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Literature for peptidase M12.241: ADAMTS13 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Abu El-Asrar,A.M., Nawaz,M.I., Ahmad,A., Siddiquei,M., Allegaert,E., Adyns,L., Vanbrabant,L., Gikandi,P.W., De Hertogh,G., Struyf,S. and Opdenakker,G.<br>ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy<br>Cells (2025) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Allmang,S., Witzel,H.R., Hausen,A., Marquard,S., Eckert,C., Marnet,N., Horner,N., Mayer,P., Heinrich,S., Dang,H., Roth,W. and Gaida,M.M.<br>Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions<br>MedComm (2020) (2025) 6, e70462-e70462. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Sloos,P.H., Vermeersch,L., Roozendaal,D.S., Delmote,A.S., Veer,C.V.'., Momanyi,T.O., Miranda,F.Z., Muia,J., Tersteeg,C., Vanhoorelbeke,K., Juffermans,N.P. and Kleinveld,D.J.B.<br>A novel role for ADAMTS13 in hyperfibrinolysis after trauma-induced shock(ƒ~Å)<br>Br J Anaesth (2025) PubMed  Europe PubMed DOI
  4. Stanley,M., Killeen,R.B. and Michalski,J.M.<br>Thrombotic Thrombocytopenic Purpura<br> (2025) PubMed  Europe PubMed
  5. Stanley,M., Killeen,R.B. and Michalski,J.M.<br>Thrombotic Thrombocytopenic Purpura<br> (2025) PubMed  Europe PubMed
    6. 2024
  6. Bendapudi,P.K., Foy,B.H., Mueller,S.B., Liu,J., Feingold,L.M., Burke,K.E., Cruz,W., Chen,M.Y., Lau,E.S., Goldberg,R.L., Tatake,I., Wilkinson,S.C., Carney,B.J., Stone,J.R., Park,D., Avelino,A.R., Hassan,S., Andrzejewski,C., Ruby,K.N., Friedman,K.D., Brunker,P.A.R., Leaf,R.K., Higgins,J., Dzik,W.H., Stefely,J.A. and Makar,R.S.<br>Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura<br>N Engl J Med (2024) 390, 1690-1698. PubMed  Europe PubMed DOI
  7. Dutta Gupta,S. and Ta,M.<br>ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress<br>Sci Rep (2024) 14, 560-560. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Hubben,A. and McCrae,K.R.<br>A "backup plan" for ADAMTS13 deficiency in TTP<br>Blood (2024) 143, 2021-2023. PubMed  Europe PubMed DOI
  9. Madarati,H., Singh,K., Sparring,T., Andrisani,P., Liaw,P.C., Fox-Robichaud,A.E. and Kretz,C.A.<br>REVIEWING THE DYSREGULATION OF ADAMTS13 AND VWF IN SEPSIS<br>Shock (2024) 61, 189-196. PubMed  Europe PubMed DOI  V
  10. Otmani,H.E., Vanhoorelbeke,K. and Tersteeg,C.<br>Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation<br>Curr Opin Hematol (2024) 31, 245-250. PubMed  Europe PubMed DOI  V
  11. Papakonstantinou,A., Kalmoukos,P., Mpalaska,A., Koravou,E.E. and Gavriilaki,E.<br>ADAMTS13 in the New Era of TTP<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Wendt,R., Volker,L., Bommer,M., Wolf,M., von Auer,C., Kuhne,L., Brinkkotter,P., Miesbach,W. and Knobl,P.<br>[100 years thrombotic thrombocytopenic purpura (TTP) - lessons learned?]<br>Dtsch Med Wochenschr (2024) 149, 1423-1430. PubMed  Europe PubMed DOI
  13. Zhao,S.C., Li,H., Wang,M., Zhao,Y.H., Li,X.J. and Jin,S.Y.<br>[ADAMTS13-Mediated Proteolytic Cleavage of Unusually Large von Willebrand Factor Polymers on Endothelial Cells in the Absence of Fluid Shear Stress]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2024) 32, 532-540. PubMed  Europe PubMed DOI
    14. 2023
  14. Barton,J.C., Anderson,C., Miranda,F.Z., Kelley,R., Kremer Hovinga,J.A., Terrell,D., Vesely,S.K., George,J.N. and Muia,J.<br>Cattle-FRETS71, a novel fluorogenic substrate with broad applicability for characterizing ADAMTS13 properties and function<br>J Thromb Haemost (2023) 21, 3393-3401. PubMed  Europe PubMed DOI
  15. Beckman,J.D. and Sparkenbaugh,E.M.<br>The invisible string of coagulation, complement, iron, and inflammation in sickle cell disease<br>Curr Opin Hematol (2023) 30, 153-158. PubMed  Europe PubMed DOI  PMC  EPMC  V
  16. Dekimpe,C., Roose,E., Sakai,K., Tersteeg,C., De Meyer,S.F. and Vanhoorelbeke,K.<br>Toward gene therapy for congenital thrombotic thrombocytopenic purpura<br>J Thromb Haemost (2023) 21, 1090-1099. PubMed  Europe PubMed DOI  V
  17. Gao,D., Zhou,Z., Ma,R., Wu,H., Nguyen,T., Liu,L. and Dong,J.<br>Recombinant ADAMTS-13 Improves Survival of Mice Subjected to Endotoxemia<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Lammle,B.<br>Mechanisms of ADAMTS13 inhibition in iTTP<br>Blood (2023) 141, 2919-2920. PubMed  Europe PubMed DOI
  19. Lin,J., Ding,X., Yang,P., Liu,S., Li,Q., Cruz,M.A., Dong,J.F., Fang,Y. and Wu,J.<br>Force-induced biphasic regulation of VWF cleavage by ADAMTS13<br>Thromb Res (2023) 229, 99-106. PubMed  Europe PubMed DOI
  20. Rossato,P., Glantschnig,H., Canneva,F., Schuster,M., Coulibaly,S., Schrenk,G., Voelkel,D., Dockal,M., Plaimauer,B., Rottensteiner,H., Gritsch,H., Federti,E., Matte,A., De Franceschi,L., Scheiflinger,F. and Hoellriegl,W.<br>Treatment with recombinant ADAMTS13, alleviates hypoxia/reoxygenation-induced pathologies in a mouse model of human sickle cell disease<br>J Thromb Haemost (2023) 21, 269-275. PubMed  Europe PubMed DOI
  21. Wang,X., Hao,X.J., Dai,C.G., Ding,Y.J., Xiong,L., Deng,J. and Jiang,J.J.<br>Identification of 8 Rare Deleterious Variants in ADAMTS13 by Next-generation Sequencing in a Chinese Population with Thrombotic Thrombocytopenic Purpura<br>Curr Med Sci (2023) 43, 1043-1050. PubMed  Europe PubMed DOI
    22. 2022
  22. Chaturvedi,S. and DeBaun,M.R.<br>Altered VWF:ADAMTS13 homeostasis is a target for therapeutic intervention in sickle cell disease<br>Proc Natl Acad Sci U S A (2022) 119, e2213079119-e2213079119. PubMed  Europe PubMed DOI  PMC  EPMC
  23. DeYoung,V., Singh,K. and Kretz,C.A.<br>Mechanisms of ADAMTS13 regulation<br>J Thromb Haemost (2022) 20, 2722-2732. PubMed  Europe PubMed DOI  V
  24. Fujimura,Y. and Holland,L.Z.<br>COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm<br>Int J Hematol (2022) 115, 457-469. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Jankowska,K.I., Meyer,D., Holcomb,D.D., Kames,J., Hamasaki-Katagiri,N., Katneni,U.K., Hunt,R.C., Ibla,J.C. and Kimchi-Sarfaty,C.<br>Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance<br>Blood Adv (2022) 6, 5364-5378. PubMed  Europe PubMed DOI
  26. Liu,W. and Xiao,Y.<br>[Advance in the diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura]<br>Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2022) 39, 442-446. PubMed  Europe PubMed DOI  V
