 20, 411-415. PubMed  Europe PubMed
    23. 1996
  23. [YEAR:5-7-1996]Habib,G.M., Barrios,R., Shi,Z.Z. and Lieberman,M.W.
    Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase
    J Biol Chem (5-7-1996) 271, 16273-16280. PubMed  Europe PubMed DOI  K  R
  24. Keynan,S., Habgood,N.T., Hooper,N.M. and Turner,A.J.
    Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization
    Biochemistry (1996) 35, 12511-12517. PubMed  Europe PubMed DOI
  25. Watanabe,T., Kera,Y., Matsumoto,T. and Yamada,R.H.
    Purification and kinetic properties of a D-amino-acid peptide hydrolyzing enzyme from pig kidney cortex and its tentative identification with renal membrane dipeptidase
    Biochim Biophys Acta (1996) 1298, 109-118. PubMed  Europe PubMed DOI  I
    26. 1995
  26. Brewis,I.A., Ferguson,M.A., Mehlert,A., Turner,A.J. and Hooper,N.M.
    Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures
    J Biol Chem (1995) 270, 22946-22956. PubMed  Europe PubMed DOI
  27. Heywood,S.P. and Hooper,N.M.
    Development and application of a fluorometric assay for mammalian membrane dipeptidase
    Anal Biochem (1995) 226, 10-14. PubMed  Europe PubMed DOI  A
    28. 1994
  28. An,S., Schmidt,F.J. and Campbell,B.J.
    Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4
    Biochim Biophys Acta (1994) 1226, 337-340. PubMed  Europe PubMed DOI
  29. Keynan,S., Hooper,N.M. and Turner,A.J.
    Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity
    FEBS Lett (1994) 349, 50-54. PubMed  Europe PubMed DOI
    30. 1993
  30. [YEAR:21-4-1993]Adachi,H., Katayama,T., Nakazato,H. and Tsujimoto,M.
    Importance of Glu-125 in the catalytic activity of human renal dipeptidase
    Biochim Biophys Acta (21-4-1993) 1163, 42-48. PubMed  Europe PubMed DOI
  31. Austruy,E., Jeanpierre,C., Antignac,C., Whitmore,S.A., Van Cong,N., Bernheim,A., Callen,D.F. and Junien,C.
    Physical and genetic mapping of the dipeptidase gene DPEP1 to 16q24.3
    Genomics (1993) 15, 684-687. PubMed  Europe PubMed DOI
  32. Brewis,I.A., Hooper,N.M. and Turner,A.J.
    Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase
    Biochem Soc Trans (1993) 21, 44S-44S. PubMed  Europe PubMed
  33. Brewis,I.A., Ferguson,M.A., Turner,A.J. and Hooper,N.M.
    Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases
    Biochem Soc Trans (1993) 21, 46S-46S. PubMed  Europe PubMed
  34. Satoh,S., Keida,Y., Konta,Y., Maeda,M., Matsumoto,Y., Niwa,M. and Kohsaka,M.
    Purification and molecular cloning of mouse renal dipeptidase
    Biochim Biophys Acta (1993) 1163, 234-242. PubMed  Europe PubMed DOI
    35. 1992
  35. [YEAR:20-10-1992]Adachi,H., Ishida,N. and Tsujimoto,M.
    Primary structure of rat renal dipeptidase and expression of its mRNA in rat tissues and COS-1 cells
    Biochim Biophys Acta (20-10-1992) 1132, 311-314. PubMed  Europe PubMed DOI
  36. Nakagawa,H., Inazawa,J., Inoue,K., Misawa,S., Kashima,K., Adachi,H., Nakazato,H. and Abe,T.
    Assignment of the human renal dipeptidase gene (DPEP1) to band q24 of chromosome 16
    Cytogenet Cell Genet (1992) 59, 258-260. PubMed  Europe PubMed
    37. 1991
  37. Igarashi,P. and Karniski,L.P.
    Cloning of cDNAs encoding a rabbit renal brush border membrane protein immunologically related to band 3. Sequence similarity with microsomal dipeptidase
    Biochem J (1991) 280, 71-78. PubMed  Europe PubMed  PMC  EPMC
    38. 1990
  38. Adachi,H., Tawaragi,Y., Inuzuka,C., Kubota,I., Tsujimoto,M., Nishihara,T. and Nakazato,H.
    Primary structure of human microsomal dipeptidase deduced from molecular cloning
    J Biol Chem (1990) 265, 3992-3995. PubMed  Europe PubMed
  39. [YEAR:16-1-1990]Campbell,B.J., Baker,S.F., Shukla,S.D., Forrester,L.J. and Zahler,W.L.
    Bioconversion of leukotriene D4 by lung dipeptidase
    Biochim Biophys Acta (16-1-1990) 1042, 107-112. PubMed  Europe PubMed DOI
  40. Hooper,N.M., Keen,J.N. and Turner,A.J.
    Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme
    Biochem J (1990) 265, 429-433. PubMed  Europe PubMed  PMC  EPMC
  41. Rached,E., Hooper,N.M., James,P., Semenza,G., Turner,A.J. and Mantei,N.
    cDNA cloning and expression in Xenopus laevis oocytes of pig renal dipeptidase, a glycosyl-phosphatidylinositol-anchored ectoenzyme
    Biochem J (1990) 271, 755-760. PubMed  Europe PubMed  PMC  EPMC
    42. 1989
  42. Adachi,H., Kubota,I., Okamura,N., Iwata,H., Tsujimoto,M., Nakazato,H., Nishihara,T. and Noguchi,T.
    Purification and characterization of human microsomal dipeptidase
    J Biochem (1989) 105, 957-961. PubMed  Europe PubMed
    43. 1985
  43. Basker,M.J., Coulton,S. and Southgate,R.
    Mutual pro-drugs of the olivanic acids and renal dipeptidase inhibitors
    J Antibiot (Tokyo) (1985) 38, 70-74. PubMed  Europe PubMed  I
    44. 1984
  44. [YEAR:10-12-1984]Campbell,B.J., Forrester,L.J., Zahler,W.L. and Burks,M.
