Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M12.311: BaP1 peptidase (Bothrops asper)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Nakamoto,M., Escalante,T., Gutierrez,J.M. and Shea,K.J.
    A Biomimetic of Endogenous Tissue Inhibitors of Metalloproteinases: Inhibition Mechanism and Contribution of Composition, Polymer Size, and Shape to the Inhibitory Effect
    Nano Lett (2021) 21, 5663-5670. PubMed  Europe PubMed DOI
    2. 2020
  2. Camacho,E., Rucavado,A., Escalante,T., Gutierrez,J.M. and Remans,K.
    Substitutions of residues in a loop surrounding the active site of a P-I snake venom metalloproteinase abrogates its hemorrhagic activity
    Toxicon (2020) 177 Suppl 1, S55-S55. PubMed  Europe PubMed DOI
  3. Viana,M.N., Leiguez,E., Gutierrez,J.M., Rucavado,A., Markus,R.P., Marcola,M., Teixeira,C. and Fernandes,C.M.
    A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with amplification by IL-1beta and the EP4 receptor
    Sci Rep (2020) 10, 3269-3269. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2019
  4. Camacho,E., Escalante,T., Remans,K., Gutierrez,J.M. and Rucavado,A.
    Site mutation of residues in a loop surrounding the active site of a PI snake venom metalloproteinase abrogates its hemorrhagic activity
    Biochem Biophys Res Commun (2019) 512, 859-863. PubMed  Europe PubMed DOI
  5. Gomes,M., Alvarez,M.A., Quellis,L.R., Becher,M.L., Castro,J.M.A., Gameiro,J., Caporrino,M.C., Moura-da-Silva,A.M. and de Oliveira Santos,M.
    Expression of an scFv antibody fragment in Nicotiana benthamiana and in vitro assessment of its neutralizing potential against the snake venom metalloproteinase BaP1 from Bothrops asper
    Toxicon (2019) 160, 38-46. PubMed  Europe PubMed DOI
    6. 2018
  6. Preciado,L.M., Pereanez,J.A., Azhagiya Singam,E.R. and Comer,J.
    Interactions between triterpenes and a P-I type snake venom metalloproteinase: molecular simulations and experiments
    Toxins (Basel) (2018) 10 PubMed  Europe PubMed DOI  I
    7. 2017
  7. Villalta-Romero,F., Borro,L., Mandic,B., Escalante,T., Rucavado,A., Gutierrez,J.M., Neshich,G. and Tasic,L.
    Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests
    Bioorg Med Chem Lett (2017) 27, 2018-2022. PubMed  Europe PubMed DOI  I
    8. 2014
  8. Castro,J.M., Oliveira,T.S., Silveira,C.R., Caporrino,M.C., Rodriguez,D., Moura-da-Silva,A.M., Ramos,O.H., Rucavado,A., Gutierrez,J.M., Magalhaes,G.S., Faquim-Mauro,E.L. and Fernandes,I.
    A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom
    Toxicon (2014) 87, 81-91. PubMed  Europe PubMed DOI
    9. 2013
  9. Pereanez,J.A., Patino,A.C., Rey-Suarez,P., Nunez,V., Henao Castaneda,I.C. and Rucavado,A.
    Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P-I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling
    Toxicon (2013) 71, 41-48. PubMed  Europe PubMed DOI  I
    10. 2012
  10. Gutierrez,J.M., Rucavado,A. and Escalante,T.
    Bothrops asper metalloproteinase BaP1
    [ISSN:978-0-12-407744-7] (2012) 3, 984-987. DOI
  11. Lingott,T., Merfort,I. and Steinbrecher,T.
    Free energy calculations on snake venom metalloproteinase BaP1
    Chem Biol Drug Des (2012) 79, 990-1000. PubMed  Europe PubMed DOI
    12. 2011
  12. Escalante,T., Ortiz,N., Rucavado,A., Sanchez,E.F., Richardson,M., Fox,J.W. and Gutierrez,J.M.
    Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases
    PLoS ONE (2011) 6, e28017-e28017. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Paes Leme,A.F., Escalante,T., Pereira,J.G., Oliveira,A.K., Sanchez,E.F., Gutierrez,J.M., Serrano,S.M. and Fox,J.W.
    High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry
    J Proteomics (2011) 74, 401-410. PubMed  Europe PubMed DOI  P
    14. 2010
  14. Brenes,O., Munoz,E., Roldan-Rodriguez,R. and Diaz,C.
    Cell death induced by Bothrops asper snake venom metalloproteinase on endothelial and other cell lines
    Exp Mol Pathol (2010) 88, 424-432. PubMed  Europe PubMed DOI
  15. Fernandes,I., Assumpcao,G.G., Silveira,C.R., Faquim-Mauro,E.L., Tanjoni,I., Carmona,A.K., Alves,M.F., Takehara,H.A., Rucavado,A., Ramos,O.H., Moura-da-Silva,A.M. and Gutierrez,J.M.
    Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom
    Toxicon (2010) 56, 1059-1065. PubMed  Europe PubMed DOI
  16. Wallnoefer,H.G., Lingott,T., Gutierrez,J.M., Merfort,I. and Liedl,K.R.
    Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases
    J Am Chem Soc (2010) 132, 10330-10337. PubMed  Europe PubMed DOI
    17. 2009
  17. Escalante,T., Rucavado,A., Pinto,A.F., Terra,R.M., Gutierrez,J.M. and Fox,J.W.
    Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins
    J Proteome Res (2009) 8, 5120-5131. PubMed  Europe PubMed DOI
  18. Lingott,T., Schleberger,C., Gutierrez,J.M. and Merfort,I.
    High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding
    Biochemistry (2009) 48, 6166-6174. PubMed  Europe PubMed DOI  S
    19. 2008
  19. Jimenez,N., Escalante,T., Gutierrez,J.M. and Rucavado,A.
    Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model
    J Invest Dermatol (2008) 128, 2421-2428. PubMed  Europe PubMed DOI
    20. 2007
  20. Fernandes,C.M., Pereira Teixeira,C., Leite,A.C., Gutierrez,J.M. and Rocha,F.A.
    The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-alpha and PGE2-dependent mechanisms
    Br J Pharmacol (2007) 151, 1254-1261. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2006
  21. [YEAR:6-10-2006]Escalante,T., Shannon,J., Moura-da-Silva,A.M., Gutierrez,J.M. and Fox,J.W.
    Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study
    Arch Biochem Biophys (6-10-2006) 455, 144-153. PubMed  Europe PubMed DOI
  22. Fernandes,C.M., Zamuner,S.R., Zuliani,J.P., Rucavado,A., Gutierrez,J.M. and Teixeira,C.
    Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines
    Toxicon (2006) 47, 549-559. PubMed  Europe PubMed DOI
    23. 2005
  23. [YEAR:15-2-2005]Diaz,C., Valverde,L., Brenes,O., Rucavado,A. and Gutierrez,J.M.
    Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells
    J Cell Biochem (15-2-2005) 94, 520-528. PubMed  Europe PubMed DOI  I
    24. 2004
  24. Escalante,T., Rucavado,A., Kamiguti,A.S., Theakston,R.D. and Gutierrez,J.M.
    Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy
    Toxicon (2004) 43, 213-217. PubMed  Europe PubMed DOI
    25. 2003
  25. Watanabe,L., Shannon,J.D., Valente,R.H., Rucavado,A., Alape-Giron,A., Kamiguti,A.S., Theakston,R.D., Fox,J.W., Gutierrez,J.M. and Arni,R.K.
    Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
    Protein Sci (2003) 12, 2273-2281. PubMed  Europe PubMed DOI  PMC  EPMC  S
    26. 2001
  26. [YEAR:1-12-2001]Trento,E.P., Garcia,O.S., Rucavado,A., Franca,S.C., Batalini,C., Arantes,E.C., Giglio,J.R. and Soares,A.M.
    Inhibitory properties of the anti-bothropic complex from Didelphis albiventris serum on toxic and pharmacological actions of metalloproteases and myotoxins from Bothrops asper venom
    Biochem Pharmacol (1-12-2001) 62, 1521-1529. PubMed  Europe PubMed DOI
    27. 2000
  27. Escalante,T., Franceschi,A., Rucavado,A. and Gutierrez,J.M.
    Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
    Biochem Pharmacol (2000) 60, 269-274. PubMed  Europe PubMed DOI  I
  28. Farsky,S.H., Goncalves,L.R., Gutierrez,J.M., Correa,A.P., Rucavado,A., Gasque,P. and Tambourgi,D.V.
    Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment
    Mediators Inflamm (2000) 9, 213-221. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Rucavado,A., Escalante,T., Franceschi,A., Chaves,F., Leon,G., Cury,Y., Ovadia,M. and Gutierrez,J.M.
    Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: Effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
    Am J Trop Med Hyg (2000) 63, 313-319. PubMed  Europe PubMed  I
    30. 1998
  30. Rucavado,A., Nunez,J. and Gutierrez,J.M.
    Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
    Int J Exp Pathol (1998) 79, 245-254. PubMed  Europe PubMed
    31. 1995
  31. Gutierrez,J.M., Romero,M., Diaz,C., Borkow,G. and Ovadia,M.
    Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)
    Toxicon (1995) 33, 19-29. PubMed  Europe PubMed DOI
  32. Rucavado,A., Lomonte,B., Ovadia,M. and Gutierrez,J.M.
    Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (terciopelo) snake venom
    Exp Mol Pathol (1995) 63, 186-199. PubMed  Europe PubMed DOI
  33. Rucavado,A., Borkow,G., Ovadia,M. and Gutierrez,J.M.
    Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper
    Toxicon (1995) 33, 1103-1106. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use