Literature for peptidase C85.003: OTUD3 peptidase (Homo sapiens)

(Topics flags: I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Jiang,L., Xu,J., Jiang,C., Jia,Y., Zhang,Y. and Sun,T.
BHLHE22, targeted by deubiquitinating enzyme OTUD3, exerts an antitumor role in triple-negative breast cancer progression via transcriptionally inhibiting CDT1
Breast Cancer Res (2026) 28, 10-10. PubMed Europe PubMed DOI PMC EPMC

2025

Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.
Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN
Bioorg Chem (2025) 157, 108223-108223. PubMed Europe PubMed DOI
Watanabe,T. and Kudo,M.
Roles of Deubiquitinases OTUD3 and OTUD5 in Inflammatory Bowel Diseases
Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC

2024

Du,T., Gu,Q., Zhang,Y., Gan,Y., Liang,R., Yang,W., Lu,Y., Xu,C., Wu,J., Ma,R., Cao,H., Jiang,J., Wang,J. and Feng,J.
Rolapitant treats lung cancer by targeting deubiquitinase OTUD3
Cell Commun Signal (2024) 22, 195-195. PubMed Europe PubMed DOI PMC EPMC
Wu,L., Zhou,Z., Yu,Y., Cheng,C., Zhou,S., Yan,Y., Yu,B., Zhang,Y. and Liu,Z.
Phosphorylation-dependent deubiquitinase OTUD3 regulates YY1 stability and promotes colorectal cancer progression
Cell Death Dis (2024) 15, 137-137. PubMed Europe PubMed DOI PMC EPMC K

2023

Job,F., Mai,C., Villavicencio-Lorini,P., Herfurth,J., Neuhaus,H., Hoffmann,K., Pfirrmann,T. and Hollemann,T.
OTUD3: A Lys6 and Lys63 specific deubiquitinase in early vertebrate development
Biochim Biophys Acta Gene Regul Mech (2023) 1866, 194901-194901. PubMed Europe PubMed DOI
Li,J., Yang,D., Lin,Y., Xu,W., Zhao,S.M. and Wang,C.
OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN
Front Pharmacol (2023) 14, 1337732-1337732. PubMed Europe PubMed DOI PMC EPMC
Lyu,H., Sun,L., Guan,Z., Li,J., Yin,C., Zhang,Y. and Jiang,H.
Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cell Rep (2023) 42, 112309-112309. PubMed Europe PubMed DOI
Xu,Q., He,L., Zhang,S., Di,X. and Jiang,H.
Deubiquitinase OTUD3: a double-edged sword in immunity and disease
Front Cell Dev Biol (2023) 11, 1237530-1237530. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Du,T., Liu,N., Wang,J., Zhang,L., Cui,C.P., Li,C., Zhang,X., Wu,B., Zhang,J., Jiang,W., Zhang,Y., Zhang,Y., Li,H. and Li,P.
Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
Cell Death Dis (2023) 14, 378-378. PubMed Europe PubMed DOI PMC EPMC I

2022

Cai,X., Zhou,Z., Zhu,J., Liu,X., Ouyang,G., Wang,J., Li,Z., Li,X., Zha,H., Zhu,C., Rong,F., Tang,J., Liao,Q., Chen,X. and Xiao,W.
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses
Cell Rep (2022) 39, 110920-110920. PubMed Europe PubMed DOI
Jia,F., Li,H., Jiao,Q., Li,C., Fu,L., Cui,C., Jiang,H. and Zhang,L.
Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2
Cell Death Dis (2022) 13, 418-418. PubMed Europe PubMed DOI PMC EPMC
Zhou,N., Qi,H., Liu,J., Zhang,G., Liu,J., Liu,N., Zhu,M., Zhao,X., Song,C., Zhou,Z., Gong,J., Li,R., Bai,X., Jin,Y., Song,Y. and Yin,Y.
Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
Cell Metab (2022) 34, 1023-1041. PubMed Europe PubMed DOI

2021

Xie,P., Chen,Y., Zhang,H., Zhou,G., Chao,Q., Wang,J., Liu,Y., Fang,J., Xie,J., Zhen,J., Wang,Z., Hao,L. and Huang,D.
The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma
Aging (Albany NY) (2021) 13, 19317-19338. PubMed Europe PubMed DOI PMC EPMC

2020

Zhang,Z., Fang,X., Wu,X., Ling,L., Chu,F., Li,J., Wang,S., Zang,J., Zhang,B., Ye,S., Zhang,L., Yang,B., Lin,S., Huang,H., Wang,A. and Zhou,F.
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
Mol Cell (2020) 79, 304-319. PubMed Europe PubMed DOI

2012