Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M12.215: ADAM15 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Aujla,P.K., Hu,M., Hartley,B., Kranrod,J.W., Viveiros,A., Kilic,T., Owen,C.A., Oudit,G.Y., Seubert,J.M., Julien,O. and Kassiri,Z.
    Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway
    Hypertension (2023) 80, 97-110. PubMed  Europe PubMed DOI  K
  2. Calligaris,M., Yang,C.Y., Bonelli,S., Spano,D.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D.
    Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics
    Front Mol Biosci (2023) 10, 1162504-1162504. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Puig-Blasco,L., Piotrowski,K.B., Michaelsen,S.R., Bager,N.S., Areskeviciutie,A., Thorseth,M.L., Sun,X.F., Keller,U.A.D., Kristensen,B.W., Madsen,D.H., Gnosa,S.P. and Kveiborg,M.
    Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors
    Int J Cancer (2023) 153, 2068-2081. PubMed  Europe PubMed DOI
    4. 2022
  4. Gruba,N., Musielak,M., Rejmak,W. and Lesner,A.
    Detection of ADAM15 in urine from patients with bladder cancer
    Anal Biochem (2022) 654, 114805-114805. PubMed  Europe PubMed DOI
  5. Yang,C.Y., Bonelli,S., Calligaris,M., Carreca,A.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D.
    Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State
    Membranes (Basel) (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2021
  6. Janczi,T., Meier,F., Fehrl,Y., Kinne,R.W., Bohm,B. and Burkhardt,H.
    A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts
    Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wang,X., Rojas-Quintero,J., Zhang,D., Nakajima,T., Walker,K.H., Peh,H.Y., Li,Y., Fucci,Q.A., Tesfaigzi,Y. and Owen,C.A.
    A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice
    Mucosal Immunol (2021) 14, 342-356. PubMed  Europe PubMed DOI  K
    8. 2018
  8. Yang,X., Meegan,J.E., Jannaway,M., Coleman,D.C. and Yuan,S.Y.
    A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation
    Cardiovasc Res (2018) 114, 1752-1763. PubMed  Europe PubMed DOI  K
    9. 2012
  9. Rawlings,N.D.
    ADAM15 peptidase
    [ISSN:978-0-12-407744-7] (2012) 3, 1122-1125. DOI
    10. 2011
  10. Bultmann,A., Li,Z., Wagner,S., Gawaz,M., Ungerer,M., Langer,H., May,A.E. and Munch,G.
    Loss of protease activity of ADAM15 abolishes protective effects on plaque progression in atherosclerosis
    Int J Cardiol (2011) 152, 382-385. PubMed  Europe PubMed DOI
    11. 2010
  11. Lu,D., Scully,M., Kakkar,V. and Lu,X.
    ADAM-15 disintegrin-like domain structure and function
    Toxins (2010) 2, 2411-2427. PubMed  Europe PubMed DOI
  12. Sun,C., Wu,M.H., Guo,M., Day,M.L., Lee,E.S. and Yuan,S.Y.
    ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling
    Cardiovasc Res (2010) 87, 348-355. PubMed  Europe PubMed DOI
    13. 2009
  13. Kleino,I., Ortiz,R.M., Yritys,M., Huovila,A.P. and Saksela,K.
    Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins
    J Cell Biochem (2009) 108, 877-885. PubMed  Europe PubMed DOI
  14. Lucas,N. and Day,M.L.
    The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression
    J Cell Biochem (2009) 106, 967-974. PubMed  Europe PubMed DOI  T
  15. Lucas,N., Najy,A.J. and Day,M.L.
    The therapeutic potential of ADAM15
    Curr Pharm Des (2009) 15, 2311-2318. PubMed  Europe PubMed DOI  V  T
  16. Maretzky,T., Yang,G., Ouerfelli,O., Overall,C.M., Worpenberg,S., Hassiepen,U., Eder,J. and Blobel,C.P.
    Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays
    Biochem J (2009) 420, 105-113. PubMed  Europe PubMed DOI  A  I
  17. Maretzky,T., Le Gall,S.M., Worpenberg-Pietruk,S., Eder,J., Overall,C.M., Huang,X.Y., Poghosyan,Z., Edwards,D.R. and Blobel,C.P.
    Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer
    Cancer Res (2009) 69, 4573-4576. PubMed  Europe PubMed DOI  R
    18. 2008
  18. Charrier-Hisamuddin,L., Laboisse,C.L. and Merlin,D.
    ADAM-15: a metalloprotease that mediates inflammation
    FASEB J (2008) 22, 641-653. PubMed  Europe PubMed DOI  V
    19. 2007
  19. Kleino,I., Ortiz,R.M. and Huovila,A.P.
    ADAM15 gene structure and differential alternative exon use in human tissues
    BMC Mol Biol (2007) 8, 90-90. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2006
  20. Kuefer,R., Day,K.C., Kleer,C.G., Sabel,M.S., Hofer,M.D., Varambally,S., Zorn,C.S., Chinnaiyan,A.M., Rubin,M.A. and Day,M.L.
