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Literature for peptidase C64.003: A20 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, M Mutation, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bai,W., Liu,S., Zhou,G., Li,X., Jiang,H., Shao,J. and Zhu,J.
    TNFAIP3 alleviates cerebral ischemia-reperfusion injury by inhibiting M1 microglia polarization via deubiquitination of RACK1
    PLoS ONE (2025) 20, e0337601-e0337601. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Blaisdell,A., Bachl,S., Sandoval,L.R., Ching,C., Bowman,C.J., Kale,N., Prabandham,M., Diolaiti,M., Havig,C., Advincula,R., Lenci,N., Li,Z., Yamashita,E., Wang,C.H., Zhang,S., Liu,Q., Achacoso,P., Stibor,D., Oynebraten,I., Seo,J., Ashworth,A., Marson,A., Ye,C.J., Malynn,B.A., Eyquem,J., Carnevale,J. and Ma,A.
    Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  3. Bowman,C.J., Stibor,D.M., Sun,X., Lenci,N., Shimizu,H., Yamashita,E.F., Advincula,R., Kim,M.C., Turnbaugh,J.A., Sun,Y., Razani,B., Turnbaugh,P.J., Ye,C.J., Malynn,B.A. and Ma,A.
    A20's linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritis
    J Clin Invest (2025) 135 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Deng,X., Jiang,S., Liu,Z., Liu,X., Lu,T. and Liu,X.
    Berbamine Targets TNFAIP3: A Bioactive Compound Alleviates Oxidative Stress and Inflammation in the Comorbidity of Insomnia and Chronic Obstructive Pulmonary Disease Through Multi-Omics Integration
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Kohler,P., Ribeiro,A., Honarpisheh,M., von Rauchhaupt,E., Lorenz,G., Li,C., Martin,L., Steiger,S., Lindenmeyer,M., Schmaderer,C., Anders,H.J., Thomasova,D. and Lech,M.
    Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton
    Cells (2025) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Luo,F., Yang,T., Cao,J., Chen,Q., Lu,Z., Lu,F., Lin,C., Xia,Z., Yang,Y., Li,P., Ma,W., Luo,M. and Zhang,R.
    A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK-beta
    Adv Sci (Weinh) (2025) , e14486-e14486. PubMed  Europe PubMed DOI  K
  7. Peng,X., Zhao,W., Yang,F., Wei,Y., Zhang,Y., Chen,S., Wei,J.Y., Huang,J., Teng,Y., Zeng,G. and Zong,S.
    Gnetol targeting of TNFAIP3 promotes SLC7A11 ubiquitination and ferroptosis in osteoclasts to ameliorate osteoporosis
    Phytomedicine (2025) 148, 157422-157422. PubMed  Europe PubMed DOI
  8. Xiao,S., Shen,Y., Zhang,M., Liu,X., Cai,T. and Wang,F.
    VacA promotes pyroptosis via TNFAIP3/TRAF1 signaling to induce onset of atrophic gastritis
    Microbiol Res (2025) 296, 128142-128142. PubMed  Europe PubMed DOI
    9. 2024
  9. Bagyinszky,E. and An,S.S.A.
    Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Culver-Cochran,A.E., Hassan,A., Hueneman,K., Choi,K., Ma,A., VanCauwenbergh,B., O'Brien,E., Wunderlich,M., Perentesis,J.P. and Starczynowski,D.T.
    Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis
    Nat Commun (2024) 15, 9189-9189. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Karri,U., Harasimowicz,M., Carpio Tumba,M. and Schwartz,D.M.
    The Complexity of Being A20: From Biological Functions to Genetic Associations
    J Clin Immunol (2024) 44, 76-76. PubMed  Europe PubMed DOI
  12. Kommer,A., Meineck,M., Classen,P. and Weinmann-Menke,J.
    A20 in Kidney Transplantation and Autoimmunity
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  V
  13. Mukohara,F., Iwata,K., Ishino,T., Inozume,T., Nagasaki,J., Ueda,Y., Suzawa,K., Ueno,T., Ikeda,H., Kawase,K., Saeki,Y., Kawashima,S., Yamashita,K., Kawahara,Y., Nakamura,Y., Honobe-Tabuchi,A., Watanabe,H., Dansako,H., Kawamura,T., Suzuki,Y., Honda,H., Mano,H., Toyooka,S., Kawazu,M. and Togashi,Y.
    Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity
    Proc Natl Acad Sci U S A (2024) 121, e2320189121-e2320189121. PubMed  Europe PubMed DOI  PMC  EPMC
  14. O'Sullivan,P.A., Aidarova,A., Afonina,I., Manils,J., Thurston,T.L.M., Instrell,R., Howell,M., Boeing,S., Ranawana,S., Herpels,M., Chetien,R., Bassa,M., Flynn,H.R., Frith,D., Snijders,A., Howes,A., Beyaert,R., Bowcock,A. and Ley,S.C.
