Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M12.215: ADAM15 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Aujla,P.K., Hu,M., Hartley,B., Kranrod,J.W., Viveiros,A., Kilic,T., Owen,C.A., Oudit,G.Y., Seubert,J.M., Julien,O. and Kassiri,Z.<br>Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway<br>Hypertension (2023) 80, 97-110. PubMed  Europe PubMed DOI  K
  2. Calligaris,M., Yang,C.Y., Bonelli,S., Spano,D.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D.<br>Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics<br>Front Mol Biosci (2023) 10, 1162504-1162504. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Puig-Blasco,L., Piotrowski,K.B., Michaelsen,S.R., Bager,N.S., Areskeviciutie,A., Thorseth,M.L., Sun,X.F., Keller,U.A.D., Kristensen,B.W., Madsen,D.H., Gnosa,S.P. and Kveiborg,M.<br>Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors<br>Int J Cancer (2023) 153, 2068-2081. PubMed  Europe PubMed DOI
    4. 2022
  4. Gruba,N., Musielak,M., Rejmak,W. and Lesner,A.<br>Detection of ADAM15 in urine from patients with bladder cancer<br>Anal Biochem (2022) 654, 114805-114805. PubMed  Europe PubMed DOI
  5. Yang,C.Y., Bonelli,S., Calligaris,M., Carreca,A.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D.<br>Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State<br>Membranes (Basel) (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2021
  6. Janczi,T., Meier,F., Fehrl,Y., Kinne,R.W., Bohm,B. and Burkhardt,H.<br>A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts<br>Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wang,X., Rojas-Quintero,J., Zhang,D., Nakajima,T., Walker,K.H., Peh,H.Y., Li,Y., Fucci,Q.A., Tesfaigzi,Y. and Owen,C.A.<br>A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice<br>Mucosal Immunol (2021) 14, 342-356. PubMed  Europe PubMed DOI  K
    8. 2018
  8. Yang,X., Meegan,J.E., Jannaway,M., Coleman,D.C. and Yuan,S.Y.<br>A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation<br>Cardiovasc Res (2018) 114, 1752-1763. PubMed  Europe PubMed DOI  K
    9. 2012
  9. Rawlings,N.D.<br>ADAM15 peptidase<br>[ISSN:978-0-12-407744-7] (2012) 3, 1122-1125. DOI
    10. 2011
  10. Bultmann,A., Li,Z., Wagner,S., Gawaz,M., Ungerer,M., Langer,H., May,A.E. and Munch,G.<br>Loss of protease activity of ADAM15 abolishes protective effects on plaque progression in atherosclerosis<br>Int J Cardiol (2011) 152, 382-385. PubMed  Europe PubMed DOI
    11. 2010
  11. Lu,D., Scully,M., Kakkar,V. and Lu,X.<br>ADAM-15 disintegrin-like domain structure and function<br>Toxins (2010) 2, 2411-2427. PubMed  Europe PubMed DOI
  12. Sun,C., Wu,M.H., Guo,M., Day,M.L., Lee,E.S. and Yuan,S.Y.<br>ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling<br>Cardiovasc Res (2010) 87, 348-355. PubMed  Europe PubMed DOI
    13. 2009
  13. Kleino,I., Ortiz,R.M., Yritys,M., Huovila,A.P. and Saksela,K.<br>Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins<br>J Cell Biochem (2009) 108, 877-885. PubMed  Europe PubMed DOI
  14. Lucas,N. and Day,M.L.<br>The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression<br>J Cell Biochem (2009) 106, 967-974. PubMed  Europe PubMed DOI  T
  15. Lucas,N., Najy,A.J. and Day,M.L.<br>The therapeutic potential of ADAM15<br>Curr Pharm Des (2009) 15, 2311-2318. PubMed  Europe PubMed DOI  V  T
  16. Maretzky,T., Yang,G., Ouerfelli,O., Overall,C.M., Worpenberg,S., Hassiepen,U., Eder,J. and Blobel,C.P.<br>Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays<br>Biochem J (2009) 420, 105-113. PubMed  Europe PubMed DOI  A  I
  17. Maretzky,T., Le Gall,S.M., Worpenberg-Pietruk,S., Eder,J., Overall,C.M., Huang,X.Y., Poghosyan,Z., Edwards,D.R. and Blobel,C.P.<br>Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer<br>Cancer Res (2009) 69, 4573-4576. PubMed  Europe PubMed DOI  R
    18. 2008
  18. Charrier-Hisamuddin,L., Laboisse,C.L. and Merlin,D.<br>ADAM-15: a metalloprotease that mediates inflammation<br>FASEB J (2008) 22, 641-653. PubMed  Europe PubMed DOI  V
    19. 2007
  19. Kleino,I., Ortiz,R.M. and Huovila,A.P.<br>ADAM15 gene structure and differential alternative exon use in human tissues<br>BMC Mol Biol (2007) 8, 90-90. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2006
