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Literature for peptidase C85.002: OTUD4 peptidase (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: M Mutation, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Liang,B., Hu,A., Lu,H., Zhou,H., Chen,Q., Jia,C., Wang,J., Jiang,L., Hong,W., Zhou,J. and Dong,J.
    OTUD4-ZMYND8-DDX3X Axis Drives Immunosuppressive Microenvironment in Spinal Metastases of Triple-Negative Breast Cancer
    Neoplasia (2026) 71, 101259-101259. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Li,Z., Guan,Y., Gao,J., Zhu,L., Zeng,Z., Jing,Q., Wan,Q., Fan,Q., Ren,X., Pei,H., Zhang,D., Rong,Y., Rong,Z., He,J., Zhang,Y., Li,N., Chen,P., Sun,L., Xu,B., Nie,Y. and Deng,Y.
    PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression
    Oncogene (2025) PubMed  Europe PubMed DOI
  3. Liu,Z., Wang,X., Wu,L., Min,L., Sheng,Y., Sun,Z., Deng,Y., Miao,L., Liu,Y., Li,J. and Zhao,Y.
    The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-kappaB signaling and inflammation
    J Biol Chem (2025) , 110784-110784. PubMed  Europe PubMed DOI
  4. Mercer,M., Dasgupta,A., Pawlowski,K. and Buszczak,M.
    Bourbon and Mycbp function with Otu to promote Sxl protein expression in the Drosophila female germline
    Proc Natl Acad Sci U S A (2025) 122, e2426524122-e2426524122. PubMed  Europe PubMed DOI
  5. Wang,S., Tian,X., Zhong,Y., Xie,X., Gao,M., Zhang,C., Cheng,X., Qi,Y., Zhong,B., Feng,P., Lan,K. and Zhang,J.
    Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy
    PLoS Pathog (2025) 21, e1013052-e1013052. PubMed  Europe PubMed DOI
    6. 2024
  6. Ci,M., Zhao,G., Li,C., Liu,R., Hu,X., Pan,J., Shen,Y., Zhang,G., Li,Y., Zhang,L., Liang,P. and Cui,H.
    OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway
    Cell Death Dis (2024) 15, 179-179. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Hu,S., Yuan,Y., Yan,R., Xie,H., Cai,R. and Xu,J.
    NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
    Biochem Biophys Res Commun (2024) 708, 149798-149798. PubMed  Europe PubMed DOI
  8. Li,Z., Tian,Y., Zong,H., Wang,X., Li,D., Keranmu,A., Xin,S., Ye,B., Bai,R., Chen,W., Yang,G., Ye,L. and Wang,S.
    Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells
    Apoptosis (2024) 29, 1051-1069. PubMed  Europe PubMed DOI
  9. Ma,X., Wan,R., Wen,Y., Liu,T., Song,Y. and Zhu,Y.
    Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
    Exp Cell Res (2024) 434, 113864-113864. PubMed  Europe PubMed DOI
  10. Wang,S., Tian,X., Zhou,Y., Xie,J., Gao,M., Zhong,Y., Zhang,C., Yu,K., Bai,L., Qin,Q., Zhong,B., Lin,D., Feng,P., Lan,K. and Zhang,J.
    Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases
    PLoS Pathog (2024) 20, e1011943-e1011943. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2023
  11. Gao,Y., Tang,J., Ma,X., Zhang,C., Huang,L., Che,J., Wen,Y., Zhang,Y., Zhu,Y., Liu,T. and Zhang,H.
    OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1
    J Cell Physiol (2023) 238, 2546-2555. PubMed  Europe PubMed DOI
  12. Wang,F., Yin,X., Fan,Y.M., Zhang,X., Ma,C., Jia,K., Zhou,W., Tang,Z., Qi,L.W. and Li,J.
    Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
    J Mol Med (Berl) (2023) 101, 743-756. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Yu,K., Guo,Y.Y., Liuyu,T., Wang,P., Zhang,Z.D., Lin,D. and Zhong,B.
    The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection
    Cell Insight (2023) 2, 100100-100100. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2022
  14. Kedia,S., Aghanoori,M.R., Burns,K.M.L., Subha,M., Williams,L., Wen,P., Kopp,D., Erickson,S.L., Harvey,E.M., Chen,X., Hua,M., Perez,J.U., Ishraque,F. and Yang,G.
    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
    Cell Rep (2022) 40, 111070-111070. PubMed  Europe PubMed DOI
  15. Ye,H., Kang,L., Yan,X., Li,S., Huang,Y., Mu,R., Duan,X. and Chen,L.
    MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway
    Front Microbiol (2022) 13, 862580-862580. PubMed  Europe PubMed DOI  PMC  EPMC  K
    16. 2020
  16. Liu,H., Fan,J., Zhang,W., Chen,Q., Zhang,Y. and Wu,Z.
    OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6
    Biochem Biophys Res Commun (2020) 523, 924-930. PubMed  Europe PubMed DOI
    17. 2019
  17. Liuyu,T., Yu,K., Ye,L., Zhang,Z., Zhang,M., Ren,Y., Cai,Z., Zhu,Q., Lin,D. and Zhong,B.
    Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS
    Cell Res (2019) 29, 67-79. PubMed  Europe PubMed DOI
    18. 2018
  18. Zhao,Y., Mudge,M.C., Soll,J.M., Rodrigues,R.B., Byrum,A.K., Schwarzkopf,E.A., Bradstreet,T.R., Gygi,S.P., Edelson,B.T. and Mosammaparast,N.
    OTUD4 Is a phospho-activated K63 deubiquitinase that regulates MyD88-dependent signaling
    Mol Cell (2018) 69, 505-516. PubMed  Europe PubMed DOI
    19. 2015
  19. Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and Mosammaparast,N.
    Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase
    EMBO J (2015) 34, 1687-1703. PubMed  Europe PubMed DOI
    20. 2013
  20. Margolin,D.H., Kousi,M., Chan,Y.M., Lim,E.T., Schmahmann,J.D., Hadjivassiliou,M., Hall,J.E., Adam,I., Dwyer,A., Plummer,L., Aldrin,S.V., O'Rourke,J., Kirby,A., Lage,K., Milunsky,A., Milunsky,J.M., Chan,J., Hedley-Whyte,E.T., Daly,M.J., Katsanis,N. and Seminara,S.B.
    Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination
    N Engl J Med (2013) 368, 1992-2003. PubMed  Europe PubMed DOI  M
  21. Tse,W.K., Jiang,Y.J. and Wong,C.K.
    Zebrafish transforming growth factor-beta-stimulated clone 22 domain 3 (TSC22D3) plays critical roles in Bmp-dependent dorsoventral patterning via two deubiquitylating enzymes Usp15 and Otud4
    Biochim Biophys Acta (2013) 1830, 4584-4593. PubMed  Europe PubMed DOI
    22. 2009
  22. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics (2009) 10, 637-637. PubMed  Europe PubMed DOI

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