  27. Merlen,C., Pepin,E., Barry,O., Cormier,A., Dubois,C., Lapeyraque,A.L., Troyanov,S., Rivard,G.E. and Bonnefoy,A.<br>Incidence of thrombotic microangiopathies in Quebec: insight from a laboratory centralizing ADAMTS-13 testing<br>Orphanet J Rare Dis (2022) 17, 308-308. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2021
  28. Beranger,N., Benghezal,S., Joly,B.S., Capdenat,S., Delton,A., Stepanian,A., Coppo,P. and Veyradier,A.<br>Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay<br>Res Pract Thromb Haemost (2021) 5, 81-93. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Del Amo-Maestro,L., Sagar,A., Pompach,P., Goulas,T., Scavenius,C., Ferrero,D.S., Castrillo-Briceno,M., Taules,M., Enghild,J.J., Bernado,P. and Gomis-Ruth,F.X.<br>An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution<br>J Mol Biol (2021) 433, 166954-166954. PubMed  Europe PubMed DOI
  30. Favaloro,E.J., Pasalic,L., Henry,B. and Lippi,G.<br>Laboratory testing for ADAMTS13: Utility for TTP diagnosis/exclusion and beyond<br>Am J Hematol (2021) 96, 1049-1055. PubMed  Europe PubMed DOI  A  V
  31. Kamenac,A., Obser,T., Wixforth,A., Schneider,M.F. and Westerhausen,C.<br>The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer<br>Sci Rep (2021) 11, 24476-24476. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Miodownik,S., Pikovsky,O., Erez,O., Kezerle,Y., Lavon,O. and Rabinovich,A.<br>Unfolding the pathophysiology of congenital thrombotic thrombocytopenic purpura in pregnancy: Lessons from a cluster of familial cases<br>Am J Obstet Gynecol (2021) 225, 177-177. PubMed  Europe PubMed DOI
  33. Popa,M., Hecker,M. and Wagner,A.H.<br>Inverse Regulation of Confluence-Dependent ADAMTS13 and von Willebrand Factor Expression in Human Endothelial Cells<br>Thromb Haemost (2021) 122, 611-622. PubMed  Europe PubMed DOI
  34. Reardon,B., Pasalic,L. and Favaloro,E.J.<br>The Intriguing Relationships of von Willebrand Factor, ADAMTS13 and Cardiac Disease<br>J Cardiovasc Dev Dis (2021) 8 PubMed  Europe PubMed DOI  PMC  EPMC  V
  35. Turecek,P.L., Peck,R.C., Rangarajan,S., Reilly-Stitt,C., Laffan,M.A., Kazmi,R., James,I., Dushianthan,A., Schrenk,G., Gritsch,H., Ewenstein,B.M., Mellgard,B., Erdlenbruch,W., Jain,N., Binder,N.B. and Mumford,A.D.<br>Recombinant ADAMTS13 reduces abnormally up-regulated von Willebrand factor in plasma from patients with severe COVID-19<br>Thromb Res (2021) 201, 100-112. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Wu,H., Li,H., Su,C., Li,H.Y., Cui,R.H. and Jin,S.Y.<br>[Biological Function of CysR Domain of ADAMTS13]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2021) 29, 893-900. PubMed  Europe PubMed DOI
  37. Yoshitaka,M.<br>[Thrombotic thrombocytopenic purpura]<br>Rinsho Ketsueki (2021) 62, 430-434. PubMed  Europe PubMed DOI  V
    38. 2020
  38. Al-Awadhi,A., Adekile,A. and Marouf,R.<br>Relationship of Thrombospondin 1 to von Willebrand Factor and ADAMTS-13 in Sickle Cell Disease Patients of Arab Ethnicity<br>Acta Haematol (2020) 144, 1-8. PubMed  Europe PubMed DOI
  39. Jacquemin,M., Van Horenbeeck,I., Debasse,M., Toelen,J., Schoeters,J., Vanlinthout,I., Peerlinck,K., Dierickx,D. and Van Laer,C.<br>Optimization of the detection of inhibitory autoantibodies against the VWF-cleaving protease ADAMTS13 with an automated chemiluminescent ADAMTS13 activity immunoassay<br>Int J Lab Hematol (2020) 43, 290-297. PubMed  Europe PubMed DOI
  40. Letzer,A., Lehmann,K., Mess,C., Konig,G., Obser,T., Peine,S., Schneppenheim,S., Budde,U., Schneider,S.W., Schneppenheim,R. and Brehm,M.A.<br>Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation<br>PLoS ONE (2020) 15, e0232637-e0232637. PubMed  Europe PubMed DOI  PMC  EPMC  M
  41. Moller,C., Schutte,A.E., Smith,W. and Botha-Le Roux,S.<br>Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: The African-PREDICT study<br>Cytokine (2020) 136, 155265-155265. PubMed  Europe PubMed DOI
  42. Stratmann,J., Ward,J.N. and Miesbach,W.<br>Evaluation of a rapid turn-over, fully-automated ADAMTS13 activity assay: a method comparison study<br>J Thromb Thrombolysis (2020) 50, 628-631. PubMed  Europe PubMed DOI  A
    43. 2019
  43. Hunt,R., Hettiarachchi,G., Katneni,U., Hernandez,N., Holcomb,D., Kames,J., Alnifaidy,R., Lin,B., Hamasaki-Katagiri,N., Wesley,A., Kafri,T., Morris,C., Bouche,L., Panico,M., Schiller,T., Ibla,J., Bar,H., Ismail,A., Morris,H., Komar,A. and Kimchi-Sarfaty,C.<br>A single synonymous variant (c.354G>A [p.P118P]) in ADAMTS13 confers enhanced specific activity<br>Int J Mol Sci (2019) 20, 5734-5734. PubMed  Europe PubMed DOI  M
  44. Ma,Z.N., Ling,J., Yin,J., Shen,F., Su,J., Xie,L.Q. and Ruan,C.G.<br>[Effect of recombinant protein in the spacer domain on ADAMTS13 activity]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2019) 27, 1596-1601. PubMed  Europe PubMed DOI  U
  45. Rottensteiner,H., Seyfried,B.K., Kaufmann,S., Fiedler,C., Dong,J.F., Zheng,X.L., Plaimauer,B. and Scheiflinger,F.<br>Identification of cysteine thiol-based linkages in ADAMTS13 in support of a non-proteolytic regulation of von Willebrand factor<br>J Thromb Haemost (2019) 17, 2099-2109. PubMed  Europe PubMed DOI
    46. 2018
  46. Abdelgawwad,M.S., Cao,W., Zheng,L., Kocher,N.K., Williams,L.A. and Zheng,X.L.<br>Transfusion of platelets loaded with recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) is efficacious for inhibiting arterial thrombosis associated with thrombotic thrombocytopenic purpura<br>Arterioscler Thromb Vasc Biol (2018) 38, 2731-2743. PubMed  Europe PubMed DOI  U
  47. Clark,C.C., Mebius,M.M., de Maat,S., Tielens,A.G.M., DE Groot,P.G., Urbanus,R.T., Fijnheer,R., Hazenberg,B.P.C., van Hellemond,J.J. and Maas,C.<br>Truncation of ADAMTS13 by plasmin enhances its activity in plasma<br>Thromb Haemost (2018) 118, 471-479. PubMed  Europe PubMed DOI
  48. Ercig,B., Wichapong,K., Reutelingsperger,C.P.M., Vanhoorelbeke,K., Voorberg,J. and Nicolaes,G.A.F.<br>Insights into 3D structure of ADAMTS13: a stepping stone towards novel therapeutic treatment of thrombotic thrombocytopenic purpura<br>Thromb Haemost (2018) 118, 28-41. PubMed  Europe PubMed DOI  S
