Literature for peptidase C83.002: phytochelatin synthase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Su,H., Zou,T., Lin,R., Zheng,J., Jian,S. and Zhang,M.
    Characterization of a phytochelatin synthase gene from Ipomoea pes-caprae involved in cadmium tolerance and accumulation in yeast and plants
    Plant Physiol Biochem155, 743-755. PubMed  Europe PubMed DOI
  2. 2017
  3. Hayashi,S., Kuramata,M., Abe,T., Takagi,H., Ozawa,K. and Ishikawa,S.
    Phytochelatin synthase OsPCS1 plays a crucial role in reducing arsenic levels in rice grains
    Plant J91, 840-848. PubMed  Europe PubMed DOI
  4. Zayneb,C., Imen,R.H., Walid,K., Grubb,C.D., Bassem,K., Franck,V., Hafedh,M. and Amine,E.
    The phytochelatin synthase gene in date palm (Phoenix dactylifera L.): phylogeny, evolution and expression
    Ecotoxicol Environ Saf140, 7-17. PubMed  Europe PubMed DOI
  5. 2013
  6. Chia,J.C., Yang,C.C., Sui,Y.T., Lin,S.Y. and Juang,R.H.
    Tentative identification of the second substrate binding site in Arabidopsis phytochelatin synthase
    PLoS ONE8, e82675-e82675. PubMed  Europe PubMed DOI
  7. 2012
  8. Arnoux,P., Pignol,D. and Gully,D.
    Phytochelatin synthase: from hydrolase to transferase
    [ISSN:978-0-12-407743-0]3, 2178-2183. DOI
  9. Liu,Z., Gu,C., Chen,F., Yang,D., Wu,K., Chen,S., Jiang,J. and Zhang,Z.
    Heterologous expression of a Nelumbo nucifera phytochelatin synthase gene enhances cadmium tolerance in Arabidopsis thaliana
    Appl Biochem Biotechnol166, 722-734. PubMed  Europe PubMed DOI
  10. Rea,P.A.
    Phytochelatin synthase: of a protease a peptide polymerase made
    Physiol Plant145, 154-164. PubMed  Europe PubMed DOI
  11. Shukla,D., Kesari,R., Mishra,S., Dwivedi,S., Tripathi,R.D., Nath,P. and Trivedi,P.K.
    Expression of phytochelatin synthase from aquatic macrophyte Ceratophyllum demersum L. enhances cadmium and arsenic accumulation in tobacco
    Plant Cell Rep31, 1687-1699. PubMed  Europe PubMed DOI
  12. 2011
  13. Bolchi,A., Ruotolo,R., Marchini,G., Vurro,E., di Toppi,L.S., Kohler,A., Tisserant,E., Martin,F. and Ottonello,S.
    Genome-wide inventory of metal homeostasis-related gene products including a functional phytochelatin synthase in the hypogeous mycorrhizal fungus Tuber melanosporum
    Fungal Genet Biol48, 573-584. PubMed  Europe PubMed DOI
  14. Brunetti,P., Zanella,L., Proia,A., De Paolis,A., Falasca,G., Altamura,M.M., Sanita di Toppi,L., Costantino,P. and Cardarelli,M.
    Cadmium tolerance and phytochelatin content of Arabidopsis seedlings over-expressing the phytochelatin synthase gene AtPCS1
    J Exp Bot62, 5509-5519. PubMed  Europe PubMed DOI
  15. Liu,G.Y., Zhang,Y.X. and Chai,T.Y.
    Phytochelatin synthase of Thlaspi caerulescens enhanced tolerance and accumulation of heavy metals when expressed in yeast and tobacco
    Plant Cell Rep30, 1067-1076. PubMed  Europe PubMed DOI
  16. Ogawa,S., Yoshidomi,T. and Yoshimura,E.
    Cadmium(II)-stimulated enzyme activation of Arabidopsis thaliana phytochelatin synthase 1
    J Inorg Biochem105, 111-117. PubMed  Europe PubMed DOI
  17. 2010
  18. Blum,R., Meyer,K.C., Wunschmann,J., Lendzian,K.J. and Grill,E.
    Cytosolic action of phytochelatin synthase
    Plant Physiol153, 159-169. PubMed  Europe PubMed DOI
  19. Ogawa,S., Yoshidomi,T., Shirabe,T. and Yoshimura,E.
    HPLC method for the determination of phytochelatin synthase activity specific for soft metal ion chelators
    J Inorg Biochem104, 442-445. PubMed  Europe PubMed DOI  A
  20. 2009
  21. Li,A.M., Yu,B.Y., Chen,F.H., Gan,H.Y., Yuan,J.G., Qiu,R., Huang,J.C., Yang,Z.Y. and Xu,Z.F.
    Characterization of the Sesbania rostrata phytochelatin synthase gene: alternative splicing and function of four isoforms
