Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C97.002: desumoylating isopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: T Target, K Knockout, E Expression, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Ou,X., Zhang,G.T., Xu,Z., Chen,J.S., Xie,Y., Liu,J.K. and Liu,X.P.
    Desumoylating isopeptidase 2 (DESI2) inhibits proliferation and promotes apoptosis of pancreatic cancer cells through regulating PI3K/AKT/mTOR signaling pathway
    Pathol Oncol Res (2019) 25, 635-646. PubMed  Europe PubMed DOI
  2. Xie,X., Wang,X., Liao,W., Fei,R., Wu,N., Cong,X., Chen,Q., Wei,L., Wang,Y. and Chen,H.
    PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis
    Apoptosis (2019) 24, 135-144. PubMed  Europe PubMed DOI  T
    3. 2017
  3. Xie,X., Wang,X., Jiang,D., Wang,J., Fei,R., Cong,X., Wei,L., Wang,Y. and Chen,H.
    PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family
    Biochem Biophys Res Commun (2017) 488, 291-296. PubMed  Europe PubMed DOI
    4. 2014
  4. Kang,Y.H., Shen,C.C., Yao,Y.Q., Yu,L., Cui,X.Y., He,Y., Yang,J.L. and Gou,L.T.
    Implications of PPPDE1 expression in the distribution of plakoglobin and beta-catenin in pancreatic ductal adenocarcinoma
    Oncol Lett (2014) 8, 1229-1233. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2013
  5. Li,L., Chen,D.B., Lin,C., Cao,K., Wan,Y., Zhao,X.Y., Nie,C.L., Yuan,Z. and Wei,Y.Q.
    hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells
    Apoptosis (2013) 18, 467-479. PubMed  Europe PubMed DOI
    6. 2012
  6. Cai,P., Xia,X., Li,F., Cui,Y., Yang,Q. and Chen,M.
    PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain
    Mol Biol Rep (2012) 39, 621-628. PubMed  Europe PubMed DOI  K
  7. Cao,K., Lin,C., Dai,Q., Li,L., Lei,T.J., Xie,Y., Tang,M.H. and Yuan,Z.
    [Cloning, expression and purification of human PNAS-4]
    Sichuan Da Xue Xue Bao Yi Xue Ban (2012) 43, 503-506. PubMed  Europe PubMed
  8. Zeng,H., Yuan,Z., Zhu,H., Li,L., Shi,H., Wang,Z., Fan,Y., Deng,Q., Zeng,J., He,Y., Xiao,J. and Li,Z.
    Expression of hPNAS-4 radiosensitizes Lewis lung cancer
    Int J Radiat Oncol Biol Phys (2012) 84, e533-e540. PubMed  Europe PubMed DOI
    9. 2011
  9. Qi,X., Song,X., Liu,P., Yi,T., Li,S., Xie,C., Zheng,Y., Bai,Y., Sun,C., Wei,Y. and Zhao,X.
    Antitumor effects of PLGA nanoparticles encapsulating the human PNAS-4 gene combined with cisplatin in ovarian cancer
    Oncol Rep (2011) 26, 703-710. PubMed  Europe PubMed DOI  U
    10. 2010
  10. Deng,H., Jiang,Q., Liang,S., Yan,F., Hou,S., Qian,Z., Li,J., Wen,Y., Yang,J. and Wei,Y.
    Prokaryotic expression, purification and characterization of a novel pro-apoptosis protein hPNAS-4
    Biotechnol Appl Biochem (2010) 55, 63-72. PubMed  Europe PubMed DOI  E
  11. Yan,F., Ruan,X.Z., Yang,H.S., Yao,S.H., Zhao,X.Y., Gou,L.T., Ma,F.X., Yuan,Z., Deng,H.X. and Wei,Y.Q.
    Identification, characterization, and effects of Xenopus laevis PNAS-4 gene on embryonic development
    J Biomed Biotechnol (2010) 2010, 134764-134764. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2009
  12. Gou,L.T., Tong,A.P., Yan,F., Yuan,Z., He,F., Wang,W., Zhou,Y., Chen,L.J., Tang,M.H. and Yang,J.L.
    Altered protein-expressing profile in hPNAS4-induced apoptosis in A549 human lung adenocarcinoma cells
    J Cell Biochem (2009) 108, 1211-1219. PubMed  Europe PubMed DOI
  13. Hou,S., Zhao,Z., Yan,F., Chen,X., Deng,H., Chen,X., Wang,Y. and Wei,Y.
    Genetic transfer of PNAS-4 induces apoptosis and enhances sensitivity to gemcitabine in lung cancer
    Cell Biol Int (2009) 33, 276-282. PubMed  Europe PubMed DOI  U
  14. Yan,F., Gou,L., Yang,J., Chen,L., Tong,A., Tang,M., Yuan,Z., Yao,S., Zhang,P. and Wei,Y.
    A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice
    Biochimie (2009) 91, 502-507. PubMed  Europe PubMed DOI
  15. Yuan,Z., Yan,F., Wang,Y.S., Liu,H.Y., Gou,L.T., Zhao,X.Y., Lai,S.T., Deng,H.X., Li,J., Ding,Z.Y., Xiong,S.Q., Kan,B., Mao,Y.Q., Chen,L.J., Wei,Y.Q. and Zhao,X.
    PNAS-4, a novel pro-apoptotic gene, can potentiate antineoplastic effects of cisplatin
    Cancer Chemother Pharmacol (2009) 65, 13-25. PubMed  Europe PubMed DOI
  16. Yuan,Z., Liu,H., Yan,F., Wang,Y., Gou,L., Nie,C., Ding,Z., Lai,S., Zhao,Y., Zhao,X., Li,J., Deng,H., Mao,Y., Chen,L., Wei,Y. and Zhao,X.
    Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene
    Cancer Sci (2009) 100, 1757-1766. PubMed  Europe PubMed DOI  U
    17. 2008
  17. Mo,D., Zhu,Z., te Pas,M.F., Li,X., Yang,S., Wang,H., Wang,H. and Li,K.
    Characterization, expression profiles, intracellular distribution and association analysis of porcine PNAS-4 gene with production traits
    BMC Genet (2008) 9, 40-40. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Yao,S., Xie,L., Qian,M., Yang,H., Zhou,L., Zhou,Q., Yan,F., Gou,L., Wei,Y., Zhao,X. and Mo,X.
    Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation
    FEBS Lett (2008) 582, 2325-2332. PubMed  Europe PubMed DOI
  19. Zhang,P., Wang,C.T., Yan,F., Gou,L., Tong,A.P., Cai,F., Li,Q., Deng,H.X. and Wei,Y.Q.
    Prokaryotic expression of a novel mouse pro-apoptosis protein PNAS-4 and application of its polyclonal antibodies
    Braz J Med Biol Res (2008) 41, 504-511. PubMed  Europe PubMed
    20. 2007
  20. Yan,F., Qian,M., Yang,F., Cai,F., Yuan,Z., Lai,S., Zhao,X., Gou,L., Hu,Z. and Deng,H.
    A novel pro-apoptosis protein PNAS-4 from Xenopus laevis: cloning, expression, purification, and polyclonal antibody production
    Biochemistry (Mosc) (2007) 72, 664-671. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use