Literature for peptidase M17.008: M17 aminopeptidase (Plasmodium spp.)

(Topics flags: S Structure, T Target, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2023
1. Mansouri,M., Daware,K., Webb,C.T. and McGowan,S.
   Understanding the structure and function of Plasmodium aminopeptidases to facilitate drug discovery
   Curr Opin Struct Biol82, 102693-102693. PubMed  Europe PubMed DOI
2022
2. Dabburu,G.R., Jain,A., Subbarao,N. and Kumar,M.
   Designing dual inhibitors against potential drug targets of Plasmodium falciparum -M17 Leucyl Aminopeptidase and Plasmepsins
   J Biomol Struct Dyn1-16. PubMed  Europe PubMed DOI
3. Edgar,R.C.S., Siddiqui,G., Hjerrild,K., Malcolm,T.R., Vinh,N.B., Webb,C.T., Holmes,C., MacRaild,C.A., Chernih,H.C., Suen,W.W., Counihan,N.A., Creek,D.J., Scammells,P.J., McGowan,S. and de Koning-Ward,T.F.
   Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway
   elife11, PubMed  Europe PubMed DOI
4. Webb,C.T., Yang,W., Riley,B.T., Hayes,B.K., Sivaraman,K.K., Malcolm,T.R., Harrop,S., Atkinson,S.C., Kass,I., Buckle,A.M., Drinkwater,N. and McGowan,S.
   A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase
   J Biol Chem298, 102119-102119. PubMed  Europe PubMed DOI
2021
5. Mathew,R., Wunderlich,J., Thivierge,K., Cwiklinski,K., Dumont,C., Tilley,L., Rohrbach,P. and Dalton,J.P.
   Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)
   Sci Rep11, 2854-2854. PubMed  Europe PubMed DOI
2019
6. Vinh,N.B., Drinkwater,N., Malcolm,T.R., Kassiou,M., Lucantoni,L., Grin,P.M., Butler,G.S., Duffy,S., Overall,C.M., Avery,V.M., Scammells,P.J. and McGowan,S.
   Hydroxamic acid inhibitors provide cross-species inhibition of Plasmodium M1 and M17 aminopeptidases
   J Med Chem62, 622-640. PubMed  Europe PubMed DOI  I
7. Wang,F., Hu,X. and Zhou,B.
   Structural characterization of plasmodial aminopeptidase: a combined molecular docking and QSAR-based in silico approaches
   Mol Divers23, 965-984. PubMed  Europe PubMed DOI
2018
8. Mnkandhla,D., Marwijk,J.V., Hoppe,H., Wilhelmi,B.S. and Whiteley,C.G.
   In vivo; in vitro interaction of silver nanoparticles with leucine aminopeptidase from human and Plasmodium falciparum
   J Nanosci Nanotechnol18, 865-871. PubMed  Europe PubMed DOI
2016
9. Chaudhary,M., Singh,V., Anvikar,A.R. and Sahi,S.
   Screening and in vitro evaluation of potential Plasmodium falciparum leucyl aminopeptidase inhibitors
   Curr Comput Aided Drug Des12, 282-293. PubMed  Europe PubMed  I
10. Drinkwater,N., Vinh,N.B., Mistry,S.N., Bamert,R.S., Ruggeri,C., Holleran,J.P., Loganathan,S., Paiardini,A., Charman,S.A., Powell,A.K., Avery,V.M., McGowan,S. and Scammells,P.J.
    Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
    Eur J Med Chem110, 43-64. PubMed  Europe PubMed DOI  I
11. Rout,S. and Mahapatra,R.K.
    In silico screening of novel inhibitors of M17 leucine amino peptidase (LAP) of Plasmodium vivax as therapeutic candidate
    Biomed Pharmacother82, 192-201. PubMed  Europe PubMed DOI  I
2015
12. Drinkwater,N., Bamert,R.S., Sivaraman,K.K., Paiardini,A. and McGowan,S.
    X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17
    Proteins83, 789-795. PubMed  Europe PubMed DOI  S  I
13. Ruggeri,C., Drinkwater,N., Sivaraman,K.K., Bamert,R.S., McGowan,S. and Paiardini,A.
    Identification and validation of a potent dual inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening
