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Literature for peptidase M10.020: fragilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jasemi,S., Molicotti,P., Fais,M., Cossu,I., Simula,E.R. and Sechi,L.A.
    Biological Mechanisms of Enterotoxigenic Bacteroides fragilis Toxin: Linking Inflammation, Colorectal Cancer, and Clinical Implications
    Toxins (Basel) (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Jamal,W., Khodakhast,F.B., AlAzmi,A., Somicronki,J., AlHashem,G. and Rotimi,V.O.
    Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait
    BMC Microbiol (2020) 20, 14-14. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2017
  3. Lv,Y., Ye,T., Wang,H.P., Zhao,J.Y., Chen,W.J., Wang,X., Shen,C.X., Wu,Y.B. and Cai,Y.K.
    Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
    World J Gastroenterol (2017) 23, 603-613. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zakharzhevskaya,N.B., Tsvetkov,V.B., Vanyushkina,A.A., Varizhuk,A.M., Rakitina,D.V., Podgorsky,V.V., Vishnyakov,I.E., Kharlampieva,D.D., Manuvera,V.A., Lisitsyn,F.V., Gushina,E.A., Lazarev,V.N. and Govorun,V.M.
    Interaction of Bacteroides fragilis toxin with outer membrane vesicles reveals new mechanism of its secretion and delivery
    Front Cell Infect Microbiol (2017) 7, 2-2. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2016
  5. Choi,V.M., Herrou,J., Hecht,A.L., Teoh,W.P., Turner,J.R., Crosson,S. and Bubeck Wardenburg,J.
    Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice
    Nat Med (2016) 22, 563-567. PubMed  Europe PubMed DOI
    6. 2015
  6. Kharlampieva,D., Manuvera,V., Podgorny,O., Grafskaia,E., Kovalchuk,S., Pobeguts,O., Altukhov,I., Govorun,V. and Lazarev,V.
    Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin
    Microb Pathog (2015) 83-84C, 47-56. PubMed  Europe PubMed DOI
    7. 2014
  7. Remacle,A.G., Shiryaev,S.A. and Strongin,A.Y.
    Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island
    PLoS ONE (2014) 9, e113896-e113896. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Shiryaev,S.A., Aleshin,A.E., Muranaka,N., Kukreja,M., Routenberg,D.A., Remacle,A.G., Liddington,R.C., Cieplak,P., Kozlov,I.A. and Strongin,A.Y.
    Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island
    FEBS J (2014) 281, 2487-2502. PubMed  Europe PubMed DOI  P  S
  9. Shiryaev,S.A., Remacle,A.G., Cieplak,P. and Strongin,A.Y.
    Peptide sequence region that is essential for the interactions of the enterotoxigenic Bacteroides fragilis metalloproteinase II with E-cadherin
    J Proteolysis (2014) 1, 3-14. PubMed  Europe PubMed  PMC  EPMC
    10. 2013
  10. Kharlampieva,D.D., Manuvera,V.A., Podgorny,O.V., Kovalchuk,S.I., Pobeguts,O.V., Altukhov,I.A., Alexeev,D.G., Lazarev,V.N. and Govorun,V.M.
    Purification and characterisation of recombinant Bacteroides fragilis toxin-2
    Biochimie (2013) 95, 2123-2131. PubMed  Europe PubMed DOI
  11. Shiryaev,S.A., Remacle,A.G., Chernov,A.V., Golubkov,V.S., Motamedchaboki,K., Muranaka,N., Dambacher,C.M., Capek,P., Kukreja,M., Kozlov,I.A., Perucho,M., Cieplak,P. and Strongin,A.Y.
    Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface
    J Biol Chem (2013) 288, 34956-34967. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Goulas,T. and Gomis-Ruth,F.X.
    Fragilysin
    [ISSN:978-0-12-407744-7] (2012) 3, 887-891. DOI
    13. 2011
  13. Goulas,T., Arolas,J.L. and Gomis-Ruth,F.X.
    Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog
    Proc Natl Acad Sci U S A (2011) 108, 1856-1861. PubMed  Europe PubMed DOI  S
    14. 2009
  14. Sears,C.L.
    Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes
    Clin Microbiol Rev (2009) 22, 349-369. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2008
  15. Holton,J.
    Enterotoxigenic Bacteroides fragilis
    Curr Infect Dis Rep (2008) 10, 99-104. PubMed  Europe PubMed
    16. 2007
  16. Wu,S., Rhee,K.J., Zhang,M., Franco,A. and Sears,C.L.
    Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage
    J Cell Sci (2007) 120, 1944-1952. PubMed  Europe PubMed DOI
    17. 2006
  17. Sears,C.L., Buckwold,S.L., Shin,J.W. and Franco,A.A.
    The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity
    Infect Immun (2006) 74, 5595-5601. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2005
  18. Franco,A.A., Buckwold,S.L., Shin,J.W., Ascon,M. and Sears,C.L.
    Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing
    Infect Immun (2005) 73, 5273-5277. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2004
  19. Vines,R.R. and Wilkins,T.D.
    Fragilysin
    [ISSN:0-12-079610-4] (2004) 2, 588-591.  V
    20. 2003
  20. Foulon,I., Pierard,D., Muyldermans,G., Vandoorslaer,K., Soetens,O., Rosseel,P. and Lauwers,S.
    Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples
    J Clin Microbiol (2003) 41, 4428-4430. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2002
  21. Wu,S., Dreyfus,L.A., Tzianabos,A.O., Hayashi,C. and Sears,C.L.
    Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis
    Infect Immun (2002) 70, 2463-2471. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2001
  22. Sears,C.L.
    The toxins of Bacteroides fragilis
    Toxicon (2001) 39, 1737-1746. PubMed  Europe PubMed DOI
    23. 2000
  23. [YEAR:1-1-2000]Kato,N., Liu,C.X., Kato,H., Watanabe,K., Tanaka,Y., Yamamoto,T., Suzuki,K. and Ueno,K.
