Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M04.006: Msp peptidase (Legionella-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: A Assay, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Scheithauer,L., Ornago,C., Selmar,J., Schutz,C., Bianchi,G., Kiefer,A., Haupenthal,J., Dellmann,A., Huynh,D., Zhang,R., Blankenfeldt,W., Hirsch,A.H. and Steinert,M.
    Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation
    Eur J Med Chem (2025) 296, 117832-117832. PubMed  Europe PubMed DOI  I
    2. 2022
  2. Scheithauer,L., Thiem,S., Unal,C.M., Dellmann,A. and Steinert,M.
    Zinc Metalloprotease ProA from Legionella pneumophila Inhibits the Pro-Inflammatory Host Response by Degradation of Bacterial Flagellin
    Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2012
  3. Lang,C., Rastew,E., Hermes,B., Siegbrecht,E., Ahrends,R., Banerji,S. and Flieger,A.
    Zinc metalloproteinase ProA directly activates Legionella pneumophila PlaC glycerophospholipid:cholesterol acyltransferase
    J Biol Chem (2012) 287, 23464-23478. PubMed  Europe PubMed DOI
  4. Poras,H., Duquesnoy,S., Dange,E., Pinon,A., Vialette,M., Fournie-Zaluski,M.C. and Ouimet,T.
    Highly sensitive quenched fluorescent substrate of Legionella major secretory protein (Msp) based on its structural analysis
    J Biol Chem (2012) 287, 20221-20230. PubMed  Europe PubMed DOI  A  P
  5. Woessner,J.F.
    Legionella metalloendopeptidase
    [ISSN:978-0-12-407744-7] (2012) 3, 592-594. DOI
    6. 2004
  6. Woessner,J.F.
    Legionella metalloendopeptidase
    [ISSN:0-12-079610-4] (2004) 2, 409-411.  V
    7. 2001
  7. Cianciotto,N.P.
    Pathogenicity of Legionella pneumophila
    Int J Med Microbiol (2001) 291, 331-343. PubMed  Europe PubMed DOI
  8. Sahney,N.N., Summersgill,J.T., Ramirez,J.A. and Miller,R.D.
    Inhibition of oxidative burst and chemotaxis in human phagocytes by Legionella pneumophila zinc metalloprotease
    J Med Microbiol (2001) 50, 517-525. PubMed  Europe PubMed
    9. 1999
  9. Hales,L.M. and Shuman,H.A.
    Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease
    Infect Immun (1999) 67, 3662-3666. PubMed  Europe PubMed  PMC  EPMC
    10. 1994
  10. Moffat,J.F., Edelstein,P.H., Regula,D.P., Jr., Cirillo,J.D. and Tompkins,L.S.
    Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model
    Mol Microbiol (1994) 12, 693-705. PubMed  Europe PubMed DOI
  11. Moffat,J.F., Black,W.J. and Tompkins,L.S.
    Further molecular characterization of the cloned Legionella pneumophila zinc metalloprotease
    Infect Immun (1994) 62, 751-753. PubMed  Europe PubMed  PMC  EPMC
    12. 1993
  12. Hell,W., Essig,A., Bohnet,S., Gatermann,S. and Marre,R.
    Cleavage of tumor necrosis factor-alpha by Legionella exoprotease
    APMIS (1993) 101, 120-126. PubMed  Europe PubMed
  13. Mintz,C.S., Miller,R.D., Gutgsell,N.S. and Malek,T.
    Legionella pneumophila protease inactivates interleukin- 2 and cleaves CD4 on human T cells