  49. Romao de Souza V Jr, Beatriz Cavalcante de Oliveira,A., Maria Vanderlei,A., Queiroz da Mota Silveira Aroucha,A., Pontes Duarte,B., Nunes Machado,A., Netto Chaer,L., Wanderley de Barros Correia,C., da Conceicao de Barros Correia,M. and Freire Hazin Costa,M.<br>Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report<br>J Med Case Rep (2018) 12, 15-15. PubMed  Europe PubMed DOI  PMC  EPMC  M
    50. 2017
  50. Aponte-Santamaria,C., Lippok,S., Mittag,J.J., Obser,T., Schneppenheim,R., Baldauf,C., Grater,F., Budde,U. and Radler,J.O.<br>Mutation G1629E increases von Willebrand factor cleavage via a cooperative destabilization mechanism<br>Biophys J (2017) 112, 57-65. PubMed  Europe PubMed DOI
  51. Cao,W.J. and Zheng,X.L.<br>Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: comment<br>J Thromb Haemost (2017) 15, 586-589. PubMed  Europe PubMed DOI
  52. Garland,K.S., Reitsma,S.E., Shirai,T., Zilberman-Rudenko,J., Tucker,E.I., Gailani,D., Gruber,A., McCarty,O.J.T. and Puy,C.<br>Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions<br>Front Med (Lausanne) (2017) 4, 232-232. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Gogia,S., Kelkar,A., Zhang,C., Dayananda,K.M. and Neelamegham,S.<br>Role of calcium in regulating the intra- and extracellular cleavage of von Willebrand factor by the protease ADAMTS13<br>Blood Adv (2017) 1, 2063-2074. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Lynch,C.J., Cawte,A.D., Millar,C.M., Rueda,D. and Lane,D.A.<br>A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct<br>PLoS ONE (2017) 12, e0188405-e0188405. PubMed  Europe PubMed DOI
  55. South,K., Freitas,M.O. and Lane,D.A.<br>Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: reply<br>J Thromb Haemost (2017) 15, 589-590. PubMed  Europe PubMed DOI
  56. South,K., Freitas,M.O. and Lane,D.A.<br>A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by Von Willebrand factor<br>J Biol Chem (2017) 292, 5760-5769. PubMed  Europe PubMed DOI
  57. Verhenne,S., Vandeputte,N., Pareyn,I., Izsvak,Z., Rottensteiner,H., Deckmyn,H., De Meyer,S.F. and Vanhoorelbeke,K.<br>Long-term prevention of congenital thrombotic thrombocytopenic purpura in ADAMTS13 knockout mice by sleeping beauty transposon-mediated gene therapy<br>Arterioscler Thromb Vasc Biol (2017) 37, 836-844. PubMed  Europe PubMed DOI  U
    58. 2016
  58. Erpenbeck,L., Demers,M., Zsengeller,Z.K., Gallant,M., Cifuni,S.M., Stillman,I.E., Karumanchi,S.A. and Wagner,D.D.<br>ADAMTS13 endopeptidase protects against vascular endothelial growth factor inhibitor-induced thrombotic microangiopathy<br>J Am Soc Nephrol (2016) 27, 120-131. PubMed  Europe PubMed DOI  U
  59. Guo,C., Tsigkou,A. and Lee,M.H.<br>ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4<br>Biomed Rep (2016) 4, 73-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
  60. Ostertag,E.M., Kacir,S., Thiboutot,M., Gulendran,G., Zheng,X.L., Cines,D.B. and Siegel,D.L.<br>ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro<br>Transfusion (2016) 56, 1763-1774. PubMed  Europe PubMed DOI
  61. South,K., Freitas,M.O. and Lane,D.A.<br>Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity<br>J Thromb Haemost (2016) 14, 2011-2022. PubMed  Europe PubMed DOI
  62. Tersteeg,C., Fijnheer,R., Pasterkamp,G., DE Groot,P.G., Vanhoorelbeke,K., de Maat,S. and Maas,C.<br>Keeping von Willebrand factor under control: alternatives for ADAMTS13<br>Semin Thromb Hemost (2016) 42, 9-17. PubMed  Europe PubMed DOI  M
    63. 2015
  63. de Groot,R., Lane,D.A. and Crawley,J.T.<br>The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis<br>Blood (2015) 125, 1968-1975. PubMed  Europe PubMed DOI
  64. Deforche,L., Roose,E., Vandenbulcke,A., Vandeputte,N., Feys,H.B., Springer,T.A., Mi,L.Z., Muia,J., Sadler,J.E., Soejima,K., Rottensteiner,H., Deckmyn,H., De Meyer,S.F. and Vanhoorelbeke,K.<br>Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13<br>J Thromb Haemost (2015) 13, 2063-2075. PubMed  Europe PubMed DOI
  65. Desch,K.C., Kretz,C., Yee,A., Gildersleeve,R., Metzger,K., Agrawal,N., Cheng,J. and Ginsburg,D.<br>Probing ADAMTS13 substrate specificity using phage display<br>PLoS ONE (2015) 10, e0122931- PubMed  Europe PubMed
  66. Dubail,J. and Apte,S.S.<br>Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics<br>Matrix Biol (2015) 44-46, 24-37. PubMed  Europe PubMed DOI
  67. Kretz,C.A., Dai,M., Soylemez,O., Yee,A., Desch,K.C., Siemieniak,D., Tomberg,K., Kondrashov,F.A., Meng,F. and Ginsburg,D.<br>Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13<br>Proc Natl Acad Sci U S A (2015) 112, 9328-9333. PubMed  Europe PubMed DOI  P
  68. Lu,R.N., Yang,S., Wu,H.M. and Zheng,X.L.<br>Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease<br>J Thromb Haemost (2015) 13, 1064-1072. PubMed  Europe PubMed DOI  I
  69. Plaimauer,B., Schiviz,A., Kaufmann,S., Hollriegl,W., Rottensteiner,H. and Scheiflinger,F.<br>Neutralization of inhibitory antibodies and restoration of therapeutic ADAMTS-13 activity levels in inhibitor-treated rats by the use of defined doses of recombinant ADAMTS-13<br>J Thromb Haemost (2015) 13, 2053-2062. PubMed  Europe PubMed DOI
  70. Wang,Y., Chen,J., Ling,M., Lopez,J.A., Chung,D.W. and Fu,X.<br>Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation<br>J Biol Chem (2015) 290, 1422-1431. PubMed  Europe PubMed DOI
    71. 2014
  71. Mancini,I., Valsecchi,C., Lotta,L.A., Deforche,L., Pontiggia,S., Bajetta,M., Palla,R., Vanhoorelbeke,K. and Peyvandi,F.<br>FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients<br>Thromb Haemost (2014) 112, 297-303. PubMed  Europe PubMed DOI  A
  72. Perez-Rodriguez,A., Loures,E., Rodriguez-Trillo,A., Costa-Pinto,J., Garcia-Rivero,A., Batlle-Lopez,A., Batlle,J. and Lopez-Fernandez,M.F.<br>Inherited ADAMTS13 deficiency (Upshaw-Schulman syndrome): a short review<br>Thromb Res (2014) 134, 1171-1175. PubMed  Europe PubMed DOI  M
  73. Wang,Q. and Han,Y.<br>[Structure and function of ADAMTS13 protease and its relation with diagnosis and treatment of TTP]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2014) 22, 1157-1161. PubMed  Europe PubMed DOI  V
    74. 2013
  74. Ling,J., Su,J., Ma,Z. and Ruan,C.<br>The WXXW motif in the TSR1 of ADAMTS13 is important for its secretion and proteolytic activity<br>Thromb Res (2013) 131, 529-534. PubMed  Europe PubMed DOI
