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Literature for peptidase M10.020: fragilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jasemi,S., Molicotti,P., Fais,M., Cossu,I., Simula,E.R. and Sechi,L.A.<br>Biological Mechanisms of Enterotoxigenic Bacteroides fragilis Toxin: Linking Inflammation, Colorectal Cancer, and Clinical Implications<br>Toxins (Basel) (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Jamal,W., Khodakhast,F.B., AlAzmi,A., Somicronki,J., AlHashem,G. and Rotimi,V.O.<br>Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait<br>BMC Microbiol (2020) 20, 14-14. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2017
  3. Lv,Y., Ye,T., Wang,H.P., Zhao,J.Y., Chen,W.J., Wang,X., Shen,C.X., Wu,Y.B. and Cai,Y.K.<br>Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo<br>World J Gastroenterol (2017) 23, 603-613. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zakharzhevskaya,N.B., Tsvetkov,V.B., Vanyushkina,A.A., Varizhuk,A.M., Rakitina,D.V., Podgorsky,V.V., Vishnyakov,I.E., Kharlampieva,D.D., Manuvera,V.A., Lisitsyn,F.V., Gushina,E.A., Lazarev,V.N. and Govorun,V.M.<br>Interaction of Bacteroides fragilis toxin with outer membrane vesicles reveals new mechanism of its secretion and delivery<br>Front Cell Infect Microbiol (2017) 7, 2-2. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2016
  5. Choi,V.M., Herrou,J., Hecht,A.L., Teoh,W.P., Turner,J.R., Crosson,S. and Bubeck Wardenburg,J.<br>Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice<br>Nat Med (2016) 22, 563-567. PubMed  Europe PubMed DOI
    6. 2015
  6. Kharlampieva,D., Manuvera,V., Podgorny,O., Grafskaia,E., Kovalchuk,S., Pobeguts,O., Altukhov,I., Govorun,V. and Lazarev,V.<br>Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin<br>Microb Pathog (2015) 83-84C, 47-56. PubMed  Europe PubMed DOI
    7. 2014
  7. Remacle,A.G., Shiryaev,S.A. and Strongin,A.Y.<br>Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island<br>PLoS ONE (2014) 9, e113896-e113896. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Shiryaev,S.A., Aleshin,A.E., Muranaka,N., Kukreja,M., Routenberg,D.A., Remacle,A.G., Liddington,R.C., Cieplak,P., Kozlov,I.A. and Strongin,A.Y.<br>Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island<br>FEBS J (2014) 281, 2487-2502. PubMed  Europe PubMed DOI  P  S
  9. Shiryaev,S.A., Remacle,A.G., Cieplak,P. and Strongin,A.Y.<br>Peptide sequence region that is essential for the interactions of the enterotoxigenic Bacteroides fragilis metalloproteinase II with E-cadherin<br>J Proteolysis (2014) 1, 3-14. PubMed  Europe PubMed  PMC  EPMC
    10. 2013
  10. Kharlampieva,D.D., Manuvera,V.A., Podgorny,O.V., Kovalchuk,S.I., Pobeguts,O.V., Altukhov,I.A., Alexeev,D.G., Lazarev,V.N. and Govorun,V.M.<br>Purification and characterisation of recombinant Bacteroides fragilis toxin-2<br>Biochimie (2013) 95, 2123-2131. PubMed  Europe PubMed DOI