    Int J Mol Sci10, 3269-3282. PubMed  Europe PubMed DOI
  22. Wang,H.C., Wu,J.S., Chia,J.C., Yang,C.C., Wu,Y.J. and Juang,R.H.
    Phytochelatin synthase is regulated by protein phosphorylation at a threonine residue near its catalytic site
    J Agric Food Chem57, 7348-7355. PubMed  Europe PubMed DOI
  23. 2008
  24. Brulle,F., Cocquerelle,C., Wamalah,A.N., Morgan,A.J., Kille,P., Lepretre,A. and Vandenbulcke,F.
    cDNA cloning and expression analysis of Eisenia fetida (Annelida: Oligochaeta) phytochelatin synthase under cadmium exposure
    Ecotoxicol Environ Saf71, 47-55. PubMed  Europe PubMed DOI
  25. Ramos,J., Naya,L., Gay,M., Abian,J. and Becana,M.
    Functional characterization of an unusual phytochelatin synthase, LjPCS3, of Lotus japonicus
    Plant Physiol148, 536-545. PubMed  Europe PubMed DOI
  26. Singh,S., Lee,W., Dasilva,N.A., Mulchandani,A. and Chen,W.
    Enhanced arsenic accumulation by engineered yeast cells expressing Arabidopsis thaliana phytochelatin synthase
    Biotechnol Bioeng99, 333-340. PubMed  Europe PubMed DOI
  27. Vestergaard,M., Matsumoto,S., Nishikori,S., Shiraki,K., Hirata,K. and Takagi,M.
    Chelation of cadmium ions by phytochelatin synthase: role of the cysteine-rich C-terminal
    Anal Sci24, 277-281. PubMed  Europe PubMed DOI
  28. 2007
  29. Blum,R., Beck,A., Korte,A., Stengel,A., Letzel,T., Lendzian,K. and Grill,E.
    Function of phytochelatin synthase in catabolism of glutathione-conjugates
    Plant J49, 740-749. PubMed  Europe PubMed DOI
  30. Gasic,K. and Korban,S.S.
    Expression of Arabidopsis phytochelatin synthase in Indian mustard (Brassica juncea) plants enhances tolerance for Cd and Zn
    Planta225, 1277-1285. PubMed  Europe PubMed DOI
  31. Gasic,K. and Korban,S.S.
    Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance
    Plant Mol Biol64, 361-369. PubMed  Europe PubMed DOI
  32. 2006
  33. Grzam,A., Tennstedt,P., Clemens,S., Hell,R. and Meyer,A.J.
    Vacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthase
    FEBS Lett580, 6384-6390. PubMed  Europe PubMed DOI
  34. Konishi,T., Matsumoto,S., Tsuruwaka,Y., Shiraki,K., Hirata,K., Tamaru,Y. and Takagi,M.
    Enhancing the tolerance of zebrafish (Danio rerio) to heavy metal toxicity by the expression of plant phytochelatin synthase
    J Biotechnol122, 316-325. PubMed  Europe PubMed DOI
  35. Peterson,A.G. and Oliver,D.J.
    Leaf-targeted phytochelatin synthase in Arabidopsis thaliana
    Plant Physiol Biochem44, 885-892. PubMed  Europe PubMed DOI
  36. Picault,N., Cazale,A.C., Beyly,A., Cuine,S., Carrier,P., Luu,D.T., Forestier,C. and Peltier,G.
    Chloroplast targeting of phytochelatin synthase in Arabidopsis: effects on heavy metal tolerance and accumulation
    Biochimie88, 1743-1750. PubMed  Europe PubMed DOI
  37. Pomponi,M., Censi,V., Di Girolamo,V., De Paolis,A., di Toppi,L.S., Aromolo,R., Costantino,P. and Cardarelli,M.
    Overexpression of Arabidopsis phytochelatin synthase in tobacco plants enhances Cd(2+) tolerance and accumulation but not translocation to the shoot
    Planta223, 180-190. PubMed  Europe PubMed DOI
  38. Rea,P.A.
    Phytochelatin synthase, papain's cousin, in stereo
    Proc Natl Acad Sci U S A103, 507-508. PubMed  Europe PubMed DOI
  39. [YEAR:19-5-2006]Romanyuk,N.D., Rigden,D.J., Vatamaniuk,O.K., Lang,A., Cahoon,R.E., Jez,J.M. and Rea,P.A.
    Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase
    Plant Physiol141, 858-869. PubMed  Europe PubMed DOI
  40. 2005
  41. Dong,R., Formentin,E., Losseso,C., Carimi,F., Benedetti,P., Terzi,M. and Schiavo,F.L.
    Molecular cloning and characterization of a phytochelatin synthase gene, PvPCS1, from Pteris vittata L
    J Ind Microbiol Biotechnol32, 527-533. PubMed  Europe PubMed DOI
  42. Tsuji,N., Nishikori,S., Iwabe,O., Matsumoto,S., Shiraki,K., Miyasaka,H., Takagi,M., Miyamoto,K. and Hirata,K.
    Comparative analysis of the two-step reaction catalyzed by prokaryotic and eukaryotic phytochelatin synthase by an ion-pair liquid chromatography assay
    Planta222, 181-191. PubMed  Europe PubMed DOI
  43. [YEAR:27-12-2005]Vivares,D., Arnoux,P. and Pignol,D.