    PLoS ONE10, e0138957-e0138957. PubMed  Europe PubMed DOI  I
2014
14. Sahi,S., Raj,U., Chaudhary,M. and Nain,V.
    Modelling of human leucyl aminopeptidases for in silico off target binding analysis of potential Plasmodium falciparum leucine aminopeptidase (PfA-M17) specific inhibitors
    Recent Pat Endocr Metab Immune Drug Discov8, 191-201. PubMed  Europe PubMed  I
2013
15. McGowan,S.
    Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum
    Bioinformation9, 661-662. PubMed  Europe PubMed DOI  I
2012
16. Nsangou,D.M.M., Mathew,R.T., Thivierge,K., Gardiner,D.L. and Dalton,J.P.
    Leucyl aminopeptidase of Plasmodium falciparum
    [ISSN:978-0-12-407743-0]3, 1481-1484. DOI
2011
17. Harbut,M.B., Velmourougane,G., Dalal,S., Reiss,G., Whisstock,J.C., Onder,O., Brisson,D., McGowan,S., Klemba,M. and Greenbaum,D.C.
    Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
    Proc Natl Acad Sci U S A108, E526-E534. PubMed  Europe PubMed DOI  I
2010
18. Lee,J.Y., Song,S.M., Seok,J.W., Jha,B.K., Han,E.T., Song,H.O., Yu,H.S., Hong,Y., Kong,H.H. and Chung,D.I.
    M17 leucine aminopeptidase of the human malaria parasite Plasmodium vivax
    Mol Biochem Parasitol170, 45-48. PubMed  Europe PubMed DOI
19. McGowan,S., Oellig,C.A., Birru,W.A., Caradoc-Davies,T.T., Stack,C.M., Lowther,J., Skinner-Adams,T., Mucha,A., Kafarski,P., Grembecka,J., Trenholme,K.R., Buckle,A.M., Gardiner,D.L., Dalton,J.P. and Whisstock,J.C.
    Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
    Proc Natl Acad Sci U S A107, 2449-2454. PubMed  Europe PubMed DOI  S
20. Skinner-Adams,T.S., Stack,C.M., Trenholme,K.R., Brown,C.L., Grembecka,J., Lowther,J., Mucha,A., Drag,M., Kafarski,P., McGowan,S., Whisstock,J.C., Gardiner,D.L. and Dalton,J.P.
    Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
    Trends Biochem Sci35, 53-61. PubMed  Europe PubMed DOI  T
2009
21. Jia,H., Terkawi,M.A., Aboge,G.O., Goo,Y.K., Luo,Y., Li,Y., Yamagishi,J., Nishikawa,Y., Igarashi,I., Sugimoto,C., Fujisaki,K. and Xuan,X.
    Characterization of a leucine aminopeptidase of Babesia gibsoni
    Parasitology136, 945-952. PubMed  Europe PubMed DOI
22. Maric,S., Donnelly,S.M., Robinson,M.W., Skinner-Adams,T., Trenholme,K.R., Gardiner,D.L., Dalton,J.P., Stack,C.M. and Lowther,J.
    The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors
    Biochemistry48, 5435-5439. PubMed  Europe PubMed DOI
2007
23. Skinner-Adams,T.S., Lowther,J., Teuscher,F., Stack,C.M., Grembecka,J., Mucha,A., Kafarski,P., Trenholme,K.R., Dalton,J.P. and Gardiner,D.L.
    Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds
    J Med Chem50, 6024-6031. PubMed  Europe PubMed DOI  T  I
24. Stack,C.M., Lowther,J., Cunningham,E., Donnelly,S., Gardiner,D.L., Trenholme,K.R., Skinner-Adams,T.S., Teuscher,F., Grembecka,J., Mucha,A., Kafarski,P., Lua,L., Bell,A. and Dalton,J.P.
    Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development
    J Biol Chem282, 2069-2080. PubMed  Europe PubMed DOI  T
2006
25. [YEAR:14-11-2006]Gardiner,D.L., Trenholme,K.R., Skinner-Adams,T.S., Stack,C.M. and Dalton,J.P.
    Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin
    J Biol Chem281, 1741-1745. PubMed  Europe PubMed DOI  I
2005
26. Goldberg,D.E.
    Hemoglobin degradation
    Curr Top Microbiol Immunol295, 275-291. PubMed  Europe PubMed
2002
27. Rosenthal,P.J.
    Hydrolysis of erythrocyte proteins by proteases of malaria parasites
    Curr Opin Hematol9, 140-145. PubMed  Europe PubMed DOI