    A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan
    FEMS Microbiol Lett (1-1-2000) 182, 171-176. PubMed  Europe PubMed DOI
  24. Sanfilippo,L., Li,C.K., Seth,R., Balwin,T.J., Menozzi,M.G. and Mahida,Y.R.
    Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-beta) by human colonic epithelial cells
    Clin Exp Immunol (2000) 119, 456-463. PubMed  Europe PubMed  PMC  EPMC
  25. Scotto d'Abusco,A.S., Sanfilippo,L., Menozzi,M.G. and Pantosti,A.
    Activity and role of BFT, an enterotoxin produced by Bacteroides fragilis
    J Nat Toxins (2000) 9, 267-280. PubMed  Europe PubMed
  26. Scottod'Abusco,A.S., DelGrosso,M., Censini,S., Covacci,A. and Pantosti,A.
    The alleles of the bft gene are distributed differently among enterotoxigenic Bacteroides fragilis strains from human sources and can be present in double copies
    J Clin Microbiol (2000) 38, 607-612.
  27. [YEAR:8-11-2000]Vines,R.R., Perdue,S.S., Moncrief,J.S., Sentz,D.R., Barroso,L.A., Wright,R.L. and Wilkins,T.D.
    Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route
    Vaccine (8-11-2000) 19, 655-660. PubMed  Europe PubMed DOI
    28. 1999
  28. Chung,G.T., Franco,A.A., Wu,S., Rhie,G.E., Cheng,R., Oh,H.B. and Sears,C.L.
    Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis
    Infect Immun (1999) 67, 4945-4949. PubMed  Europe PubMed  PMC  EPMC
  29. Riegler,M., Lotz,M., Sears,C., Pothoulakis,C., Castagliuolo,I., Wang,C.C., Sedivy,R., Sogukoglu,T., Cosentini,E., Bischof,G., Feil,W., Teleky,B., Hamilton,G., LaMont,J.T. and Wenzl,E.
    Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro
    Gut (1999) 44, 504-510. PubMed  Europe PubMed  PMC  EPMC
    30. 1998
  30. Moncrief,J.S., Duncan,A.J., Wright,R.L., Barroso,L.A. and Wilkins,T.D.
    Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis
    Infect Immun (1998) 66, 1735-1739. PubMed  Europe PubMed  PMC  EPMC
  31. [YEAR:8-12-1998]Wu,S., Lim,K.C., Huang,J., Saidi,R.F. and Sears,C.L.
    Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
    Proc Natl Acad Sci U S A (8-12-1998) 95, 14979-14984. PubMed  Europe PubMed  PMC  EPMC
    32. 1997
  32. Franco,A.A., Mundy,L.M., Trucksis,M., Wu,S., Kaper,J.B. and Sears,C.L.
    Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene
    Infect Immun (1997) 65, 1007-1013. PubMed  Europe PubMed  PMC  EPMC
  33. Kling,J.J., Wright,R.L., Moncrief,J.S. and Wilkins,T.D.
    Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis
    FEMS Microbiol Lett (1997) 146, 279-284. PubMed  Europe PubMed DOI
  34. Obiso,R.J., Jr., Bevan,D.R. and Wilkins,T.D.
    Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin
    Clin Infect Dis (1997) 25 Suppl 2, S153-S155. PubMed  Europe PubMed
  35. Obiso,R.J., Jr., Azghani,A.O. and Wilkins,T.D.
    The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells
    Infect Immun (1997) 65, 1431-1439. PubMed  Europe PubMed  PMC  EPMC
  36. Saidi,R.F., Jaeger,K., Montrose,M.H., Wu,S. and Sears,C.L.
    Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content
    Cell Motil Cytoskeleton (1997) 37, 159-165. PubMed  Europe PubMed DOI
    37. 1996
  37. Donelli,G., Fabbri,A. and Fiorentini,C.
    Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells
    Infect Immun (1996) 64, 113-119. PubMed  Europe PubMed  PMC  EPMC
  38. Koshy,S.S., Montrose,M.H. and Sears,C.L.
    Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis
    Infect Immun (1996) 64, 5022-5028. PubMed  Europe PubMed  PMC  EPMC
  39. Saidi,R.F. and Sears,C.L.
    Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro
    Infect Immun (1996) 64, 5029-5034. PubMed  Europe PubMed  PMC  EPMC
    40. 1995
  40. Moncrief,J.S., Obiso,R., Jr., Barroso,L.A., Kling,J.J., Wright,R.L., Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.
    The enterotoxin of Bacteroides fragilis is a metalloprotease
    Infect Immun (1995) 63, 175-181. PubMed  Europe PubMed  PMC  EPMC
  41. Obiso,R.J., Jr., Lyerly,D.M., Van Tassell,R.L. and Wilkins,T.D.
    Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo
    Infect Immun (1995) 63, 3820-3826. PubMed  Europe PubMed  PMC  EPMC
    42. 1992
  42. Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.
    Purification and characterization of an enterotoxin from Bacteroides fragilis
    Infect Immun (1992) 60, 1343-1350. PubMed  Europe PubMed  PMC  EPMC
  43. Weikel,C.S., Grieco,F.D., Reuben,J., Myers,L.L. and Sack,R.B.
    Human colonic epithelial cells, HT29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology
    Infect Immun (1992) 60, 321-327. PubMed  Europe PubMed  PMC  EPMC

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