    CARD14 SIGNALOSOME FORMATION IS ASSOCIATED WITH ITS ENDOSOMAL RELOCATION AND mTORC1-INDUCED KERATINOCYTE PROLIFERATION
    Biochem J (2024) PubMed  Europe PubMed DOI
  15. Petta,I., Thorp,M., Ciers,M., Blancke,G., Boon,L., Meese,T., Van Nieuwerburgh,F., Wullaert,A., Grencis,R., Elewaut,D., Van Loo,G. and Vereecke,L.
    Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance
    Front Immunol (2024) 15, 1373745-1373745. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Sorada,T., Walinda,E. and Morimoto,D.
    Cyclization of ubiquitin chains reinforces their recognition by ZNF216
    FEBS Lett (2024) 598, 2249-2258. PubMed  Europe PubMed DOI
  17. Wang,J., Rong,Q., Ye,L., Fang,B., Zhao,Y., Sun,Y., Zhou,H., Wang,D., He,J., Cui,Z., Zhang,Q., Kang,D. and Hu,L.
    Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors
    J Med Chem (2024) 67, 7197-7223. PubMed  Europe PubMed DOI
    18. 2023
  18. El Khouri,E., Diab,F., Louvrier,C., Assrawi,E., Daskalopoulou,A., Nguyen,A., Piterboth,W., Deshayes,S., Desdoits,A., Copin,B., Dastot Le Moal,F., Karabina,S.A., Amselem,S., Aouba,A. and Giurgea,I.
    A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation
    elife (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.
    The Role of DNA Viruses in Human Cancer
    Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. Giang,N.H., Lien,N.T.K., Trang,D.T., Huong,P.T., Hoang,N.H. and Xuan,N.T.
    Associations of A20, CYLD, Cezanne and JAK2 Genes and Immunophenotype with Psoriasis Susceptibility
    Medicina (Kaunas) (2023) 59 PubMed  Europe PubMed DOI  PMC  EPMC  M
  21. Han,Y., Zhang,J., Yang,Z., Jian,W., Zhu,Y., Gao,S., Liu,Y., Li,Y., He,S., Zhang,C., Li,Y., You,B., Liu,J. and Du,J.
    Palmdelphin Deficiency Evokes NF-kappaB Signaling in Valvular Endothelial Cells and Aggravates Aortic Valvular Remodeling
    JACC Basic Transl Sci (2023) 8, 1457-1472. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Liu,Y., Xu,K., Yao,Y. and Liu,Z.
    Current research into A20 mediation of allergic respiratory diseases and its potential usefulness as a therapeutic target
    Front Immunol (2023) 14, 1166928-1166928. PubMed  Europe PubMed DOI  PMC  EPMC  V
  23. Peng,Z.M., Zhang,Y.Y., Wei,D., Zhang,X.J., Liu,B., Peng,J. and Luo,X.J.
    MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway
    Arch Biochem Biophys (2023) 735, 109502-109502. PubMed  Europe PubMed DOI  K
  24. Rogers,N.M., Zammit,N., Nguyen-Ngo,D., Souilmi,Y., Minhas,N., Meijles,D.N., Self,E., Walters,S.N., Warren,J., Cultrone,D., El-Rashid,M., Li,J., Chtanova,T., O'Connell,P.J. and Grey,S.T.
    The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-kappaB activation in acute kidney injury
    Kidney Int (2023) 103, 1105-1119. PubMed  Europe PubMed DOI
  25. Sheveleva,O., Protasova,E., Nenasheva,T., Butorina,N., Melnikova,V., Gerasimova,T., Sakovnich,O., Kurinov,A., Grigor'eva,E., Medvedev,S. and Lyadova,I.
    A Model of iPSC-Derived Macrophages with TNFAIP3 Overexpression Reveals the Peculiarities of TNFAIP3 Protein Expression and Function in Human Macrophages
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2022
  26. Bai,W., Huo,S., Li,J. and Shao,J.
    Advances in the Study of the Ubiquitin-Editing Enzyme A20
    Front Pharmacol (2022) 13, 845262-845262. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Jantaree,P., Yu,Y., Chaithongyot,S., Tager,C., Sarabi,M.A., Meyer,T.F., Boccellato,F., Maubach,G. and Naumann,M.
    Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori
    Biochim Biophys Acta Mol Cell Res (2022) 1869, 119364-119364. PubMed  Europe PubMed DOI
  28. Wang,W., Bale,S., Wei,J., Yalavarthi,B., Bhattacharyya,D., Yan,J.J., Abdala-Valencia,H., Xu,D., Sun,H., Marangoni,R.G., Herzog,E., Berdnikovs,S., Miller,S.D., Sawalha,A.H., Tsou,P.S., Awaji,K., Yamashita,T., Sato,S., Asano,Y., Tiruppathi,C., Yeldandi,A., Schock,B.C., Bhattacharyya,S. and Varga,J.
    Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs
    Nat Commun (2022) 13, 6358-6358. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Wang,Y.T., Liu,T.Y., Shen,C.H., Lin,S.Y., Hung,C.C., Hsu,L.C. and Chen,G.C.
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
    Cell Rep (2022) 38, 110354-110354. PubMed  Europe PubMed DOI
  30. Yang,F.M., Shen,L., Fan,D.D., Bai,Y., Li,B. and Lee,J.
    YAP9/A20 complex suppresses proinflammatory responses and provides novel anti-inflammatory therapeutic potentials
    Front Immunol (2022) 13, 914381-914381. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Yokoyama,Y., Tamachi,T., Iwata,A., Maezawa,Y., Meguro,K., Yokota,M., Takatori,H., Suto,A., Suzuki,K., Hirose,K., Yamaguchi,N., Honda,H. and Nakajima,H.
    A20 (Tnfaip3) expressed in CD4(+) T cells suppresses Th2 cell-mediated allergic airway inflammation in mice
    Biochem Biophys Res Commun (2022) 629, 47-53. PubMed  Europe PubMed DOI
    32. 2021
  32. Li,S., Zheng,X., Hu,Y., You,K. and Wang,J.
    RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-kappaB signaling pathway
    Chem Biol Interact (2021) 348, 109623-109623. PubMed  Europe PubMed DOI  K
  33. Liu,S., Lv,X., Wei,X., Liu,C., Li,Q., Min,J., Hua,F., Zhang,X., Li,K., Li,P., Xiao,Y., Hu,Z. and Cui,B.
    TRIB3GSK-3beta interaction promotes lung fibrosis and serves as a potential therapeutic target
    Acta Pharm Sin B (2021) 11, 3105-3119. PubMed  Europe PubMed DOI  PMC  EPMC  K
  34. Meng,Z., Xu,R., Xie,L., Wu,Y., He,Q., Gao,P., He,X., Chen,Q., Xie,Q., Zhang,J. and Yang,Q.
    A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1
    J Biol Chem (2021) 297, 100811-100811. PubMed  Europe PubMed DOI
  35. Zhou,M., He,J., Shi,Y., Liu,X., Luo,S., Cheng,C., Ge,W., Qu,C., Du,P. and Chen,Y.
    ABIN3 negatively regulates necroptosis-induced intestinal inflammation through recruiting A20 and restricting the ubiquitination of RIPK3 in inflammatory bowel disease
    J Crohns Colitis (2021) 15, 99-114. PubMed  Europe PubMed DOI
  36. Zou,J., Xia,H., Zhang,C., Xu,H., Tang,Q., Zhu,G., Li,J. and Bi,F.
    Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy
    Cancer Sci (2021) 112, 2664-2678. PubMed  Europe PubMed DOI
    37. 2020
  37. Chen,D., Ma,L., Hu,T., Liu,J., Chen,B., Yang,P. and Liu,Z.
    A20 Restores impaired intestinal permeability and inhibits Th2 response in mice with colitis
    Dig Dis Sci (2020) 65, 1340-1347. PubMed  Europe PubMed DOI
  38. Downey,A., Olcott,M., Spector,D., Bird,K., Ter Doest,A., Pierce,Z., Quach,E., Sparks,S., Super,C., Naifeh,J., Powers,A., White,M. and Hensley,K.
    Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
    Free Radic Biol Med (2020) 161, 115-124. PubMed  Europe PubMed DOI
  39. Feng,Y., Zhang,Y., Cai,Y., Liu,R., Lu,M., Li,T., Fu,Y., Guo,M., Huang,H., Ou,Y. and Chen,Y.
    A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma
    Cell Death Dis (2020) 11, 89-89. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Feoktistova,M., Makarov,R., Brenji,S., Schneider,A.T., Hooiveld,G.J., Luedde,T., Leverkus,M., Yazdi,A.S. and Panayotova-Dimitrova,D.
    A20 Promotes ripoptosome formation and TNF-induced apoptosis via cIAPs regulation and NIK stabilization in keratinocytes
    Cells (2020) 9 PubMed  Europe PubMed DOI
  41. Liang,J., Zhang,J.J., Huang,H.I., Kanayama,M., Youssef,N., Jin,Y.J., Reyes,E.Y., Abram,C.L., Yang,S., Lowell,C.A., Wang,D., Shao,L., Shinohara,M.L., Zhang,J.Y. and Hammer,G.E.
