Literature for peptidase M02.002: peptidyl-dipeptidase Acer

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Vecchie',D., Faber,V.G., Jumbo-Lucioni,P., Anholt,R.R.H., Mackay,T.F.C. and De Luca,M. Angiotensin-Converting Enzyme Inhibitors and Metabolic Aging: A Drosophila Perspective Biomolecules (2025) 15 PubMed Europe PubMed DOI PMC EPMC

2023

Herrera,P. and Cauchi,R.J. Functional characterisation of the ACE2 orthologues in Drosophila provides insights into the neuromuscular complications of COVID-19 Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166818-166818. PubMed Europe PubMed DOI K

2022

Duarte,T., Silva,M.M., Michelotti,P., Barbosa,N.B.V., Feltes,B.C., Dorn,M., Rocha,J.B.T.D. and Dalla Corte,C.L. The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathology Biochim Biophys Acta Mol Basis Dis (2022) 1868, 166551-166551. PubMed Europe PubMed DOI PMC EPMC

2019

Glover,Z., Hodges,M.D., Dravecz,N., Cameron,J., Askwith,H., Shirras,A. and Broughton,S.J. Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts behavioural and metabolic responses to diet in Drosophila melanogaster J Exp Biol (2019) 222, jeb194332-jeb194332. PubMed Europe PubMed DOI K

2012

Isaac,R.E. and Shirras,A.D. Peptidyl-dipeptidase A (invertebrate) [ISSN:978-0-12-407744-7] (2012) 3, 494-498. DOI

2011

Carhan,A., Tang,K., Shirras,C.A., Shirras,A.D. and Isaac,R.E. Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogaster J Exp Biol (2011) 214, 680-686. PubMed Europe PubMed DOI K

2007

Isaac,R.E., Lamango,N.S., Ekbote,U., Taylor,C.A., Hurst,D., Weaver,R.J., Carhan,A., Burnham,S. and Shirras,A.D. Angiotensin-converting enzyme as a target for the development of novel insect growth regulators Peptides (2007) 28, 153-162. PubMed Europe PubMed DOI

2006

Bingham,R.J., Dive,V., Phillips,S.E., Shirras,A.D. and Isaac,R.E. Structural diversity of angiotensin-converting enzyme - insights from structure-activity comparisons of two Drosophila enzymes FEBS J (2006) 273, 362-373. PubMed Europe PubMed DOI

2005

Burnham,S., Smith,J.A., Lee,A.J., Isaac,R.E. and Shirras,A.D. The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae BMC Genomics (2005) 6, 172-172. PubMed Europe PubMed DOI PMC EPMC

2004

Isaac,R.E. Peptidyl-dipeptidase A (invertebrate) [ISSN:0-12-079610-4] (2004) 2, 347-349. V
Macours,N. and Hens,K. Zinc-metalloproteases in insects: ACE and ECE Insect Biochem Mol Biol (2004) 34, 501-510. PubMed Europe PubMed DOI

2002

Siviter,R.J., Nachman,R.J., Dani,M.P., Keen,J.N., Shirras,A.D. and Isaac,R.E. Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme Peptides (2002) 23, 2025-2034. PubMed Europe PubMed DOI

2001

Quan,G.X., Mita,K., Okano,K., Shimada,T., Ugajin,N., Xia,Z., Goto,N., Kanke,E. and Kawasaki,H. Isolation and expression of the ecdysteroid-inducible angiotensin-converting enzyme-related gene in wing discs of Bombyx mori Insect Biochem Mol Biol (2001) 31, 97-103. PubMed Europe PubMed DOI
Vandingenen,A., Hens,K., Macours,N., Zhu,W., Janssen,I., Breuer,M., De Loof,A. and Huybrechts,R. Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshfly Neobellieria bullata Arch Insect Biochem Physiol (2001) 47, 161-167. PubMed Europe PubMed DOI I

2000

[YEAR:1-8-2000]Coates,D., Isaac,R.E., Cotton,J., Siviter,R., Williams,T.A., Shirras,A., Corvol,P. and Dive,V. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme Biochemistry (1-8-2000) 39, 8963-8969. PubMed Europe PubMed DOI I