    Infect Immun (1993) 61, 3416-3421. PubMed  Europe PubMed  PMC  EPMC
    14. 1992
  14. Dowling,J.N., Saha,A.K. and Glew,R.H.
    Virulence factors of the family Legionellaceae
    Microbiol Rev (1992) 56, 32-60. PubMed  Europe PubMed  PMC  EPMC
  15. Rechnitzer,C., Williams,A., Wright,J.B., Dowsett,A.B., Milman,N. and Fitzgeorge,R.B.
    Demonstration of the intracellular production of tissue-destructive protease by Legionella pneumophila multiplying within guinea-pig and human alveolar macrophages
    J Gen Microbiol (1992) 138, 1671-1677. PubMed  Europe PubMed
  16. Rechnitzer,C. and Kharazmi,A.
    Effect of Legionella pneumophila cytotoxic protease on human neutrophil and monocyte function
    Microb Pathog (1992) 12, 115-125. PubMed  Europe PubMed DOI
    17. 1991
  17. McIntyre,M., Quinn,F.D., Fields,P.I. and Berdal,B.P.
    Rapid identification of Legionella pneumophila zinc metalloprotease using chromogenic detection
    APMIS (1991) 99, 316-320. PubMed  Europe PubMed
    18. 1990
  18. Black,W.J., Quinn,F.D. and Tompkins,L.S.
    Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase
    J Bacteriol (1990) 172, 2608-2613. PubMed  Europe PubMed  PMC  EPMC
  19. Stepanov,V.M., Lavrenova,G.I., Terent'eva,E.Yu. and Khodova,O.M.
    Prochymosin activation by non-aspartic proteinases
    FEBS Lett (1990) 260, 173-175. PubMed  Europe PubMed DOI
  20. Szeto,L. and Shuman,H.A.
    The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing
    Infect Immun (1990) 58, 2585-2592. PubMed  Europe PubMed  PMC  EPMC
    21. 1989
  21. Quinn,F.D. and Tompkins,L.S.
    Analysis of a cloned sequence of Legionella pneumophila encoding a 38 kD metalloprotease possessing haemolytic and cytotoxic activities
    Mol Microbiol (1989) 3, 797-805. PubMed  Europe PubMed
  22. Rechnitzer,C., Diamant,M. and Pedersen,B.K.
    Inhibition of human natural killer cell activity by Legionella pneumophila protease
    Eur J Clin Microbiol Infect Dis (1989) 8, 989-992. PubMed  Europe PubMed
  23. Rechnitzer,C., Tvede,M. and Doring,G.
    A rapid method for purification of homogeneous Legionella pneumophila cytotoxic protease using fast protein liquid chromatography
    FEMS Microbiol Lett (1989) 50, 39-44. PubMed  Europe PubMed
    24. 1988
  24. Conlan,J.W., Williams,A. and Ashworth,L.A.
    Inactivation of human alpha-1-antitrypsin by a tissue-destructive protease of Legionella pneumophila
    J Gen Microbiol (1988) 134, 481-487. PubMed  Europe PubMed
  25. Conlan,J.W., Williams,A. and Ashworth,L.A.
    In vivo production of a tissue-destructive protease by Legionella pneumophila in the lungs of experimentally infected guinea-pigs
    J Gen Microbiol (1988) 134, 143-149. PubMed  Europe PubMed
    26. 1986
  26. Baskerville,A., Conlan,J.W., Ashworth,L.A. and Dowsett,A.B.
    Pulmonary damage caused by a protease from Legionella pneumophila
    Br J Exp Pathol (1986) 67, 527-536. PubMed  Europe PubMed
  27. Conlan,J.W., Baskerville,A. and Ashworth,L.A.
    Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung
    J Gen Microbiol (1986) 132, 1565-1574. PubMed  Europe PubMed
  28. Dreyfus,L.A. and Iglewski,B.H.
    Purification and characterization of an extracellular protease of Legionella pneumophila
    Infect Immun (1986) 51, 736-743. PubMed  Europe PubMed  PMC  EPMC
    29. 1982
  29. Berdal,B.P., Hushovd,O., Olsvik,O., odegard,O.R. and Bergan,T.
    Demonstration of extracellular proteolytic enzymes from Legionella species strains by using synthetic chromogenic peptide substrates
    Acta Pathol Microbiol Immunol Scand [B] (1982) 90, 119-123. PubMed  Europe PubMed
    30. 1981
  30. Thompson,M.R., Miller,R.D. and Iglewski,B.H.
    In vitro production of an extracellular protease by Legionella pneumophila
    Infect Immun (1981) 34, 299-302. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use