  75. Ling,J., Ma,Z.N., Su,J. and Ruan,C.G.<br>[Construction of ADAMTS13-pEGFP-N1 vector and its expression in HeLa cells]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2013) 21, 126-129. PubMed  Europe PubMed DOI  U
  76. Lotta,L.A., Wu,H.M., Musallam,K.M. and Peyvandi,F.<br>The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura<br>Blood Rev (2013) 27, 71-76. PubMed  Europe PubMed DOI  V
  77. Zheng,X.L.<br>Structure-function and regulation of ADAMTS-13 protease<br>J Thromb Haemost (2013) 11 Suppl 1, 11-23. PubMed  Europe PubMed DOI  PMC  EPMC
    78. 2012
  78. Ferrari,S., Rottensteiner,H. and Scheiflinger,F.<br>ADAMTS13: von Willebrand factor-cleaving protease<br>[ISSN:978-0-12-407744-7] (2012) 3, 1199-1206. DOI
  79. Gao,W., Zhu,J., Westfield,L.A., Tuley,E.A., Anderson,P.J. and Sadler,J.E.<br>Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases<br>J Biol Chem (2012) 287, 26944-26952. PubMed  Europe PubMed DOI
  80. Maruyama,H., Ito,K., Okabayashi,K., Sakai,M., Kano,R., Watari,T., Hasegawa,A. and Kamata,H.<br>Molecular cloning, in vitro expression and functional characterization of canine ADAMTS13<br>Res Vet Sci (2012) 93, 213-218. PubMed  Europe PubMed DOI  E
  81. Pozzi,N., Lancellotti,S., De Cristofaro,R. and De Filippis,V.<br>Modeling ADAMTS13-von Willebrand factor interaction: implications for oxidative stress-related cardiovascular diseases and type 2A von Willebrand Disease<br>Biophys Chem (2012) 160, 1-11. PubMed  Europe PubMed DOI
  82. Schiviz,A., Wuersch,K., Piskernik,C., Dietrich,B., Hoellriegl,W., Rottensteiner,H., Scheiflinger,F., Schwarz,H.P. and Muchitsch,E.M.<br>A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13<br>Blood (2012) 119, 6128-6135. PubMed  Europe PubMed DOI  U
  83. Shin,Y., Akiyama,M., Kokame,K., Soejima,K. and Miyata,T.<br>Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)<br>J Biochem (2012) 152, 251-258. PubMed  Europe PubMed DOI
    84. 2011
  84. Crawley,J.T., de Groot,R., Xiang,Y., Luken,B.M. and Lane,D.A.<br>Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor<br>Blood (2011) 118, 3212-3221. PubMed  Europe PubMed DOI  P
  85. De Ceunynck,K., Rocha,S., Feys,H.B., De Meyer,S.F., Uji,I., Deckmyn,H., Hofkens,J. and Vanhoorelbeke,K.<br>Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis<br>J Biol Chem (2011) 286, 36361-36367. PubMed  Europe PubMed DOI
  86. Hunt,R.C., Geetha,S., Allen,C.E., Hershko,K., Fathke,R., Kong,P.L., Plum,E., Struble,E.B., Soejima,K., Friedman,S., Garfield,S., Balaji,S. and Kimchi-Sarfaty,C.<br>Detection of a secreted metalloprotease within the nuclei of liver cells<br>Mol Biosyst (2011) 7, 2012-2018. PubMed  Europe PubMed DOI
  87. Lancellotti,S. and De Cristofaro,R.<br>Structure and proteolytic properties of ADAMTS13, a metalloprotease involved in the pathogenesis of thrombotic microangiopathies<br>Prog Mol Biol Transl Sci (2011) 99, 105-144. PubMed  Europe PubMed DOI  V
  88. Plaimauer,B., Kremer Hovinga,J.A., Juno,C., Wolfsegger,M.J., Skalicky,S., Schmidt,M., Grillberger,L., Hasslacher,M., Knobl,P., Ehrlich,H. and Scheiflinger,F.<br>Recombinant ADAMTS13 normalizes von Willebrand factor-cleaving activity in plasma of acquired TTP patients by overriding inhibitory antibodies<br>J Thromb Haemost (2011) 9, 936-944. PubMed  Europe PubMed DOI  U
  89. Xiang,Y., de Groot,R., Crawley,J.T. and Lane,D.A.<br>Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)<br>Proc Natl Acad Sci U S A (2011) 108, 11602-11607. PubMed  Europe PubMed DOI  P
  90. Xiao,J., Jin,S.Y., Xue,J., Sorvillo,N., Voorberg,J. and Zheng,X.L.<br>Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis<br>Arterioscler Thromb Vasc Biol (2011) 31, 2261-2269. PubMed  Europe PubMed DOI
    91. 2010
  91. Badirou,I., Kurdi,M., Rayes,J., Legendre,P., Christophe,O.D., Lenting,P.J. and Denis,C.V.<br>von Willebrand factor clearance does not involve proteolysis by ADAMTS-13<br>J Thromb Haemost (2010) 8, 2338-2340. PubMed  Europe PubMed DOI  K
  92. de Groot,R., Lane,D.A. and Crawley,J.T.<br>The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity<br>Blood (2010) 116, 3064-3072. PubMed  Europe PubMed DOI
  93. De Maeyer,B., De Meyer,S.F., Feys,H.B., Pareyn,I., Vandeputte,N., Deckmyn,H. and Vanhoorelbeke,K.<br>The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo<br>J Thromb Haemost (2010) 8, 2305-2312. PubMed  Europe PubMed DOI
  94. Hiura,H., Matsui,T., Matsumoto,M., Hori,Y., Isonishi,A., Kato,S., Iwamoto,T., Mori,T. and Fujimura,Y.<br>Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody<br>J Biochem (2010) 148, 403-411. PubMed  Europe PubMed DOI
  95. Just,S.<br>Methodologies and clinical utility of ADAMTS-13 activity testing<br>Semin Thromb Hemost (2010) 36, 82-90. PubMed  Europe PubMed DOI  A  V
  96. Lotta,L.A., Garagiola,I., Palla,R., Cairo,A. and Peyvandi,F.<br>ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura<br>Hum Mutat (2010) 31, 11-19. PubMed  Europe PubMed DOI  M  V
  97. Ma,Z., Dong,N., Zhang,J., Su,J., Wang,A. and Ruan,C.<br>[Stable expression and characterization of the von Willebrand factor cleaving protease]<br>Sheng Wu Gong Cheng Xue Bao (2010) 26, 244-248. PubMed  Europe PubMed  E
  98. Wu,T., Lin,J., Cruz,M.A., Dong,J.F. and Zhu,C.<br>Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13<br>Blood (2010) 115, 370-378. PubMed  Europe PubMed DOI  PMC  EPMC
    99. 2009
  99. Akiyama,M., Takeda,S., Kokame,K., Takagi,J. and Miyata,T.<br>Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (2009) 65, 739-742. PubMed  Europe PubMed DOI  PMC  EPMC
  100. Akiyama,M., Takeda,S., Kokame,K., Takagi,J. and Miyata,T.<br>Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor<br>Proc Natl Acad Sci U S A (2009) 106, 19274-19279. PubMed  Europe PubMed DOI  PMC  EPMC
  101. Banno,F., Chauhan,A.K., Kokame,K., Yang,J., Miyata,S., Wagner,D.D. and Miyata,T.<br>The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation<br>Blood (2009) 113, 5323-5329. PubMed  Europe PubMed DOI  PMC  EPMC
  102. Feys,H.B., Deckmyn,H. and Vanhoorelbeke,K.<br>ADAMTS13 in health and disease<br>Acta Haematol (2009) 121, 183-185. PubMed  Europe PubMed DOI
