Literature for peptidase C80.003: self-cleaving toxin B (Clostridium-type)

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2019
1. Ivarsson,M.E., Durantie,E., Huberli,C., Huwiler,S., Hegde,C., Friedman,J., Altamura,F., Lu,J., Verdu,E.F., Bercik,P., Logan,S.M., Chen,W., Leroux,J.C. and Castagner,B.
   Small-molecule allosteric triggers of Clostridium difficile toxin B auto-proteolysis as a therapeutic strategy
   Cell Chem Biol26, 17-26. PubMed  Europe PubMed DOI
2018
2. Chen,P., Tao,L., Wang,T., Zhang,J., He,A., Lam,K.H., Liu,Z., He,X., Perry,K., Dong,M. and Jin,R.
   Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
   Science360, 664-669. PubMed  Europe PubMed DOI
3. Chen,X. and Kelly,C.P.
   On and off: a dual role for cysteine protease autoprocessing of C difficile toxin B on cytotoxicity vs proinflammatory toxin actions?
   Cell Mol Gastroenterol Hepatol5, 654-655. PubMed  Europe PubMed DOI
4. di Masi,A., Leboffe,L., Polticelli,F., Tonon,F., Zennaro,C., Caterino,M., Stano,P., Fischer,S., Hagele,M., Muller,M., Kleger,A., Papatheodorou,P., Nocca,G., Arcovito,A., Gori,A., Ruoppolo,M., Barth,H., Petrosillo,N., Ascenzi,P. and Di Bella,S.
   Human serum albumin is an essential component of the host defense mechanism against Clostridium difficile intoxication
   J Infect Dis218, 1424-1435. PubMed  Europe PubMed DOI
5. Zhang,Y., Li,S., Yang,Z., Shi,L., Yu,H., Salerno-Goncalves,R., Saint Fleur,A. and Feng,H.
   Cysteine protease-mediated autocleavage of Clostridium difficile toxins regulates their proinflammatory activity
   Cell Mol Gastroenterol Hepatol5, 611-625. PubMed  Europe PubMed DOI
2015
6. Bender,K.O., Garland,M., Ferreyra,J.A., Hryckowian,A.J., Child,M.A., Puri,A.W., Solow-Cordero,D.E., Higginbottom,S.K., Segal,E., Banaei,N., Shen,A., Sonnenburg,J.L. and Bogyo,M.
   A small-molecule antivirulence agent for treating Clostridium difficile infection
   Sci Transl Med7, 306ra148-306ra. PubMed  Europe PubMed DOI  I
7. Li,S., Shi,L., Yang,Z., Zhang,Y., Perez-Cordon,G., Huang,T., Ramsey,J., Oezguen,N., Savidge,T.C. and Feng,H.
   Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis
   Infect Immun83, 502-513. PubMed  Europe PubMed DOI
2014
8. Murase,T., Eugenio,L., Schorr,M., Hussack,G., Tanha,J., Kitova,E.N., Klassen,J.S. and Ng,K.K.
   Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile
   J Biol Chem289, 2331-2343. PubMed  Europe PubMed DOI
9. Olling,A., Huls,C., Goy,S., Muller,M., Krooss,S., Rudolf,I., Tatge,H. and Gerhard,R.
   The combined repetitive oligopeptides of Clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation
   Toxins (Basel)6, 2162-2176. PubMed  Europe PubMed DOI
2013
10. Li,S., Shi,L., Yang,Z. and Feng,H.
    Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol
    Pathog Dis67, 11-18. PubMed  Europe PubMed DOI
11. Zhang,Y., Shi,L., Li,S., Yang,Z., Standley,C., Yang,Z., Zhuge,R., Savidge,T., Wang,X. and Feng,H.
    A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity
    PLoS ONE8, e58634-e58634. PubMed  Europe PubMed DOI
2012
12. Chumbler,N.M., Farrow,M.A., LaPierre,L.A., Franklin,J.L., Haslam,D., Goldenring,J.R. and Lacy,D.B.
    Clostridium difficile toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism
    PLoS Pathog8, e1003072-e1003072. PubMed  Europe PubMed DOI
13. Shen,A. and Bogyo,M.
    Self-cleaving bacterial toxins
    [ISSN:978-0-12-407743-0]3, 2350-2355. DOI
2011
14. Guttenberg,G., Papatheodorou,P., Genisyuerek,S., Lu,W., Jank,T., Einsle,O. and Aktories,K.
    Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin
    J Biol Chem286, 14779-14786. PubMed  Europe PubMed DOI  P
15. Shen,A., Lupardus,P.J., Gersch,M.M., Puri,A.W., Albrow,V.E., Garcia,K.C. and Bogyo,M.
    Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
    Nat Struct Mol Biol18, 364-371. PubMed  Europe PubMed DOI
2010
16. Albesa-Jove,D., Bertrand,T., Carpenter,E.P., Swain,G.V., Lim,J., Zhang,J., Haire,L.F., Vasisht,N., Braun,V., Lange,A., von Eichel-Streiber,C., Svergun,D.I., Fairweather,N.F. and Brown,K.A.
    Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS
    J Mol Biol396, 1260-1270. PubMed  Europe PubMed DOI  S
17. Pruitt,R.N., Chambers,M.G., Ng,K.K., Ohi,M.D. and Lacy,D.B.
    Structural organization of the functional domains of Clostridium difficile toxins A and B
    Proc Natl Acad Sci U S A107, 13467-13472. PubMed  Europe PubMed DOI  S
18. Puri,A.W., Lupardus,P.J., Deu,E., Albrow,V.E., Garcia,K.C., Bogyo,M. and Shen,A.
    Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB
    Chem Biol17, 1201-1211. PubMed  Europe PubMed DOI  S  I
2009
19. Egerer,M., Giesemann,T., Herrmann,C. and Aktories,K.
    Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate
    J Biol Chem284, 3389-3395. PubMed  Europe PubMed DOI
2008
20. Giesemann,T., Guttenberg,G. and Aktories,K.
    Human alpha-defensins inhibit Clostridium difficile toxin B
    Gastroenterology134, 2049-2058. PubMed  Europe PubMed DOI
21. Giesemann,T., Egerer,M., Jank,T. and Aktories,K.
    Processing of Clostridium difficile toxins
    J Med Microbiol57, 690-696. PubMed  Europe PubMed DOI
22. Yang,G., Zhou,B., Wang,J., He,X., Sun,X., Nie,W., Tzipori,S. and Feng,H.
    Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
    BMC Microbiol8, 192-192. PubMed  Europe PubMed DOI  E
2007
23. Egerer,M., Giesemann,T., Jank,T., Satchell,K.J. and Aktories,K.
    Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity
    J Biol Chem282, 25314-25321. PubMed  Europe PubMed DOI
24. Reineke,J., Tenzer,S., Rupnik,M., Koschinski,A., Hasselmayer,O., Schrattenholz,A., Schild,H. and von Eichel-Streiber,C.
    Autocatalytic cleavage of Clostridium difficile toxin B
    Nature446, 415-419. PubMed  Europe PubMed DOI
2005
25. Reinert,D.J., Jank,T., Aktories,K. and Schulz,G.E.
    Structural basis for the function of Clostridium difficile toxin B
    J Mol Biol351, 973-981. PubMed  Europe PubMed DOI  S
26. Rupnik,M., Pabst,S., Rupnik,M., von Eichel-Streiber,C., Urlaub,H. and Soling,H.D.
    Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells
    Microbiology (Reading)151, 199-208. PubMed  Europe PubMed DOI  P
27. Voth,D.E. and Ballard,J.D.
    Clostridium difficile toxins: mechanism of action and role in disease
    Clin Microbiol Rev18, 247-263. PubMed  Europe PubMed DOI
2000
28. Qa'Dan,M., Spyres,L.M. and Ballard,J.D.
    pH-induced conformational changes in Clostridium difficile toxin B
    Infect Immun68, 2470-2474. PubMed  Europe PubMed DOI
1997
29. Hofmann,F., Busch,C., Prepens,U., Just,I. and Aktories,K.
    Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin
    J Biol Chem272, 11074-11078. PubMed  Europe PubMed DOI
1995
30. Green,G.A., Schue,V. and Monteil,H.
    Cloning and characterization of the cytotoxin L-encoding gene of Clostridium sordellii: homology with Clostridium difficile cytotoxin B
    Gene161, 57-61. PubMed  Europe PubMed DOI
1994
31. Barroso,L.A., Moncrief,J.S., Lyerly,D.M. and Wilkins,T.D.
    Mutagenesis of the Clostridium difficile toxin B gene and effect on cytotoxic activity
    Microb Pathog16, 297-303. PubMed  Europe PubMed DOI
1992
32. von Eichel-Streiber,C., Laufenberg-Feldmann,R., Sartingen,S., Schulze,J. and Sauerborn,M.
    Comparative sequence analysis of the Clostridium difficile toxins A and B
    Mol Gen Genet233, 260-268. PubMed  Europe PubMed DOI
1988
33. Lyerly,D.M., Krivan,H.C. and Wilkins,T.D.
    Clostridium difficile: its disease and toxins
    Clin Microbiol Rev1, 1-18. PubMed  Europe PubMed