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Literature for peptidase C85.007: YOD1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,J., Chen,F., She,L., Zeng,Y., Tang,H., Ye,B., Zheng,W., Xiong,L., Li,L., Li,L., Yu,Q., Chen,L., Wang,W., Liang,G. and Zhao,X.
    YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease
    Acta Pharm Sin B (2025) 15, 331-348. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Wu,Y., Deng,Y., Ai,Q., Li,Y., Qin,F., Hammad,M., Meng,Z., Xu,X., Wei,J., Yu,H., Liang,G. and Zhao,X.
    Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential
    Mol Med (2025) 31, 329-329. PubMed  Europe PubMed DOI
  3. Yan,X., Chen,Y., Li,X., Qi,C., Xu,L., Chen,Y., Huang,C., Ruan,T., Xu,G., Chen,C., Li,S. and Zhang,X.
    YOD1 promotes ferroptosis in acute lung injury by deubiquitination of NCOA4
    Commun Biol (2025) PubMed  Europe PubMed DOI
  4. Ye,B., Lin,W., Jiang,Y., Zheng,Z., Jin,Y., Xu,D., Liao,Y., Jia,Z., Chen,J., Wu,G., Shan,P. and Liang,G.
    Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3
    Sci Adv (2025) 11, eadu8422-eadu8422. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zhao,X., Sun,J., Chen,F., Tang,H., Zeng,Y., Li,L., Yu,Q., Chen,L., Hammad,M., Xu,X., Meng,Z., Wang,W. and Liang,G.
    YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2
    Clin Transl Med (2025) 15, e70420-e70420. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Zhi-Xiong,C.
    Decoding YOD1: Insights into tumour regulation and translational opportunities
    Biochem Pharmacol (2025) 236, 116889-116889. PubMed  Europe PubMed DOI  V
    7. 2024
  7. Chen,H., Chen,X., Yang,L., Sheng,S., Yang,J., Lu,Y., Sun,Y., Zhang,X. and Jiang,C.
    TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in rat tendon-derived stem cells
    J Biol Chem (2024) 300, 105510-105510. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Lin,W.T., Jiang,Y.C., Mei,Y.L., Chen,Y.H., Zheng,Z.Z., Han,X., Wu,G.J., Huang,W.J., Ye,B.Z. and Liang,G.
    Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating beta-catenin
    Acta Pharmacol Sin (2024) 45, 1618-1631. PubMed  Europe PubMed DOI
  9. Liu,C., Fan,C., Liu,J., Zhang,S., Tang,H., Liu,Y., Zhang,S., Wu,Q., Zhang,J., Qi,Z. and Shen,Y.
    YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3
    Cell Death Dis (2024) 15, 360-360. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Shen,J., Lou,L., Du,X., Zhou,B., Xu,Y., Mei,F., Wu,L., Li,J., Waisman,A., Ruan,J. and Wang,X.
    YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2
    EMBO Rep (2024) 25, 4827-4845. PubMed  Europe PubMed DOI
    11. 2023
  11. Farkas,A., Zsindely,N., Nagy,G., Kovacs,L., Deak,P. and Bodai,L.
    The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila
    Sci Rep (2023) 13, 21951-21951. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Han,Z., Jia,Q., Zhang,J., Chen,M., Wang,L., Tong,K., He,W., Zhang,Y., Zhu,W., Qin,J., Wang,T., Liu,T., Ma,Y., Chen,Y., Zha,S. and Zhang,C.
    Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
    J Exp Clin Cancer Res (2023) 42, 228-228. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Park,S.S., Do,H.A., Park,H.B., Choi,H.S. and Baek,K.H.
    Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes alpha-synuclein
    Biochem Biophys Res Commun (2023) 645, 124-131. PubMed  Europe PubMed DOI
  14. Park,S.S. and Baek,K.H.
    Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
    Cancer Cell Int (2023) 23, 209-209. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Pei,H.Z., Peng,Z., Zhuang,X., Wang,X., Lu,B., Guo,Y., Zhao,Y., Zhang,D., Xiao,Y., Gao,T., Yu,L., He,C., Wu,S., Baek,S.H., Zhao,Z.J., Xu,X. and Chen,Y.
    miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
    Cell Death Discov (2023) 9, 249-249. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2020
  16. Park,J.H., Kim,S.Y., Cho,H.J., Lee,S.Y. and Baek,K.H.
    YOD1 deubiquitinates NEDD4 involved in the Hippo signaling pathway
    Cell Physiol Biochem (2020) 54, 1-14. PubMed  Europe PubMed DOI
    17. 2019
  17. Liu,C., Huang,S., Wang,X., Wen,M., Zheng,J., Wang,W., Fu,Y., Tian,S., Li,L., Li,Z. and Wang,X.
    The otubain YOD1 suppresses aggregation and activation of the signaling adaptor MAVS through Lys63-linked deubiquitination
    J Immunol (2019) 202, 2957-2970. PubMed  Europe PubMed DOI
    18. 2018
  18. Tanji,K., Mori,F., Miki,Y., Utsumi,J., Sasaki,H., Kakita,A., Takahashi,H. and Wakabayashi,K.
    YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity
    Neurobiol Dis (2018) 112, 14-23. PubMed  Europe PubMed DOI
  19. Zhou,X.L., Chen,G., Li,M.X., Wang,H.X., Hong,J.W., Shen,J.Y., Wang,Q., Ge,X., Ding,Z. and Xu,L.C.
    Targeting YOD1 by RNA interference inhibits proliferation and migration of human oral keratinocytes through transforming growth factor-beta3 signaling pathway
    Biomed Res Int (2018) 2018, 6254308-6254308. PubMed  Europe PubMed DOI  PMC  EPMC  K
    20. 2017
  20. Kim,Y., Kim,W., Song,Y., Kim,J.R., Cho,K., Moon,H., Ro,S.W., Seo,E., Ryu,Y.M., Myung,S.J. and Jho,E.H.
    Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability
    Proc Natl Acad Sci U S A (2017) 114, 4691-4696. PubMed  Europe PubMed DOI
  21. Kim,Y. and Jho,E.H.
    Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
    BMB Rep (2017) 50, 281-282. PubMed  Europe PubMed
  22. Schimmack,G., Schorpp,K., Kutzner,K., Gehring,T., Brenke,J.K., Hadian,K. and Krappmann,D.
    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB
    elife (2017) 6 PubMed  Europe PubMed DOI
    23. 2016
  23. Flierman,D., van der Heden van Noort,G.J., Ekkebus,R., Geurink,P.P., Mevissen,T.E., Hospenthal,M.K., Komander,D. and Ovaa,H.
    Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets
    Cell Chem Biol (2016) 23, 472-482. PubMed  Europe PubMed DOI
    24. 2015
  24. Sasset,L., Petris,G., Cesaratto,F. and Burrone,O.R.
    The VCP/p97 and YOD1 proteins have different substrate-dependent activities in endoplasmic reticulum-associated degradation (ERAD)
    J Biol Chem (2015) 290, 28175-28188. PubMed  Europe PubMed DOI
    25. 2013
  25. Bernardi,K.M., Williams,J.M., Inoue,T., Schultz,A. and Tsai,B.
    A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates
    Mol Biol Cell (2013) 24, 3545-3556. PubMed  Europe PubMed DOI
  26. Sehrawat,S., Koenig,P.A., Kirak,O., Schlieker,C., Fankhauser,M. and Ploegh,H.L.
    A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation
    Blood (2013) 121, 1145-1156. PubMed  Europe PubMed DOI
    27. 2012
  27. Sanyal,S., Claessen,J.H. and Ploegh,H.L.
    A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells
    J Biol Chem (2012) 287, 23594-23603. PubMed  Europe PubMed DOI
    28. 2009
  28. Ernst,R., Mueller,B., Ploegh,H.L. and Schlieker,C.
    The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER
    Mol Cell (2009) 36, 28-38. PubMed  Europe PubMed DOI  PMC  EPMC

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