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Literature for peptidase M02.002: peptidyl-dipeptidase Acer

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Vecchie',D., Faber,V.G., Jumbo-Lucioni,P., Anholt,R.R.H., Mackay,T.F.C. and De Luca,M.
    Angiotensin-Converting Enzyme Inhibitors and Metabolic Aging: A Drosophila Perspective
    Biomolecules (2025) 15 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Herrera,P. and Cauchi,R.J.
    Functional characterisation of the ACE2 orthologues in Drosophila provides insights into the neuromuscular complications of COVID-19
    Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166818-166818. PubMed  Europe PubMed DOI  K
    3. 2022
  3. Duarte,T., Silva,M.M., Michelotti,P., Barbosa,N.B.V., Feltes,B.C., Dorn,M., Rocha,J.B.T.D. and Dalla Corte,C.L.
    The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathology
    Biochim Biophys Acta Mol Basis Dis (2022) 1868, 166551-166551. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2019
  4. Glover,Z., Hodges,M.D., Dravecz,N., Cameron,J., Askwith,H., Shirras,A. and Broughton,S.J.
    Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts behavioural and metabolic responses to diet in Drosophila melanogaster
    J Exp Biol (2019) 222, jeb194332-jeb194332. PubMed  Europe PubMed DOI  K
    5. 2012
  5. Isaac,R.E. and Shirras,A.D.
    Peptidyl-dipeptidase A (invertebrate)
    [ISSN:978-0-12-407744-7] (2012) 3, 494-498. DOI
    6. 2011
  6. Carhan,A., Tang,K., Shirras,C.A., Shirras,A.D. and Isaac,R.E.
    Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogaster
    J Exp Biol (2011) 214, 680-686. PubMed  Europe PubMed DOI  K
    7. 2007
  7. Isaac,R.E., Lamango,N.S., Ekbote,U., Taylor,C.A., Hurst,D., Weaver,R.J., Carhan,A., Burnham,S. and Shirras,A.D.
    Angiotensin-converting enzyme as a target for the development of novel insect growth regulators
    Peptides (2007) 28, 153-162. PubMed  Europe PubMed DOI
    8. 2006
  8. Bingham,R.J., Dive,V., Phillips,S.E., Shirras,A.D. and Isaac,R.E.
    Structural diversity of angiotensin-converting enzyme - insights from structure-activity comparisons of two Drosophila enzymes
    FEBS J (2006) 273, 362-373. PubMed  Europe PubMed DOI
    9. 2005
  9. Burnham,S., Smith,J.A., Lee,A.J., Isaac,R.E. and Shirras,A.D.
    The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae
    BMC Genomics (2005) 6, 172-172. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2004
  10. Isaac,R.E.
    Peptidyl-dipeptidase A (invertebrate)
    [ISSN:0-12-079610-4] (2004) 2, 347-349.  V
  11. Macours,N. and Hens,K.
    Zinc-metalloproteases in insects: ACE and ECE
    Insect Biochem Mol Biol (2004) 34, 501-510. PubMed  Europe PubMed DOI
    12. 2002
  12. Siviter,R.J., Nachman,R.J., Dani,M.P., Keen,J.N., Shirras,A.D. and Isaac,R.E.
    Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme
    Peptides (2002) 23, 2025-2034. PubMed  Europe PubMed DOI
    13. 2001
  13. Quan,G.X., Mita,K., Okano,K., Shimada,T., Ugajin,N., Xia,Z., Goto,N., Kanke,E. and Kawasaki,H.
    Isolation and expression of the ecdysteroid-inducible angiotensin-converting enzyme-related gene in wing discs of Bombyx mori
    Insect Biochem Mol Biol (2001) 31, 97-103. PubMed  Europe PubMed DOI
  14. Vandingenen,A., Hens,K., Macours,N., Zhu,W., Janssen,I., Breuer,M., De Loof,A. and Huybrechts,R.
    Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshfly Neobellieria bullata
    Arch Insect Biochem Physiol (2001) 47, 161-167. PubMed  Europe PubMed DOI  I
    15. 2000
  15. [YEAR:1-8-2000]Coates,D., Isaac,R.E., Cotton,J., Siviter,R., Williams,T.A., Shirras,A., Corvol,P. and Dive,V.
    Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme
    Biochemistry (1-8-2000) 39, 8963-8969. PubMed  Europe PubMed DOI  I
    16. 1999
  16. [YEAR:23-7-1999]Ekbote,U., Coates,D. and Isaac,R.E.
