Literature for peptidase C80.002: self-cleaving toxin A (Clostridium-type)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Cummer,R., Grosjean,F., Bolteau,R., Vasegh,S.E., Veyron,S., Keogh,L., Trempe,J.F. and Castagner,B. Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B J Med Chem (2024) 67, 16576-16597. PubMed Europe PubMed DOI

2018

di Masi,A., Leboffe,L., Polticelli,F., Tonon,F., Zennaro,C., Caterino,M., Stano,P., Fischer,S., Hagele,M., Muller,M., Kleger,A., Papatheodorou,P., Nocca,G., Arcovito,A., Gori,A., Ruoppolo,M., Barth,H., Petrosillo,N., Ascenzi,P. and Di Bella,S. Human serum albumin is an essential component of the host defense mechanism against Clostridium difficile intoxication J Infect Dis (2018) 218, 1424-1435. PubMed Europe PubMed DOI
Zhang,Y., Li,S., Yang,Z., Shi,L., Yu,H., Salerno-Goncalves,R., Saint Fleur,A. and Feng,H. Cysteine protease-mediated autocleavage of Clostridium difficile toxins regulates their proinflammatory activity Cell Mol Gastroenterol Hepatol (2018) 5, 611-625. PubMed Europe PubMed DOI PMC EPMC

2017

Hisao,G.S., Brothers,M.C., Ho,M., Wilson,B.A. and Rienstra,C.M. The membrane localization domains of two distinct bacterial toxins form a 4-helix-bundle in solution Protein Sci (2017) 26, 497-504. PubMed Europe PubMed DOI S

2015

Bender,K.O., Garland,M., Ferreyra,J.A., Hryckowian,A.J., Child,M.A., Puri,A.W., Solow-Cordero,D.E., Higginbottom,S.K., Segal,E., Banaei,N., Shen,A., Sonnenburg,J.L. and Bogyo,M. A small-molecule antivirulence agent for treating Clostridium difficile infection Sci Transl Med (2015) 7, 306ra148-306ra. PubMed Europe PubMed DOI I
Zhang,Y., Hamza,T., Gao,S. and Feng,H. Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides Biochem Biophys Res Commun (2015) 459, 259-263. PubMed Europe PubMed DOI

2014

Murase,T., Eugenio,L., Schorr,M., Hussack,G., Tanha,J., Kitova,E.N., Klassen,J.S. and Ng,K.K. Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile J Biol Chem (2014) 289, 2331-2343. PubMed Europe PubMed DOI PMC EPMC
Olling,A., Huls,C., Goy,S., Muller,M., Krooss,S., Rudolf,I., Tatge,H. and Gerhard,R. The combined repetitive oligopeptides of Clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation Toxins (Basel) (2014) 6, 2162-2176. PubMed Europe PubMed DOI PMC EPMC

2012

D'Urzo,N., Malito,E., Biancucci,M., Bottomley,M.J., Maione,D., Scarselli,M. and Martinelli,M. The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release FEBS J (2012) 279, 3085-3097. PubMed Europe PubMed DOI S
Shen,A. and Bogyo,M. Self-cleaving bacterial toxins [ISSN:978-0-12-407743-0] (2012) 3, 2350-2355. DOI

2011

Kreimeyer,I., Euler,F., Marckscheffel,A., Tatge,H., Pich,A., Olling,A., Schwarz,J., Just,I. and Gerhard,R. Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A Naunyn Schmiedebergs Arch Pharmacol (2011) 383, 253-262. PubMed Europe PubMed DOI
Savidge,T.C., Urvil,P., Oezguen,N., Ali,K., Choudhury,A., Acharya,V., Pinchuk,I., Torres,A.G., English,R.D., Wiktorowicz,J.E., Loeffelholz,M., Kumar,R., Shi,L., Nie,W., Braun,W., Herman,B., Hausladen,A., Feng,H., Stamler,J.S. and Pothoulakis,C. Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins Nat Med (2011) 17, 1136-1141. PubMed Europe PubMed DOI

2010

Pruitt,R.N., Chambers,M.G., Ng,K.K., Ohi,M.D. and Lacy,D.B. Structural organization of the functional domains of Clostridium difficile toxins A and B Proc Natl Acad Sci U S A (2010) 107, 13467-13472. PubMed Europe PubMed DOI S

2009

Pruitt,R.N., Chagot,B., Cover,M., Chazin,W.J., Spiller,B. and Lacy,D.B. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A J Biol Chem (2009) 284, 21934-21940. PubMed Europe PubMed DOI PMC EPMC S

2008

Giesemann,T., Egerer,M., Jank,T. and Aktories,K. Processing of Clostridium difficile toxins J Med Microbiol (2008) 57, 690-696. PubMed Europe PubMed DOI
Yang,G., Zhou,B., Wang,J., He,X., Sun,X., Nie,W., Tzipori,S. and Feng,H. Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium BMC Microbiol (2008) 8, 192-192. PubMed Europe PubMed DOI PMC EPMC E

2007

Egerer,M., Giesemann,T., Jank,T., Satchell,K.J. and Aktories,K. Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity J Biol Chem (2007) 282, 25314-25321. PubMed Europe PubMed DOI

2006

Greco,A., Ho,J.G., Lin,S.J., Palcic,M.M., Rupnik,M. and Ng,K.K. Carbohydrate recognition by Clostridium difficile toxin A Nat Struct Mol Biol (2006) 13, 460-461. PubMed Europe PubMed DOI S

2005

Ho,J.G., Greco,A., Rupnik,M. and Ng,K.K. Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A Proc Natl Acad Sci U S A (2005) 102, 18373-18378. PubMed Europe PubMed DOI PMC EPMC S
Voth,D.E. and Ballard,J.D. Clostridium difficile toxins: mechanism of action and role in disease Clin Microbiol Rev (2005) 18, 247-263. PubMed Europe PubMed DOI PMC EPMC

1992

von Eichel-Streiber,C., Laufenberg-Feldmann,R., Sartingen,S., Schulze,J. and Sauerborn,M. Comparative sequence analysis of the Clostridium difficile toxins A and B Mol Gen Genet (1992) 233, 260-268. PubMed Europe PubMed DOI

1988

Lyerly,D.M., Krivan,H.C. and Wilkins,T.D. Clostridium difficile: its disease and toxins Clin Microbiol Rev (1988) 1, 1-18. PubMed Europe PubMed PMC EPMC

1987

Henriques,B., Florin,I. and Thelestam,M. Cellular internalisation of Clostridium difficile toxin A Microb Pathog (1987) 2, 455-463. PubMed Europe PubMed