  11. Shiryaev,S.A., Remacle,A.G., Chernov,A.V., Golubkov,V.S., Motamedchaboki,K., Muranaka,N., Dambacher,C.M., Capek,P., Kukreja,M., Kozlov,I.A., Perucho,M., Cieplak,P. and Strongin,A.Y.<br>Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface<br>J Biol Chem (2013) 288, 34956-34967. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Goulas,T. and Gomis-Ruth,F.X.<br>Fragilysin<br>[ISSN:978-0-12-407744-7] (2012) 3, 887-891. DOI
    13. 2011
  13. Goulas,T., Arolas,J.L. and Gomis-Ruth,F.X.<br>Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog<br>Proc Natl Acad Sci U S A (2011) 108, 1856-1861. PubMed  Europe PubMed DOI  S
    14. 2009
  14. Sears,C.L.<br>Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes<br>Clin Microbiol Rev (2009) 22, 349-369. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2008
  15. Holton,J.<br>Enterotoxigenic Bacteroides fragilis<br>Curr Infect Dis Rep (2008) 10, 99-104. PubMed  Europe PubMed
    16. 2007
  16. Wu,S., Rhee,K.J., Zhang,M., Franco,A. and Sears,C.L.<br>Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage<br>J Cell Sci (2007) 120, 1944-1952. PubMed  Europe PubMed DOI
    17. 2006
  17. Sears,C.L., Buckwold,S.L., Shin,J.W. and Franco,A.A.<br>The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity<br>Infect Immun (2006) 74, 5595-5601. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2005
  18. Franco,A.A., Buckwold,S.L., Shin,J.W., Ascon,M. and Sears,C.L.<br>Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing<br>Infect Immun (2005) 73, 5273-5277. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2004
  19. Vines,R.R. and Wilkins,T.D.<br>Fragilysin<br>[ISSN:0-12-079610-4] (2004) 2, 588-591.  V
    20. 2003
  20. Foulon,I., Pierard,D., Muyldermans,G., Vandoorslaer,K., Soetens,O., Rosseel,P. and Lauwers,S.<br>Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples<br>J Clin Microbiol (2003) 41, 4428-4430. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2002
  21. Wu,S., Dreyfus,L.A., Tzianabos,A.O., Hayashi,C. and Sears,C.L.<br>Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis<br>Infect Immun (2002) 70, 2463-2471. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2001
  22. Sears,C.L.<br>The toxins of Bacteroides fragilis<br>Toxicon (2001) 39, 1737-1746. PubMed  Europe PubMed DOI
    23. 2000
  23. [YEAR:1-1-2000]Kato,N., Liu,C.X., Kato,H., Watanabe,K., Tanaka,Y., Yamamoto,T., Suzuki,K. and Ueno,K.<br>A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan<br>FEMS Microbiol Lett (1-1-2000) 182, 171-176. PubMed  Europe PubMed DOI
  24. Sanfilippo,L., Li,C.K., Seth,R., Balwin,T.J., Menozzi,M.G. and Mahida,Y.R.<br>Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-beta) by human colonic epithelial cells<br>Clin Exp Immunol (2000) 119, 456-463. PubMed  Europe PubMed  PMC  EPMC
  25. Scotto d'Abusco,A.S., Sanfilippo,L., Menozzi,M.G. and Pantosti,A.<br>Activity and role of BFT, an enterotoxin produced by Bacteroides fragilis<br>J Nat Toxins (2000) 9, 267-280. PubMed  Europe PubMed
  26. Scottod'Abusco,A.S., DelGrosso,M., Censini,S., Covacci,A. and Pantosti,A.<br>The alleles of the bft gene are distributed differently among enterotoxigenic Bacteroides fragilis strains from human sources and can be present in double copies<br>J Clin Microbiol (2000) 38, 607-612.