  103. Feys,H.B., Pareyn,I., Vancraenenbroeck,R., De Maeyer,M., Deckmyn,H., Van Geet,C. and Vanhoorelbeke,K.<br>Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura<br>Blood (2009) 114, 4749-4752. PubMed  Europe PubMed DOI  M
  104. Gardner,M.D., Chion,C.K., de Groot,R., Shah,A., Crawley,J.T. and Lane,D.A.<br>A functional calcium-binding site in the metalloprotease domain of ADAMTS13<br>Blood (2009) 113, 1149-1157. PubMed  Europe PubMed DOI
  105. Loirat,C., Girma,J.P., Desconclois,C., Coppo,P. and Veyradier,A.<br>Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children<br>Pediatr Nephrol (2009) 24, 19-29. PubMed  Europe PubMed DOI  M
  106. Varadi,K., Rottensteiner,H., Vejda,S., Weber,A., Muchitsch,E.M., Turecek,P.L., Ehrlich,H.J., Scheiflinger,F. and Schwarz,H.P.<br>Species-dependent variability of ADAMTS13-mediated proteolysis of human recombinant von Willebrand factor<br>J Thromb Haemost (2009) 7, 1134-1142. PubMed  Europe PubMed DOI  P
  107. Zhao,B.Q., Chauhan,A.K., Canault,M., Patten,I.S., Yang,J.J., Dockal,M., Scheiflinger,F. and Wagner,D.D.<br>Von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke<br>Blood (2009) 114, 3329-3334. PubMed  Europe PubMed DOI
    108. 2008
  108. Camilleri,R.S., Cohen,H., Mackie,I.J., Scully,M., Starke,R.D., Crawley,J.T., Lane,D.A. and Machin,S.J.<br>Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura<br>J Thromb Haemost (2008) 6, 331-338. PubMed  Europe PubMed DOI  M
  109. Di Stasio,E., Lancellotti,S., Peyvandi,F., Palla,R., Mannucci,P.M. and De Cristofaro,R.<br>Mechanistic studies on ADAMTS13 catalysis<br>Biophys J (2008) 95, 2450-2461. PubMed  Europe PubMed DOI  PMC  EPMC
  110. Kokame,K.<br>[Genetic polymorphism of von Willebrand factor (VWF)-cleaving protease, ADAMTS13]<br>Brain Nerve (2008) 60, 1325-1332. PubMed  Europe PubMed
  111. Pruss,C.M., Notley,C.R., Hegadorn,C.A., O'Brien,L.A. and Lillicrap,D.<br>ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor<br>Br J Haematol (2008) 143, 552-558. PubMed  Europe PubMed DOI
    112. 2007
  112. Hommais,A., Rayes,J., Houllier,A., Obert,B., Legendre,P., Veyradier,A., Girma,J.P. and Ribba,A.S.<br>Molecular characterization of four ADAMTS13 mutations responsible for congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome)<br>Thromb Haemost (2007) 98, 593-599. PubMed  Europe PubMed DOI  M
  113. Keeney,S., Grundy,P., Collins,P.W. and Bowen,D.J.<br>C1584 in von Willebrand factor is necessary for enhanced proteolysis by ADAMTS13 in vitro<br>Haemophilia (2007) 13, 405-408. PubMed  Europe PubMed DOI
  114. Miyata,T., Kokame,K., Banno,F., Shin,Y. and Akiyama,M.<br>ADAMTS13 assays and ADAMTS13-deficient mice<br>Curr Opin Hematol (2007) 14, 277-283. PubMed  Europe PubMed DOI  A  K
  115. Scott,E.A., Puca,K.E., Pietz,B.C., Duchateau,B.K. and Friedman,K.D.<br>Comparison and stability of ADAMTS13 activity in therapeutic plasma products<br>Transfusion (2007) 47, 120-125. PubMed  Europe PubMed DOI  U
  116. Zhang,P., Pan,W., Rux,A.H., Sachais,B.S. and Zheng,X.L.<br>The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow<br>Blood (2007) 110, 1887-1894. PubMed  Europe PubMed DOI  PMC  EPMC
    117. 2006
  117. Donadelli,R., Banterla,F., Galbusera,M., Capoferri,C., Bucchioni,S., Gastoldi,S., Nosari,S., Monteferrante,G., Ruggeri,Z.M., Bresin,E., Scheiflinger,F., Rossi,E., Martinez,C., Coppo,R., Remuzzi,G. and Noris,M.<br>In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura<br>Thromb Haemost (2006) 96, 454-464. PubMed  Europe PubMed DOI  M
  118. Feys,H.B., Liu,F., Dong,N., Pareyn,I., Vauterin,S., Vandeputte,N., Noppe,W., Ruan,C., Deckmyn,H. and Vanhoorelbeke,K.<br>ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences<br>J Thromb Haemost (2006) 4, 955-962. PubMed  Europe PubMed DOI
  119. [YEAR:1-2-2006]Peyvandi,F., Lavoretano,S., Palla,R., Valsecchi,C., Merati,G., De Cristofaro,R., Rossi,E. and Mannuccio Mannucci,P.<br>Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity<br>Hum Mutat (1-2-2006) 27, 330-336. PubMed  Europe PubMed DOI  M
  120. [YEAR:4-4-2006]Shang,D., Zheng,X.W., Niiya,M. and Zheng,X.L.<br>Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts<br>Blood (4-4-2006) 108, 2207-2215. PubMed  Europe PubMed DOI  M
  121. [YEAR:31-1-2006]Shibagaki,Y., Matsumoto,M., Kokame,K., Ohba,S., Miyata,T., Fujimura,Y. and Fujita,T.<br>Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure<br>Nephrol Dial Transplant (31-1-2006) 21, 1289-1292. PubMed  Europe PubMed DOI  M
    122. 2005
  122. Bruno,K., Volkel,D., Plaimauer,B., Antoine,G., Pable,S., Motto,D.G., Lemmerhirt,H.L., Dorner,F., Zimmermann,K. and Scheiflinger,F.<br>Cloning, expression and functional characterization of the full-length murine ADAMTS13<br>J Thromb Haemost (2005) 3, 1064-1073. PubMed  Europe PubMed DOI  E  I
  123. [YEAR:4-4-2005]De Cristofaro,R., Peyvandi,F., Palla,R., Lavoretano,S., Lombardi,R., Merati,G., Romitelli,F., Di Stasio,E. and Mannucci,P.M.<br>Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13<br>J Biol Chem (4-4-2005) 280, 23295-23302. PubMed  Europe PubMed DOI
  124. Kokame,K., Nobe,Y., Kokubo,Y., Okayama,A. and Miyata,T.<br>FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay<br>Br J Haematol (2005) 129, 93-100. PubMed  Europe PubMed DOI  A
  125. [YEAR:17-3-2005]Levy,G.G., Motto,D.G. and Ginsburg,D.<br>ADAMTS13 turns 3<br>Blood (17-3-2005) 106, 11-17. PubMed  Europe PubMed DOI  V
  126. Luken,B.M., Turenhout,E.A., Hulstein,J.J., Van Mourik,J.A., Fijnheer,R. and Voorberg,J.<br>The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura<br>Thromb Haemost (2005) 93, 267-274. PubMed  Europe PubMed DOI
  127. [YEAR:1-10-2005]Motto,D.G., Chauhan,A.K., Zhu,G., Homeister,J., Lamb,C.B., Desch,K.C., Zhang,W., Tsai,H.M., Wagner,D.D. and Ginsburg,D.<br>Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice<br>J Clin Invest (1-10-2005) 115, 2752-2761. PubMed  Europe PubMed DOI  PMC  EPMC  K
  128. [YEAR:30-3-2005]Noris,M., Bucchioni,S., Galbusera,M., Donadelli,R., Bresin,E., Castelletti,F., Caprioli,J., Brioschi,S., Scheiflinger,F. and Remuzzi,G.<br>Complement factor H mutation in familial thrombotic thrombocytopenic purpura with ADAMTS13 deficiency and renal involvement<br>J Am Soc Nephrol (30-3-2005) 16, 1177-1183. PubMed  Europe PubMed DOI
