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Literature for peptidase M01.013: aminopeptidase N (insect)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Sun,D., Zhu,L., Guo,L., Wang,S., Wu,Q., Crickmore,N., Zhou,X., Bravo,A., Soberon,M., Guo,Z. and Zhang,Y.
    A versatile contribution of both aminopeptidases N and ABC transporters to Bt Cry1Ac toxicity in the diamondback moth
    BMC Biol20, 33-33. PubMed  Europe PubMed DOI
    2. 2021
  2. Chauhan,V.K., Dhania,N.K., Lokya,V., Bhuvanachandra,B., Padmasree,K. and Dutta-Gupta,A.
    Midgut aminopeptidase N expression profile in castor semilooper (Achaea janata) during sublethal Cry toxin exposure
    J Biosci46, 29-29. PubMed  Europe PubMed
  3. Jakhar,R. and Gakhar,S.K.
    Identification and Characterization of Aminopeptidase N 1 Gene of the Indian Malaria Vector Anopheles culicifacies (Diptera: Culicidae)
    J Med Entomol PubMed  Europe PubMed DOI
  4. Wang,J., Yang,X., He,H., Chen,J., Liu,Y., Huang,W., Ou,L., Yang,Z., Guan,X., Zhang,L. and Wu,S.
    Knockout of Two Cry-Binding Aminopeptidase N Isoforms Does Not Change Susceptibility of Aedes aegypti Larvae to Bacillus thuringiensis subsp. israelensis Cry4Ba and Cry11Aa Toxins
    Insects12, PubMed  Europe PubMed DOI
    5. 2019
  5. Jakhar,R., Kumar,P., Sehrawat,N. and Gakhar,S.K.
    A comprehensive analysis of amino-peptidase N1 protein (APN) from Anopheles culicifacies for epitope design using Immuno-informatics models
    Bioinformation15, 600-612. PubMed  Europe PubMed DOI
    6. 2017
  6. Fu,J., Lin,P., Feng,T., Cheng,D., Zhang,Q., Xia,Q. and Cheng,T.
    [Interaction of aminopeptidase (BmAPN5) and parasporal crystal (PC) toxin isolated from Bacillus bombysepticus]
    Sheng Wu Gong Cheng Xue Bao33, 90-98. PubMed  Europe PubMed DOI
    7. 2014
  7. Hughes,A.L.
    Evolutionary diversification of aminopeptidase N in Lepidoptera by conserved clade-specific amino acid residues
    Mol Phylogenet Evol76, 127-133. PubMed  Europe PubMed DOI
  8. Xu,L., Wang,Z., Zhang,J., Ferry,N., Edwards,M.G., Gatehouse,A.M. and He,K.
    Characterization of four midgut aminopeptidase N isozymes from Ostrinia furnacalis strains with different susceptibilities to Bacillus thuringiensis
    J Invertebr Pathol115, 95-98. PubMed  Europe PubMed DOI
    9. 2013
  9. Crava,C.M., Bel,Y., Jakubowska,A.K., Ferre,J. and Escriche,B.
    Midgut aminopeptidase N isoforms from Ostrinia nubilalis: Activity characterization and differential binding to Cry1Ab and Cry1Fa proteins from Bacillus thuringiensis
