Literature for peptidase C66.001: IdeS peptidase

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Beaudrey,T., Apithy,M.J., Olagne,J., Lemonnier,L., Perrin,P., Vargas,G.G., Jahn,I., Radosavljevic,M., Bahram,S., Carapito,R. and Caillard,S.
   Evolution of anti-MICA antibodies after imlifidase infusion for a high immunological risk kidney transplantation
   Hum Immunol (2025) 86, 111213-111213. PubMed  Europe PubMed DOI
2. Cao,M., Katial,R., Liu,Y., Lu,X., Gu,Q., Chen,C., Liu,K., Zhu,Z., Marshall,M.R., Yu,Y. and Wang,Z.
   Safety, efficacy, and immunogenicity of a novel IgG degrading enzyme (KJ103): results from two randomised, blinded, phase 1 clinical trials
   Gene Ther (2025) PubMed  Europe PubMed DOI
2024
3. Daventure,V., Bou-Jaoudeh,M., Hannachi,E., Reyes-Ruiz,A., Trecco,A., Delignat,S., Lacroix-Desmazes,S. and Deligne,C.
   Half-Life Extension of the IgG-Degrading Enzyme (IdeS) Using Fc-Fusion Technology
   Eur J Immunol (2024) , e202451264-e202451264. PubMed  Europe PubMed DOI
4. Vo,A., Ammerman,N. and Jordan,S.C.
   New therapies for highly sensitized patients on the waiting list
   Kidney360 (2024) 5, 1207-1225. PubMed  Europe PubMed DOI
2023
5. Boksha,I.S., Lunin,V.G., Danilova,T.A., Poponova,M.S., Polyakov,N.B., Lyashchuk,A.M., Konstantinova,S.V., Galushkina,Z.M. and Ustenko,E.V.
   Recombinant Endopeptidases IdeS and IdeZ and Their Potential Application
   Biochemistry (Mosc) (2023) 88, 731-740. PubMed  Europe PubMed DOI
6. Frick,I.M., Happonen,L., Wrighton,S., Nordenfelt,P. and Bjorck,L.
   IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies
   J Biol Chem (2023) 299, 105345-105345. PubMed  Europe PubMed DOI  PMC  EPMC
7. Lindh,T., Collin,M., Lood,R. and Carlquist,M.
   Expression of the Bacterial Enzyme IdeS Using a GFP Fusion in the Yeast Saccharomyces cerevisiae
   Methods Mol Biol (2023) 2674, 131-146. PubMed  Europe PubMed DOI
8. Sethi,S. and Jordan,S.C.
   Novel therapies for treatment of antibody-mediated rejection of the kidney
   Curr Opin Organ Transplant (2023) 28, 29-35. PubMed  Europe PubMed DOI  V
2022
9. Lynch,D.R., Stringham,E.N., Zhang,B., Balbin-Cuesta,G., Curtis,B.R., Palumbo,J.S., Greineder,C.F. and Tourdot,B.E.
   Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies
   Blood Adv (2022) 6, 4645-4656. PubMed  Europe PubMed DOI
10. McClain,A., Zhang,Y., Yin,Y., Wang,Q., Hwang,L.Y., Gu,Y., Beckman,J. and Ludwig,R.
    Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis
    Anal Chem (2022) 94, 17388-17395. PubMed  Europe PubMed DOI  PMC  EPMC
2020
11. Al-Salama,Z.T.
    Imlifidase: First Approval
    Drugs (2020) 80, 1859-1864. PubMed  Europe PubMed DOI
12. Rosenstein,S., Vaisman-Mentesh,A., Levy,L., Kigel,A., Dror,Y. and Wine,Y.
    Production of F(ab')2 from monoclonal and polyclonal antibodies
    Curr Protoc Mol Biol (2020) 131, e119-e119. PubMed  Europe PubMed DOI  E
2019
13. Kizlik-Masson,C., Deveuve,Q., Zhou,Y., Vayne,C., Thibault,G., McKenzie,S.E., Pouplard,C., Loyau,S., Gruel,Y. and Rollin,J.
    Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia
    Blood (2019) 133, 2427-2435. PubMed  Europe PubMed DOI
14. Rafat,C. and Luque,Y.
    IdeS in anti-glomerular basement membrane disease: is this the new deal?
