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Literature for peptidase M10.020: fragilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Jamal,W., Khodakhast,F.B., AlAzmi,A., Somicronki,J., AlHashem,G. and Rotimi,V.O.
    Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait
    BMC Microbiol20, 14-14. PubMed  Europe PubMed DOI
    2. 2017
  2. Lv,Y., Ye,T., Wang,H.P., Zhao,J.Y., Chen,W.J., Wang,X., Shen,C.X., Wu,Y.B. and Cai,Y.K.
    Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
    World J Gastroenterol23, 603-613. PubMed  Europe PubMed DOI
  3. Zakharzhevskaya,N.B., Tsvetkov,V.B., Vanyushkina,A.A., Varizhuk,A.M., Rakitina,D.V., Podgorsky,V.V., Vishnyakov,I.E., Kharlampieva,D.D., Manuvera,V.A., Lisitsyn,F.V., Gushina,E.A., Lazarev,V.N. and Govorun,V.M.
    Interaction of Bacteroides fragilis toxin with outer membrane vesicles reveals new mechanism of its secretion and delivery
    Front Cell Infect Microbiol7, 2-2. PubMed  Europe PubMed DOI
    4. 2016
  4. Choi,V.M., Herrou,J., Hecht,A.L., Teoh,W.P., Turner,J.R., Crosson,S. and Bubeck Wardenburg,J.
    Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice
    Nat Med22, 563-567. PubMed  Europe PubMed DOI
    5. 2015
  5. Kharlampieva,D., Manuvera,V., Podgorny,O., Grafskaia,E., Kovalchuk,S., Pobeguts,O., Altukhov,I., Govorun,V. and Lazarev,V.
    Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin
    Microb Pathog83-84C, 47-56. PubMed  Europe PubMed DOI
    6. 2014
  6. Remacle,A.G., Shiryaev,S.A. and Strongin,A.Y.
    Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island
    PLoS ONE9, e113896-e113896. PubMed  Europe PubMed DOI
  7. Shiryaev,S.A., Remacle,A.G., Cieplak,P. and Strongin,A.Y.
    Peptide sequence region that is essential for the interactions of the enterotoxigenic Bacteroides fragilis metalloproteinase II with E-cadherin
    J Proteolysis1, 3-14. PubMed  Europe PubMed
  8. Shiryaev,S.A., Aleshin,A.E., Muranaka,N., Kukreja,M., Routenberg,D.A., Remacle,A.G., Liddington,R.C., Cieplak,P., Kozlov,I.A. and Strongin,A.Y.
    Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island
    FEBS J281, 2487-2502. PubMed  Europe PubMed DOI  P  S
    9. 2013
  9. Kharlampieva,D.D., Manuvera,V.A., Podgorny,O.V., Kovalchuk,S.I., Pobeguts,O.V., Altukhov,I.A., Alexeev,D.G., Lazarev,V.N. and Govorun,V.M.
    Purification and characterisation of recombinant Bacteroides fragilis toxin-2
    Biochimie95, 2123-2131. PubMed  Europe PubMed DOI
  10. Shiryaev,S.A., Remacle,A.G., Chernov,A.V., Golubkov,V.S., Motamedchaboki,K., Muranaka,N., Dambacher,C.M., Capek,P., Kukreja,M., Kozlov,I.A., Perucho,M., Cieplak,P. and Strongin,A.Y.
    Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface
    J Biol Chem288, 34956-34967. PubMed  Europe PubMed DOI  P
    11. 2012
  11. Goulas,T. and Gomis-Ruth,F.X.
    Fragilysin
    [ISSN:978-0-12-407744-7]3, 887-891. DOI
    12. 2011
  12. Goulas,T., Arolas,J.L. and Gomis-Ruth,F.X.
    Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog
    Proc Natl Acad Sci U S A108, 1856-1861. PubMed  Europe PubMed DOI  S
    13. 2009
  13. Sears,C.L.
    Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes
    Clin Microbiol Rev22, 349-369. PubMed  Europe PubMed DOI
    14. 2008
  14. Holton,J.
    Enterotoxigenic Bacteroides fragilis
    Curr Infect Dis Rep10, 99-104. PubMed  Europe PubMed
    15. 2007
  15. Wu,S., Rhee,K.J., Zhang,M., Franco,A. and Sears,C.L.
    Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage
    J Cell Sci120, 1944-1952. PubMed  Europe PubMed DOI
    16. 2006
  16. Sears,C.L., Buckwold,S.L., Shin,J.W. and Franco,A.A.
    The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity
    Infect Immun74, 5595-5601. PubMed  Europe PubMed DOI
    17. 2005
  17. Franco,A.A., Buckwold,S.L., Shin,J.W., Ascon,M. and Sears,C.L.
    Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing
    Infect Immun73, 5273-5277. PubMed  Europe PubMed DOI
    18. 2004
  18. Vines,R.R. and Wilkins,T.D.
    Fragilysin
    [ISSN:0-12-079610-4]2, 588-591.  V
    19. 2003
  19. Foulon,I., Pierard,D., Muyldermans,G., Vandoorslaer,K., Soetens,O., Rosseel,P. and Lauwers,S.
    Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples
    J Clin Microbiol41, 4428-4430. PubMed  Europe PubMed DOI
    20. 2002
  20. Wu,S., Dreyfus,L.A., Tzianabos,A.O., Hayashi,C. and Sears,C.L.
    Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis
    Infect Immun70, 2463-2471. PubMed  Europe PubMed DOI
    21. 2001
  21. Sears,C.L.
    The toxins of Bacteroides fragilis
    Toxicon39, 1737-1746. PubMed  Europe PubMed DOI
    22. 2000
  22. [YEAR:1-1-2000]Kato,N., Liu,C.X., Kato,H., Watanabe,K., Tanaka,Y., Yamamoto,T., Suzuki,K. and Ueno,K.