  20. Kuefer,R., Day,K.C., Kleer,C.G., Sabel,M.S., Hofer,M.D., Varambally,S., Zorn,C.S., Chinnaiyan,A.M., Rubin,M.A. and Day,M.L.<br>ADAM15 Disintegrin Is Associated with Aggressive Prostate and Breast Cancer Disease<br>Neoplasia (2006) 8, 319-329. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2005
  21. [YEAR:9-9-2005]Charrier,L., Yan,Y., Driss,A., Laboisse,C.L., Sitaraman,S.V. and Merlin,D.<br>ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers<br>Am J Physiol Gastrointest Liver Physiol (9-9-2005) 288, G346-G353. PubMed  Europe PubMed DOI
  22. Komiya,K., Enomoto,H., Inoki,I., Okazaki,S., Fujita,Y., Ikeda,E., Ohuchi,E., Matsumoto,H., Toyama,Y. and Okada,Y.<br>Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis<br>Arthritis Res Ther (2005) 7, R1158-R1173. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Langer,H., May,A.E., Bultmann,A. and Gawaz,M.<br>ADAM 15 is an adhesion receptor for platelet GPIIb-IIIa and induces platelet activation<br>Thromb Haemost (2005) 94, 555-561. PubMed  Europe PubMed DOI
    24. 2004
  24. [YEAR:26-8-2004]Schafer,B., Marg,B., Gschwind,A. and Ullrich,A.<br>Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival<br>J Biol Chem (26-8-2004) 279, 47929-47938. PubMed  Europe PubMed DOI
  25. Wolfsberg,T.G. and White,J.M.<br>ADAM metalloproteinases<br>[ISSN:0-12-079610-4] (2004) 2, 709-714.  V
    26. 2003
  26. [YEAR:15-8-2003]Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.<br>Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23<br>J Biol Chem (15-8-2003) 278, 30469-30477. PubMed  Europe PubMed DOI
  27. Horiuchi,K., Weskamp,G., Lum,L., Hammes,H.P., Cai,H., Brodie,T.A., Ludwig,T., Chiusaroli,R., Baron,R., Preissner,K.T., Manova,K. and Blobel,C.P.<br>Potential role for ADAM15 in pathological neovascularization in mice<br>Mol Cell Biol (2003) 23, 5614-5624. PubMed  Europe PubMed DOI  PMC  EPMC
  28. [YEAR:3-10-2003]Shimizu,E., Yasui,A., Matsuura,K., Hijiya,N., Higuchi,Y. and Yamamoto,S.<br>Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins<br>Biochem Biophys Res Commun (3-10-2003) 309, 779-785. PubMed  Europe PubMed DOI
    29. 2002
  29. [YEAR:1-10-2002]Ham,C., Levkau,B., Raines,E.W. and Herren,B.<br>ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin<br>Exp Cell Res (1-10-2002) 279, 239-247. PubMed  Europe PubMed DOI
  30. [YEAR:13-9-2002]Martin,J., Eynstone,L.V., Davies,M., Williams,J.D. and Steadman,R.<br>The role of ADAM 15 in glomerular mesangial cell migration<br>J Biol Chem (13-9-2002) 277, 33683-33689. PubMed  Europe PubMed DOI  I
  31. [YEAR:15-2-2002]Poghosyan,Z., Robbins,S.M., Houslay,M.D., Webster,A., Murphy,G. and Edwards,D.R.<br>Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases<br>J Biol Chem (15-2-2002) 277, 4999-5007. PubMed  Europe PubMed DOI
    32. 2001
  32. Bohm,B.B., Aigner,T., Blobel,C.P., Kalden,J.R. and Burkhardt,H.<br>Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue<br>Arthritis Rheum (2001) 44, 2046-2054. PubMed  Europe PubMed DOI
  33. [YEAR:15-11-2001]Herren,B., Garton,K.J., Coats,S., Bowen-Pope,D.F., Ross,R. and Raines,E.W.<br>ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions<br>Exp Cell Res (15-11-2001) 271, 152-160. PubMed  Europe PubMed DOI
    34. 2000
  34. Karkkainen,I., Karhu,R. and Huovila,A.P.J.<br>Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization<br>Cytogenet Cell Genet (2000) 88, 206-207. PubMed  Europe PubMed
    35. 1999
  35. Nath,D., Slocombe,P.M., Stephens,P.E., Warn,A., Hutchinson,G.R., Yamada,K.M., Docherty,A.J. and Murphy,G.<br>Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells<br>J Cell Sci (1999) 112, 579-587. PubMed  Europe PubMed
    36. 1998
  36. [YEAR:2-10-1998]Lum,L., Reid,M.S. and Blobel,C.P.<br>Intracellular maturation of the mouse metalloprotease disintegrin MDC15<br>J Biol Chem (2-10-1998) 273, 26236-26247. PubMed  Europe PubMed DOI
    37. 1997
  37. Herren,B., Raines,E.W. and Ross,R.<br>Expression of a disintegrin-like protein in cultured human vascular cells and in vivo<br>FASEB J (1997) 11, 173-180. PubMed  Europe PubMed
    38. 1996
  38. Kratzschmar,J., Lum,L. and Blobel,C.P.<br>Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence<br>J Biol Chem (1996) 271, 4593-4596. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use