Literature for peptidase M12.311: BaP1 peptidase (Bothrops asper)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Nakamoto,M., Escalante,T., Gutierrez,J.M. and Shea,K.J.
    A Biomimetic of Endogenous Tissue Inhibitors of Metalloproteinases: Inhibition Mechanism and Contribution of Composition, Polymer Size, and Shape to the Inhibitory Effect
    Nano Lett21, 5663-5670. PubMed  Europe PubMed DOI
  2. 2020
  3. Camacho,E., Rucavado,A., Escalante,T., Gutierrez,J.M. and Remans,K.
    Substitutions of residues in a loop surrounding the active site of a P-I snake venom metalloproteinase abrogates its hemorrhagic activity
    Toxicon177 Suppl 1, S55-S55. PubMed  Europe PubMed DOI
  4. Viana,M.N., Leiguez,E., Gutierrez,J.M., Rucavado,A., Markus,R.P., Marcola,M., Teixeira,C. and Fernandes,C.M.
    A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with amplification by IL-1beta and the EP4 receptor
    Sci Rep10, 3269-3269. PubMed  Europe PubMed DOI
  5. 2019
  6. Camacho,E., Escalante,T., Remans,K., Gutierrez,J.M. and Rucavado,A.
    Site mutation of residues in a loop surrounding the active site of a PI snake venom metalloproteinase abrogates its hemorrhagic activity
    Biochem Biophys Res Commun512, 859-863. PubMed  Europe PubMed DOI
  7. Gomes,M., Alvarez,M.A., Quellis,L.R., Becher,M.L., Castro,J.M.A., Gameiro,J., Caporrino,M.C., Moura-da-Silva,A.M. and de Oliveira Santos,M.
    Expression of an scFv antibody fragment in Nicotiana benthamiana and in vitro assessment of its neutralizing potential against the snake venom metalloproteinase BaP1 from Bothrops asper
    Toxicon160, 38-46. PubMed  Europe PubMed DOI
  8. 2018
  9. Preciado,L.M., Pereanez,J.A., Azhagiya Singam,E.R. and Comer,J.
    Interactions between triterpenes and a P-I type snake venom metalloproteinase: molecular simulations and experiments
    Toxins (Basel)10, PubMed  Europe PubMed DOI  I
  10. 2017
  11. Villalta-Romero,F., Borro,L., Mandic,B., Escalante,T., Rucavado,A., Gutierrez,J.M., Neshich,G. and Tasic,L.
    Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests
    Bioorg Med Chem Lett27, 2018-2022. PubMed  Europe PubMed DOI  I
  12. 2014
  13. Castro,J.M., Oliveira,T.S., Silveira,C.R., Caporrino,M.C., Rodriguez,D., Moura-da-Silva,A.M., Ramos,O.H., Rucavado,A., Gutierrez,J.M., Magalhaes,G.S., Faquim-Mauro,E.L. and Fernandes,I.
    A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom
    Toxicon87, 81-91. PubMed  Europe PubMed DOI
  14. 2013
  15. Pereanez,J.A., Patino,A.C., Rey-Suarez,P., Nunez,V., Henao Castaneda,I.C. and Rucavado,A.
    Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P-I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling
    Toxicon71, 41-48. PubMed  Europe PubMed DOI  I
  16. 2012
  17. Gutierrez,J.M., Rucavado,A. and Escalante,T.
    Bothrops asper metalloproteinase BaP1
    [ISSN:978-0-12-407744-7]3, 984-987. DOI
  18. Lingott,T., Merfort,I. and Steinbrecher,T.
    Free energy calculations on snake venom metalloproteinase BaP1
    Chem Biol Drug Des79, 990-1000. PubMed  Europe PubMed DOI
  19. 2011
  20. Escalante,T., Ortiz,N., Rucavado,A., Sanchez,E.F., Richardson,M., Fox,J.W. and Gutierrez,J.M.
    Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases
    PLoS ONE6, e28017-e28017. PubMed  Europe PubMed DOI
  21. Paes Leme,A.F., Escalante,T., Pereira,J.G., Oliveira,A.K., Sanchez,E.F., Gutierrez,J.M., Serrano,S.M. and Fox,J.W.
    High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry
    J Proteomics74, 401-410. PubMed  Europe PubMed DOI  P
  22. 2010
  23. Brenes,O., Munoz,E., Roldan-Rodriguez,R. and Diaz,C.
    Cell death induced by Bothrops asper snake venom metalloproteinase on endothelial and other cell lines
    Exp Mol Pathol88, 424-432. PubMed  Europe PubMed DOI
  24. Fernandes,I., Assumpcao,G.G., Silveira,C.R., Faquim-Mauro,E.L., Tanjoni,I., Carmona,A.K., Alves,M.F., Takehara,H.A., Rucavado,A., Ramos,O.H., Moura-da-Silva,A.M. and Gutierrez,J.M.
    Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom
    Toxicon56, 1059-1065. PubMed  Europe PubMed DOI
  25. Wallnoefer,H.G., Lingott,T., Gutierrez,J.M., Merfort,I. and Liedl,K.R.
    Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases
    J Am Chem Soc132, 10330-10337. PubMed  Europe PubMed DOI
  26. 2009
  27. Escalante,T., Rucavado,A., Pinto,A.F., Terra,R.M., Gutierrez,J.M. and Fox,J.W.
    Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins
    J Proteome Res8, 5120-5131. PubMed  Europe PubMed DOI
  28. Lingott,T., Schleberger,C., Gutierrez,J.M. and Merfort,I.
    High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding
    Biochemistry48, 6166-6174. PubMed  Europe PubMed DOI  S
  29. 2008
  30. Jimenez,N., Escalante,T., Gutierrez,J.M. and Rucavado,A.
    Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model
    J Invest Dermatol128, 2421-2428. PubMed  Europe PubMed DOI
  31. 2007
  32. Fernandes,C.M., Pereira Teixeira,C., Leite,A.C., Gutierrez,J.M. and Rocha,F.A.
    The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-alpha and PGE2-dependent mechanisms
    Br J Pharmacol151, 1254-1261. PubMed  Europe PubMed DOI
  33. 2006
  34. [YEAR:6-10-2006]Escalante,T., Shannon,J., Moura-da-Silva,A.M., Gutierrez,J.M. and Fox,J.W.
    Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study
    Arch Biochem Biophys455, 144-153. PubMed  Europe PubMed DOI
  35. Fernandes,C.M., Zamuner,S.R., Zuliani,J.P., Rucavado,A., Gutierrez,J.M. and Teixeira,C.
    Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines
    Toxicon47, 549-559. PubMed  Europe PubMed DOI
  36. 2005
  37. [YEAR:15-2-2005]Diaz,C., Valverde,L., Brenes,O., Rucavado,A. and Gutierrez,J.M.
    Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells
    J Cell Biochem94, 520-528. PubMed  Europe PubMed DOI  I
  38. 2004
  39. Escalante,T., Rucavado,A., Kamiguti,A.S., Theakston,R.D. and Gutierrez,J.M.
    Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy
    Toxicon43, 213-217. PubMed  Europe PubMed DOI
  40. 2003
  41. Watanabe,L., Shannon,J.D., Valente,R.H., Rucavado,A., Alape-Giron,A., Kamiguti,A.S., Theakston,R.D., Fox,J.W., Gutierrez,J.M. and Arni,R.K.
    Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
    Protein Sci12, 2273-2281. PubMed  Europe PubMed DOI  S
  42. 2001
  43. [YEAR:1-12-2001]Trento,E.P., Garcia,O.S., Rucavado,A., Franca,S.C., Batalini,C., Arantes,E.C., Giglio,J.R. and Soares,A.M.
    Inhibitory properties of the anti-bothropic complex from Didelphis albiventris serum on toxic and pharmacological actions of metalloproteases and myotoxins from Bothrops asper venom
    Biochem Pharmacol62, 1521-1529. PubMed  Europe PubMed DOI
  44. 2000
  45. Escalante,T., Franceschi,A., Rucavado,A. and Gutierrez,J.M.
    Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
    Biochem Pharmacol60, 269-274. PubMed  Europe PubMed DOI  I
  46. Farsky,S.H., Goncalves,L.R., Gutierrez,J.M., Correa,A.P., Rucavado,A., Gasque,P. and Tambourgi,D.V.
    Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment
    Mediators Inflamm9, 213-221. PubMed  Europe PubMed DOI
  47. Rucavado,A., Escalante,T., Franceschi,A., Chaves,F., Leon,G., Cury,Y., Ovadia,M. and Gutierrez,J.M.
    Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: Effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
    Am J Trop Med Hyg63, 313-319. PubMed  Europe PubMed  I
  48. 1998
  49. Rucavado,A., Nunez,J. and Gutierrez,J.M.
    Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
    Int J Exp Pathol79, 245-254. PubMed  Europe PubMed
  50. 1995
  51. Gutierrez,J.M., Romero,M., Diaz,C., Borkow,G. and Ovadia,M.
    Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)
    Toxicon33, 19-29. PubMed  Europe PubMed DOI
  52. Rucavado,A., Borkow,G., Ovadia,M. and Gutierrez,J.M.
    Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper
    Toxicon33, 1103-1106. PubMed  Europe PubMed DOI
  53. Rucavado,A., Lomonte,B., Ovadia,M. and Gutierrez,J.M.
    Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (terciopelo) snake venom
    Exp Mol Pathol63, 186-199. PubMed  Europe PubMed DOI