Literature for peptidase C85.008: OTU2 peptidase (Saccharomyces cerevisiae-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jiang,Q., Song,P., Zhang,S., Ren,Q., Zhu,M., Ge,J., Bu,L., Chen,W., Wu,X., Han,S., Su,Y., Wang,L., Xie,W., Cheng,C., Peng,Z. and Guo,J.<br>TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance<br>Nat Struct Mol Biol (2025) PubMed  Europe PubMed DOI
  2. Zhao,Y., Jin,T., Xu,T., Fang,Y., Zheng,Q., Luo,W., Zhu,W., Chen,Y., Wang,J., Chen,Y., Zuo,W., Huang,L., Liang,G. and Wang,Y.<br>Deubiquitinase OTUD6A alleviates acetaminophen-induced liver injury by targeting EZH2 to reduce cell death in hepatocytes<br>Acta Pharm Sin B (2025) 15, 4772-4788. PubMed  Europe PubMed DOI  PMC  EPMC
  3. 2024
  4. Cui,J., Liu,X., Shang,Q., Sun,S., Chen,S., Dong,J., Zhu,Y., Liu,L., Xia,Y., Wang,Y., Xiang,L., Fan,B., Zhan,J., Zhou,Y., Chen,P., Zhao,R., Liu,X., Xing,N., Wu,D., Shi,B. and Zou,Y.<br>Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance<br>Mol Cancer (2024) 23, 86-86. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Fang,Z., Han,J., Lin,L., Ye,B., Qu,X., Zhang,Y., Zhao,Y., Xu,D., Lin,W., Shen,S., Min,J., Wu,G., Huang,Z. and Liang,G.<br>Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING<br>Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167061-167061. PubMed  Europe PubMed DOI
  6. Kim,H.J., Choi,Y., Lee,Y., Hwangbo,M. and Kim,J.<br>OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs<br>FEBS Lett (2024) 598, 1045-1060. PubMed  Europe PubMed DOI
  7. Villa,S., Dwivedi,P., Stahl,A., Hinkle,T., Rose,C.M., Kirkpatrick,D.S., Tomchik,S.M., Dixit,V.M. and Wolf,F.W.<br>OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress<br>Nat Commun (2024) 15, 6873-6873. PubMed  Europe PubMed DOI  PMC  EPMC
  8. 2023
  9. Ikeuchi,K., Ivic,N., Buschauer,R., Cheng,J., Frohlich,T., Matsuo,Y., Berninghausen,O., Inada,T., Becker,T. and Beckmann,R.<br>Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2<br>Nat Commun (2023) 14, 2730-2730. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Li,Z., Li,G., Li,Y., Luo,Y., Jiang,Y., Zhang,Z., Zhou,Z., Liu,S., Wu,C. and You,F.<br>Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13<br>Viruses (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Liu,X., Fang,Y., Lv,X., Hu,C., Chen,G., Zhang,L., Jin,B., Huang,L., Luo,W., Liang,G. and Wang,Y.<br>Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3<br>Cell Death Differ (2023) 30, 1457-1471. PubMed  Europe PubMed DOI  PMC  EPMC
  12. 2022
  13. Fu,X., Zhao,J., Yu,G., Zhang,X., Sun,J., Li,L., Yin,J., Niu,Y., Ren,S., Zhu,Y., Xu,B. and Huang,L.<br>OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR<br>Commun Biol (2022) 5, 182-182. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Zhao,Y., Huang,X., Zhu,D., Wei,M., Luo,J., Yu,S., Tian,Y. and Zheng,X.<br>Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy<br>Cell Death Differ (2022) PubMed  Europe PubMed DOI
  15. 2018
  16. Kim,S.Y., Kwon,S.K., Lee,S.Y. and Baek,K.H.<br>Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells<br>Int J Oncol (2018) 52, 1705-1714. PubMed  Europe PubMed DOI
  17. 2011
  18. Schaefer,J.B. and Morgan,D.O.<br>Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes<br>J Biol Chem (2011) 286, 45186-45196. PubMed  Europe PubMed DOI