Literature for peptidase M08.001: leishmanolysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Hernandez-Ramirez,V.I., Matus-Meza,A.S., Oviedo,N., Magos-Castro,M.A., Osorio-Trujillo,C., Salazar-Villatoro,L., Constantino-Jonapa,L.A. and Talamas-Rohana,P. Exploration of the Binding Site of Arachidonic Acid in gp63 of Leishmania mexicana and in Orthologous Proteins in Clinically Important Parasites Pathogens (2024) 13 PubMed Europe PubMed DOI PMC EPMC

2023

Devsani,N., Vemula,D. and Bhandari,V. The glycoprotein gp63- a potential pan drug target for developing new antileishmanial agents Biochimie (2023) 207, 75-82. PubMed Europe PubMed DOI V
Oliveira,S.S.C., Correia,C.A., Santos,V.S., Da Cunha,E.F.F., de Castro,A.A., Ramalho,T.C., Devereux,M., McCann,M., Branquinha,M.H. and Santos,A.L.S. Silver(I) and Copper(II) 1,10-Phenanthroline-5,6-dione Complexes as Promising Antivirulence Strategy against Leishmania: Focus on Gp63 (Leishmanolysin) Trop Med Infect Dis (2023) 8 PubMed Europe PubMed DOI PMC EPMC I
Pereira-Filho,A.A., Queiroz,D.C., Saab,N.A.A., D'Avila Pessoa,G.C., Koerich,L.B., Pereira,M.H., Sant'Anna,M.R.V., Araujo,R.N., Bartholomeu,D.C. and Gontijo,N.F. Evasion of the complement system by Leishmania through the uptake of C4bBP, a complement regulatory protein, and probably by the action of GP63 on C4b molecules deposited on parasite surface Acta Trop (2023) 242, 106908-106908. PubMed Europe PubMed DOI

2022

Guay-Vincent,M.M., Matte,C., Berthiaume,A.M., Olivier,M., Jaramillo,M. and Descoteaux,A. Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates PLoS Pathog (2022) 18, e1010640-e1010640. PubMed Europe PubMed DOI PMC EPMC
Sen,S., Bal,S.K., Yadav,S., Mishra,P., G,V.V., Rastogi,R. and Mukhopadhyay,C.K. Intracellular pathogen Leishmania intervenes in iron loading into ferritin by cleaving chaperones in host macrophages as an iron acquisition strategy J Biol Chem (2022) 298, 102646-102646. PubMed Europe PubMed DOI PMC EPMC

2021

Antonia,A.L., Barnes,A.B., Martin,A.T., Wang,L. and Ko,D.C. Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor PLoS Negl Trop Dis (2021) 15, e0009224-e0009224. PubMed Europe PubMed DOI PMC EPMC
da Silva Lira Filho,A., Fajardo,E.F., Chang,K.P., Clement,P. and Olivier,M. Leishmania Exosomes/Extracellular Vesicles Containing GP63 Are Essential for Enhance Cutaneous Leishmaniasis Development Upon Co-Inoculation of Leishmania amazonensis and Its Exosomes Front Cell Infect Microbiol (2021) 11, 709258-709258. PubMed Europe PubMed DOI PMC EPMC
Khatoon,S., Aroosh,A., Islam,A., Kalsoom,S., Ahmad,F., Hameed,S., Abbasi,S.W., Yasinzai,M. and Naseer,M.M. Novel coumarin-isatin hybrids as potent antileishmanial agents: Synthesis, in silico and in vitro evaluations Bioorg Chem (2021) 110, 104816-104816. PubMed Europe PubMed DOI

2020

Mercado-Camargo,J., Cervantes-Ceballos,L., Vivas-Reyes,R., Pedretti,A., Serrano-Garcia,M.L. and Gomez-Estrada,H. Homology Modeling of Leishmanolysin (gp63) from Leishmania panamensis and Molecular Docking of Flavonoids ACS Omega (2020) 5, 14741-14749. PubMed Europe PubMed DOI PMC EPMC

