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Literature for peptidase C83.002: phytochelatin synthase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Su,H., Zou,T., Lin,R., Zheng,J., Jian,S. and Zhang,M.<br>Characterization of a phytochelatin synthase gene from Ipomoea pes-caprae involved in cadmium tolerance and accumulation in yeast and plants<br>Plant Physiol Biochem (2020) 155, 743-755. PubMed  Europe PubMed DOI
    2. 2017
  2. Hayashi,S., Kuramata,M., Abe,T., Takagi,H., Ozawa,K. and Ishikawa,S.<br>Phytochelatin synthase OsPCS1 plays a crucial role in reducing arsenic levels in rice grains<br>Plant J (2017) 91, 840-848. PubMed  Europe PubMed DOI
  3. Zayneb,C., Imen,R.H., Walid,K., Grubb,C.D., Bassem,K., Franck,V., Hafedh,M. and Amine,E.<br>The phytochelatin synthase gene in date palm (Phoenix dactylifera L.): phylogeny, evolution and expression<br>Ecotoxicol Environ Saf (2017) 140, 7-17. PubMed  Europe PubMed DOI
    4. 2013
  4. Chia,J.C., Yang,C.C., Sui,Y.T., Lin,S.Y. and Juang,R.H.<br>Tentative identification of the second substrate binding site in Arabidopsis phytochelatin synthase<br>PLoS ONE (2013) 8, e82675-e82675. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2012
  5. Arnoux,P., Pignol,D. and Gully,D.<br>Phytochelatin synthase: from hydrolase to transferase<br>[ISSN:978-0-12-407743-0] (2012) 3, 2178-2183. DOI
  6. Liu,Z., Gu,C., Chen,F., Yang,D., Wu,K., Chen,S., Jiang,J. and Zhang,Z.<br>Heterologous expression of a Nelumbo nucifera phytochelatin synthase gene enhances cadmium tolerance in Arabidopsis thaliana<br>Appl Biochem Biotechnol (2012) 166, 722-734. PubMed  Europe PubMed DOI
  7. Rea,P.A.<br>Phytochelatin synthase: of a protease a peptide polymerase made<br>Physiol Plant (2012) 145, 154-164. PubMed  Europe PubMed DOI
  8. Shukla,D., Kesari,R., Mishra,S., Dwivedi,S., Tripathi,R.D., Nath,P. and Trivedi,P.K.<br>Expression of phytochelatin synthase from aquatic macrophyte Ceratophyllum demersum L. enhances cadmium and arsenic accumulation in tobacco<br>Plant Cell Rep (2012) 31, 1687-1699. PubMed  Europe PubMed DOI
    9. 2011
  9. Bolchi,A., Ruotolo,R., Marchini,G., Vurro,E., di Toppi,L.S., Kohler,A., Tisserant,E., Martin,F. and Ottonello,S.<br>Genome-wide inventory of metal homeostasis-related gene products including a functional phytochelatin synthase in the hypogeous mycorrhizal fungus Tuber melanosporum<br>Fungal Genet Biol (2011) 48, 573-584. PubMed  Europe PubMed DOI
  10. Brunetti,P., Zanella,L., Proia,A., De Paolis,A., Falasca,G., Altamura,M.M., Sanita di Toppi,L., Costantino,P. and Cardarelli,M.<br>Cadmium tolerance and phytochelatin content of Arabidopsis seedlings over-expressing the phytochelatin synthase gene AtPCS1<br>J Exp Bot (2011) 62, 5509-5519. PubMed  Europe PubMed DOI
  11. Liu,G.Y., Zhang,Y.X. and Chai,T.Y.<br>Phytochelatin synthase of Thlaspi caerulescens enhanced tolerance and accumulation of heavy metals when expressed in yeast and tobacco<br>Plant Cell Rep (2011) 30, 1067-1076. PubMed  Europe PubMed DOI
  12. Ogawa,S., Yoshidomi,T. and Yoshimura,E.<br>Cadmium(II)-stimulated enzyme activation of Arabidopsis thaliana phytochelatin synthase 1<br>J Inorg Biochem (2011) 105, 111-117. PubMed  Europe PubMed DOI