    Kidney Int (2019) 96, 1068-1070. PubMed  Europe PubMed DOI  U
15. Soveri,I., Molne,J., Uhlin,F., Nilsson,T., Kjellman,C., Sonesson,E. and Segelmark,M.
    The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease
    Kidney Int (2019) 96, 1234-1238. PubMed  Europe PubMed DOI  U
16. Stubbs,M.J., Thomas,M., Vendramin,C., Sonesson,E., Kjellman,C., Jarnum,S., Stenberg,Y., Elfving,C. and Scully,M.
    Administration of immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) for persistent anti-ADAMTS13 antibodies in patients with thrombotic thrombocytopenic purpura in clinical remission
    Br J Haematol (2019) 186, 137-140. PubMed  Europe PubMed DOI  U
2018
17. Burner,J.D. and Goldfinger,D.
    Potential use of IgG endopeptidase in the management of platelet refractoriness due to HLA alloimmunization
    Transfus Apher Sci (2018) 57, 409-410. PubMed  Europe PubMed DOI
18. Huang,E. and Jordan,S.C.
    Immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS), desensitization, and the kidney allocation system: complementary approaches to increase transplantation in highly HLA sensitized patients
    Clin J Am Soc Nephrol (2018) 13, 799-801. PubMed  Europe PubMed DOI  PMC  EPMC
19. Karlsson,C.A.Q., Jarnum,S., Winstedt,L., Kjellman,C., Bjorck,L., Linder,A. and Malmstrom,J.A.
    Streptococcus pyogenes infection and the human proteome with a special focus on the immunoglobulin G-cleaving enzyme IdeS
    Mol Cell Proteomics (2018) 17, 1097-1111. PubMed  Europe PubMed DOI  PMC  EPMC
20. Lonze,B.E., Tatapudi,V.S., Weldon,E.P., Min,E.S., Ali,N.M., Deterville,C.L., Gelb,B.E., Benstein,J.A., Dagher,N.N., Wu,M. and Montgomery,R.A.
    IdeS (Imlifidase): a novel agent that cleaves human IgG and permits successful kidney transplantation across high-strength donor-specific antibody
    Ann Surg (2018) 268, 488-496. PubMed  Europe PubMed DOI  U
21. Montgomery,R.A., Lonze,B.E. and Tatapudi,V.S.
    IgG degrading enzyme of Streptococcus pyogenes: an exciting new development in desensitization therapy
    Transplantation (2018) 102, 2-4. PubMed  Europe PubMed DOI  U
2017
22. Collin,M. and Bjorck,L.
    Toward clinical use of the IgG specific enzymes IdeS and EndoS against antibody-mediated diseases
    Methods Mol Biol (2017) 1535, 339-351. PubMed  Europe PubMed DOI  U
23. Faid,V., Leblanc,Y., Bihoreau,N. and Chevreux,G.
    Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: investigation of free sulfhydryls
    J Pharm Biomed Anal (2017) 149, 541-546. PubMed  Europe PubMed DOI
24. Falkenburg,W.J., van Schaardenburg,D., Ooijevaar-de Heer,P., Tsang-A-Sjoe,M.W., Bultink,I.E., Voskuyl,A.E., Bentlage,A.E., Vidarsson,G., Wolbink,G. and Rispens,T.
    Anti-hinge antibodies recognize IgG subclass- and protease-restricted neoepitopes
    J Immunol (2017) 198, 82-93. PubMed  Europe PubMed DOI
25. Ingelfinger,J.R.
    A bacterial IgG-degrading enzyme to unhinge antibodies
    N Engl J Med (2017) 377, 487-489. PubMed  Europe PubMed DOI
26. Jarnum,S., Runstrom,A., Bockermann,R., Winstedt,L., Crispin,M. and Kjellman,C.
    Enzymatic inactivation of endogenous IgG by IdeS enhances therapeutic antibody efficacy
    Mol Cancer Ther (2017) 16, 1887-1897. PubMed  Europe PubMed DOI  U
27. Jordan,S.C., Lorant,T., Choi,J., Kjellman,C., Winstedt,L., Bengtsson,M., Zhang,X., Eich,T., Toyoda,M., Eriksson,B.M., Ge,S., Peng,A., Jarnum,S., Wood,K.J., Lundgren,T., Wennberg,L., Backman,L., Larsson,E., Villicana,R., Kahwaji,J., Louie,S., Kang,A., Haas,M., Nast,C., Vo,A. and Tufveson,G.
