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Literature for peptidase C85.001: OTUD5 peptidase (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jin,S.K. and Baek,K.H.
    Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers
    Biochim Biophys Acta Rev Cancer (2025) 1880, 189297-189297. PubMed  Europe PubMed DOI  V
  2. Morita,M., Takao,M., Tokuhisa,H., Chiba,R., Tomomatsu,S., Akizuki,Y., Tomita,T., Endo,A., Saeki,Y., Sato,Y. and Ohtake,F.
    Combinatorial ubiquitin code degrades deubiquitylation-protected substrates
    Nat Commun (2025) 16, 2496-2496. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Watanabe,T. and Kudo,M.
    Roles of Deubiquitinases OTUD3 and OTUD5 in Inflammatory Bowel Diseases
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zhang,J., Tian,T., Li,X., Xu,K., Lu,Y., Li,X., Zhao,X., Cui,Z., Wang,Z., Zhou,Y., Xu,Y., Li,H., Zhang,Y., Du,Y., Lv,L. and Xu,Y.
    p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer
    Clin Transl Med (2025) 15, e70271-e70271. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zhou,B., Yin,M., Su,X., Sheng,S., Du,X., Shen,J., Chen,K., Wang,D., Zhu,Z., Xu,Y., Li,Z., Li,J., Li,Y., Ruan,J. and Wang,X.
    DUBA sustains the stability of NOD2 and RIPK2 to enhance innate immune responses
    Cell Death Differ (2025) PubMed  Europe PubMed DOI
  6. Zhu,Z., Li,Z., Lambertsen,K.L., Cao,Z., Chen,M., Xu,Y., Clausen,B.H., Jin,K., Lu,Y., Mei,F., Du,X., Chen,K., Bai,H., Su,X., Zhou,B., Liu,B., Li,R., Wang,C., Li,Y., Cai,X., Schluter,D., Song,W. and Wang,X.
    Regulation of Neuroinflammation by Microglial DUBA-IRAK1-IKKbeta Signaling Loop
    Adv Sci (Weinh) (2025) , e03972-e03972. PubMed  Europe PubMed DOI
    7. 2024
  7. Dai,J., Zhang,L., Zhang,R., Ge,J., Yao,F., Zhou,S., Xu,J., Yu,K., Xu,J., Jiang,L., Jin,K., Dai,X., Li,J. and Li,Q.
    Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis
    Cell Mol Gastroenterol Hepatol (2024) 17, 399-421. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Lam,S.Y., van der Lugt,R., Cerutti,A., Yalcin,Z., Thouin,A.M., Simonetta,M. and Jacobs,J.J.L.
    OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1(S824)
    Nat Commun (2024) 15, 8960-8960. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.
    USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
    Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  10. Tian,W., Li,H., Li,Y., Guo,J., Wang,H., Yang,B., Li,P., Cui,X. and Liu,L.
    A novel missense variant in OTUD5 causes X-linked multiple congenital anomalies-neurodevelopmental syndrome
    Mol Genet Genomic Med (2024) 12, e2325-e2325. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zhao,Y., Fan,S., Zhu,H., Zhao,Q., Fang,Z., Xu,D., Lin,W., Lin,L., Hu,X., Wu,G., Min,J. and Liang,G.
    Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury
    Nat Commun (2024) 15, 5441-5441. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2023
  12. de Vivo,A., Song,H., Lee,Y., Tirado-Class,N., Sanchez,A., Westerheide,S., Dungrawala,H. and Kee,Y.
    OTUD5 limits replication fork instability by organizing chromatin remodelers
    Nucleic Acids Res (2023) 51, 10467-10483. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Fu,L., Lu,K., Jiao,Q., Chen,X. and Jia,F.
    The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Liu,L., Pang,J., Qin,D., Li,R., Zou,D., Chi,K., Wu,W., Rui,H., Yu,H., Zhu,W., Liu,K., Wu,X., Wang,J., Xu,P., Song,X., Cao,Y., Wang,J., Xu,F., Xue,L. and Chen,Y.
    Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury
    Adv Sci (Weinh) (2023) 10, e2301852-e2301852. PubMed  Europe PubMed DOI  PMC  EPMC  I
  15. Lou,B., Ma,G., Yu,X., Lv,F., Xu,F., Sun,C. and Chen,Y.
    Deubiquitinase OTUD5 promotes hepatitis B virus replication by removing K48-linked ubiquitination of HBV core/precore and upregulates HNF4a expressions by inhibiting the ERK1/2/mitogen-activated protein kinase pathway
    Cell Mol Life Sci (2023) 80, 336-336. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Masuta,Y., Otsuka,Y., Minaga,K., Honjo,H., Kudo,M. and Watanabe,T.
    Regulation of type I IFN responses by deubiquitinating enzyme A in inflammatory bowel diseases
    J Clin Biochem Nutr (2023) 73, 103-107. PubMed  Europe PubMed DOI  PMC  EPMC  V
    17. 2022
  17. Hou,T., Dan,W., Liu,T., Liu,B., Wei,Y., Yue,C., Que,T., Ma,B., Lei,Y., Wang,Z., Zeng,J., Fan,Y. and Li,L.
    Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression
    Cell Death Dis (2022) 13, 778-778. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Li,X., Lu,B., Zhang,L., Yang,J., Cheng,Y. and Yan,D.
    Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration
    Bosn J Basic Med Sci (2022) 22, 901-911. PubMed  Europe PubMed DOI
  19. Pahi,Z.G., Kovacs,L., Szucs,D., Borsos,B.N., Deak,P. and Pankotai,T.
    Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster
    Sci Rep (2022) 12, 5870-5870. PubMed  Europe PubMed DOI  PMC  EPMC  K
    20. 2021
  20. Kabra,A. and Li,Y.
    Conformational Dynamics of Deubiquitinase A and Functional Implications
    Biochemistry (2021) 60, 201-209. PubMed  Europe PubMed DOI
  21. Saida,K., Fukuda,T., Scott,D.A., Sengoku,T., Ogata,K., Nicosia,A., Hernandez-Garcia,A., Lalani,S.R., Azamian,M.S., Streff,H., Liu,P., Dai,H., Mizuguchi,T., Miyatake,S., Asahina,M., Ogata,T., Miyake,N. and Matsumoto,N.
    OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation
    Front Cell Dev Biol (2021) 9, 631428-631428. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zhang,Y., Fan,Y., Jing,X., Zhao,L., Liu,T., Wang,L., Zhang,L., Gu,S., Zhao,X. and Teng,Y.
    OTUD5-mediated deubiquitination of YAP in macrophage promotes M2 phenotype polarization and favors triple-negative breast cancer progression
    Cancer Lett (2021) 504, 104-115. PubMed  Europe PubMed DOI
    23. 2020
  23. Bai,M., Che,Y., Lu,K. and Fu,L.
    Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis
    PeerJ (2020) 8, e9146-e9146. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Cho,J.H., Kim,K., Kim,S.A., Park,S., Park,B.O., Kim,J.H., Kim,S.Y., Kwon,M.J., Han,M.H., Lee,S.B., Park,B.C., Park,S.G., Kim,J.H. and Kim,S.
    Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways
    Cell Death Differ (2020) PubMed  Europe PubMed DOI  K
  25. Kabra,A., Rumpa,E. and Li,Y.
    Modulation of conformational equilibrium by phosphorylation underlies the activation of deubiquitinase A
    J Biol Chem (2020) 295, 3945-3951. PubMed  Europe PubMed DOI
  26. Kang,X.Y., Zhang,J., Tang,L., Huang,L., Tong,J. and Fu,Q.
    OTU Deubiquitinase 5 inhibits the progression of non-small cell lung cancer via regulating p53 and PDCD5
    Chem Biol Drug Des (2020) PubMed  Europe PubMed DOI
  27. Li,F., Sun,Q., Liu,K., Zhang,L., Lin,N., You,K., Liu,M., Kon,N., Tian,F., Mao,Z., Li,T., Tong,T., Qin,J., Gu,W., Li,D. and Zhao,W.
    OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity
    Nat Commun (2020) 11, 4184-4184. PubMed  Europe PubMed DOI  PMC  EPMC  K
    28. 2019
  28. de Vivo,A., Sanchez,A., Yegres,J., Kim,J., Emly,S. and Kee,Y.