2019

Rebello,K.M., Uehara,L.A., Ennes-Vidal,V., Garcia-Gomes,A.S., Britto,C., Azambuja,P., Menna-Barreto,R.F.S., Santos,A.L.S., Branquinha,M.H. and D'Avila-Levy,C.M. Participation of Trypanosoma cruzi gp63 molecules on the interaction with Rhodnius prolixus Parasitology (2019) 146, 1075-1082. PubMed Europe PubMed DOI
Yorek,M.S., Poudel,B., Mazgaeen,L., Pope,R.M., Wilson,M.E. and Gurung,P. Leishmania major degrades murine CXCL1 - an immune evasion strategy PLoS Negl Trop Dis (2019) 13, e0007533-e0007533. PubMed Europe PubMed DOI P

2018

Estrada-Figueroa,L.A., Diaz-Gandarilla,J.A., Hernandez-Ramirez,V.I., Arrieta-Gonzalez,M.M., Osorio-Trujillo,C., Rosales-Encina,J.L., Toledo-Leyva,A. and Talamas-Rohana,P. Leishmania mexicana gp63 is the enzyme responsible for cyclooxygenase (COX) activity in this parasitic protozoa Biochimie (2018) 151, 73-84. PubMed Europe PubMed DOI
Marshall,S., Kelly,P.H., Singh,B.K., Pope,R.M., Kim,P., Zhanbolat,B., Wilson,M.E. and Yao,C. Extracellular release of virulence factor major surface protease via exosomes in Leishmania infantum promastigotes Parasit Vectors (2018) 11, 355-355. PubMed Europe PubMed DOI PMC EPMC

2017

Khan,H., Nadhman,A., Azam,S.S., Anees,M., Khan,I., Ullah,I., Sohail,M.F., Shahnaz,G. and Yasinzai,M. In-vitro antileishmanial potential of peptide drug hirudin Chem Biol Drug Des (2017) 89, 67-73. PubMed Europe PubMed DOI
Sutter,A., Antunes,D., Silva-Almeida,M., Costa,M.G.S. and Caffarena,E.R. Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis Mem Inst Oswaldo Cruz (2017) 112, 617-625. PubMed Europe PubMed DOI PMC EPMC

2016

Casgrain,P.A., Martel,C., McMaster,W.R., Mottram,J.C., Olivier,M. and Descoteaux,A. Cysteine peptidase B regulates Leishmania mexicana virulence through the modulation of GP63 expression PLoS Pathog (2016) 12, e1005658-e1005658. PubMed Europe PubMed DOI
Medina,L.S., Souza,B.A., Queiroz,A., Guimaraes,L.H., Lima Machado,P.R., M Carvalho,E., Wilson,M.E. and Schriefer,A. The gp63 gene cluster is highly polymorphic in natural Leishmania (Viannia) braziliensis populations, but functional sites are conserved PLoS ONE (2016) 11, e0163284-e0163284. PubMed Europe PubMed DOI
Waghmare,S., Buxi,A., Nandurkar,Y., Shelke,A. and Chavan,R. In silico sequence analysis, homology modeling and function annotation of leishmanolysin from Leishmania donovani J Parasitic Dis (2016) 40, 1266-1269. DOI

2015

Isnard,A., Christian,J.G., Kodiha,M., Stochaj,U., McMaster,W.R. and Olivier,M. Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity PLoS Pathog (2015) 11, e1004776-e1004776. PubMed Europe PubMed DOI PMC EPMC
Llewellyn,M.S., Messenger,L.A., Luquetti,A.O., Garcia,L., Torrico,F., Tavares,S.B., Cheaib,B., Derome,N., Delepine,M., Baulard,C., Deleuze,J.F., Sauer,S. and Miles,M.A. Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients PLoS Negl Trop Dis (2015) 9, e0003458-e0003458. PubMed Europe PubMed DOI
Shio,M.T., Christian,J.G., Jung,J.Y., Chang,K.P. and Olivier,M. PKC/ROS-mediated NLRP3 inflammasome activation is attenuated by Leishmania zinc-metalloprotease during infection PLoS Negl Trop Dis (2015) 9, e0003868-e0003868. PubMed Europe PubMed DOI PMC EPMC

2014

Hassani,K., Shio,M.T., Martel,C., Faubert,D. and Olivier,M. Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes PLoS ONE (2014) 9, e95007-e95007. PubMed Europe PubMed DOI PMC EPMC K
Iorns,E., Gunn,W., Erath,J., Rodriguez,A., Zhou,J. and Benzinou,M. Replication attempt: "Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival" PLoS ONE (2014) 9, e114614-e114614. PubMed Europe PubMed DOI