    IgG endopeptidase in highly sensitized patients undergoing transplantation
    N Engl J Med (2017) 377, 442-453. PubMed  Europe PubMed DOI  U
28. Rungelrath,V., Wohlsein,J.C., Siebert,U., Stott,J., Prenger-Berninghoff,E., VonPawel-Rammingen,U., Valentin-Weigand,P., Baums,C.G. and Seele,J.
    Identification of a novel host-specific IgG protease in Streptococcus phocae subsp. phocae
    Vet Microbiol (2017) 201, 42-48. PubMed  Europe PubMed DOI  I
29. Sjogren,J., Andersson,L., Mejare,M. and Olsson,F.
    Generating and purifying Fab fragments from human and mouse IgG using the bacterial enzymes IdeS, SpeB and Kgp
    Methods Mol Biol (2017) 1535, 319-329. PubMed  Europe PubMed DOI
30. Wang,Y., Shi,Q., Lv,H., Hu,M., Wang,W., Wang,Q., Qiao,B., Zhang,G., Lv,Z., Kjellman,C., Jarnum,S., Winstedt,L., Zhang,Y., Wen,J., Hao,Y. and Yuki,N.
    IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barre syndrome
    Exp Neurol (2017) 291, 134-140. PubMed  Europe PubMed DOI  U
2016
31. Kirley,T.L., Greis,K.D. and Norman,A.B.
    Structural characterization of expressed monoclonal antibodies by single sample mass spectral analysis after IdeS proteolysis
    Biochem Biophys Res Commun (2016) 477, 363-368. PubMed  Europe PubMed DOI
32. Novarra,S., Grinberg,L., Rickert,K.W., Barnes,A., Wilson,S. and Baca,M.
    A hingeless Fc fusion system for site-specific cleavage by IdeS
    MAbs (2016) 8, 1118-1125. PubMed  Europe PubMed DOI
2015
33. Jarnum,S., Bockermann,R., Runstrom,A., Winstedt,L. and Kjellman,C.
    The bacterial enzyme IdeS cleaves the IgG-type of B cell receptor (BCR), abolishes BCR-mediated cell signaling, and inhibits memory B cell activation
    J Immunol (2015) 195, 5592-5601. PubMed  Europe PubMed DOI  PMC  EPMC
34. Persson,H., Soderberg,J.J., Vindebro,R., Johansson,B.P. and von Pawel-Rammingen,U.
    Proteolytic processing of the streptococcal IgG endopeptidase IdeS modulates the functional properties of the enzyme and results in reduced immunorecognition
    Mol Immunol (2015) 68, 176-184. PubMed  Europe PubMed DOI
35. Postnikov,P., Krotov,G., Mesonzhnik,N., Efimova,Y. and Rodchenkov,G.
    Fc-fragment removal allows the EPO-Fc fusion protein to be detected in blood samples by IEF-PAGE
    Drug Test Anal (2015) 7, 999-1008. PubMed  Europe PubMed DOI
36. Winstedt,L., Jarnum,S., Nordahl,E.A., Olsson,A., Runstrom,A., Bockermann,R., Karlsson,C., Malmstrom,J., Palmgren,G.S., Malmqvist,U., Bjorck,L. and Kjellman,C.
    Complete removal of extracellular IgG antibodies in a randomized dose-escalation phase I Study with the bacterial enzyme IdeS - a novel therapeutic opportunity
    PLoS ONE (2015) 10, e0132011-e0132011. PubMed  Europe PubMed DOI  PMC  EPMC  U
2014
37. An,Y., Zhang,Y., Mueller,H.M., Shameem,M. and Chen,X.
    A new tool for monoclonal antibody analysis: application of IdeS proteolysis in IgG domain-specific characterization
    MAbs (2014) 6, 879-893. PubMed  Europe PubMed DOI
38. Brezski,R.J., Kinder,M., Grugan,K.D., Soring,K.L., Carton,J., Greenplate,A.R., Petley,T., Capaldi,D., Brosnan,K., Emmell,E., Watson,S. and Jordan,R.E.
    A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo
    MAbs (2014) 6, 1265-1273. PubMed  Europe PubMed DOI
39. Leblanc,Y., Romanin,M., Bihoreau,N. and Chevreux,G.
    LC-MS analysis of polyclonal IgGs using IdeS enzymatic proteolysis for oxidation monitoring
    J Chromatogr B Analyt Technol Biomed Life Sci (2014) 961, 1-4. PubMed  Europe PubMed DOI
40. Wagner-Rousset,E., Janin-Bussat,M.-C., Colas,O., Excoffier,M., Ayoub,D., Haeuw,J.-F., Rilatt,I., Perez,M., Corvaia,N. and Beck,A.
    Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
    MAbs (2014) 6, 273-285. PubMed  Europe PubMed DOI
2013
41. Janin-Bussat,M.C., Tonini,L., Huillet,C., Colas,O., Klinguer-Hamour,C., Corvaia,N. and Beck,A.
    Cetuximab Fab and Fc N-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry
    Methods Mol Biol (2013) 988, 93-113. PubMed  Europe PubMed DOI
42. Okumura,C.Y., Anderson,E.L., Dohrmann,S., Tran,D.N., Olson,J., von Pawel-Rammingen,U. and Nizet,V.
    IgG protease Mac/IdeS is not essential for phagocyte resistance or mouse virulence of M1T1 group A Streptococcus
    MBio (2013) 4, e00499-13. PubMed  Europe PubMed DOI  PMC  EPMC
43. Vindebro,R., Spoerry,C. and von Pawel-Rammingen,U.
    Rapid IgG heavy chain cleavage by the streptococcal IgG endopeptidase IdeS is mediated by IdeS monomers and is not due to enzyme dimerization
    FEBS Lett (2013) 587, 1818-1822. PubMed  Europe PubMed DOI
2012
44. Berggren,K., Vindebro,R., Bergstrom,C., Spoerry,C., Persson,H., Fex,T., Kihlberg,J., von Pawel-Rammingen,U. and Luthman,K.
    3-Aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS
    J Med Chem (2012) 55, 2549-2560. PubMed  Europe PubMed DOI  I
45. Pawel-Rammingen,U.
    IdeS peptidase
    [ISSN:978-0-12-407743-0] (2012) 3, 2175-2178. DOI
2011
46. Chevreux,G., Tilly,N. and Bihoreau,N.
    Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry
    Anal Biochem (2011) 415, 212-214. PubMed  Europe PubMed DOI
47. Su,Y.F., Chuang,W.J., Wang,S.M., Chen,W.Y., Chiang-Ni,C., Lin,Y.S., Wu,J.J. and Liu,C.C.
    The deficient cleavage of M protein-bound IgG by IdeS: insight into the escape of Streptococcus pyogenes from antibody-mediated immunity
    Mol Immunol (2011) 49, 134-142. PubMed  Europe PubMed DOI
2010
48. Yang,R., Otten,M.A., Hellmark,T., Collin,M., Bjorck,L., Zhao,M.H., Daha,M.R. and Segelmark,M.
    Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes
    Nephrol Dial Transplant (2010) 25, 2479-2486. PubMed  Europe PubMed DOI  U
2009
49. Berggren,K., Johansson,B., Fex,T., Kihlberg,J., Bjorck,L. and Luthman,K.
    Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
    Bioorg Med Chem (2009) 17, 3463-3470. PubMed  Europe PubMed DOI  I
50. Radaev,S., Agniswamy,J. and Sun,P.D.
    A case of structure determination using pseudosymmetry
    Acta Crystallogr D Biol Crystallogr (2009) 65, 1334-1340. PubMed  Europe PubMed DOI  PMC  EPMC  S
2008
51. Johansson,B.P., Shannon,O. and Bjorck,L.
    IdeS: a bacterial proteolytic enzyme with therapeutic potential
    PLoS ONE (2008) 3, e1692-e1692. PubMed  Europe PubMed DOI  PMC  EPMC  U
52. Nandakumar,K.S. and Holmdahl,R.
    Therapeutic cleavage of IgG: new avenues for treating inflammation
    Trends Immunol (2008) 29, 173-178. PubMed  Europe PubMed DOI  U
53. Shen,A. and Bogyo,M.
    Friend or foe? Turning a host defense protein into a pathogen's accomplice
    Chem Biol (2008) 15, 879-880. PubMed  Europe PubMed DOI
54. Soderberg,J.J. and von Pawel-Rammingen,U.
    The streptococcal protease IdeS modulates bacterial IgGFc binding and generates 1/2Fc fragments with the ability to prime polymorphonuclear leucocytes
