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Literature for peptidase C85.004: OTUD1 peptidase (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: M Mutation, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Han,X., Zheng,R., Zhang,J., Liu,Y., Li,Z., Liu,G., Zheng,J., Li,W., Liang,Z., Wang,M., Yu,J., Shi,Q., Ying,H. and Liang,G.
    Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKalpha2 and inducing mitochondrial dysfunction
    Nat Commun (2025) 16, 6668-6668. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zhang,M.D., Chen,F., He,W.Q., Lu,Y., Liu,F.L., Zhang,H.G., Yang,L.M., Dong,C.S., Xiong,S.D. and Zheng,Y.T.
    The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2
    Viruses (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Lin,H., Han,Y., Sang,Y., Wu,Y., Tian,M., Chen,X., Lin,X. and Lin,X.
    OTUD1 enhances gastric cancer aggressiveness by deubiquitinating EBV-encoded protein BALF1 to stabilize the apoptosis inhibitor Bcl-2
    Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167132-167132. PubMed  Europe PubMed DOI
  4. Wang,Q., Liang,S., Qian,J., Xu,J., Zheng,Q., Wang,M., Guo,X., Min,J., Wu,G., Zhuang,Z., Luo,W. and Liang,G.
    OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes
    Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167018-167018. PubMed  Europe PubMed DOI  K
  5. Zhang,Q., Chen,Z., Li,J., Huang,K., Ding,Z., Chen,B., Ren,T., Xu,P., Wang,G., Zhang,H., Zhang,X.D., Zhang,J. and Wang,H.
    The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury
    Redox Biol (2024) 75, 103287-103287. PubMed  Europe PubMed DOI
    6. 2023
  6. Cheng,Q., Wang,D., Lai,X., Liu,Y., Zuo,Y., Zhang,W., Lei,L., Chen,J., Liu,H., Wang,Y., Liu,H., Zheng,H., Wu,D. and Xu,Y.
    The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease
    Blood (2023) 141, 1474-1488. PubMed  Europe PubMed DOI
  7. Huang,Z., Shen,S., Wang,M., Li,W., Wu,G., Huang,W., Luo,W. and Liang,G.
    Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3
    EMBO Rep (2023) 24, e56135-e56135. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Li,J.J., Wang,J.H., Tian,T., Liu,J., Zheng,Y.Q., Mo,H.Y., Sheng,H., Chen,Y.X., Wu,Q.N., Han,Y., Liao,K., Pan,Y.Q., Zeng,Z.L., Liu,Z.X., Yang,W., Xu,R.H. and Ju,H.Q.
    The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer
    Nat Commun (2023) 14, 6690-6690. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Liu,Q., Mallette,E., Zheng,H. and Zhang,W.
    Development of an OTUD1 ubiquitin variant inhibitor
    Biochem J (2023) 480, 1317-1330. PubMed  Europe PubMed DOI
  10. Wang,M., Han,X., Yu,T., Wang,M., Luo,W., Zou,C., Li,X., Li,G., Wu,G., Wang,Y. and Liang,G.
    OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes
    Theranostics (2023) 13, 2263-2280. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zhang,Q., Li,J., Chen,Z., Jiang,K., Yang,K., Huang,F., Huang,A., Zhang,X., Zhang,J. and Wang,H.
    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
    Cell Oncol (Dordr) (2023) 46, 1001-1014. PubMed  Europe PubMed DOI
    12. 2022
  12. Chen,X., Zhang,H., Wang,X., Shao,Z., Li,Y., Zhao,G., Liu,F., Liu,B., Zheng,Y., Chen,T., Zheng,H., Zhang,L. and Gao,C.
    Correction: OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9
    J Immunol (2022) 208, 1305-1306. PubMed  Europe PubMed DOI
  13. Liu,W., Yan,B., Yu,H., Ren,J., Peng,M., Zhu,L., Wang,Y., Jin,X. and Yi,L.
    OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs
    Int J Biol Sci (2022) 18, 1401-1414. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Ma,X., Wang,L., Shi,G. and Sun,S.
    The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4
    Thorac Cancer (2022) 13, 761-770. PubMed  Europe PubMed DOI  PMC  EPMC  K
  15. Oikawa,D., Gi,M., Kosako,H., Shimizu,K., Takahashi,H., Shiota,M., Hosomi,S., Komakura,K., Wanibuchi,H., Tsuruta,D., Sawasaki,T. and Tokunaga,F.
    OTUD1 deubiquitinase regulates NF-kappaB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways
    Cell Death Dis (2022) 13, 694-694. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Snaurova,R., Vdovin,A., Durech,M., Nezval,J., Zihala,D., Jelinek,T., Hajek,R. and Simicek,M.
    Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs
    Mol Cell Biol (2022) 42, e0026522-e0026522. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Vdovin,A., Jelinek,T., Zihala,D., Sevcikova,T., Durech,M., Sahinbegovic,H., Snaurova,R., Radhakrishnan,D., Turi,M., Chyra,Z., Popkova,T., Venglar,O., Hrdinka,M., Hajek,R. and Simicek,M.
    The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
    Nat Commun (2022) 13, 6820-6820. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Woo,S.M., Seo,S.U., Min,K.J. and Kwon,T.K.
    Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation
    J Pineal Res (2022) 72, e12781-e12781. PubMed  Europe PubMed DOI  K
    19. 2021
  19. Chen,X., Zhang,H., Wang,X., Shao,Z., Li,Y., Zhao,G., Liu,F., Liu,B., Zheng,Y., Chen,T., Zheng,H., Zhang,L. and Gao,C.
    OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9
    J Immunol (2021) 206, 1832-1843. PubMed  Europe PubMed DOI
  20. Luo,Q., Wu,X., Zhao,P., Nan,Y., Chang,W., Zhu,X., Su,D. and Liu,Z.
    OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation
    Adv Sci (Weinh) (2021) 8, 2002874-2002874. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Song,J., Liu,T., Yin,Y., Zhao,W., Lin,Z., Yin,Y., Lu,D. and You,F.
    The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity
    EMBO Rep (2021) , e51162-e51162. PubMed  Europe PubMed DOI
    22. 2020
  22. Wang,S., Hou,P., Pan,W., He,W., He,D.C., Wang,H. and He,H.
    DDIT3 targets innate immunity via the DDIT3-OTUD1-MAVS pathway to promote BVDV replication
    J Virol (2020) PubMed  Europe PubMed DOI  K
    23. 2018
  23. Lu,D., Song,J., Sun,Y., Qi,F., Liu,L., Jin,Y., McNutt,M.A. and Yin,Y.
    Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders
    J Autoimmun (2018) 94, 156-165. PubMed  Europe PubMed DOI  M
  24. Oikawa,D., Shiota,M., Goto,E., Komakura,K., Wanibuchi,H. and Tokunaga,F.
    Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1
    Monoclon Antib Immunodiagn Immunother (2018) 37, 180-184. PubMed  Europe PubMed DOI
  25. Zhang,L., Liu,J., Qian,L., Feng,Q., Wang,X., Yuan,Y., Zuo,Y., Cheng,Q., Miao,Y., Guo,T., Zheng,X. and Zheng,H.
    Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome
    PLoS Pathog (2018) 14, e1007067-e1007067. PubMed  Europe PubMed DOI  K
    26. 2012
  26. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0] (2012) 3, 2113-2120. DOI

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