Literature for peptidase C65.002: otubain-2

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Nan,Y., Wu,X., Luo,Q., Chang,W., Zhao,P., Zhang,L. and Liu,Z.
   OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
   Proc Natl Acad Sci U S A121, e2315348121-e2315348121. PubMed  Europe PubMed DOI
2. Ren,W., Xu,Z., Chang,Y., Ju,F., Wu,H., Liang,Z., Zhao,M., Wang,N., Lin,Y., Xu,C., Chen,S., Rao,Y., Lin,C., Yang,J., Liu,P., Zhang,J., Huang,C. and Xia,N.
   Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
   Nat Commun15, 9-9. PubMed  Europe PubMed DOI
3. Zhu,W., Wu,C., Liu,Z., Zhao,S. and Huang,J.
   OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression
   Cell Commun Signal22, 420-420. PubMed  Europe PubMed DOI  K
2023
4. Gan,J., de Vries,J., Akkermans,J.J.L.L., Mohammed,Y., Tjokrodirijo,R.T.N., de Ru,A.H., Kim,R.Q., Vargas,D.A., Pol,V., Fasan,R., van Veelen,P.A., Neefjes,J., van Dam,H., Ovaa,H., Sapmaz,A. and Geurink,P.P.
   Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2
   ACS Chem Biol18, 2003-2013. PubMed  Europe PubMed DOI  I
5. Song,Y. and Wu,Q.
   RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling
   Environ Toxicol38, 2155-2164. PubMed  Europe PubMed DOI  K
6. Zhang,Q., Zhang,J., Yao,A., Tian,X., Han,Z., Yuan,Y., Tao,K. and Yang,X.
   OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway
   Cell Biol Int47, 428-438. PubMed  Europe PubMed DOI
2022
7. Chang,W., Luo,Q., Wu,X., Nan,Y., Zhao,P., Zhang,L., Luo,A., Jiao,W., Zhu,Q., Fu,Y. and Liu,Z.
   OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
   Cell Rep41, 111561-111561. PubMed  Europe PubMed DOI
8. Hu,G., Yang,J., Zhang,H., Huang,Z. and Yang,H.
   OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation
   Cell Mol Bioeng15, 281-292. PubMed  Europe PubMed DOI  K
9. Li,J., Zhang,N., Li,M., Hong,T., Meng,W. and Ouyang,T.
   The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function
   Front Cell Dev Biol10, 820781-820781. PubMed  Europe PubMed DOI  V
10. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W.
    OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
    Cell Death Discov8, 45-45. PubMed  Europe PubMed DOI
11. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W.
    Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
    Cell Death Discov8, 211-211. PubMed  Europe PubMed DOI
2021
12. Liu,G., Guo,W., Qin,J. and Lin,Z.
    OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties
    Front Oncol11, 711735-711735. PubMed  Europe PubMed DOI  K
13. Sivakumar,D. and Stein,M.
    Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases
    Biomolecules11, PubMed  Europe PubMed DOI
14. Yu,S., Zang,W., Qiu,Y., Liao,L. and Zheng,X.
    Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis
    Oncogene41, 46-56. PubMed  Europe PubMed DOI
15. Zhu,Q., Fu,Y., Li,L., Liu,C.H. and Zhang,L.
    The functions and regulation of Otubains in protein homeostasis and diseases
    Ageing Res Rev67, 101303-101303. PubMed  Europe PubMed DOI  V
2020
16. Gu,Z.L., Huang,J. and Zhen,L.L.
    Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling
    Kaohsiung J Med Sci PubMed  Europe PubMed DOI  K
17. Sivakumar,D., Kumar,V., Naumann,M. and Stein,M.
    Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
    J Biol Chem295, 6972-6982. PubMed  Europe PubMed DOI
18. Wan,Q., Chen,Q., Cai,D., Zhao,Y. and Wu,X.
    OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer
    Cell Transplant29, 963689720931433-963689720931433. PubMed  Europe PubMed DOI  K
2019
19. Li,J., Cheng,D., Zhu,M., Yu,H., Pan,Z., Liu,L., Geng,Q., Pan,H., Yan,M. and Yao,M.
    OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
    Theranostics9, 179-195. PubMed  Europe PubMed DOI
20. Resnick,E., Bradley,A., Gan,J., Douangamath,A., Krojer,T., Sethi,R., Geurink,P.P., Aimon,A., Amitai,G., Bellini,D., Bennett,J., Fairhead,M., Fedorov,O., Gabizon,R., Gan,J., Guo,J., Plotnikov,A., Reznik,N., Ruda,G.F., Diaz-Saez,L., Straub,V.M., Szommer,T., Velupillai,S., Zaidman,D., Zhang,Y., Coker,A.R., Dowson,C.G., Barr,H.M., Wang,C., Huber,K.V.M., Brennan,P.E., Ovaa,H., von Delft,F. and London,N.
    Rapid covalent-probe discovery by electrophile-fragment screening
    J Am Chem Soc141, 8951-8968. PubMed  Europe PubMed DOI  I
21. Zhang,Z., Du,J., Wang,S., Shao,L., Jin,K., Li,F., Wei,B., Ding,W., Fu,P., van Dam,H., Wang,A., Jin,J., Ding,C., Yang,B., Zheng,M., Feng,X.H., Guan,K.L. and Zhang,L.
    OTUB2 Promotes cancer metastasis via Hippo-independent activation of YAP and TAZ
    Mol Cell73, 7-21. PubMed  Europe PubMed DOI
2018
22. Li,X.Y., Mao,X.F., Tang,X.Q., Han,Q.Q., Jiang,L.X., Qiu,Y.M., Dai,J. and Wang,Y.X.
    Regulation of Gli2 stability by deubiquitinase OTUB2
    Biochem Biophys Res Commun505, 113-118. PubMed  Europe PubMed DOI
2015
23. Altun,M., Walter,T.S., Kramer,H.B., Herr,P., Iphofer,A., Bostrom,J., David,Y., Komsany,A., Ternette,N., Navon,A., Stuart,D.I., Ren,J. and Kessler,B.M.
    The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages
    PLoS ONE10, e0115344-e0115344. PubMed  Europe PubMed DOI  S
2013
24. Beck,A., Vinik,Y., Shatz-Azoulay,H., Isaac,R., Streim,S., Jona,G., Boura-Halfon,S. and Zick,Y.
    Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets
    Diabetologia56, 1317-1326. PubMed  Europe PubMed DOI
2012
25. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0]3, 2113-2120. DOI
2004
26. Nanao,M.H., Tcherniuk,S.O., Chroboczek,J., Dideberg,O., Dessen,A. and Balakirev,M.Y.
    Crystal structure of human otubain 2
    EMBO Rep5, 783-788. PubMed  Europe PubMed DOI  S
2003
27. Balakirev,M.Y., Tcherniuk,S.O., Jaquinod,M. and Chroboczek,J.
    Otubains: a new family of cysteine proteases in the ubiquitin pathway
    EMBO Rep4, 517-522. PubMed  Europe PubMed DOI  I