Literature for peptidase C86.005: JosD2 peptidase

(Topics flags: S Structure, I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Du,J., Fan,Y., Fu,J., Ge,F., Zhu,H., Yang,S., Dai,J., Yuan,T., He,Q., Yang,B., Zhu,H. and Dong,X.
   Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer
   Oncoimmunology (2025) 14, 2590245-2590245. PubMed  Europe PubMed DOI  PMC  EPMC
2. Shen,S.R., Huang,Z.Q., Yang,Y.D., Han,J.B., Fang,Z.M., Guan,Y., Xu,J.C., Min,J.L., Wang,Y., Wu,G.J., Xiao,Z.X., Luo,W., Huang,Z.Q. and Liang,G.
   JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
   Acta Pharmacol Sin (2025) PubMed  Europe PubMed DOI
3. Yuan,T., Liu,Y., Wu,R., Qian,M., Wang,W., Li,Y., Zhu,H., Wang,J., Ge,F., Zeng,C., Dai,X., Hu,R., Zhou,T., He,Q., Zhu,H. and Yang,B.
   Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer
   Nat Commun (2025) 16, 3623-3623. PubMed  Europe PubMed DOI  PMC  EPMC  K
4. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.
   A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)
   J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
2024
5. Wang,W.P., Shi,D., Yun,D., Hu,J., Wang,J.F., Liu,J., Yang,Y.P., Li,M.R., Wang,J.F. and Kong,D.L.
   Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma
   World J Gastroenterol (2024) 30, 565-578. PubMed  Europe PubMed DOI  PMC  EPMC  K
2023
6. Han,J., Fang,Z., Han,B., Ye,B., Lin,W., Jiang,Y., Han,X., Wang,X., Wu,G., Wang,Y. and Liang,G.
   Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes
   Nat Cardiovasc Res (2023) 2, 764-777. PubMed  Europe PubMed DOI
7. Wang,Y., Li,Z.X., Wang,J.G., Li,L.H., Shen,W.L. and Dang,X.W.
   Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma
   Genes Genomics (2023) 45, 215-224. PubMed  Europe PubMed DOI  K
2021
8. Krassikova,L., Zhang,B., Nagarajan,D., Queiroz,A.L., Kacal,M., Samakidis,E., Vakifahmetoglu-Norberg,H. and Norberg,E.
   The deubiquitinase JOSD2 is a positive regulator of glucose metabolism
   Cell Death Differ (2021) 28, 1091-1109. PubMed  Europe PubMed DOI  PMC  EPMC
9. Zhou,L., Liu,T., Huang,B., Luo,M., Chen,Z., Zhao,Z., Wang,J., Leung,D., Yang,X., Chan,K.W., Liu,Y., Xiong,L., Chen,P., Wang,H., Ye,L., Liang,H., Masters,S.L., Lew,A.M., Gong,S., Bai,F., Yang,J., Pui-Wah,L.e., Yang,W., Zhang,Y., Lau,Y.L., Geng,L., Zhang,Y. and Cui,J.
   Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development
   J Allergy Clin Immunol (2021) 147, 267-279. PubMed  Europe PubMed DOI
2019
10. Grasty,K.C., Weeks,S.D. and Loll,P.J.
    Structural insights into the activity and regulation of human Josephin-2
    J Struct Biol X (2019) 3, 100011-100011. PubMed  Europe PubMed DOI  PMC  EPMC
2013
11. Seki,T., Gong,L., Williams,A.J., Sakai,N., Todi,S.V. and Paulson,H.L.
    JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis
    J Biol Chem (2013) 288, 17145-17155. PubMed  Europe PubMed DOI
2011
12. Weeks,S.D., Grasty,K.C., Hernandez-Cuebas,L. and Loll,P.J.
    Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ATAXIN-3 deubiquitinating activity
    J Biol Chem (2011) 286, 4555-4565. PubMed  Europe PubMed DOI  S