2013

Calixto,P.H., Bitar,M., Ferreira,K.A., Abrahao,O., Jr., Lages-Silva,E., Franco,G.R., Ramirez,L.E. and Pedrosa,A.L. Gene identification and comparative molecular modeling of a Trypanosoma rangeli major surface protease J Mol Model (2013) 19, 3053-3064. PubMed Europe PubMed DOI

2012

Isnard,A., Shio,M.T. and Olivier,M. Impact of Leishmania metalloprotease GP63 on macrophage signaling Front Cell Infect Microbiol (2012) 2, 72-72. PubMed Europe PubMed DOI PMC EPMC
Olivier,M. and Isnard,A. Leishmanolysin [ISSN:978-0-12-407744-7] (2012) 3, 1231-1237. DOI
Olivier,M., Atayde,V.D., Isnard,A., Hassani,K. and Shio,M.T. Leishmania virulence factors: focus on the metalloprotease GP63 Microbes Infect (2012) 14, 1377-1389. PubMed Europe PubMed DOI V
Reyes-Uribe,P., Pereira-Dos-Santos,T., De Jesus,J.B., Mesquita-Rodrigues,C., Arevalo,J., Cupolillo,E. and Cuervo,P. Comparative zymographic analysis of metallopeptidase of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis isolates from Peru Parasitol Int (2012) 61, 513-519. PubMed Europe PubMed DOI

2011

Lynn,M.A., Kindrachuk,J., Marr,A.K., Jenssen,H., Pante,N., Elliott,M.R., Napper,S., Hancock,R.E. and McMaster,W.R. Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival PLoS Negl Trop Dis (2011) 5, e1141-e1141. PubMed Europe PubMed DOI PMC EPMC
Ma,L., Chen,K., Meng,Q., Liu,Q., Tang,P., Hu,S. and Yu,J. An evolutionary analysis of trypanosomatid GP63 proteases Parasitol Res (2011) 109, 1075-1084. PubMed Europe PubMed DOI

2010

Contreras,I., Gomez,M.A., Nguyen,O., Shio,M.T., McMaster,R.W. and Olivier,M. Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63 PLoS Pathog (2010) 6, e1001148-e1001148. PubMed Europe PubMed DOI PMC EPMC
Ferreira,K.A., Ruiz,J.C., Dias,F.C., Lages-Silva,E., Tosi,L.R., Ramirez,L.E. and Pedrosa,A.L. Genome survey sequence analysis and identification of homologs of major surface protease (gp63) genes in Trypanosoma rangeli Vector Borne Zoonotic Dis (2010) 10, 847-853. PubMed Europe PubMed DOI
Gomez,M.A. and Olivier,M. Proteases and phosphatases during Leishmania-macrophage interaction: paving the road for pathogenesis Virulence (2010) 1, 314-318. PubMed Europe PubMed DOI
Marcoux,V., Wei,G., Tabel,H. and Bull,H.J. Characterization of major surface protease homologues of Trypanosoma congolense J Biomed Biotechnol (2010) 2010, 418157-418157. PubMed Europe PubMed DOI PMC EPMC
Mazumder,S., Ganguly,A. and Ali,N. The effect of C-terminal domain deletion on the catalytic activity of Leishmania donovani surface proteinase GP63: role of Ser446 in proteolysis Biochimie (2010) 92, 1876-1885. PubMed Europe PubMed DOI
Pereira,F.M., Santos-Mallet,J.R., Branquinha,M.H., D'Avila-Levy,C.M. and Santos,A.L. Influence of leishmanolysin-like molecules of Herpetomonas samuelpessoai on the interaction with macrophages Microbes Infect (2010) 12, 1061-1070. PubMed Europe PubMed DOI
Yao,C. Major surface protease of trypanosomatids: one size fits all? Infect Immun (2010) 78, 22-31. PubMed Europe PubMed DOI V