    Insect Biochem Mol Biol43, 924-935. PubMed  Europe PubMed DOI
    10. 2012
  10. Adang,M.J.
    Insect aminopeptidase N
    [ISSN:978-0-12-407744-7]3, 405-409. DOI
    11. 2011
  11. Likitvivatanavong,S., Chen,J., Evans,A.M., Bravo,A., Soberon,M. and Gill,S.S.
    Multiple receptors as targets of Cry toxins in mosquitoes
    J Agric Food Chem59, 2829-2838. PubMed  Europe PubMed DOI
  12. Tiewsiri,K. and Wang,P.
    Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper
    Proc Natl Acad Sci U S A108, 14037-14042. PubMed  Europe PubMed DOI
    13. 2010
  13. Crava,C.M., Bel,Y., Lee,S.F., Manachini,B., Heckel,D.G. and Escriche,B.
    Study of the aminopeptidase N gene family in the lepidopterans Ostrinia nubilalis (Hubner) and Bombyx mori (L.): Sequences, mapping and expression
    Insect Biochem Mol Biol40, 506-515. PubMed  Europe PubMed DOI
  14. Yang,Y., Zhu,Y.C., Ottea,J., Husseneder,C., Rogers Leonard,B., Abel,C. and Huang,F.
    Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacillus thuringiensis-susceptible and -resistant strains of sugarcane borer, Diatraea saccharalis
    Insect Biochem Mol Biol40, 592-603. PubMed  Europe PubMed DOI
    15. 2009
  15. Singh,A. and Sivaprasad,C.
    Functional interpretation of APN receptor from M.sexta using a molecular model
    Bioinformation3, 321-325. PubMed  Europe PubMed
  16. Zhang,S., Cheng,H., Gao,Y., Wang,G., Liang,G. and Wu,K.
    Mutation of an aminopeptidase N gene is associated with Helicoverpa armigera resistance to Bacillus thuringiensis Cry1Ac toxin
    Insect Biochem Mol Biol39, 421-429. PubMed  Europe PubMed DOI  M
    17. 2008
  17. Angelucci,C., Barrett-Wilt,G.A., Hunt,D.F., Akhurst,R.J., East,P.D., Gordon,K.H. and Campbell,P.M.
    Diversity of aminopeptidases, derived from four lepidopteran gene duplications, and polycalins expressed in the midgut of Helicoverpa armigera: identification of proteins binding the delta-endotoxin, Cry1Ac of Bacillus thuringiensis
    Insect Biochem Mol Biol38, 685-696. PubMed  Europe PubMed DOI
  18. Zhang,R., Hua,G., Andacht,T.M. and Adang,M.J.
    A 106-kDa aminopeptidase is a putative receptor for Bacillus thuringiensis Cry11Ba toxin in the mosquito Anopheles gambiae
    Biochemistry47, 11263-11272. PubMed  Europe PubMed DOI
    19. 2007
  19. Budatha,M., Meur,G. and Dutta-Gupta,A.
    A novel aminopeptidase in the fat body of the moth Achaea janata as a receptor for Bacillus thuringiensis Cry toxins and its comparison with midgut aminopeptidase
    Biochem J405, 287-297. PubMed  Europe PubMed DOI
  20. Budatha,M., Meur,G., Kirti,P.B. and Dutta Gupta,A.
    Characterization of Bacillus thuringiensis Cry toxin binding novel GPI anchored aminopeptidase from fat body of the moth Spodoptera litura
    Biotechnol Lett29, 1651-1657. PubMed  Europe PubMed DOI
  21. Dinglasan,R.R., Kalume,D.E., Kanzok,S.M., Ghosh,A.K., Muratova,O., Pandey,A. and Jacobs-Lorena,M.
    Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen
    Proc Natl Acad Sci U S A104, 13461-13466. PubMed  Europe PubMed DOI
  22. Kaur,R., Agrawal,N. and Bhatnagar,R.
    Purification and characterization of aminopeptidase N from Spodoptera litura expressed in Sf21 insect cells
    Protein Expr Purif54, 267-274. PubMed  Europe PubMed DOI
  23. Sivakumar,S., Rajagopal,R., Venkatesh,G.R., Srivastava,A. and Bhatnagar,R.K.
    Knockdown of aminopeptidase-N from Helicoverpa armigera larvae and in transfected Sf21 cells by RNA interference reveals its functional interaction with Bacillus thuringiensis insecticidal protein Cry1Ac
    J Biol Chem282, 7312-7319. PubMed  Europe PubMed DOI
    24. 2006
  24. Cristofoletti,P.T., de Sousa,F.A., Rahbe,Y. and Terra,W.R.
    Characterization of a membrane-bound aminopeptidase purified from Acyrthosiphon pisum midgut cells. A major binding site for toxic mannose lectins