  129. [YEAR:15-1-2005]Studt,J.D., Hovinga,J.A., Antoine,G., Hermann,M., Rieger,M., Scheiflinger,F. and Lammle,B.<br>Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS13 inhibitor: in vitro inhibition of ADAMTS13 activity by hemoglobin<br>Blood (15-1-2005) 105, 542-544. PubMed  Europe PubMed DOI
  130. [YEAR:1-9-2005]Tao,Z., Peng,Y., Nolasco,L., Cal,S., Lopez-Otin,C., Li,R., Moake,J.L., Lopez,J.A. and Dong,J.F.<br>Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions<br>Blood (1-9-2005) 106, 4139-4145. PubMed  Europe PubMed DOI  PMC  EPMC
  131. [YEAR:3-10-2005]Zhou,W., Dong,L., Ginsburg,D., Bouhassira,E.E. and Tsai,H.M.<br>Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?<br>J Biol Chem (3-10-2005) 280, 39934-39941. PubMed  Europe PubMed DOI  PMC  EPMC
    132. 2004
  132. [YEAR:10-5-2004]Banno,F., Kaminaka,K., Soejima,K., Kokame,K. and Miyata,T.<br>Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease<br>J Biol Chem (10-5-2004) 279, 30896-30903. PubMed  Europe PubMed DOI  M
  133. Bowen,D.<br>Type 1 von Willebrand disease: a possible novel mechanism<br>Blood Coagul Fibrinolysis (2004) 15 Suppl 1, S21-S23. PubMed  Europe PubMed DOI
  134. [YEAR:1-2-2004]Bowen,D.J. and Collins,P.W.<br>An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13<br>Blood (1-2-2004) 103, 941-947. PubMed  Europe PubMed DOI
  135. Chung,D.W. and Sadler,J.E.<br>ADAMTS13: von Willebrand factor-cleaving protease<br>[ISSN:0-12-079610-4] (2004) 2, 747-751.  V
  136. Coppo,P., Bengoufa,D., Veyradier,A., Wolf,M., Bussel,A., Millot,G.A., Malot,S., Heshmati,F., Mira,J.P., Boulanger,E., Galicier,L., Durey-Dragon,M.A., Fremeaux-Bacchi,V., Ramakers,M., Pruna,A., Bordessoule,D., Gouilleux,V., Scrobohaci,M.L., Vernant,J.P., Moreau,D., Azoulay,E., Schlemmer,B., Guillevin,L. and Lassoued,K.<br>Severe ADAMTS13 deficiency in adult idiopathic thrombotic microangiopathies defines a subset of patients characterized by various autoimmune manifestations, lower platelet count, and mild renal involvement<br>Medicine (Baltimore) (2004) 83, 233-244. PubMed  Europe PubMed DOI
  137. [YEAR:9-11-2004]Kawahara,M., Kanno,M., Matsumoto,M., Nakamura,S., Fujimura,Y. and Ueno,S.<br>Diffuse neurodeficits in intravascular lymphomatosis with ADAMTS13 inhibitor<br>Neurology (9-11-2004) 63, 1731-1733. PubMed  Europe PubMed
  138. [YEAR:4-3-2004]Klaus,C., Plaimauer,B., Studt,J.D., Dorner,F., Lammle,B., Mannucci,P.M. and Scheiflinger,F.<br>Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura<br>Blood (4-3-2004) 103, 4514-4519. PubMed  Europe PubMed DOI
  139. Knovich,M.A., Craver,K., Matulis,M.D., Lawson,H. and Owen,J.<br>Simplified assay for VWF cleaving protease (ADAMTS13) activity and inhibitor in plasma<br>Am J Hematol (2004) 76, 286-290. PubMed  Europe PubMed DOI  A
  140. [YEAR:15-1-2004]Kokame,K., Matsumoto,M., Fujimura,Y. and Miyata,T.<br>VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13<br>Blood (15-1-2004) 103, 607-612. PubMed  Europe PubMed DOI  P
  141. Licht,C., Stapenhorst,L., Simon,T., Budde,U., Schneppenheim,R. and Hoppe,B.<br>Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)<br>Kidney Int (2004) 66, 955-958. PubMed  Europe PubMed DOI  M
  142. Mannucci,P.M., Capoferri,C. and Canciani,M.T.<br>Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease<br>Br J Haematol (2004) 126, 213-218. PubMed  Europe PubMed DOI
  143. [YEAR:15-2-2004]Matsumoto,M., Kokame,K., Soejima,K., Miura,M., Hayashi,S., Fujii,Y., Iwai,A., Ito,E., Tsuji,Y., Takeda-Shitaka,M., Iwadate,M., Umeyama,H., Yagi,H., Ishizashi,H., Banno,F., Nakagaki,T., Miyata,T. and Fujimura,Y.<br>Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome<br>Blood (15-2-2004) 103, 1305-1310. PubMed  Europe PubMed DOI  M
  144. [YEAR:20-7-2004]Nishio,K., Anderson,P.J., Zheng,X.L. and Sadler,J.E.<br>Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13<br>Proc Natl Acad Sci U S A (20-7-2004) 101, 10578-10583. PubMed  Europe PubMed DOI  PMC  EPMC
  145. Peyvandi,F., Ferrari,S., Lavoretano,S., Canciani,M.T. and Mannucci,P.M.<br>von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura<br>Br J Haematol (2004) 127, 433-439. PubMed  Europe PubMed DOI  M
  146. [YEAR:15-1-2004]Pimanda,J.E., Maekawa,A., Wind,T., Paxton,J., Chesterman,C.N. and Hogg,P.J.<br>Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13<br>Blood (15-1-2004) 103, 627-629. PubMed  Europe PubMed DOI  M
  147. Plaimauer,B. and Scheiflinger,F.<br>Expression and characterization of recombinant human ADAMTS-13<br>Semin Hematol (2004) 41, 24-33. PubMed  Europe PubMed DOI
  148. Raife,T., Atkinson,B., Montgomery,R., Vesely,S. and Friedman,K.<br>Severe deficiency of VWF-cleaving protease (ADAMTS13) activity defines a distinct population of thrombotic microangiopathy patients<br>Transfusion (2004) 44, 146-150. PubMed  Europe PubMed DOI
  149. Snider,C.E., Moore,J.C., Warkentin,T.E., Finch,C.N., Hayward,C.P. and Kelton,J.G.<br>Dissociation between the level of von Willebrand factor-cleaving protease activity and disease in a patient with congenital thrombotic thrombocytopenic purpura<br>Am J Hematol (2004) 77, 387-390. PubMed  Europe PubMed DOI
  150. [YEAR:2-1-2004]Suzuki,M., Murata,M., Matsubara,Y., Uchida,T., Ishihara,H., Shibano,T., Ashida,S., Soejima,K., Okada,Y. and Ikeda,Y.<br>Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets<br>Biochem Biophys Res Commun (2-1-2004) 313, 212-216. PubMed  Europe PubMed DOI
  151. [YEAR:4-5-2004]Uchida,T., Wada,H., Mizutani,M., Iwashita,M., Ishihara,H., Shibano,T., Suzuki,M., Matsubara,Y., Soejima,K., Matsumoto,M., Fujimura,Y., Ikeda,Y. and Murata,M.<br>Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura<br>Blood (4-5-2004) 104, 2081-2083. PubMed  Europe PubMed DOI  M
  152. Zhou,W. and Tsai,H.M.<br>An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations<br>Thromb Haemost (2004) 91, 806-811. PubMed  Europe PubMed DOI  A
    153. 2003
  153. Antoine,G., Zimmermann,K., Plaimauer,B., Grillowitzer,M., Studt,J.D., Lammle,B. and Scheiflinger,F.<br>ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor-cleaving protease activity by recombinant human ADAMTS13<br>Br J Haematol (2003) 120, 821-824. PubMed  Europe PubMed DOI  M