2009

Gomez,M.A., Contreras,I., Halle,M., Tremblay,M.L., McMaster,R.W. and Olivier,M. Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases Sci Signal (2009) 2, ra58-ra58. PubMed Europe PubMed DOI
Halle,M., Gomez,M.A., Stuible,M., Shimizu,H., McMaster,W.R., Olivier,M. and Tremblay,M.L. The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation J Biol Chem (2009) 284, 6893-6908. PubMed Europe PubMed DOI PMC EPMC
Helm,J.R., Wilson,M.E. and Donelson,J.E. Differential expression of a protease gene family in African trypanosomes Mol Biochem Parasitol (2009) 163, 8-18. PubMed Europe PubMed DOI PMC EPMC
Matteoli,F.P., D'Avila-Levy,C.M., Santos,L.O., Barbosa,G.M., Holandino,C., Branquinha,M.H. and Santos,A.L. Roles of the endosymbiont and leishmanolysin-like molecules expressed by Crithidia deanei in the interaction with mammalian fibroblasts Exp Parasitol (2009) 121, 246-253. PubMed Europe PubMed DOI

2008

Hsiao,C.H., Yao,C., Storlie,P., Donelson,J.E. and Wilson,M.E. The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi Mol Biochem Parasitol (2008) 157, 148-159. PubMed Europe PubMed DOI PMC EPMC
Kulkarni,M.M., Jones,E.A., McMaster,W.R. and McGwire,B.S. Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation Infect Immun (2008) 76, 1738-1747. PubMed Europe PubMed DOI PMC EPMC
Tan,C.W., Jesudhasan,P. and Woo,P.T. Towards a metalloprotease-DNA vaccine against piscine cryptobiosis caused by Cryptobia salmositica Parasitol Res (2008) 102, 265-275. PubMed Europe PubMed DOI T

2007

Grandgenett,P.M., Otsu,K., Wilson,H.R., Wilson,M.E. and Donelson,J.E. A function for a specific zinc metalloprotease of african trypanosomes PLoS Pathog (2007) 3, 1432-1445. PubMed Europe PubMed DOI PMC EPMC
Mauricio,I.L., Gaunt,M.W., Stothard,J.R. and Miles,M.A. Glycoprotein 63 (gp63) genes show gene conversion and reveal the evolution of Old World Leishmania Int J Parasitol (2007) 37, 565-576. PubMed Europe PubMed DOI

2006

[YEAR:3-10-2006]Cuervo,P., Saboia-Vahia,L., Costa Silva-Filho,F., Fernandes,O., Cupolillo,E. and De Jesus,J.B. A zymographic study of metalloprotease activities in extracts and extracellular secretions of Leishmania (Viannia) braziliensis strains Parasitology (3-10-2006) 132, 177-185. PubMed Europe PubMed DOI
[YEAR:31-1-2006]Nogueira de Melo,A.C., D'Avila-Levy,C.M., Dias,F.A., Armada,J.L., Silva,H.D., Lopes,A.H., Santos,A.L., Branquinha,M.H. and Vermelho,A.B. Peptidases and gp63-like proteins in Herpetomonas megaseliae: possible involvement in the adhesion to the invertebrate host Int J Parasitol (31-1-2006) 36, 415-422. PubMed Europe PubMed DOI
Santos,A.L., Branquinha,M.H. and D'Avila-Levy,C.M. The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function An Acad Bras Cienc (2006) 78, 687-714. PubMed Europe PubMed

2005

[YEAR:9-4-2005]Purdy,J.E., Donelson,J.E. and Wilson,M.E. Regulation of genes encoding the major surface protease of Leishmania chagasi via mRNA stability Mol Biochem Parasitol (9-4-2005) 142, 88-97. PubMed Europe PubMed DOI
Yao,C., Luo,J., Hsiao,C., Donelson,J.E. and Wilson,M.E. Internal and surface subpopulations of the major surface protease (MSP) of Leishmania chagasi Mol Biochem Parasitol (2005) 139, 173-183. PubMed Europe PubMed DOI

2004

Bouvier,J. Leishmanolysin [ISSN:0-12-079610-4] (2004) 2, 764-769. V
Hajmova,M., Chang,K.P., Kolli,B. and Volf,P. Down-regulation of gp63 in Leishmania amazonensis reduces its early development in Lutzomyia longipalpis Microbes Infect (2004) 6, 646-649. PubMed Europe PubMed DOI
Yao,C., Luo,J., Storlie,P., Donelson,J.E. and Wilson,M.E. Multiple products of the Leishmania chagasi major surface protease (MSP or GP63) gene family Mol Biochem Parasitol (2004) 135, 171-183. PubMed Europe PubMed DOI