    FEBS J273, 5574-5588. PubMed  Europe PubMed DOI
  25. Duncan,A.M., Ren,H., Bound,F., Tully,J., Chandler,D.S. and Sandeman,R.M.
    Assessment of novel inhibitors of Helicoverpa aminopeptidases as anti-insect agents
    Pest Manag Sci62, 1098-1108. PubMed  Europe PubMed DOI  I
    26. 2005
  26. Herrero,S., Gechev,T., Bakker,P.L., Moar,W.J. and de Maagd,R.A.
    Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four aminopeptidase N genes
    BMC Genomics6, 96-96. PubMed  Europe PubMed DOI
  27. Wang,P., Zhang,X. and Zhang,J.
    Molecular characterization of four midgut aminopeptidase N isozymes from the cabbage looper, Trichoplusia ni
    Insect Biochem Mol Biol35, 611-620. PubMed  Europe PubMed DOI
    28. 2004
  28. [YEAR:17-11-2004]Bravo,A., Gomez,I., Conde,J., Munoz-Garay,C., Sanchez,J., Miranda,R., Zhuang,M., Gill,S.S. and Soberon,M.
    Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains
    Biochim Biophys Acta1667, 38-46. PubMed  Europe PubMed DOI
  29. Knight,P.J., Carroll,J. and Ellar,D.J.
    Analysis of glycan structures on the 120 kDa aminopeptidase N of Manduca sexta and their interactions with Bacillus thuringiensis Cry1Ac toxin
    Insect Biochem Mol Biol34, 101-112. PubMed  Europe PubMed DOI
  30. Stephens,E., Sugars,J., Maslen,S.L., Williams,D.H., Packman,L.C. and Ellar,D.J.
    The N-linked oligosaccharides of aminopeptidase N from Manduca sexta: site localization and identification of novel N-glycan structures
    Eur J Biochem271, 4241-4258. PubMed  Europe PubMed DOI
    31. 2003
  31. Banks,D.J., Hua,G. and Adang,M.J.
    Cloning of a Heliothis virescens 110 kDa aminopeptidase N and expression in Drosophila S2 cells
    Insect Biochem Mol Biol33, 499-508. PubMed  Europe PubMed DOI
  32. [YEAR:15-3-2003]Rajagopal,R., Agrawal,N., Selvapandiyan,A., Sivakumar,S., Ahmad,S. and Bhatnagar,R.K.
    Recombinantly expressed isoenzymic aminopeptidases from Helicoverpa armigera (American cotton bollworm) midgut display differential interaction with closely related Bacillus thuringiensis insecticidal proteins
    Biochem J370, 971-978. PubMed  Europe PubMed DOI
    33. 2002
  33. Agrawal,N., Malhotra,P. and Bhatnagar,R.K.
    Interaction of gene-cloned and insect cell-expressed aminopeptidase N of Spodoptera litura with insecticidal crystal protein Cry1C
    Appl Environ Microbiol68, 4583-4592. PubMed  Europe PubMed DOI  E
  34. [YEAR:22-5-2002]Nakanishi,K., Yaoi,K., Nagino,Y., Hara,H., Kitami,M., Atsumi,S., Miura,N. and Sato,R.
    Aminopeptidase N isoforms from the midgut of Bombyx mori and Plutella xylostella - their classification and the factors that determine their binding specificity to Bacillus thuringiensis Cry1A toxin
    FEBS Lett519, 215-220. PubMed  Europe PubMed DOI
  35. [YEAR:6-12-2002]Rajagopal,R., Sivakumar,S., Agrawal,N., Malhotra,P. and Bhatnagar,R.K.
    Silencing of midgut aminopeptidase N of Spodoptera litura by double-stranded RNA establishes its role as bacillus thuringiensis toxin receptor
    J Biol Chem277, 46849-46851. PubMed  Europe PubMed DOI
    36. 2001
  36. [YEAR:26-7-2001]Emmerling,M., Chandler,D. and Sandeman,M.
    Molecular cloning of three cDNAs encoding aminopeptidases from the midgut of Helicoverpa punctigera, the Australian native budworm
    Insect Biochem Mol Biol31, 899-907. PubMed  Europe PubMed DOI
  37. [YEAR:25-5-2001]Lee,M.K., Jenkins,J.L., You,T.H., Curtiss,A., Son,J.J., Adang,M.J. and Dean,D.H.