    Mol Immunol (2008) 45, 3347-3353. PubMed  Europe PubMed DOI
55. Soderberg,J.J., Engstrom,P. and von Pawel-Rammingen,U.
    The intrinsic immunoglobulin G endopeptidase activity of streptococcal Mac-2 proteins implies a unique role for the enzymatically impaired Mac-2 protein of M28 serotype strains
    Infect Immun (2008) 76, 2183-2188. PubMed  Europe PubMed DOI  PMC  EPMC
56. Vincents,B., Vindebro,R., Abrahamson,M. and von Pawel-Rammingen,U.
    The human protease inhibitor cystatin C is an activating cofactor for the streptococcal cysteine protease IdeS
    Chem Biol (2008) 15, 960-968. PubMed  Europe PubMed DOI
2007
57. Hess,J.L., Porsch,E.A., Shertz,C.A. and Boyle,M.D.
    Immunoglobulin cleavage by the streptococcal cysteine protease IdeS can be detected using protein G capture and mass spectrometry
    J Microbiol Methods (2007) 70, 284-291. PubMed  Europe PubMed DOI  PMC  EPMC
58. Nandakumar,K.S., Johansson,B.P., Bjorck,L. and Holmdahl,R.
    Blocking of experimental arthritis by cleavage of IgG antibodies in vivo
    Arthritis Rheum (2007) 56, 3253-3260. PubMed  Europe PubMed DOI
2006
59. Agniswamy,J., Nagiec,M.J., Liu,M., Schuck,P., Musser,J.M. and Sun,P.D.
    Crystal structure of group A Streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG
    Structure (2006) 14, 225-235. PubMed  Europe PubMed DOI  S
60. Akesson,P., Moritz,L., Truedsson,M., Christensson,B. and von Pawel-Rammingen,U.
    IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection
    Infect Immun (2006) 74, 497-503. PubMed  Europe PubMed DOI  PMC  EPMC
2004
61. Agniswamy,J., Lei,B., Musser,J.M. and Sun,P.D.
    Insight of host immune evasion mediated by two variants of group a Streptococcus Mac protein
    J Biol Chem (2004) 279, 52789-52796. PubMed  Europe PubMed DOI
62. [YEAR:14-12-2004]Vincents,B., von Pawel-Rammingen,U., Bjorck,L. and Abrahamson,M.
    Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for IgG cleavage due to exosite binding
    Biochemistry (14-12-2004) 43, 15540-15549. PubMed  Europe PubMed DOI  P
63. [YEAR:14-12-2004]Wenig,K., Chatwell,L., von Pawel-Rammingen,U., Bjorck,L., Huber,R. and Sondermann,P.
    Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG
    Proc Natl Acad Sci U S A (14-12-2004) 101, 17371-17376. PubMed  Europe PubMed DOI  PMC  EPMC  S
2003
64. Lei,B., Liu,M., Meyers,E.G., Manning,H.M., Nagiec,M.J. and Musser,J.M.
    Histidine and aspartic acid residues important for immunoglobulin G endopeptidase activity of the group A Streptococcus opsonophagocytosis-inhibiting Mac protein
    Infect Immun (2003) 71, 2881-2884. PubMed  Europe PubMed DOI  PMC  EPMC
65. von Pawel-Rammingen,U. and Bjorck,L.
    IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes
    Curr Opin Microbiol (2003) 6, 50-55. PubMed  Europe PubMed DOI
2002
66. Lei,B., DeLeo,F.R., Reid,S.D., Voyich,J.M., Magoun,L., Liu,M., Braughton,K.R., Ricklefs,S., Hoe,N.P., Cole,R.L., Leong,J.M. and Musser,J.M.
    Opsonophagocytosis-inhibiting Mac protein of Group A Streptococcus: identification and characteristics of two genetic complexes
    Infect Immun (2002) 70, 6880-6890. PubMed  Europe PubMed DOI  PMC  EPMC
67. [YEAR:1-4-2002]von Pawel-Rammingen,U., Johansson,B.P. and Bjorck,L.
    IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
    EMBO J (1-4-2002) 21, 1607-1615. PubMed  Europe PubMed DOI  PMC  EPMC
2001
68. Lei,B., DeLeo,F.R., Hoe,N.P., Graham,M.R., Mackie,S.M., Cole,R.L., Liu,M., Hill,H.R., Low,D.E., Federle,M.J., Scott,J.R. and Musser,J.M.
    Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis
    Nat Med (2001) 7, 1298-1305. PubMed  Europe PubMed DOI
2000
69. Lei,B., Mackie,S., Lukomski,S. and Musser,J.M.
    Identification and immunogenicity of group A Streptococcus culture supernatant proteins
    Infect Immun (2000) 68, 6807-6818. PubMed  Europe PubMed DOI  PMC  EPMC