2003

Cuevas,I.C., Cazzulo,J.J. and Sanchez,D.O. gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection Infect Immun (2003) 71, 5739-5749. PubMed Europe PubMed DOI PMC EPMC
[YEAR:4-7-2003]LaCount,D.J., Gruszynski,A.E., Grandgenett,P.M., Bangs,J.D. and Donelson,J.E. Expression and function of the Trypanosoma brucei major surface protease (GP63) genes J Biol Chem (4-7-2003) 278, 24658-24664. PubMed Europe PubMed DOI
McGwire,B.S., Chang,K.P. and Engman,D.M. Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63 Infect Immun (2003) 71, 1008-1010. PubMed Europe PubMed DOI PMC EPMC
Yao,C., Donelson,J.E. and Wilson,M.E. The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function Mol Biochem Parasitol (2003) 132, 1-16. PubMed Europe PubMed DOI

2002

[YEAR:1-11-2002]Corradin,S., Ransijn,A., Corradin,G., Bouvier,J., Delgado,M.B., Fernandez-Carneado,J., Mottram,J.C., Vergeres,G. and Mauel,J. Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein Biochem J (1-11-2002) 367, 761-769. PubMed Europe PubMed DOI PMC EPMC I
Joshi,P.B., Kelly,B.L., Kamhawi,S., Sacks,D.L. and McMaster,W.R. Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor Mol Biochem Parasitol (2002) 120, 33-40. PubMed Europe PubMed
[YEAR:15-3-2002]McGwire,B.S., O'Connell,W.A., Chang,K.P. and Engman,D.M. Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence J Biol Chem (15-3-2002) 277, 8802-8809. PubMed Europe PubMed DOI
[YEAR:30-4-2002]Yao,C., Leidal,K.G., Brittingham,A., Tarr,D.E., Donelson,J.E. and Wilson,M.E. Biosynthesis of the major surface protease GP63 of Leishmania chagasi Mol Biochem Parasitol (30-4-2002) 121, 119-128. PubMed Europe PubMed DOI

2001

[YEAR:25-4-2001]Bangs,J.D., Ransom,D.A., Nimick,M., Christie,G. and Hooper,N.M. In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors Mol Biochem Parasitol (25-4-2001) 114, 111-117. PubMed Europe PubMed DOI I

2000

Alvarez-Valin,F., Tort,J.F. and Bernardi,G. Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania Genetics (2000) 155, 1683-1692. PubMed Europe PubMed PMC EPMC

1999

[YEAR:3-9-1999]Corradin,S., Ransijn,A., Corradin,G., Roggero,M.A., Schmitz,A.A., Schneider,P., Mauel,J. and Vergeres,G. MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63) J Biol Chem (3-9-1999) 274, 25411-25418. PubMed Europe PubMed DOI
Puentes,F., Guzman,F., Marin,V., Alonso,C., Patarroyo,M.E. and Moreno,A. Leishmania: fine mapping of the leishmanolysin molecule's conserved core domains involved in binding and internalization Exp Parasitol (1999) 93, 7-22. PubMed Europe PubMed DOI
[YEAR:17-3-1999]Spitzer,N., Jardim,A., Lippert,D. and Olafson,R.W. Long-term protection of mice against Leishmania major with a synthetic peptide vaccine Vaccine (17-3-1999) 17, 1298-1300. PubMed Europe PubMed DOI

1998

[YEAR:15-8-1998]Schlagenhauf,E., Etges,R. and Metcalf,P. The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63) Structure (15-8-1998) 6, 1035-1046. PubMed Europe PubMed S
[YEAR:15-5-1998]Voth,B.R., Kelly,B.L., Joshi,P.B., Ivens,A.C. and McMaster,W.R. Differentially expressed Leishmania major gp63 genes encode cell surface leishmanolysin with distinct signals for glycosylphosphatidylinositol attachment Mol Biochem Parasitol (15-5-1998) 93, 31-41. PubMed Europe PubMed DOI