  154. Assink,K., Schiphorst,R., Allford,S., Karpman,D., Etzioni,A., Brichard,B., van de Kar,N., Monnens,L. and van den Heuvel,L.<br>Mutation analysis and clinical implications of von Willebrand factor-cleaving protease deficiency<br>Kidney Int (2003) 63, 1995-1999. PubMed  Europe PubMed DOI  M
  155. Cruz,M.A., Whitelock,J. and Dong,J.F.<br>Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate<br>Thromb Haemost (2003) 90, 1204-1209. PubMed  Europe PubMed DOI
  156. [YEAR:8-8-2003]Dong,J.F., Moake,J.L., Bernardo,A., Fujikawa,K., Ball,C., Nolasco,L., Lopez,J.A. and Cruz,M.A.<br>ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor<br>J Biol Chem (8-8-2003) 278, 29633-29639. PubMed  Europe PubMed DOI
  157. Pimanda,J.E., Chesterman,C.N. and Hogg,P.J.<br>A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura<br>Eur J Haematol (2003) 70, 257-262. PubMed  Europe PubMed DOI  M
  158. [YEAR:1-6-2003]Savasan,S., Lee,S.K., Ginsburg,D. and Tsai,H.M.<br>ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity<br>Blood (1-6-2003) 101, 4449-4451. PubMed  Europe PubMed DOI  M
  159. [YEAR:1-3-2003]Schneppenheim,R., Budde,U., Oyen,F., Angerhaus,D., Aumann,V., Drewke,E., Hassenpflug,W., Haberle,J., Kentouche,K., Kohne,E., Kurnik,K., Mueller-Wiefel,D., Obser,T., Santer,R. and Sykora,K.W.<br>von Willebrand factor cleaving protease and ADAMTS13 mutations in childhood TTP<br>Blood (1-3-2003) 101, 1845-1850. PubMed  Europe PubMed DOI  M
  160. [YEAR:1-11-2003]Soejima,K., Matsumoto,M., Kokame,K., Yagi,H., Ishizashi,H., Maeda,H., Nozaki,C., Miyata,T., Fujimura,Y. and Nakagaki,T.<br>ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage<br>Blood (1-11-2003) 102, 3232-3237. PubMed  Europe PubMed DOI
  161. Tsai,H.M.<br>Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura<br>Arterioscler Thromb Vasc Biol (2003) 23, 388-396. PubMed  Europe PubMed DOI
  162. [YEAR:1-7-2003]Vesely,S.K., George,J.N., Lammle,B., Studt,J.D., Alberio,L., El-Harake,M.A. and Raskob,G.E.<br>ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients<br>Blood (1-7-2003) 102, 60-68. PubMed  Europe PubMed DOI
  163. Veyradier,A., Obert,B., Haddad,E., Cloarec,S., Nivet,H., Foulard,M., Lesure,F., Delattre,P., Lakhdari,M., Meyer,D., Girma,J.P. and Loriat,C.<br>Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome<br>J Pediatr (2003) 142, 310-317. PubMed  Europe PubMed DOI
  164. Yoo,G., Blomback,M., Schenck-Gustafsson,K. and He,S.<br>Decreased levels of von Willebrand factor-cleaving protease in coronary heart disease and thrombotic thrombocytopenic purpura: study of a simplified method for assaying the enzyme activity based on ristocetin-induced platelet aggregation<br>Br J Haematol (2003) 121, 123-129. PubMed  Europe PubMed DOI  A
  165. [YEAR:8-8-2003]Zheng,X., Nishio,K., Majerus,E.M. and Sadler,J.E.<br>Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13<br>J Biol Chem (8-8-2003) 278, 30136-30141. PubMed  Europe PubMed DOI
    166. 2002
  166. Ashida,A., Nakamura,H., Yoden,A., Tamai,H., Ishizashi,H., Yagi,H., Matsumoto,M. and Fujimura,Y.<br>Successful treatment of a young infant who developed high-titer inhibitors against VWF-cleaving protease (ADAMTS-13): important discrimination from Upshaw-Schulman syndrome<br>Am J Hematol (2002) 71, 318-322. PubMed  Europe PubMed DOI
  167. [YEAR:15-7-2002]Bianchi,V., Robles,R., Alberio,L., Furlan,M. and Lammle,B.<br>Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura<br>Blood (15-7-2002) 100, 710-713. PubMed  Europe PubMed DOI
  168. [YEAR:23-1-2002]Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and Lopez-Otin,C.<br>Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains<br>Gene (23-1-2002) 283, 49-62. PubMed  Europe PubMed DOI
  169. [YEAR:1-12-2002]Dong,J.F., Moake,J.L., Nolasco,L., Bernardo,A., Arceneaux,W., Shrimpton,C.N., Schade,A.J., McIntire,L.V., Fujikawa,K. and Lopez,J.A.<br>ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions<br>Blood (1-12-2002) 100, 4033-4039. PubMed  Europe PubMed DOI
  170. Furlan,M. and Lammle,B.<br>Assays of von Willebrand factor-cleaving protease: a test for diagnosis of familial and acquired thrombotic thrombocytopenic purpura<br>Semin Thromb Hemost (2002) 28, 167-172. PubMed  Europe PubMed DOI  A
  171. [YEAR:3-9-2002]Kokame,K., Matsumoto,M., Soejima,K., Yagi,H., Ishizashi,H., Funato,M., Tamai,H., Konno,M., Kamide,K., Kawano,Y., Miyata,T. and Fujimura,Y.<br>Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity<br>Proc Natl Acad Sci U S A (3-9-2002) 99, 11902-11907. PubMed  Europe PubMed DOI  PMC  EPMC  M
  172. [YEAR:15-3-2002]Koo,B.H., Oh,D., Chung,S.Y., Kim,N.K., Park,S., Jang,Y. and Chung,K.H.<br>Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients<br>Thromb Res (15-3-2002) 105, 471-476. PubMed  Europe PubMed DOI
  173. Moake,J.L.<br>Thrombotic thrombocytopenic purpura: The systemic clumping "Plague"<br>Annu Rev Med (2002) 53, 75-88. PubMed  Europe PubMed DOI
  174. Park,Y.D., Yoshioka,A., Kawa,K., Ishizashi,H., Yagi,H., Yamamoto,Y., Matsumoto,M. and Fujimura,Y.<br>Impaired activity of plasma von Willebrand factor-cleaving protease may predict the occurrence of hepatic veno-occlusive disease after stem cell transplantation<br>Bone Marrow Transplant (2002) 29, 789-794. PubMed  Europe PubMed DOI
  175. [YEAR:27-10-2002]Pham,P.T., Danovitch,G.M., Wilkinson,A.H., Gritsch,H.A., Pham,P.C., Eric,T.M., Kendrick,E., Charles,L.R. and Tsai,H.M.<br>Inhibitors of ADAMTS13: a potential factor in the cause of thrombotic microangiopathy in a renal allograft recipient<br>Transplantation (27-10-2002) 74, 1077-1080. PubMed  Europe PubMed DOI  I
  176. [YEAR:15-11-2002]Plaimauer,B., Zimmermann,K., Volkel,D., Antoine,G., Kerschbaumer,R., Jenab,P., Furlan,M., Gerritsen,H., Lammle,B., Schwarz,H.P. and Scheiflinger,F.<br>Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13)<br>Blood (15-11-2002) 100, 3626-3632. PubMed  Europe PubMed DOI
  177. [YEAR:1-8-2002]Remuzzi,G., Galbusera,M., Noris,M., Canciani,M.T., Daina,E., Bresin,E., Contaretti,S., Caprioli,J., Gamba,S., Ruggenenti,P., Perico,N. and Mannucci,P.M.<br>von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome<br>Blood (1-8-2002) 100, 778-785. PubMed  Europe PubMed DOI  M