  27. [YEAR:8-11-2000]Vines,R.R., Perdue,S.S., Moncrief,J.S., Sentz,D.R., Barroso,L.A., Wright,R.L. and Wilkins,T.D.<br>Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route<br>Vaccine (8-11-2000) 19, 655-660. PubMed  Europe PubMed DOI
    28. 1999
  28. Chung,G.T., Franco,A.A., Wu,S., Rhie,G.E., Cheng,R., Oh,H.B. and Sears,C.L.<br>Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis<br>Infect Immun (1999) 67, 4945-4949. PubMed  Europe PubMed  PMC  EPMC
  29. Riegler,M., Lotz,M., Sears,C., Pothoulakis,C., Castagliuolo,I., Wang,C.C., Sedivy,R., Sogukoglu,T., Cosentini,E., Bischof,G., Feil,W., Teleky,B., Hamilton,G., LaMont,J.T. and Wenzl,E.<br>Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro<br>Gut (1999) 44, 504-510. PubMed  Europe PubMed  PMC  EPMC
    30. 1998
  30. Moncrief,J.S., Duncan,A.J., Wright,R.L., Barroso,L.A. and Wilkins,T.D.<br>Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis<br>Infect Immun (1998) 66, 1735-1739. PubMed  Europe PubMed  PMC  EPMC
  31. [YEAR:8-12-1998]Wu,S., Lim,K.C., Huang,J., Saidi,R.F. and Sears,C.L.<br>Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin<br>Proc Natl Acad Sci U S A (8-12-1998) 95, 14979-14984. PubMed  Europe PubMed  PMC  EPMC
    32. 1997
  32. Franco,A.A., Mundy,L.M., Trucksis,M., Wu,S., Kaper,J.B. and Sears,C.L.<br>Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene<br>Infect Immun (1997) 65, 1007-1013. PubMed  Europe PubMed  PMC  EPMC
  33. Kling,J.J., Wright,R.L., Moncrief,J.S. and Wilkins,T.D.<br>Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis<br>FEMS Microbiol Lett (1997) 146, 279-284. PubMed  Europe PubMed DOI
  34. Obiso,R.J., Jr., Bevan,D.R. and Wilkins,T.D.<br>Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin<br>Clin Infect Dis (1997) 25 Suppl 2, S153-S155. PubMed  Europe PubMed
  35. Obiso,R.J., Jr., Azghani,A.O. and Wilkins,T.D.<br>The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells<br>Infect Immun (1997) 65, 1431-1439. PubMed  Europe PubMed  PMC  EPMC
  36. Saidi,R.F., Jaeger,K., Montrose,M.H., Wu,S. and Sears,C.L.<br>Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content<br>Cell Motil Cytoskeleton (1997) 37, 159-165. PubMed  Europe PubMed DOI
    37. 1996
  37. Donelli,G., Fabbri,A. and Fiorentini,C.<br>Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells<br>Infect Immun (1996) 64, 113-119. PubMed  Europe PubMed  PMC  EPMC
  38. Koshy,S.S., Montrose,M.H. and Sears,C.L.<br>Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis<br>Infect Immun (1996) 64, 5022-5028. PubMed  Europe PubMed  PMC  EPMC
  39. Saidi,R.F. and Sears,C.L.<br>Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro<br>Infect Immun (1996) 64, 5029-5034. PubMed  Europe PubMed  PMC  EPMC
    40. 1995
  40. Moncrief,J.S., Obiso,R., Jr., Barroso,L.A., Kling,J.J., Wright,R.L., Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.<br>The enterotoxin of Bacteroides fragilis is a metalloprotease<br>Infect Immun (1995) 63, 175-181. PubMed  Europe PubMed  PMC  EPMC
  41. Obiso,R.J., Jr., Lyerly,D.M., Van Tassell,R.L. and Wilkins,T.D.<br>Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo<br>Infect Immun (1995) 63, 3820-3826. PubMed  Europe PubMed  PMC  EPMC
    42. 1992
  42. Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.<br>Purification and characterization of an enterotoxin from Bacteroides fragilis<br>Infect Immun (1992) 60, 1343-1350. PubMed  Europe PubMed  PMC  EPMC
  43. Weikel,C.S., Grieco,F.D., Reuben,J., Myers,L.L. and Sack,R.B.<br>Human colonic epithelial cells, HT29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology<br>Infect Immun (1992) 60, 321-327. PubMed  Europe PubMed  PMC  EPMC

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