1997

Bangs,J.D., Ransom,D.M., McDowell,M.A. and Brouch,E.M. Expression of bloodstream variant surface glycoproteins in procyclic stage Trypanosoma brucei: role of GPI anchors in secretion EMBO J (1997) 16, 4285-4294. PubMed Europe PubMed DOI PMC EPMC
El-Sayed,N.M. and Donelson,J.E. African trypanosomes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease J Biol Chem (1997) 272, 26742-26748. PubMed Europe PubMed DOI
Garcia,M.R., Graham,S., Harris,R.A., Beverley,S.M. and Kaye,P.M. Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation Eur J Immunol (1997) 27, 1005-1013. PubMed Europe PubMed DOI
Gonzalez-Aseguinolaza,G., Almazan,F., Rodriguez,J.F., Marquet,A. and Larraga,V. Cloning of the gp63 surface protease of Leishmania infantum. Differential post-translational modifications correlated with different infective forms Biochim Biophys Acta (1997) 1361, 92-102. PubMed Europe PubMed DOI
Morrison,C.J., McMaster,W.R. and Piret,J.M. Differential stability of proteolytically active and inactive recombinant metalloproteinase in chinese hamster ovary cells Biotechnol Bioeng (1997) 53, 594-600. PubMed Europe PubMed DOI

1996

McGwire,B.S. and Chang,K.P. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit J Biol Chem (1996) 271, 7903-7909. PubMed Europe PubMed
Seay,M.B., Heard,P.L. and Chaudhuri,G. Surface Zn-proteinase as a molecule for defense of Leishmania mexicana amazonensis promastigotes against cytolysis inside macrophage phagolysosomes Infect Immun (1996) 64, 5129-5137. PubMed Europe PubMed PMC EPMC

1995

Bouvier,J., Schneider,P. and Etges,R. Leishmanolysin: surface metalloproteinase of Leishmania Methods Enzymol (1995) 248, 614-633. PubMed Europe PubMed DOI V
Brittingham,A., Morrison,C.J., McMaster,W.R., McGwire,B.S., Chang,K.P. and Mosser,D.M. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis J Immunol (1995) 155, 3102-3111. PubMed Europe PubMed
Macdonald,M.H., Morrison,C.J. and McMaster,W.R. Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63 Biochim Biophys Acta (1995) 1253, 199-207. PubMed Europe PubMed DOI
[YEAR:19-5-1995]Ramamoorthy,R., Swihart,K.G., McCoy,J.J., Wilson,M.E. and Donelson,J.E. Intergenic regions between tandem gp63 genes influence the differential expression of gp63 RNAs in Leishmania chagasi promastigotes J Biol Chem (19-5-1995) 270, 12133-12139. PubMed Europe PubMed DOI
Xu,D. and Liew,F.Y. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major Immunology (1995) 84, 173-176. PubMed Europe PubMed PMC EPMC

1994

Funk,V.A., Jardim,A. and Olafson,R.W. An investigation into the significance of the N-linked oligosaccharides of Leishmania gp63 Mol Biochem Parasitol (1994) 63, 23-35. PubMed Europe PubMed DOI
Hey,A.S., Theander,T.G., Hviid,L., Hazrati,S.M., Kemp,M. and Kharazmi,A. The major surface glycoprotein (gp63) from Leishmania major and Leishmania donovani cleaves CD4 molecules on human T cells J Immunol (1994) 152, 4542-4548. PubMed Europe PubMed
Kemp,M., Hey,A.S., Bendtzen,K., Kharazmi,A. and Theander,T.G. Th1-like human T-cell clones recognizing Leishmania gp63 inhibit Leishmania major in human macrophages Scand J Immunol (1994) 40, 629-635. PubMed Europe PubMed DOI

1993

[YEAR:30-11-1993]Button,L.L., Wilson,G., Astell,C.R. and McMaster,W.R. Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinase Gene (30-11-1993) 134, 75-81. PubMed Europe PubMed DOI E
Inverso,J.A., Medina-Acosta,E., O'Connor,J., Russell,D.G. and Cross,G.A. Crithidia fasciculata contains a transcribed leishmanial surface proteinase (gp63) gene homologue Mol Biochem Parasitol (1993) 57, 47-54. PubMed Europe PubMed DOI
Medina-Acosta,E., Beverley,S.M. and Russell,D.G. Evolution and expression of the Leishmania surface proteinase (gp63) gene locus Infect Agents Dis (1993) 2, 25-34. PubMed Europe PubMed