    A mosquito (Anopheles stephensi) angiotensin I-converting enzyme (ACE) is induced by a blood meal and accumulates in the developing ovary
    FEBS Lett (23-7-1999) 455, 219-222. PubMed  Europe PubMed DOI
  17. Isaac,R.E., Ekbote,U., Coates,D. and Shirras,A.D.
    Insect angiotensin-converting enzyme. A processing enzyme with broad substrate specificity and a role in reproduction
    Ann N Y Acad Sci (1999) 897, 342-347. PubMed  Europe PubMed
    18. 1998
  18. Houard,X., Williams,T.A., Michaud,A., Dani,P., Isaac,R.E., Shirras,A.D., Coates,D. and Corvol,P.
    The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance - distinct enzymic characteristics and alternative expression during pupal development
    Eur J Biochem (1998) 257, 599-606. PubMed  Europe PubMed  I
  19. [YEAR:15-2-1998]Isaac,R., Schoofs,L., Williams,T.A., Veelaert,D., Sajid,M., Corvol,P. and Coates,D.
    A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide
    Biochem J (15-2-1998) 330, 61-65. PubMed  Europe PubMed  PMC  EPMC
  20. Isaac,R.E., Schoofs,L., Williams,T.A., Corvol,P., Veelaert,D., Sajid,M. and Coates,D.
    Toward a role for angiotensin-converting enzyme in insects
    Ann N Y Acad Sci (1998) 839, 288-292. PubMed  Europe PubMed DOI
  21. Loeb,M.J., De Loof,A., Schoofs,L. and Isaac,E.
    Angiotensin II and angiotensin-converting enzyme as candidate compounds modulating the effects of testis ecdysiotropin in testes of the gypsy moth, Lymantria dispar
    Gen Comp Endocrinol (1998) 112, 232-239. PubMed  Europe PubMed DOI
    22. 1997
  22. Lamango,N.S., Nachman,R.J., Hayes,T.K., Strey,A. and Isaac,R.E.
    Hydrolysis of insect neuropeptides by an angiotensin-converting enzyme from the housefly, Musca domestica
    Peptides (1997) 18, 47-52. PubMed  Europe PubMed DOI
  23. Nachman,R.J., Isaac,R.E., Coast,G.M. and Holman,G.M.
    Aib-containing analogues of the insect kinin neuropeptide family demonstrate resistance to an insect angiotensin-converting enzyme and potent diuretic activity
    Peptides (1997) 18, 53-57. PubMed  Europe PubMed DOI
  24. Rusch,J. and Levine,M.
    Regulation of a dpp target gene in the Drosophila embryo
    Development (1997) 124, 303-311. PubMed  Europe PubMed
  25. Wijffels,G., Gough,J., Muharsini,S., Donaldson,A. and Eisemann,C.
    Expression of angiotensin-converting enzyme-related carboxydipeptidases in the larvae of four species of fly
    Insect Biochem Mol Biol (1997) 27, 451-460. PubMed  Europe PubMed DOI
    26. 1996
  26. Lamango,N.S., Sajid,M. and Isaac,R.E.
    The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an angiotensin-converting enzyme from the housefly, Musca domestica
    Biochem J (1996) 314, 639-646. PubMed  Europe PubMed
  27. Taylor,C.A., Coates,D. and Shirras,A.D.
    The Acer gene of Drosophila codes for an angiotensin- converting enzyme homologue
    Gene (1996) 181, 191-197. PubMed  Europe PubMed DOI
  28. Williams,T.A., Michaud,A., Houard,X., Chauvet,M.T., Soubrier,F. and Corvol,P.
    Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity
    Biochem J (1996) 318, 125-131. PubMed  Europe PubMed  PMC  EPMC  E
    29. 1995
  29. Cornell,M.J., Williams,T.A., Lamango,N.S., Coates,D., Corvol,P., Soubrier,F., Hoheisel,J., Lehrach,H. and Isaac,R.E.
    Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster
    J Biol Chem (1995) 270, 13613-13619. PubMed  Europe PubMed DOI
  30. Tatei,K., Cai,H., Ip,Y.T. and Levine,M.
    Race: A Drosophila homologue of the angiotensin converting enzyme
    Mech Dev (1995) 51, 157-168. PubMed  Europe PubMed DOI
    31. 1994
  31. Lamango,N.S. and Isaac,R.E.
    Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme
    Biochem J (1994) 299, 651-657. PubMed  Europe PubMed  PMC  EPMC

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