Literature for peptidase C85.002: OTUD4 peptidase (Homo sapiens)

(Topics flags: M Mutation, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Li,Z., Guan,Y., Gao,J., Zhu,L., Zeng,Z., Jing,Q., Wan,Q., Fan,Q., Ren,X., Pei,H., Zhang,D., Rong,Y., Rong,Z., He,J., Zhang,Y., Li,N., Chen,P., Sun,L., Xu,B., Nie,Y. and Deng,Y.
   PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression
   Oncogene PubMed  Europe PubMed DOI
2. Wang,S., Tian,X., Zhong,Y., Xie,X., Gao,M., Zhang,C., Cheng,X., Qi,Y., Zhong,B., Feng,P., Lan,K. and Zhang,J.
   Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy
   PLoS Pathog21, e1013052-e1013052. PubMed  Europe PubMed DOI
2024
3. Ci,M., Zhao,G., Li,C., Liu,R., Hu,X., Pan,J., Shen,Y., Zhang,G., Li,Y., Zhang,L., Liang,P. and Cui,H.
   OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway
   Cell Death Dis15, 179-179. PubMed  Europe PubMed DOI
4. Hu,S., Yuan,Y., Yan,R., Xie,H., Cai,R. and Xu,J.
   NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
   Biochem Biophys Res Commun708, 149798-149798. PubMed  Europe PubMed DOI
5. Li,Z., Tian,Y., Zong,H., Wang,X., Li,D., Keranmu,A., Xin,S., Ye,B., Bai,R., Chen,W., Yang,G., Ye,L. and Wang,S.
   Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells
   Apoptosis29, 1051-1069. PubMed  Europe PubMed DOI
6. Ma,X., Wan,R., Wen,Y., Liu,T., Song,Y. and Zhu,Y.
   Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
   Exp Cell Res434, 113864-113864. PubMed  Europe PubMed DOI
7. Wang,S., Tian,X., Zhou,Y., Xie,J., Gao,M., Zhong,Y., Zhang,C., Yu,K., Bai,L., Qin,Q., Zhong,B., Lin,D., Feng,P., Lan,K. and Zhang,J.
   Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases
   PLoS Pathog20, e1011943-e1011943. PubMed  Europe PubMed DOI
2023
8. Gao,Y., Tang,J., Ma,X., Zhang,C., Huang,L., Che,J., Wen,Y., Zhang,Y., Zhu,Y., Liu,T. and Zhang,H.
   OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1
   J Cell Physiol238, 2546-2555. PubMed  Europe PubMed DOI
9. Wang,F., Yin,X., Fan,Y.M., Zhang,X., Ma,C., Jia,K., Zhou,W., Tang,Z., Qi,L.W. and Li,J.
   Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
   J Mol Med (Berl)101, 743-756. PubMed  Europe PubMed DOI
10. Yu,K., Guo,Y.Y., Liuyu,T., Wang,P., Zhang,Z.D., Lin,D. and Zhong,B.
    The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection
    Cell Insight2, 100100-100100. PubMed  Europe PubMed DOI
2022
11. Kedia,S., Aghanoori,M.R., Burns,K.M.L., Subha,M., Williams,L., Wen,P., Kopp,D., Erickson,S.L., Harvey,E.M., Chen,X., Hua,M., Perez,J.U., Ishraque,F. and Yang,G.
    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
    Cell Rep40, 111070-111070. PubMed  Europe PubMed DOI
12. Ye,H., Kang,L., Yan,X., Li,S., Huang,Y., Mu,R., Duan,X. and Chen,L.
    MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway
    Front Microbiol13, 862580-862580. PubMed  Europe PubMed DOI  K
2020
13. Liu,H., Fan,J., Zhang,W., Chen,Q., Zhang,Y. and Wu,Z.
    OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6
    Biochem Biophys Res Commun523, 924-930. PubMed  Europe PubMed DOI
2019
14. Liuyu,T., Yu,K., Ye,L., Zhang,Z., Zhang,M., Ren,Y., Cai,Z., Zhu,Q., Lin,D. and Zhong,B.
    Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS
    Cell Res29, 67-79. PubMed  Europe PubMed DOI
2018
15. Zhao,Y., Mudge,M.C., Soll,J.M., Rodrigues,R.B., Byrum,A.K., Schwarzkopf,E.A., Bradstreet,T.R., Gygi,S.P., Edelson,B.T. and Mosammaparast,N.
    OTUD4 Is a phospho-activated K63 deubiquitinase that regulates MyD88-dependent signaling
    Mol Cell69, 505-516. PubMed  Europe PubMed DOI
2015
16. Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and Mosammaparast,N.
    Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase
    EMBO J34, 1687-1703. PubMed  Europe PubMed DOI
2013
17. Margolin,D.H., Kousi,M., Chan,Y.M., Lim,E.T., Schmahmann,J.D., Hadjivassiliou,M., Hall,J.E., Adam,I., Dwyer,A., Plummer,L., Aldrin,S.V., O'Rourke,J., Kirby,A., Lage,K., Milunsky,A., Milunsky,J.M., Chan,J., Hedley-Whyte,E.T., Daly,M.J., Katsanis,N. and Seminara,S.B.
    Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination
    N Engl J Med368, 1992-2003. PubMed  Europe PubMed DOI  M
18. Tse,W.K., Jiang,Y.J. and Wong,C.K.
    Zebrafish transforming growth factor-beta-stimulated clone 22 domain 3 (TSC22D3) plays critical roles in Bmp-dependent dorsoventral patterning via two deubiquitylating enzymes Usp15 and Otud4
    Biochim Biophys Acta1830, 4584-4593. PubMed  Europe PubMed DOI
2009
19. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics10, 637-637. PubMed  Europe PubMed DOI