Literature for peptidase C87.001: nairovirus deubiquitinylating peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Beckmann,L., Liessmann,F., Icker,M., Rieger,D., Schlegel,P., Urban,N., Schaefer,M., Meiler,J., Schoeder,C.T. and Tretbar,M.
    Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus
    Bioorg Med Chem120, 118093-118093. PubMed  Europe PubMed DOI  I
  2. 2020
  3. Dzimianski,J.V., Mace,S.L., Williams,I.L., Freitas,B.T. and Pegan,S.D.
    Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis
    Acta Crystallogr D Struct Biol76, 1114-1123. PubMed  Europe PubMed DOI
  4. 2019
  5. Dzimianski,J.V., Scholte,F.E.M., Williams,I.L., Langley,C., Freitas,B.T., Spengler,J.R., Bergeron,E. and Pegan,S.D.
    Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases
    PLoS ONE14, e0226415-e0226415. PubMed  Europe PubMed DOI  S
  6. Dzimianski,J.V., Beldon,B.S., Daczkowski,C.M., Goodwin,O.Y., Scholte,F.E.M., Bergeron,E. and Pegan,S.D.
    Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
    PLoS Pathog15, e1007515-e1007515. PubMed  Europe PubMed DOI  S
  7. Scholte,F.E.M., Hua,B.L., Spengler,J.R., Dzimianski,J.V., Coleman-McCray,J.D., Welch,S.R., McMullan,L.K., Nichol,S.T., Pegan,S.D., Spiropoulou,C.F. and Bergeron,E.
    Stable occupancy of the Crimean-Congo hemorrhagic fever virus-encoded deubiquitinase blocks viral infection
    MBio10, PubMed  Europe PubMed DOI
  8. 2017
  9. Scholte,F.E.M., Zivcec,M., Dzimianski,J.V., Deaton,M.K., Spengler,J.R., Welch,S.R., Nichol,S.T., Pegan,S.D., Spiropoulou,C.F. and Bergeron,E.
    Crimean-Congo hemorrhagic fever virus suppresses innate immune responses via a ubiquitin and ISG15 specific protease
    Cell Rep20, 2396-2407. PubMed  Europe PubMed DOI
  10. 2016
  11. Kocabas,F. and Ergin,E.K.
    Identification of small molecule binding pocket for inhibition of Crimean - Congo hemorrhagic fever virus OTU protease
    Turk J Biol40, 239-249. DOI  I
  12. 2015
  13. Eisenmesser,E.Z., Capodagli,G.C., Armstrong,G.S., Holliday,M.J., Isern,N.G., Zhang,F. and Pegan,S.D.
    Inherent dynamics within the Crimean-Congo hemorrhagic fever virus protease are localized to the same region as substrate interactions
    Protein Sci24, 651-660. PubMed  Europe PubMed DOI  S
  14. Kocabas,F. and Aslan,G.S.
    Fluorometric CCHFV OTU protease assay with potent inhibitors
    Virus Genes51, 190-197. PubMed  Europe PubMed DOI  A  I
  15. 2013
  16. Capodagli,G.C., Deaton,M.K., Baker,E.A., Lumpkin,R.J. and Pegan,S.D.
    Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases
    J Virol87, 3815-3827. PubMed  Europe PubMed DOI  S
  17. 2012
  18. Garcia-Sastre,A. and Levingston Macleod,J.M.
    Nairovirus deuquitinylating peptidase
    [ISSN:978-0-12-407743-0]3, 2218-2224. DOI
  19. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0]3, 2113-2120. DOI
  20. van Kasteren,P.B., Beugeling,C., Ninaber,D.K., Frias-Staheli,N., van Boheemen,S., Garcia-Sastre,A., Snijder,E.J. and Kikkert,M.
    Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling
    J Virol86, 773-785. PubMed  Europe PubMed DOI
  21. 2011
  22. Capodagli,G.C., McKercher,M.A., Baker,E.A., Masters,E.M., Brunzelle,J.S. and Pegan,S.D.
    Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with covalently bonded ubiquitin
    J Virol85, 3621-3630. PubMed  Europe PubMed DOI  S
  23. Holzer,B., Bakshi,S., Bridgen,A. and Baron,M.D.
    Inhibition of interferon induction and action by the nairovirus nairobi sheep disease virus/ganjam virus
    PLoS ONE6, e28594-e28594. PubMed  Europe PubMed DOI
  24. James,T.W., Frias-Staheli,N., Bacik,J.P., Levingston Macleod,J.M., Khajehpour,M., Garcia-Sastre,A. and Mark,B.L.
    Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease
    Proc Natl Acad Sci U S A108, 2222-2227. PubMed  Europe PubMed DOI  S
  25. Srinivasan,P., Kumar,S.P., Karthikeyan,M., Jeyakanthan,J., Jasrai,Y.T., Pandya,H.A., Rawal,R.M. and Patel,S.K.
    Epitope-based immunoinformatics and molecular docking studies of nucleocapsid protein and ovarian tumor domain of Crimean-Congo hemorrhagic fever virus
    Front Genet2, 72-72. PubMed  Europe PubMed DOI
  26. 2010
  27. Bergeron,E., Albarino,C.G., Khristova,M.L. and Nichol,S.T.
    Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor protease activity is dispensable for virus RNA polymerase function
    J Virol84, 216-226. PubMed  Europe PubMed DOI
  28. 2007
  29. Arguello,M.D. and Hiscott,J.
    Ub Surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates
    Cell Host Microbe2, 367-369. PubMed  Europe PubMed DOI
  30. Frias-Staheli,N., Giannakopoulos,N.V., Kikkert,M., Taylor,S.L., Bridgen,A., Paragas,J., Richt,J.A., Rowland,R.R., Schmaljohn,C.S., Lenschow,D.J., Snijder,E.J., Garcia-Sastre,A. and Virgin,H.W.
    Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses
    Cell Host Microbe2, 404-416. PubMed  Europe PubMed DOI
  31. 2004
  32. Honig,J.E., Osborne,J.C. and Nichol,S.T.
    Crimean-Congo hemorrhagic fever virus genome L RNA segment and encoded protein
    Virology321, 29-35. PubMed  Europe PubMed DOI
  33. [YEAR:30-3-2004]Kinsella,E., Martin,S.G., Grolla,A., Czub,M., Feldmann,H. and Flick,R.
    Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment
    Virology321, 23-28. PubMed  Europe PubMed DOI