    Beta-lactamase activity of purified and partially characterized human renal dipeptidase
    J Biol Chem (10-12-1984) 259, 14586-14590. PubMed  Europe PubMed  I
    45. 1983
  45. Kahan,F.M., Kropp,H., Sundelof,J.G. and Birnbaum,J.
    Thienamycin: development of imipenen-cilastatin
    J Antimicrob Chemother (1983) 12 Suppl D, 1-35. PubMed  Europe PubMed  I
    46. 1982
  46. [YEAR:29-10-1982]Kim,H.S. and Campbell,B.J.
    beta-Lactamase activity of renal dipeptidase against N-formimidoyl-thienamycin
    Biochem Biophys Res Commun (29-10-1982) 108, 1638-1642. PubMed  Europe PubMed
  47. [YEAR:10-6-1982]Kozak,E.M. and Tate,S.S.
    Glutathione-degrading enzymes of microvillus membranes
    J Biol Chem (10-6-1982) 257, 6322-6327. PubMed  Europe PubMed
  48. Kropp,H., Sundelof,J.G., Hajdu,R. and Kahan,F.M.
    Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase
    Antimicrobial Agents Chemother (1982) 22, 62-70. PubMed  Europe PubMed  PMC  EPMC
  49. [YEAR:25-10-1982]McIntyre,T. and Curthoys,N.P.
    Renal catabolism of glutathione. Characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine
    J Biol Chem (25-10-1982) 257, 11915-11921. PubMed  Europe PubMed
    50. 1974
  50. [YEAR:9-4-1974]Armstrong,D.J., Mukhopadhyay,S.K. and Campbell,B.J.
    Physicochemical characterization of renal dipeptidase
    Biochemistry (9-4-1974) 13, 1745-1750. PubMed  Europe PubMed
    51. 1971
  51. [YEAR:20-8-1971]Harper,C., Rene,A. and Campbell,B.J.
    Renal dipeptidase: localization and inhibition
    Biochim Biophys Acta (20-8-1971) 242, 446-458. PubMed  Europe PubMed
    52. 1970
  52. Campbell,B.J.
    Renal dipeptidase
    Methods Enzymol (1970) 19, 722-729. DOI  V
    53. 1969
  53. [YEAR:25-3-1969]Rene,A.M. and Campbell,B.J.
    Amino acid composition and effect of pH on the kinetic parameters of renal dipeptidase
    J Biol Chem (25-3-1969) 244, 1445-1450. PubMed  Europe PubMed
    54. 1966
  54. Campbell,B.J., Lin,Y.C., Davis,R.V. and Ballew,E.
    The purification and properties of a particulate renal dipeptidase
    Biochim Biophys Acta (1966) 118, 371-386. PubMed  Europe PubMed
    55. 1963
  55. Campbell,B.J., Lin,Y.C. and Bird,M.E.
    Renal aminopeptidase- and copper-activated peptide hydrolysis
    J Biol Chem (1963) 238, 3632-3639. PubMed  Europe PubMed
    56. 1949
  56. Price,V.E. and Meister,A.
    The separation of dehydropeptidase and analogous L- and D-peptidases
    J Biol Chem (1949) 181, 535-547. PubMed  Europe PubMed
    57. 1948
  57. Greenstein,J.P.
    Dehydropeptidases
    Adv Enzymol Relat Subj Biochem (1948) 8, 117-169.
  58. Greenstein,J.P., Price,V.E. and Leuthardt,F.M.
    Studies on the possible multiple nature of dehydropeptidase I
    J Biol Chem (1948) 175, 953-962. PubMed  Europe PubMed
  59. Rice,V.E. and Greenstein,J.P.
    Enzymatic hydrolysis of analogous saturated and unsaturated peptides
    J Biol Chem (1948) 175, 969-974.
    60. 1947
  60. Yudkin,W.H. and Fruton,J.S.
    The activation of dehydropeptidase by zinc
    J Biol Chem (1947) 170, 421-422.
  61. Yudkin,W.H. and Fruton,J.S.
    On the proteolytic enzymes of animal tissues. VI. Dehydropeptidase
    J Biol Chem (1947) 169, 521-529. PubMed  Europe PubMed
    62. 1932
  62. Bergmann,M.
    [Dehydrodipeptidase. Enzymic cleavage of compounds of pyruvic acid and amino acids]
    Hoppe Seylers Z Physiol Chem (1932) 207, 235-240.
  63. Bergmann,M. and Schleich,H.
    [On the enzymatic cleavage of dehydropeptides. Discovery of a dehydropeptidase]
    Hoppe Seylers Z Physiol Chem (1932) 205, 65-82.

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