Literature for peptidase C65.002: otubain-2

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Wang,Y., Wang,Y., Tong,F., Gao,Q., Li,B. and Zhao,Y.
   OTUB2/NR4A1 restrains the development of preeclampsia by suppressing macrophage M1 polarization
   Commun Biol (2025) 8, 1304-1304. PubMed  Europe PubMed DOI  PMC  EPMC
2024
2. Nan,Y., Wu,X., Luo,Q., Chang,W., Zhao,P., Zhang,L. and Liu,Z.
   OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
   Proc Natl Acad Sci U S A (2024) 121, e2315348121-e2315348121. PubMed  Europe PubMed DOI  PMC  EPMC
3. Ren,W., Xu,Z., Chang,Y., Ju,F., Wu,H., Liang,Z., Zhao,M., Wang,N., Lin,Y., Xu,C., Chen,S., Rao,Y., Lin,C., Yang,J., Liu,P., Zhang,J., Huang,C. and Xia,N.
   Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
   Nat Commun (2024) 15, 9-9. PubMed  Europe PubMed DOI  PMC  EPMC
4. Zhu,W., Wu,C., Liu,Z., Zhao,S. and Huang,J.
   OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression
   Cell Commun Signal (2024) 22, 420-420. PubMed  Europe PubMed DOI  PMC  EPMC  K
2023
5. Gan,J., de Vries,J., Akkermans,J.J.L.L., Mohammed,Y., Tjokrodirijo,R.T.N., de Ru,A.H., Kim,R.Q., Vargas,D.A., Pol,V., Fasan,R., van Veelen,P.A., Neefjes,J., van Dam,H., Ovaa,H., Sapmaz,A. and Geurink,P.P.
   Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2
   ACS Chem Biol (2023) 18, 2003-2013. PubMed  Europe PubMed DOI  PMC  EPMC  I
6. Song,Y. and Wu,Q.
   RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling
   Environ Toxicol (2023) 38, 2155-2164. PubMed  Europe PubMed DOI  K
7. Zhang,Q., Zhang,J., Yao,A., Tian,X., Han,Z., Yuan,Y., Tao,K. and Yang,X.
   OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway
   Cell Biol Int (2023) 47, 428-438. PubMed  Europe PubMed DOI
2022
8. Chang,W., Luo,Q., Wu,X., Nan,Y., Zhao,P., Zhang,L., Luo,A., Jiao,W., Zhu,Q., Fu,Y. and Liu,Z.
   OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
   Cell Rep (2022) 41, 111561-111561. PubMed  Europe PubMed DOI
9. Hu,G., Yang,J., Zhang,H., Huang,Z. and Yang,H.
   OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation
   Cell Mol Bioeng (2022) 15, 281-292. PubMed  Europe PubMed DOI  PMC  EPMC  K
10. Li,J., Zhang,N., Li,M., Hong,T., Meng,W. and Ouyang,T.
    The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function
    Front Cell Dev Biol (2022) 10, 820781-820781. PubMed  Europe PubMed DOI  PMC  EPMC  V
11. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W.
    OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
    Cell Death Discov (2022) 8, 45-45. PubMed  Europe PubMed DOI  PMC  EPMC
12. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W.
    Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
    Cell Death Discov (2022) 8, 211-211. PubMed  Europe PubMed DOI  PMC  EPMC
2021
13. Liu,G., Guo,W., Qin,J. and Lin,Z.
    OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties
    Front Oncol (2021) 11, 711735-711735. PubMed  Europe PubMed DOI  PMC  EPMC  K
14. Sivakumar,D. and Stein,M.
    Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases
    Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
15. Yu,S., Zang,W., Qiu,Y., Liao,L. and Zheng,X.
    Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis
    Oncogene (2021) 41, 46-56. PubMed  Europe PubMed DOI
16. Zhu,Q., Fu,Y., Li,L., Liu,C.H. and Zhang,L.
    The functions and regulation of Otubains in protein homeostasis and diseases
    Ageing Res Rev (2021) 67, 101303-101303. PubMed  Europe PubMed DOI  V
2020
17. Gu,Z.L., Huang,J. and Zhen,L.L.
    Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling
    Kaohsiung J Med Sci (2020) PubMed  Europe PubMed DOI  K
18. Sivakumar,D., Kumar,V., Naumann,M. and Stein,M.
    Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
    J Biol Chem (2020) 295, 6972-6982. PubMed  Europe PubMed DOI
19. Wan,Q., Chen,Q., Cai,D., Zhao,Y. and Wu,X.
    OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer
    Cell Transplant (2020) 29, 963689720931433-963689720931433. PubMed  Europe PubMed DOI  K
2019
20. Li,J., Cheng,D., Zhu,M., Yu,H., Pan,Z., Liu,L., Geng,Q., Pan,H., Yan,M. and Yao,M.
    OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
    Theranostics (2019) 9, 179-195. PubMed  Europe PubMed DOI  PMC  EPMC
21. Resnick,E., Bradley,A., Gan,J., Douangamath,A., Krojer,T., Sethi,R., Geurink,P.P., Aimon,A., Amitai,G., Bellini,D., Bennett,J., Fairhead,M., Fedorov,O., Gabizon,R., Gan,J., Guo,J., Plotnikov,A., Reznik,N., Ruda,G.F., Diaz-Saez,L., Straub,V.M., Szommer,T., Velupillai,S., Zaidman,D., Zhang,Y., Coker,A.R., Dowson,C.G., Barr,H.M., Wang,C., Huber,K.V.M., Brennan,P.E., Ovaa,H., von Delft,F. and London,N.
    Rapid covalent-probe discovery by electrophile-fragment screening
    J Am Chem Soc (2019) 141, 8951-8968. PubMed  Europe PubMed DOI  I
22. Zhang,Z., Du,J., Wang,S., Shao,L., Jin,K., Li,F., Wei,B., Ding,W., Fu,P., van Dam,H., Wang,A., Jin,J., Ding,C., Yang,B., Zheng,M., Feng,X.H., Guan,K.L. and Zhang,L.
    OTUB2 Promotes cancer metastasis via Hippo-independent activation of YAP and TAZ
    Mol Cell (2019) 73, 7-21. PubMed  Europe PubMed DOI
2018
23. Li,X.Y., Mao,X.F., Tang,X.Q., Han,Q.Q., Jiang,L.X., Qiu,Y.M., Dai,J. and Wang,Y.X.
    Regulation of Gli2 stability by deubiquitinase OTUB2
    Biochem Biophys Res Commun (2018) 505, 113-118. PubMed  Europe PubMed DOI
2015
24. Altun,M., Walter,T.S., Kramer,H.B., Herr,P., Iphofer,A., Bostrom,J., David,Y., Komsany,A., Ternette,N., Navon,A., Stuart,D.I., Ren,J. and Kessler,B.M.
    The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages
    PLoS ONE (2015) 10, e0115344-e0115344. PubMed  Europe PubMed DOI  PMC  EPMC  S
2013
25. Beck,A., Vinik,Y., Shatz-Azoulay,H., Isaac,R., Streim,S., Jona,G., Boura-Halfon,S. and Zick,Y.
    Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets
    Diabetologia (2013) 56, 1317-1326. PubMed  Europe PubMed DOI
2012
26. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0] (2012) 3, 2113-2120. DOI
2004
27. Nanao,M.H., Tcherniuk,S.O., Chroboczek,J., Dideberg,O., Dessen,A. and Balakirev,M.Y.
    Crystal structure of human otubain 2
    EMBO Rep (2004) 5, 783-788. PubMed  Europe PubMed DOI  PMC  EPMC  S
2003
28. Balakirev,M.Y., Tcherniuk,S.O., Jaquinod,M. and Chroboczek,J.
    Otubains: a new family of cysteine proteases in the ubiquitin pathway
    EMBO Rep (2003) 4, 517-522. PubMed  Europe PubMed DOI  PMC  EPMC  I