    Mutations at the arginine residues in alpha8 loop of Bacillus thuringiensis delta-endotoxin Cry1Ac affect toxicity and binding to Manduca sexta and Lymantria dispar aminopeptidase N
    FEBS Lett497, 108-112. PubMed  Europe PubMed DOI
    38. 2000
  38. [YEAR:15-6-2000]Cristofoletti,P.T. and Terra,W.R.
    The role of amino acid residues in the active site of a midgut microvillar aminopeptidase from the beetle Tenebrio molitor
    Biochim Biophys Acta1479, 185-195. PubMed  Europe PubMed DOI
  39. Simpson,R.M. and Newcomb,R.D.
    Binding of Bacillus thuringiensis delta-endotoxins Cry1Ac and Cry1Ba to a 120-kDa aminopeptidase-N of Epiphyas postvittana purified from both brush border membrane vesicles and baculovirus-infected Sf9 cells
    Insect Biochem Mol Biol30, 1069-1078. PubMed  Europe PubMed DOI
  40. Zhu,Y.C., Kramer,K.J., Oppert,B. and Dowdy,A.K.
    cDNAs of aminopeptidase-like protein genes from Plodia interpunctella strains with different susceptibilities to Bacillus thuringiensis toxins
    Insect Biochem Mol Biol30, 215-224. PubMed  Europe PubMed DOI
    41. 1999
  41. Cristofoletti,P.T. and Terra,W.R.
    Specificity, anchoring, and subsites in the active center of a microvillar aminopeptidase purified from Tenebrio molitor (Coleoptera) midgut cells
    Insect Biochem Mol Biol29, 185-195.  P
  42. Garner,K.J., Hiremath,S., Lehtoma,K. and Valaitis,A.P.
    Cloning and complete sequence characterization of two gypsy moth aminopeptidase-N cDNAs, including the receptor for Bacillus thuringiensis Cry1Ac toxin
    Insect Biochem Mol Biol29, 527-535. PubMed  Europe PubMed DOI
  43. [YEAR:3-12-1999]Jenkins,J.L., Lee,M.K., Sangadala,S., Adang,M.J. and Dean,D.H.
    Binding of Bacillus thuringiensis Cry1Ac toxin to Manduca sexta aminopeptidase-N receptor is not directly related to toxicity
    FEBS Lett462, 373-376. PubMed  Europe PubMed DOI
  44. [YEAR:15-6-1999]Nakanishi,K., Yaoi,K., Shimada,N., Kadotani,T. and Sato,R.
    Bacillus thuringiensis insecticidal Cry1Aa toxin binds to a highly conserved region of aminopeptidase N in the host insect leading to its evolutionary success
    Biochim Biophys Acta1432, 57-63. PubMed  Europe PubMed DOI
  45. [YEAR:18-1-1999]Yaoi,K., Nakanishi,K., Kadotani,T., Imamura,M., Koizumi,N., Iwahana,H. and Sato,R.
    cDNA cloning and expression of Bacillus thuringiensis Cry1Aa toxin binding 120 kDa aminopeptidase N from Bombyx mori
    Biochim Biophys Acta1444, 131-137. PubMed  Europe PubMed DOI
  46. [YEAR:17-12-1999]Yaoi,K., Nakanishi,K., Kadotani,T., Imamura,M., Koizumi,N., Iwahana,H. and Sato,R.
    Bacillus thuringiensis Cry1Aa toxin-binding region of Bombyx mori aminopeptidase N
    FEBS Lett463, 221-224. PubMed  Europe PubMed DOI
    47. 1998
  47. [YEAR:3-7-1998]Hua,G., Tsukamoto,K., Rasilo,M.L. and Ikezawa,H.
    Molecular cloning of a GPI-anchored aminopeptidase N from Bombyx mori midgut: a putative receptor for Bacillus thuringiensis CryIA toxin
    Gene214, 177-185. PubMed  Europe PubMed DOI
  48. Hua,G., Tsukamoto,K. and Ikezawa,H.
    Cloning and sequence analysis of the aminopeptidase N isozyme (APN2) from Bombyx mori midgut
    Comp Biochem Physiol B Biochem Mol Biol121, 213-222. PubMed  Europe PubMed DOI
  49. [YEAR:2-4-1998]Hua,G., Tsukamoto,K., Taguchi,R., Tomita,M., Miyajima,S. and Ikezawa,H.