    13. 2010
  13. Blum,R., Meyer,K.C., Wunschmann,J., Lendzian,K.J. and Grill,E.<br>Cytosolic action of phytochelatin synthase<br>Plant Physiol (2010) 153, 159-169. PubMed  Europe PubMed DOI
  14. Ogawa,S., Yoshidomi,T., Shirabe,T. and Yoshimura,E.<br>HPLC method for the determination of phytochelatin synthase activity specific for soft metal ion chelators<br>J Inorg Biochem (2010) 104, 442-445. PubMed  Europe PubMed DOI  A
    15. 2009
  15. Li,A.M., Yu,B.Y., Chen,F.H., Gan,H.Y., Yuan,J.G., Qiu,R., Huang,J.C., Yang,Z.Y. and Xu,Z.F.<br>Characterization of the Sesbania rostrata phytochelatin synthase gene: alternative splicing and function of four isoforms<br>Int J Mol Sci (2009) 10, 3269-3282. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Wang,H.C., Wu,J.S., Chia,J.C., Yang,C.C., Wu,Y.J. and Juang,R.H.<br>Phytochelatin synthase is regulated by protein phosphorylation at a threonine residue near its catalytic site<br>J Agric Food Chem (2009) 57, 7348-7355. PubMed  Europe PubMed DOI
    17. 2008
  17. Brulle,F., Cocquerelle,C., Wamalah,A.N., Morgan,A.J., Kille,P., Lepretre,A. and Vandenbulcke,F.<br>cDNA cloning and expression analysis of Eisenia fetida (Annelida: Oligochaeta) phytochelatin synthase under cadmium exposure<br>Ecotoxicol Environ Saf (2008) 71, 47-55. PubMed  Europe PubMed DOI
  18. Ramos,J., Naya,L., Gay,M., Abian,J. and Becana,M.<br>Functional characterization of an unusual phytochelatin synthase, LjPCS3, of Lotus japonicus<br>Plant Physiol (2008) 148, 536-545. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Singh,S., Lee,W., Dasilva,N.A., Mulchandani,A. and Chen,W.<br>Enhanced arsenic accumulation by engineered yeast cells expressing Arabidopsis thaliana phytochelatin synthase<br>Biotechnol Bioeng (2008) 99, 333-340. PubMed  Europe PubMed DOI
  20. Vestergaard,M., Matsumoto,S., Nishikori,S., Shiraki,K., Hirata,K. and Takagi,M.<br>Chelation of cadmium ions by phytochelatin synthase: role of the cysteine-rich C-terminal<br>Anal Sci (2008) 24, 277-281. PubMed  Europe PubMed DOI
    21. 2007
  21. Blum,R., Beck,A., Korte,A., Stengel,A., Letzel,T., Lendzian,K. and Grill,E.<br>Function of phytochelatin synthase in catabolism of glutathione-conjugates<br>Plant J (2007) 49, 740-749. PubMed  Europe PubMed DOI
  22. Gasic,K. and Korban,S.S.<br>Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance<br>Plant Mol Biol (2007) 64, 361-369. PubMed  Europe PubMed DOI
  23. Gasic,K. and Korban,S.S.<br>Expression of Arabidopsis phytochelatin synthase in Indian mustard (Brassica juncea) plants enhances tolerance for Cd and Zn<br>Planta (2007) 225, 1277-1285. PubMed  Europe PubMed DOI
    24. 2006
  24. Grzam,A., Tennstedt,P., Clemens,S., Hell,R. and Meyer,A.J.<br>Vacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthase<br>FEBS Lett (2006) 580, 6384-6390. PubMed  Europe PubMed DOI
  25. Konishi,T., Matsumoto,S., Tsuruwaka,Y., Shiraki,K., Hirata,K., Tamaru,Y. and Takagi,M.<br>Enhancing the tolerance of zebrafish (Danio rerio) to heavy metal toxicity by the expression of plant phytochelatin synthase<br>J Biotechnol (2006) 122, 316-325. PubMed  Europe PubMed DOI