1992

Steinkraus,H.B. and Langer,P.J. The protein sequence predicted from a Leishmania guyanensis gp63 major surface glycoprotein gene is divergent as compared with other Leishmania species Mol Biochem Parasitol (1992) 52, 141-144. PubMed Europe PubMed DOI

1990

Bouvier,J., Schneider,P., Etges,R. and Bordier,C. Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania Biochemistry (1990) 29, 10113-10119. PubMed Europe PubMed
[YEAR:1-1-1990]Frommel,T.O., Button,L.L., Fujikura,Y. and McMaster,W.R. The major surface glycoprotein (GP63) is present in both life stages of Leishmania Mol Biochem Parasitol (1-1-1990) 38, 25-32. PubMed Europe PubMed DOI
Handman,E., Button,L.L. and McMaster,R.W. Leishmania major: production of recombinant gp63, its antigenicity and immunogenicity in mice Exp Parasitol (1990) 70, 427-435. PubMed Europe PubMed DOI
Ip,H.S., Orn,A., Russell,D.G. and Cross,G.A. Leishmania mexicana mexicana gp63 is a site-specific neutral endopeptidase Mol Biochem Parasitol (1990) 40, 163-172. PubMed Europe PubMed
[YEAR:25-7-1990]Olafson,R.W., Thomas,J.R., Ferguson,M.A., Dwek,R.A., Chaudhuri,M., Chang,K.P. and Rademacher,T.W. Structures of the N-linked oligosaccharides of Gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis J Biol Chem (25-7-1990) 265, 12240-12247. PubMed Europe PubMed

1989

Bouvier,J., Bordier,C., Vogel,H., Reichelt,R. and Etges,R. Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase Mol Biochem Parasitol (1989) 37, 235-245. PubMed Europe PubMed
[YEAR:15-1-1989]Button,L.L., Russell,D.G., Klein,H.L., Medina-Acosta,E., Karess,R.E. and McMaster,W.R. Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed Mol Biochem Parasitol (15-1-1989) 32, 271-283. PubMed Europe PubMed
Chaudhuri,G., Chaudhuri,M., Pan,A. and Chang,K.P. Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages J Biol Chem (1989) 264, 7483-7489. PubMed Europe PubMed

1988

[YEAR:1-2-1988]Button,L.L. and McMaster,W.R. Molecular cloning of the major surface antigen of Leishmania J Exp Med (1-2-1988) 167, 724-729. PubMed Europe PubMed PMC EPMC
[YEAR:1-1-1988]Chaudhuri,G. and Chang,K.P. Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes Mol Biochem Parasitol (1-1-1988) 27, 43-52. PubMed Europe PubMed
[YEAR:5-12-1988]Jahnig,F. and Etges,R. Secondary structure of the promastigote surface protease of Leishmania FEBS Lett (5-12-1988) 241, 79-82. PubMed Europe PubMed DOI

1987

Bordier,C. The promastigote surface protease of leishmania Parasitol Today (1987) 3, 151-153. PubMed Europe PubMed
Bouvier,J., Etges,R. and Bordier,C. Identification of the promastigote surface protease in seven species of Leishmania Mol Biochem Parasitol (1987) 24, 73-79. PubMed Europe PubMed
[YEAR:1-4-1987]Russell,D.G. The macrophage-attachment glycoprotein gp63 is the predominant C3-acceptor site on Leishmania mexicana promastigotes Eur J Biochem (1-4-1987) 164, 213-221. PubMed Europe PubMed

1986

Chang,C.S., Inserra,T.J., Kink,J.A., Fong,D. and Chang,K.P. Expression and size heterogeneity of a 63 kilodalton membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensis Mol Biochem Parasitol (1986) 18, 197-210. PubMed Europe PubMed
Etges,R., Bouvier,J. and Bordier,C. The major surface protein of Leishmania promastigotes is a protease J Biol Chem (1986) 261, 9098-9101. PubMed Europe PubMed
Etges,R., Bouvier,J. and Bordier,C. The major surface protein of Leishmania promastigotes is anchored in the membrane by a myristic acid-labeled phospholipid EMBO J (1986) 5, 597-601. PubMed Europe PubMed PMC EPMC