    ADAM15 Disintegrin Is Associated with Aggressive Prostate and Breast Cancer Disease
    Neoplasia (2006) 8, 319-329. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2005
  21. [YEAR:9-9-2005]Charrier,L., Yan,Y., Driss,A., Laboisse,C.L., Sitaraman,S.V. and Merlin,D.
    ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers
    Am J Physiol Gastrointest Liver Physiol (9-9-2005) 288, G346-G353. PubMed  Europe PubMed DOI
  22. Komiya,K., Enomoto,H., Inoki,I., Okazaki,S., Fujita,Y., Ikeda,E., Ohuchi,E., Matsumoto,H., Toyama,Y. and Okada,Y.
    Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis
    Arthritis Res Ther (2005) 7, R1158-R1173. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Langer,H., May,A.E., Bultmann,A. and Gawaz,M.
    ADAM 15 is an adhesion receptor for platelet GPIIb-IIIa and induces platelet activation
    Thromb Haemost (2005) 94, 555-561. PubMed  Europe PubMed DOI
    24. 2004
  24. [YEAR:26-8-2004]Schafer,B., Marg,B., Gschwind,A. and Ullrich,A.
    Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
    J Biol Chem (26-8-2004) 279, 47929-47938. PubMed  Europe PubMed DOI
  25. Wolfsberg,T.G. and White,J.M.
    ADAM metalloproteinases
    [ISSN:0-12-079610-4] (2004) 2, 709-714.  V
    26. 2003
  26. [YEAR:15-8-2003]Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
    Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23
    J Biol Chem (15-8-2003) 278, 30469-30477. PubMed  Europe PubMed DOI
  27. Horiuchi,K., Weskamp,G., Lum,L., Hammes,H.P., Cai,H., Brodie,T.A., Ludwig,T., Chiusaroli,R., Baron,R., Preissner,K.T., Manova,K. and Blobel,C.P.
    Potential role for ADAM15 in pathological neovascularization in mice
    Mol Cell Biol (2003) 23, 5614-5624. PubMed  Europe PubMed DOI  PMC  EPMC
  28. [YEAR:3-10-2003]Shimizu,E., Yasui,A., Matsuura,K., Hijiya,N., Higuchi,Y. and Yamamoto,S.
    Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins
    Biochem Biophys Res Commun (3-10-2003) 309, 779-785. PubMed  Europe PubMed DOI
    29. 2002
  29. [YEAR:1-10-2002]Ham,C., Levkau,B., Raines,E.W. and Herren,B.
    ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin
    Exp Cell Res (1-10-2002) 279, 239-247. PubMed  Europe PubMed DOI
  30. [YEAR:13-9-2002]Martin,J., Eynstone,L.V., Davies,M., Williams,J.D. and Steadman,R.
    The role of ADAM 15 in glomerular mesangial cell migration
    J Biol Chem (13-9-2002) 277, 33683-33689. PubMed  Europe PubMed DOI  I
  31. [YEAR:15-2-2002]Poghosyan,Z., Robbins,S.M., Houslay,M.D., Webster,A., Murphy,G. and Edwards,D.R.
    Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    J Biol Chem (15-2-2002) 277, 4999-5007. PubMed  Europe PubMed DOI
    32. 2001
  32. Bohm,B.B., Aigner,T., Blobel,C.P., Kalden,J.R. and Burkhardt,H.
    Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue
    Arthritis Rheum (2001) 44, 2046-2054. PubMed  Europe PubMed DOI
  33. [YEAR:15-11-2001]Herren,B., Garton,K.J., Coats,S., Bowen-Pope,D.F., Ross,R. and Raines,E.W.
    ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions
    Exp Cell Res (15-11-2001) 271, 152-160. PubMed  Europe PubMed DOI
    34. 2000
  34. Karkkainen,I., Karhu,R. and Huovila,A.P.J.
    Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization
    Cytogenet Cell Genet (2000) 88, 206-207. PubMed  Europe PubMed
    35. 1999
  35. Nath,D., Slocombe,P.M., Stephens,P.E., Warn,A., Hutchinson,G.R., Yamada,K.M., Docherty,A.J. and Murphy,G.
    Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells
    J Cell Sci (1999) 112, 579-587. PubMed  Europe PubMed
    36. 1998
  36. [YEAR:2-10-1998]Lum,L., Reid,M.S. and Blobel,C.P.
    Intracellular maturation of the mouse metalloprotease disintegrin MDC15
    J Biol Chem (2-10-1998) 273, 26236-26247. PubMed  Europe PubMed DOI
    37. 1997
  37. Herren,B., Raines,E.W. and Ross,R.
    Expression of a disintegrin-like protein in cultured human vascular cells and in vivo
    FASEB J (1997) 11, 173-180. PubMed  Europe PubMed
    38. 1996
  38. Kratzschmar,J., Lum,L. and Blobel,C.P.
    Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence
    J Biol Chem (1996) 271, 4593-4596. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use