  26. Peterson,A.G. and Oliver,D.J.<br>Leaf-targeted phytochelatin synthase in Arabidopsis thaliana<br>Plant Physiol Biochem (2006) 44, 885-892. PubMed  Europe PubMed DOI
  27. Picault,N., Cazale,A.C., Beyly,A., Cuine,S., Carrier,P., Luu,D.T., Forestier,C. and Peltier,G.<br>Chloroplast targeting of phytochelatin synthase in Arabidopsis: effects on heavy metal tolerance and accumulation<br>Biochimie (2006) 88, 1743-1750. PubMed  Europe PubMed DOI
  28. Pomponi,M., Censi,V., Di Girolamo,V., De Paolis,A., di Toppi,L.S., Aromolo,R., Costantino,P. and Cardarelli,M.<br>Overexpression of Arabidopsis phytochelatin synthase in tobacco plants enhances Cd(2+) tolerance and accumulation but not translocation to the shoot<br>Planta (2006) 223, 180-190. PubMed  Europe PubMed DOI
  29. Rea,P.A.<br>Phytochelatin synthase, papain's cousin, in stereo<br>Proc Natl Acad Sci U S A (2006) 103, 507-508. PubMed  Europe PubMed DOI  PMC  EPMC
  30. [YEAR:19-5-2006]Romanyuk,N.D., Rigden,D.J., Vatamaniuk,O.K., Lang,A., Cahoon,R.E., Jez,J.M. and Rea,P.A.<br>Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase<br>Plant Physiol (19-5-2006) 141, 858-869. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2005
  31. Dong,R., Formentin,E., Losseso,C., Carimi,F., Benedetti,P., Terzi,M. and Schiavo,F.L.<br>Molecular cloning and characterization of a phytochelatin synthase gene, PvPCS1, from Pteris vittata L<br>J Ind Microbiol Biotechnol (2005) 32, 527-533. PubMed  Europe PubMed DOI
  32. Tsuji,N., Nishikori,S., Iwabe,O., Matsumoto,S., Shiraki,K., Miyasaka,H., Takagi,M., Miyamoto,K. and Hirata,K.<br>Comparative analysis of the two-step reaction catalyzed by prokaryotic and eukaryotic phytochelatin synthase by an ion-pair liquid chromatography assay<br>Planta (2005) 222, 181-191. PubMed  Europe PubMed DOI
  33. [YEAR:27-12-2005]Vivares,D., Arnoux,P. and Pignol,D.<br>A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis<br>Proc Natl Acad Sci U S A (27-12-2005) 102, 18848-18853. PubMed  Europe PubMed DOI  PMC  EPMC  S
    34. 2004
  34. Li,Y., Dhankher,O.P., Carreira,L., Lee,D., Chen,A., Schroeder,J.I., Balish,R.S. and Meagher,R.B.<br>Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity<br>Plant Cell Physiol (2004) 45, 1787-1797. PubMed  Europe PubMed DOI
  35. Rea,P.A., Vatamaniuk,O.K. and Rigden,D.J.<br>Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase<br>Plant Physiol (2004) 136, 2463-2474. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Ruotolo,R., Peracchi,A., Bolchi,A., Infusini,G., Amoresano,A. and Ottonello,S.<br>Domain organization of phytochelatin synthase: functional properties of truncated enzyme species identified by limited proteolysis<br>J Biol Chem (2004) 279, 14686-14693. PubMed  Europe PubMed DOI
  37. [YEAR:21-5-2004]Vatamaniuk,O.K., Mari,S., Lang,A., Chalasani,S., Demkiv,L.O. and Rea,P.A.<br>Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis<br>J Biol Chem (21-5-2004) 279, 22449-22460. PubMed  Europe PubMed DOI
    38. 2003
  38. Beck,A., Lendzian,K., Oven,M., Christmann,A. and Grill,E.<br>Phytochelatin synthase catalyzes key step in turnover of glutathione conjugates<br>Phytochemistry (2003) 62, 423-431. PubMed  Europe PubMed DOI