1999

[YEAR:23-7-1999]Ekbote,U., Coates,D. and Isaac,R.E. A mosquito (Anopheles stephensi) angiotensin I-converting enzyme (ACE) is induced by a blood meal and accumulates in the developing ovary FEBS Lett (23-7-1999) 455, 219-222. PubMed Europe PubMed DOI
Isaac,R.E., Ekbote,U., Coates,D. and Shirras,A.D. Insect angiotensin-converting enzyme. A processing enzyme with broad substrate specificity and a role in reproduction Ann N Y Acad Sci (1999) 897, 342-347. PubMed Europe PubMed

1998

Houard,X., Williams,T.A., Michaud,A., Dani,P., Isaac,R.E., Shirras,A.D., Coates,D. and Corvol,P. The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance - distinct enzymic characteristics and alternative expression during pupal development Eur J Biochem (1998) 257, 599-606. PubMed Europe PubMed I
[YEAR:15-2-1998]Isaac,R., Schoofs,L., Williams,T.A., Veelaert,D., Sajid,M., Corvol,P. and Coates,D. A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide Biochem J (15-2-1998) 330, 61-65. PubMed Europe PubMed PMC EPMC
Isaac,R.E., Schoofs,L., Williams,T.A., Corvol,P., Veelaert,D., Sajid,M. and Coates,D. Toward a role for angiotensin-converting enzyme in insects Ann N Y Acad Sci (1998) 839, 288-292. PubMed Europe PubMed DOI
Loeb,M.J., De Loof,A., Schoofs,L. and Isaac,E. Angiotensin II and angiotensin-converting enzyme as candidate compounds modulating the effects of testis ecdysiotropin in testes of the gypsy moth, Lymantria dispar Gen Comp Endocrinol (1998) 112, 232-239. PubMed Europe PubMed DOI

1997

Lamango,N.S., Nachman,R.J., Hayes,T.K., Strey,A. and Isaac,R.E. Hydrolysis of insect neuropeptides by an angiotensin-converting enzyme from the housefly, Musca domestica Peptides (1997) 18, 47-52. PubMed Europe PubMed DOI
Nachman,R.J., Isaac,R.E., Coast,G.M. and Holman,G.M. Aib-containing analogues of the insect kinin neuropeptide family demonstrate resistance to an insect angiotensin-converting enzyme and potent diuretic activity Peptides (1997) 18, 53-57. PubMed Europe PubMed DOI
Rusch,J. and Levine,M. Regulation of a dpp target gene in the Drosophila embryo Development (1997) 124, 303-311. PubMed Europe PubMed
Wijffels,G., Gough,J., Muharsini,S., Donaldson,A. and Eisemann,C. Expression of angiotensin-converting enzyme-related carboxydipeptidases in the larvae of four species of fly Insect Biochem Mol Biol (1997) 27, 451-460. PubMed Europe PubMed DOI

1996

Lamango,N.S., Sajid,M. and Isaac,R.E. The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an angiotensin-converting enzyme from the housefly, Musca domestica Biochem J (1996) 314, 639-646. PubMed Europe PubMed
Taylor,C.A., Coates,D. and Shirras,A.D. The Acer gene of Drosophila codes for an angiotensin- converting enzyme homologue Gene (1996) 181, 191-197. PubMed Europe PubMed DOI
Williams,T.A., Michaud,A., Houard,X., Chauvet,M.T., Soubrier,F. and Corvol,P. Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity Biochem J (1996) 318, 125-131. PubMed Europe PubMed PMC EPMC E

1995

Cornell,M.J., Williams,T.A., Lamango,N.S., Coates,D., Corvol,P., Soubrier,F., Hoheisel,J., Lehrach,H. and Isaac,R.E. Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster J Biol Chem (1995) 270, 13613-13619. PubMed Europe PubMed DOI
Tatei,K., Cai,H., Ip,Y.T. and Levine,M. Race: A Drosophila homologue of the angiotensin converting enzyme Mech Dev (1995) 51, 157-168. PubMed Europe PubMed DOI

1994

Lamango,N.S. and Isaac,R.E. Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme Biochem J (1994) 299, 651-657. PubMed Europe PubMed PMC EPMC