Literature for peptidase C85.007: YOD1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,J., Chen,F., She,L., Zeng,Y., Tang,H., Ye,B., Zheng,W., Xiong,L., Li,L., Li,L., Yu,Q., Chen,L., Wang,W., Liang,G. and Zhao,X.
    YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease
    Acta Pharm Sin B15, 331-348. PubMed  Europe PubMed DOI
  2. Zhi-Xiong,C.
    Decoding YOD1: Insights into tumour regulation and translational opportunities
    Biochem Pharmacol236, 116889-116889. PubMed  Europe PubMed DOI  V
  3. 2024
  4. Chen,H., Chen,X., Yang,L., Sheng,S., Yang,J., Lu,Y., Sun,Y., Zhang,X. and Jiang,C.
    TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in rat tendon-derived stem cells
    J Biol Chem300, 105510-105510. PubMed  Europe PubMed DOI
  5. Lin,W.T., Jiang,Y.C., Mei,Y.L., Chen,Y.H., Zheng,Z.Z., Han,X., Wu,G.J., Huang,W.J., Ye,B.Z. and Liang,G.
    Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating beta-catenin
    Acta Pharmacol Sin45, 1618-1631. PubMed  Europe PubMed DOI
  6. Liu,C., Fan,C., Liu,J., Zhang,S., Tang,H., Liu,Y., Zhang,S., Wu,Q., Zhang,J., Qi,Z. and Shen,Y.
    YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3
    Cell Death Dis15, 360-360. PubMed  Europe PubMed DOI
  7. Shen,J., Lou,L., Du,X., Zhou,B., Xu,Y., Mei,F., Wu,L., Li,J., Waisman,A., Ruan,J. and Wang,X.
    YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2
    EMBO Rep25, 4827-4845. PubMed  Europe PubMed DOI
  8. 2023
  9. Farkas,A., Zsindely,N., Nagy,G., Kovacs,L., Deak,P. and Bodai,L.
    The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila
    Sci Rep13, 21951-21951. PubMed  Europe PubMed DOI
  10. Han,Z., Jia,Q., Zhang,J., Chen,M., Wang,L., Tong,K., He,W., Zhang,Y., Zhu,W., Qin,J., Wang,T., Liu,T., Ma,Y., Chen,Y., Zha,S. and Zhang,C.
    Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
    J Exp Clin Cancer Res42, 228-228. PubMed  Europe PubMed DOI  K
  11. Park,S.S. and Baek,K.H.
    Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
    Cancer Cell Int23, 209-209. PubMed  Europe PubMed DOI
  12. Park,S.S., Do,H.A., Park,H.B., Choi,H.S. and Baek,K.H.
    Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes alpha-synuclein
    Biochem Biophys Res Commun645, 124-131. PubMed  Europe PubMed DOI
  13. Pei,H.Z., Peng,Z., Zhuang,X., Wang,X., Lu,B., Guo,Y., Zhao,Y., Zhang,D., Xiao,Y., Gao,T., Yu,L., He,C., Wu,S., Baek,S.H., Zhao,Z.J., Xu,X. and Chen,Y.
    miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
    Cell Death Discov9, 249-249. PubMed  Europe PubMed DOI
  14. 2020
  15. Park,J.H., Kim,S.Y., Cho,H.J., Lee,S.Y. and Baek,K.H.
    YOD1 deubiquitinates NEDD4 involved in the Hippo signaling pathway
    Cell Physiol Biochem54, 1-14. PubMed  Europe PubMed DOI
  16. 2019
  17. Liu,C., Huang,S., Wang,X., Wen,M., Zheng,J., Wang,W., Fu,Y., Tian,S., Li,L., Li,Z. and Wang,X.
    The otubain YOD1 suppresses aggregation and activation of the signaling adaptor MAVS through Lys63-linked deubiquitination
    J Immunol202, 2957-2970. PubMed  Europe PubMed DOI
  18. 2018
  19. Tanji,K., Mori,F., Miki,Y., Utsumi,J., Sasaki,H., Kakita,A., Takahashi,H. and Wakabayashi,K.
    YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity
    Neurobiol Dis112, 14-23. PubMed  Europe PubMed DOI
  20. Zhou,X.L., Chen,G., Li,M.X., Wang,H.X., Hong,J.W., Shen,J.Y., Wang,Q., Ge,X., Ding,Z. and Xu,L.C.
    Targeting YOD1 by RNA interference inhibits proliferation and migration of human oral keratinocytes through transforming growth factor-beta3 signaling pathway
    Biomed Res Int2018, 6254308-6254308. PubMed  Europe PubMed DOI  K
  21. 2017
  22. Kim,Y., Kim,W., Song,Y., Kim,J.R., Cho,K., Moon,H., Ro,S.W., Seo,E., Ryu,Y.M., Myung,S.J. and Jho,E.H.
    Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability
    Proc Natl Acad Sci U S A114, 4691-4696. PubMed  Europe PubMed DOI
  23. Kim,Y. and Jho,E.H.
    Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
    BMB Rep50, 281-282. PubMed  Europe PubMed
  24. Schimmack,G., Schorpp,K., Kutzner,K., Gehring,T., Brenke,J.K., Hadian,K. and Krappmann,D.
    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB
    elife6, PubMed  Europe PubMed DOI
  25. 2016
  26. Flierman,D., van der Heden van Noort,G.J., Ekkebus,R., Geurink,P.P., Mevissen,T.E., Hospenthal,M.K., Komander,D. and Ovaa,H.
    Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets
    Cell Chem Biol23, 472-482. PubMed  Europe PubMed DOI
  27. 2015
  28. Sasset,L., Petris,G., Cesaratto,F. and Burrone,O.R.
    The VCP/p97 and YOD1 proteins have different substrate-dependent activities in endoplasmic reticulum-associated degradation (ERAD)
    J Biol Chem290, 28175-28188. PubMed  Europe PubMed DOI
  29. 2013
  30. Bernardi,K.M., Williams,J.M., Inoue,T., Schultz,A. and Tsai,B.
    A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates
    Mol Biol Cell24, 3545-3556. PubMed  Europe PubMed DOI
  31. Sehrawat,S., Koenig,P.A., Kirak,O., Schlieker,C., Fankhauser,M. and Ploegh,H.L.
    A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation
    Blood121, 1145-1156. PubMed  Europe PubMed DOI
  32. 2012
  33. Sanyal,S., Claessen,J.H. and Ploegh,H.L.
    A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells
    J Biol Chem287, 23594-23603. PubMed  Europe PubMed DOI
  34. 2009
  35. Ernst,R., Mueller,B., Ploegh,H.L. and Schlieker,C.
    The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER
    Mol Cell36, 28-38. PubMed  Europe PubMed DOI