  39. Heiss,S., Wachter,A., Bogs,J., Cobbett,C. and Rausch,T.<br>Phytochelatin synthase (PCS) protein is induced in Brassica juncea leaves after prolonged Cd exposure<br>J Exp Bot (2003) 54, 1833-1839. PubMed  Europe PubMed DOI
  40. Lee,S., Moon,J.S., Ko,T.S., Petros,D., Goldsbrough,P.B. and Korban,S.S.<br>Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress<br>Plant Physiol (2003) 131, 656-663. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Maier,T., Yu,C., Kullertz,G. and Clemens,S.<br>Localization and functional characterization of metal-binding sites in phytochelatin synthases<br>Planta (2003) 218, 300-308. PubMed  Europe PubMed DOI
  42. Sauge-Merle,S., Cuine,S., Carrier,P., Lecomte-Pradines,C., Luu,D.T. and Peltier,G.<br>Enhanced toxic metal accumulation in engineered bacterial cells expressing Arabidopsis thaliana phytochelatin synthase<br>Appl Environ Microbiol (2003) 69, 490-494. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Sriprang,R., Hayashi,M., Ono,H., Takagi,M., Hirata,K. and Murooka,Y.<br>Enhanced accumulation of Cd2+ by a Mesorhizobium sp. transformed with a gene from Arabidopsis thaliana coding for phytochelatin synthase<br>Appl Environ Microbiol (2003) 69, 1791-1796. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2002
  44. Lee,S. and Korban,S.S.<br>Transcriptional regulation of Arabidopsis thaliana phytochelatin synthase (AtPCS1) by cadmium during early stages of plant development<br>Planta (2002) 215, 689-693. PubMed  Europe PubMed DOI
  45. Oven,M., Page,J.E., Zenk,M.H. and Kutchan,T.M.<br>Molecular characterization of the homo-phytochelatin synthase of soybean Glycine max: relation to phytochelatin synthase<br>J Biol Chem (2002) 277, 4747-4754. PubMed  Europe PubMed DOI
    46. 2000
  46. [YEAR:6-10-2000]Vatamaniuk,O.K., Mari,S., Lu,Y.P. and Rea,P.A.<br>Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides<br>J Biol Chem (6-10-2000) 275, 31451-31459. PubMed  Europe PubMed DOI
  47. Yan,S.L., Tsay,C.C. and Chen,Y.R.<br>Isolation and characterization of phytochelatin synthase in rice seedlings<br>Proc Natl Sci Counc Repub China B (2000) 24, 202-207. PubMed  Europe PubMed
    48. 1999
  48. Cobbett,C.S.<br>A family of phytochelatin synthase genes from plant, fungal and animal species<br>Trends Plant Sci (1999) 4, 335-337. PubMed  Europe PubMed
  49. Ha,S.B., Smith,A.P., Howden,R., Dietrich,W.M., Bugg,S., O'Connell,M.J., Goldsbrough,P.B. and Cobbett,C.S.<br>Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe<br>Plant Cell (1999) 11, 1153-1164. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Vatamaniuk,O.K., Mari,S., Lu,Y.P. and Rea,P.A.<br>AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution<br>Proc Natl Acad Sci U S A (1999) 96, 7110-7115. PubMed  Europe PubMed DOI  PMC  EPMC
    51. 1995
  51. Howden,R., Goldsbrough,P.B., Andersen,C.R. and Cobbett,C.S.<br>Cadmium-sensitive, cad1 mutants of Arabidopsis thaliana are phytochelatin deficient<br>Plant Physiol (1995) 107, 1059-1066. PubMed  Europe PubMed  PMC  EPMC  M
    52. 1989
  52. Grill,E., Loffler,S., Winnacker,E.L. and Zenk,M.H.<br>Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)<br>Proc Natl Acad Sci U S A (1989) 86, 6838-6842. PubMed  Europe PubMed  PMC  EPMC

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