    Characterization of aminopeptidase N from the brush border membrane of the larvae midgut of silkworm, Bombyx mori as a zinc enzyme
    Biochim Biophys Acta1383, 301-310. PubMed  Europe PubMed DOI  I
    50. 1997
  50. Francis,B.R. and Bulla,L.A., Jr.
    Further characterization of BT-R1, the cadherin-like receptor for Cry1Ab toxin in tobacco hornworm (Manduca sexta) midguts
    Insect Biochem Mol Biol27, 541-550. PubMed  Europe PubMed DOI
  51. Luo,K., Sangadala,S., Masson,L., Mazza,A., Brousseau,R. and Adang,M.J.
    The Heliothis virescens 170 kDa aminopeptidase functions as "receptor A" by mediating specific Bacillus thuringiensis Cry1A delta-endotoxin binding and pore formation
    Insect Biochem Mol Biol27, 735-743. PubMed  Europe PubMed DOI
  52. Yaoi,K., Kadotani,T., Kuwana,H., Shinkawa,A., Takahashi,T., Iwahana,H. and Sato,R.
    Aminopeptidase N from Bombyx mori as a candidate for the receptor of Bacillus thuringiensis Cry1Aa toxin
    Eur J Biochem246, 652-657. PubMed  Europe PubMed
    53. 1996
  53. Lee,M.K., You,T.H., Young,B.A., Cotrill,J.A., Valaitis,A.P. and Dean,D.H.
    Aminopeptidase N purified from gypsy moth brush border membrane vesicles is a specific receptor for Bacillus thuringiensis CryIAc toxin
    Appl Environ Microbiol62, 2845-2849. PubMed  Europe PubMed
  54. Lu,Y.J. and Adang,M.J.
    Conversion of Bacillus thuringiensis CryIAc-binding aminopeptidase to a soluble form by endogenous phosphatidylinositol phospholipase C
    Insect Biochem Mol Biol26, 33-40.
  55. Luo,K., Lu,Y.J. and Adang,M.J.
    A 106-kDa form of aminopeptidase is a receptor for Bacillus thuringiensis CryIC d-endotoxin in the brush border membrane of Manduca sexta
    Insect Biochem Molec Biol26, 33-40.
  56. Luo,K., Lu,Y.J. and Adang,M.J.
    A 106 kDa form of aminopeptidase is a receptor for Bacillus thuringiensis CryIC delta-endotoxin in the brush border membrane of Manduca sexta
    Insect Biochem Mol Biol26, 783-791.
    57. 1995
  57. Gill,S.S., Cowles,E.A. and Francis,V.
    Identification, isolation, and cloning of a Bacillus thuringiensis CryIAc toxin-binding protein from the midgut of the lepidopteran insect Heliothis virescens
    J Biol Chem270, 27277-27282. PubMed  Europe PubMed DOI
  58. Knight,P.J., Knowles,B.H. and Ellar,D.J.
    Molecular cloning of an insect aminopeptidase N that serves as a receptor for Bacillus thuringiensis CryIA(c) toxin
    J Biol Chem270, 17765-17770. PubMed  Europe PubMed DOI
  59. Valaitis,A.P., Lee,M.K., Rajamohan,F. and Dean,D.H.
    Brush border membrane aminopeptidase-N in the midgut of the gypsy moth serves as the receptor for the CryIA(c) delta-endotoxin of Bacillus thuringiensis
    Insect Biochem Mol Biol25, 1143-1151. PubMed  Europe PubMed DOI
    60. 1994
  60. Knight,P.J., Crickmore,N. and Ellar,D.J.
    The receptor for Bacillus thuringiensis CrylA(c) delta-endotoxin in the brush border membrane of the lepidopteran Manduca sexta is aminopeptidase N
    Mol Microbiol11, 429-436. PubMed  Europe PubMed DOI

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