  178. Rick,M.E., Moll,S., Taylor,M.A., Krizek,D.M., White,G.C. and Aronson,D.L.<br>Clinical use of a rapid collagen binding assay for von Willebrand factor cleaving protease in patients with thrombotic thrombocytopenic purpura<br>Thromb Haemost (2002) 88, 598-604. PubMed  Europe PubMed DOI  A
  179. Sahud,M.A., Claster,S., Liu,L., Ero,M., Harris,K. and Furlan,M.<br>von Willebrand factor-cleaving protease inhibitor in a patient with human immunodeficiency syndrome-associated thrombotic thrombocytopenic purpura<br>Br J Haematol (2002) 116, 909-911. PubMed  Europe PubMed DOI
  180. Tsai,H.M.<br>Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura<br>J Mol Med (2002) 80, 639-647. PubMed  Europe PubMed DOI
  181. [YEAR:1-11-2002]Tsai,H.M., Sarode,R. and Downes,K.A.<br>Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood<br>Thromb Res (1-11-2002) 108, 121-125. PubMed  Europe PubMed DOI
    182. 2001
  182. Aronson,D.L., Krizek,D.M. and Rick,M.E.<br>A rapid assay for the vWF protease<br>Thromb Haemost (2001) 85, 184-185. PubMed  Europe PubMed  A
  183. Barbot,J., Costa,E., Guerra,M., Barreirinho,M.S., Isvarlal,P., Robles,R., Gerritsen,H.E., Lammle,B. and Furlan,M.<br>Ten years of prophylactic treatment with fresh-frozen plasma in a child with chronic relapsing thrombotic thrombocytopenic purpura as a result of a congenital deficiency of von Willebrand factor-cleaving protease<br>Br J Haematol (2001) 113, 649-651. PubMed  Europe PubMed DOI
  184. [YEAR:15-9-2001]Fujikawa,K., Suzuki,H., McMullen,B. and Chung,D.<br>Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family<br>Blood (15-9-2001) 98, 1662-1666. PubMed  Europe PubMed DOI
  185. [YEAR:15-9-2001]Gerritsen,H.E., Robles,R., Lammle,B. and Furlan,M.<br>Partial amino acid sequence of purified von Willebrand factor-cleaving protease<br>Blood (15-9-2001) 98, 1654-1661. PubMed  Europe PubMed DOI
  186. Kinoshita,S., Yoshioka,A., Park,Y.D., Ishizashi,H., Konno,M., Funato,M., Matsui,T., Titani,K., Yagi,H., Matsumoto,M. and Fujimura,Y.<br>Upshaw-Schulman syndrome revisited: a concept of congenital thrombotic thrombocytopenic purpura<br>Int J Hematol (2001) 74, 101-108. PubMed  Europe PubMed
  187. Kirzek,D.M. and Rick,M.E.<br>Clinical application of a rapid method using agarose gel electrophoresis and Western blotting to evaluate von Willebrand factor protease activity<br>Electrophoresis (2001) 22, 946-949. PubMed  Europe PubMed DOI
  188. [YEAR:4-10-2001]Levy,G.G., Nichols,W.C., Lian,E.C., Foroud,T., McClintick,J.N., McGee,B.M., Yang,A.Y., Siemieniak,D.R., Stark,K.R., Gruppo,R., Sarode,R., Shurin,S.B., Chandrasekaran,V., Stabler,S.P., Sabio,H., Bouhassira,E.E., Upshaw,J.D., Jr., Ginsburg,D. and Tsai,H.M.<br>Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura<br>Nature (4-10-2001) 413, 488-494. PubMed  Europe PubMed DOI  M
  189. [YEAR:1-11-2001]Mannucci,P.M., Canciani,M.T., Forza,I., Lussana,F., Lattuada,A. and Rossi,E.<br>Changes in health and disease of the metalloprotease that cleaves von Willebrand factor<br>Blood (1-11-2001) 98, 2730-2735. PubMed  Europe PubMed DOI
  190. [YEAR:15-9-2001]Moore,J.C., Hayward,C.P., Warkentin,T.E. and Kelton,J.G.<br>Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders<br>Blood (15-9-2001) 98, 1842-1846. PubMed  Europe PubMed DOI
  191. Soejima,K., Mimura,N., Hirashima,M., Maeda,H., Hamamoto,T., Nakagaki,T. and Nozaki,C.<br>A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?<br>J Biochem (2001) 130, 475-480. PubMed  Europe PubMed
  192. [YEAR:15-9-2001]Veyradier,A., Obert,B., Houllier,A., Meyer,D. and Girma,J.P.<br>Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases<br>Blood (15-9-2001) 98, 1765-1772. PubMed  Europe PubMed DOI
  193. [YEAR:2-11-2001]Zheng,X., Chung,D., Takayama,T.K., Majerus,E.M., Sadler,J.E. and Fujikawa,K.<br>Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura<br>J Biol Chem (2-11-2001) 276, 41059-41063. PubMed  Europe PubMed DOI
    194. 2000
  194. Allford,S.L., Harrison,P., Lawrie,A.S., Liesner,R., Mackie,I.J. and Machin,S.J.<br>von Willebrand factor-cleaving protease activity in congenital thrombotic thrombocytopenic purpura<br>Br J Haematol (2000) 111, 1215-1222. PubMed  Europe PubMed DOI
  195. te Loo,D.M., Levtchenko,E., Furlan,M., Roosendaal,G.P. and van den Heuvel,L.P.<br>Autosomal recessive inheritance of von Willebrand factor-cleaving protease deficiency<br>Pediatr Nephrol (2000) 14, 762-765. PubMed  Europe PubMed
  196. Tsai,H.M.<br>High titers of inhibitors of von Willebrand factor-cleaving metalloproteinase in a fatal case of acute thrombotic thrombocytopenic purpura<br>Am J Hematol (2000) 65, 251-255. PubMed  Europe PubMed DOI
    197. 1999
  197. [YEAR:1-5-1999]Oleksowicz,L., Bhagwati,N. and DeLeon-Fernandez,M.<br>Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies<br>Cancer Res (1-5-1999) 59, 2244-2250. PubMed  Europe PubMed
  198. [YEAR:1-6-1999]van der Plas,R.M., Schiphorst,M.E., Huizinga,E.G., Hene,R.J., Verdonck,L.F., Sixma,J.J. and Fijnheer,R.<br>von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura<br>Blood (1-6-1999) 93, 3798-3802. PubMed  Europe PubMed
    199. 1998
  199. [YEAR:15-4-1998]Furlan,M., Robles,R., Solenthaler,M. and Lammle,B.<br>Acquired deficiency of von Willebrand factor-cleaving protease in a patient with thrombotic thrombocytopenic purpura<br>Blood (15-4-1998) 91, 2839-2846. PubMed  Europe PubMed
    200. 1996
  200. Furlan,M., Robles,R. and Lammle,B.<br>Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis<br>Blood (1996) 87, 4223-4234. PubMed  Europe PubMed
  201. Tsai,H.M.<br>Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion<br>Blood (1996) 87, 4235-4244. PubMed  Europe PubMed
    202. 1982
  202. [YEAR:2-12-1982]Moake,J.L., Rudy,C.K., Troll,J.H., Weinstein,M.J., Colannino,N.M., Azocar,J., Seder,R.H., Hong,S.L. and Deykin,D.<br>Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura<br>N Engl J Med (2-12-1982) 307, 1432-1435. PubMed  Europe PubMed DOI
    203. 1978
  203. [YEAR:15-6-1978]Upshaw,J.D., Jr.<br>Congenital deficiency of a factor in normal plasma that reverses microangiopathic hemolysis and thrombocytopenia<br>N Engl J Med (15-6-1978) 298, 1350-1352. PubMed  Europe PubMed DOI

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