    The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin
    Nucleic Acids Res (2019) 47, 729-746. PubMed  Europe PubMed DOI
  29. Kabra,A., Benson,C.A. and Li,Y.
    Backbone (1)H, (13)C, and (15)N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms
    Biomol NMR Assign (2019) 13, 37-42. PubMed  Europe PubMed DOI  S
  30. Li,F., Sun,Q., Liu,K., Han,H., Lin,N., Cheng,Z., Cai,Y., Tian,F., Mao,Z., Tong,T. and Zhao,W.
    The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining
    Cell Mol Life Sci (2019) 76, 3861-3873. PubMed  Europe PubMed DOI
  31. Yin,F., He,H., Zhang,B., Zheng,J., Wang,M., Zhang,M. and Cui,H.
    Effect of deubiquitinase ovarian tumor domain-containing protein 5 (OTUD5) on radiosensitivity of cervical cancer by regulating the ubiquitination of Akt and its mechanism
    Med Sci Monit (2019) 25, 3469-3475. PubMed  Europe PubMed DOI
    32. 2018
  32. Suen,D.F., Tsai,Y.H., Cheng,Y.T., Radjacommare,R., Ahirwar,R.N., Fu,H. and Schmidt,W.
    The deubiquitinase OTU5 regulates root responses to phosphate starvation
    Plant Physiol (2018) 176, 2441-2455. PubMed  Europe PubMed DOI
  33. Suen,D.F. and Schmidt,W.
    OTU5 Tunes environmental responses by sustaining chromatin structure
    Plant Signal Behav (2018) 13, e1435963-e1435963. PubMed  Europe PubMed DOI
    34. 2017
  34. Yen,M.R., Suen,D.F., Hsu,F.M., Tsai,Y.H., Fu,H., Schmidt,W. and Chen,P.Y.
    Deubiquitinating enzyme OTU5 contributes to DNA methylation patterns and is critical for phosphate nutrition signals
    Plant Physiol (2017) 175, 1826-1838. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2016
  35. Keren,I. and Citovsky,V.
    The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth
    Sci Signal (2016) 9, ra125-ra125. PubMed  Europe PubMed DOI
    36. 2013
  36. Huang,O.W. and Cochran,A.G.
    Regulation of deubiquitinase proteolytic activity
    Curr Opin Struct Biol (2013) 23, 806-811. PubMed  Europe PubMed DOI  S
  37. Luo,J., Lu,Z., Lu,X., Chen,L., Cao,J., Zhang,S., Ling,Y. and Zhou,X.
    OTUD5 regulates p53 stability by deubiquitinating p53
    PLoS ONE (2013) 8, e77682-e77682. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2012
  38. Huang,O.W., Ma,X., Yin,J., Flinders,J., Maurer,T., Kayagaki,N., Phung,Q., Bosanac,I., Arnott,D., Dixit,V.M., Hymowitz,S.G., Starovasnik,M.A. and Cochran,A.G.
    Phosphorylation-dependent activity of the deubiquitinase DUBA
    Nat Struct Mol Biol (2012) 19, 171-175. PubMed  Europe PubMed DOI  S  I
  39. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0] (2012) 3, 2113-2120. DOI
  40. Renatus,M. and Farady,C.J.
    Phosphorylation meets proteolysis
    Structure (2012) 20, 570-571. PubMed  Europe PubMed DOI
    41. 2011
  41. Krichevsky,A., Zaltsman,A., Lacroix,B. and Citovsky,V.
    Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression
    Proc Natl Acad Sci U S A (2011) 108, 11157-11162. PubMed  Europe PubMed DOI
    42. 2010
  42. Gonzalez-Navajas,J.M., Law,J., Nguyen,K.P., Bhargava,M., Corr,M.P., Varki,N., Eckmann,L., Hoffman,H.M., Lee,J. and Raz,E.
    Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
    J Exp Med (2010) 207, 2799-2807. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2007
  43. Kayagaki,N., Phung,Q., Chan,S., Chaudhari,R., Quan,C., O'Rourke,K.M., Eby,M., Pietras,E., Cheng,G., Bazan,J.F., Zhang,Z., Arnott,D. and Dixit,V.M.
    DUBA: a deubiquitinase that regulates type I interferon production
    Science (2007) 318, 1628-1632. PubMed  Europe PubMed DOI

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