    A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan
    FEMS Microbiol Lett182, 171-176. PubMed  Europe PubMed DOI
  23. Sanfilippo,L., Li,C.K., Seth,R., Balwin,T.J., Menozzi,M.G. and Mahida,Y.R.
    Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-beta) by human colonic epithelial cells
    Clin Exp Immunol119, 456-463. PubMed  Europe PubMed
  24. Scotto d'Abusco,A.S., Sanfilippo,L., Menozzi,M.G. and Pantosti,A.
    Activity and role of BFT, an enterotoxin produced by Bacteroides fragilis
    J Nat Toxins9, 267-280. PubMed  Europe PubMed
  25. Scottod'Abusco,A.S., DelGrosso,M., Censini,S., Covacci,A. and Pantosti,A.
    The alleles of the bft gene are distributed differently among enterotoxigenic Bacteroides fragilis strains from human sources and can be present in double copies
    J Clin Microbiol38, 607-612.
  26. [YEAR:8-11-2000]Vines,R.R., Perdue,S.S., Moncrief,J.S., Sentz,D.R., Barroso,L.A., Wright,R.L. and Wilkins,T.D.
    Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route
    Vaccine19, 655-660. PubMed  Europe PubMed DOI
    27. 1999
  27. Chung,G.T., Franco,A.A., Wu,S., Rhie,G.E., Cheng,R., Oh,H.B. and Sears,C.L.
    Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis
    Infect Immun67, 4945-4949. PubMed  Europe PubMed
  28. Riegler,M., Lotz,M., Sears,C., Pothoulakis,C., Castagliuolo,I., Wang,C.C., Sedivy,R., Sogukoglu,T., Cosentini,E., Bischof,G., Feil,W., Teleky,B., Hamilton,G., LaMont,J.T. and Wenzl,E.
    Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro
    Gut44, 504-510. PubMed  Europe PubMed
    29. 1998
  29. Moncrief,J.S., Duncan,A.J., Wright,R.L., Barroso,L.A. and Wilkins,T.D.
    Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis
    Infect Immun66, 1735-1739. PubMed  Europe PubMed
  30. [YEAR:8-12-1998]Wu,S., Lim,K.C., Huang,J., Saidi,R.F. and Sears,C.L.
    Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
    Proc Natl Acad Sci U S A95, 14979-14984. PubMed  Europe PubMed
    31. 1997
  31. Franco,A.A., Mundy,L.M., Trucksis,M., Wu,S., Kaper,J.B. and Sears,C.L.
    Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene
    Infect Immun65, 1007-1013. PubMed  Europe PubMed
  32. Kling,J.J., Wright,R.L., Moncrief,J.S. and Wilkins,T.D.
    Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis
    FEMS Microbiol Lett146, 279-284. PubMed  Europe PubMed DOI
  33. Obiso,R.J., Jr., Azghani,A.O. and Wilkins,T.D.
    The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells
    Infect Immun65, 1431-1439. PubMed  Europe PubMed
  34. Obiso,R.J., Jr., Bevan,D.R. and Wilkins,T.D.
    Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin
    Clin Infect Dis25 Suppl 2, S153-S155. PubMed  Europe PubMed
  35. Saidi,R.F., Jaeger,K., Montrose,M.H., Wu,S. and Sears,C.L.
    Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content
    Cell Motil Cytoskeleton37, 159-165. PubMed  Europe PubMed DOI
    36. 1996
  36. Donelli,G., Fabbri,A. and Fiorentini,C.
    Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells
    Infect Immun64, 113-119. PubMed  Europe PubMed
  37. Koshy,S.S., Montrose,M.H. and Sears,C.L.
    Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis
    Infect Immun64, 5022-5028. PubMed  Europe PubMed
  38. Saidi,R.F. and Sears,C.L.
    Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro
    Infect Immun64, 5029-5034. PubMed  Europe PubMed
    39. 1995
  39. Moncrief,J.S., Obiso,R., Jr., Barroso,L.A., Kling,J.J., Wright,R.L., Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.
    The enterotoxin of Bacteroides fragilis is a metalloprotease
    Infect Immun63, 175-181. PubMed  Europe PubMed
  40. Obiso,R.J., Jr., Lyerly,D.M., Van Tassell,R.L. and Wilkins,T.D.
    Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo
    Infect Immun63, 3820-3826. PubMed  Europe PubMed
    41. 1992
  41. Van Tassell,R.L., Lyerly,D.M. and Wilkins,T.D.
    Purification and characterization of an enterotoxin from Bacteroides fragilis
    Infect Immun60, 1343-1350. PubMed  Europe PubMed
  42. Weikel,C.S., Grieco,F.D., Reuben,J., Myers,L.L. and Sack,R.B.
    Human colonic epithelial cells, HT29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology
    Infect Immun60, 321-327. PubMed  Europe PubMed

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