    A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis
    Proc Natl Acad Sci U S A102, 18848-18853. PubMed  Europe PubMed DOI  S
  44. 2004
  45. Li,Y., Dhankher,O.P., Carreira,L., Lee,D., Chen,A., Schroeder,J.I., Balish,R.S. and Meagher,R.B.
    Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity
    Plant Cell Physiol45, 1787-1797. PubMed  Europe PubMed DOI
  46. Rea,P.A., Vatamaniuk,O.K. and Rigden,D.J.
    Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase
    Plant Physiol136, 2463-2474. PubMed  Europe PubMed DOI
  47. Ruotolo,R., Peracchi,A., Bolchi,A., Infusini,G., Amoresano,A. and Ottonello,S.
    Domain organization of phytochelatin synthase: functional properties of truncated enzyme species identified by limited proteolysis
    J Biol Chem279, 14686-14693. PubMed  Europe PubMed DOI
  48. [YEAR:21-5-2004]Vatamaniuk,O.K., Mari,S., Lang,A., Chalasani,S., Demkiv,L.O. and Rea,P.A.
    Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis
    J Biol Chem279, 22449-22460. PubMed  Europe PubMed DOI
  49. 2003
  50. Beck,A., Lendzian,K., Oven,M., Christmann,A. and Grill,E.
    Phytochelatin synthase catalyzes key step in turnover of glutathione conjugates
    Phytochemistry62, 423-431. PubMed  Europe PubMed DOI
  51. Heiss,S., Wachter,A., Bogs,J., Cobbett,C. and Rausch,T.
    Phytochelatin synthase (PCS) protein is induced in Brassica juncea leaves after prolonged Cd exposure
    J Exp Bot54, 1833-1839. PubMed  Europe PubMed DOI
  52. Lee,S., Moon,J.S., Ko,T.S., Petros,D., Goldsbrough,P.B. and Korban,S.S.
    Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress
    Plant Physiol131, 656-663. PubMed  Europe PubMed DOI
  53. Maier,T., Yu,C., Kullertz,G. and Clemens,S.
    Localization and functional characterization of metal-binding sites in phytochelatin synthases
    Planta218, 300-308. PubMed  Europe PubMed DOI
  54. Sauge-Merle,S., Cuine,S., Carrier,P., Lecomte-Pradines,C., Luu,D.T. and Peltier,G.
    Enhanced toxic metal accumulation in engineered bacterial cells expressing Arabidopsis thaliana phytochelatin synthase
    Appl Environ Microbiol69, 490-494. PubMed  Europe PubMed DOI
  55. Sriprang,R., Hayashi,M., Ono,H., Takagi,M., Hirata,K. and Murooka,Y.
    Enhanced accumulation of Cd2+ by a Mesorhizobium sp. transformed with a gene from Arabidopsis thaliana coding for phytochelatin synthase
    Appl Environ Microbiol69, 1791-1796. PubMed  Europe PubMed DOI
  56. 2002
  57. Lee,S. and Korban,S.S.
    Transcriptional regulation of Arabidopsis thaliana phytochelatin synthase (AtPCS1) by cadmium during early stages of plant development
    Planta215, 689-693. PubMed  Europe PubMed DOI
  58. Oven,M., Page,J.E., Zenk,M.H. and Kutchan,T.M.
    Molecular characterization of the homo-phytochelatin synthase of soybean Glycine max: relation to phytochelatin synthase
    J Biol Chem277, 4747-4754. PubMed  Europe PubMed DOI
  59. 2000
  60. [YEAR:6-10-2000]Vatamaniuk,O.K., Mari,S., Lu,Y.P. and Rea,P.A.
    Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides
    J Biol Chem275, 31451-31459. PubMed  Europe PubMed DOI
  61. Yan,S.L., Tsay,C.C. and Chen,Y.R.
    Isolation and characterization of phytochelatin synthase in rice seedlings
    Proc Natl Sci Counc Repub China B24, 202-207. PubMed  Europe PubMed
  62. 1999
  63. Cobbett,C.S.
    A family of phytochelatin synthase genes from plant, fungal and animal species
    Trends Plant Sci4, 335-337. PubMed  Europe PubMed
  64. Ha,S.B., Smith,A.P., Howden,R., Dietrich,W.M., Bugg,S., O'Connell,M.J., Goldsbrough,P.B. and Cobbett,C.S.
    Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe
    Plant Cell11, 1153-1164. PubMed  Europe PubMed DOI
  65. Vatamaniuk,O.K., Mari,S., Lu,Y.P. and Rea,P.A.
    AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution
    Proc Natl Acad Sci U S A96, 7110-7115. PubMed  Europe PubMed DOI
  66. 1995
  67. Howden,R., Goldsbrough,P.B., Andersen,C.R. and Cobbett,C.S.
    Cadmium-sensitive, cad1 mutants of Arabidopsis thaliana are phytochelatin deficient
    Plant Physiol107, 1059-1066. PubMed  Europe PubMed  M
  68. 1989
  69. Grill,E., Loffler,S., Winnacker,E.L. and Zenk,M.H.
    Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)
    Proc Natl Acad Sci U S A86, 6838-6842. PubMed  Europe PubMed