    The ubiquitin-modifying enzyme A20 terminates C-type lectin receptor signals and is a suppressor of host defense against systemic fungal infection
    Infect Immun (2020) PubMed  Europe PubMed DOI
  42. Martens,A., Priem,D., Hoste,E., Vetters,J., Rennen,S., Catrysse,L., Voet,S., Deelen,L., Sze,M., Vikkula,H., Slowicka,K., Hochepied,T., Iliaki,K., Wullaert,A., Janssens,S., Lamkanfi,M., Beyaert,R., Armaka,M., Bertrand,M.J.M. and Van Loo,G.
    Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
    Nat Immunol (2020) 21, 381-387. PubMed  Europe PubMed DOI
  43. Mei,S., Ruan,H., Ma,Q. and Yao,W.D.
    The ubiquitin-editing enzyme A20 regulates synapse remodeling and efficacy
    Brain Res (2020) 1727, 146569-146569. PubMed  Europe PubMed DOI
  44. Mooney,E.C. and Sahingur,S.E.
    The Ubiquitin System and A20: Implications in Health and Disease
    J Dent Res (2020) , 22034520949486-22034520949486. PubMed  Europe PubMed DOI  V
  45. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  46. Razani,B., Malynn,B.A. and Ma,A.
    Preserving immune homeostasis with A20
    Adv Immunol (2020) 148, 1-48. PubMed  Europe PubMed DOI
  47. Song,Z., Wei,W., Xiao,W., Al-Saleem,E.D., Nejati,R., Chen,L., Yin,J., Fabrizio,J., Petrus,M.N., Waldmann,T.A. and Yang,Y.
    Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma
    Proc Natl Acad Sci U S A (2020) 117, 28980-28991. PubMed  Europe PubMed DOI
  48. Sun,S.C.
    A20 restricts inflammation via ubiquitin binding
    Nat Immunol (2020) 21, 362-364. PubMed  Europe PubMed DOI
  49. Xiao,Y., Huang,Q., Wu,Z. and Chen,W.
    Roles of protein ubiquitination in inflammatory bowel disease
    Immunobiology (2020) 225, 152026-152026. PubMed  Europe PubMed DOI  V
  50. Yan,K., Wu,C., Ye,Y., Li,L., Wang,X., He,W., Ren,S. and Xu,Y.
    A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia
    Cell Prolif (2020) , e12778-e12778. PubMed  Europe PubMed DOI
    51. 2019
  51. Chen,X., Qian,B., Kong,X., Hao,J., Ye,Y., Yang,K., Xu,T. and Zhang,F.
    A20 protects neuronal apoptosis stimulated by lipopolysaccharide-induced microglial exosomes
    Neurosci Lett (2019) 712, 134480-134480. PubMed  Europe PubMed DOI
  52. Duan,R., Liu,Q., Li,J., Bian,X., Yuan,Q., Li,Y., Long,F., Gao,S., Wei,S., Li,P., Gao,F., Sun,W., Li,X. and Liu,Q.
    A de novo frameshift mutation in TNFAIP3 impairs A20 deubiquitination function to cause neuropsychiatric systemic lupus erythematosus
    J Clin Immunol (2019) 39, 795-804. PubMed  Europe PubMed DOI  M
  53. Priem,D., Devos,M., Druwe,S., Martens,A., Slowicka,K., Ting,A.T., Pasparakis,M., Declerq,W., Vandenabeele,P., Van Loo,G. and Bertrand,M.J.M.
    A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
    Cell Death Dis (2019) 10, 692-692. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Zammit,N.W., Siggs,O.M., Gray,P.E., Horikawa,K., Langley,D.B., Walters,S.N., Daley,S.R., Loetsch,C., Warren,J., Yap,J.Y., Cultrone,D., Russell,A., Malle,E.K., Villanueva,J.E., Cowley,M.J., Gayevskiy,V., Dinger,M.E., Brink,R., Zahra,D., Chaudhri,G., Karupiah,G., Whittle,B., Roots,C., Bertram,E., Yamada,M., Jeelall,Y., Enders,A., Clifton,B.E., Mabbitt,P.D., Jackson,C.J., Watson,S.R., Jenne,C.N., Lanier,L.L., Wiltshire,T., Spitzer,M.H., Nolan,G.P., Schmitz,F., Aderem,A., Porebski,B.T., Buckle,A.M., Abbott,D.W., Ziegler,J.B., Craig,M.E., Benitez-Aguirre,P., Teo,J., Tangye,S.G., King,C., Wong,M., Cox,M.P., Phung,W., Tang,J., Sandoval,W., Wertz,I.E., Christ,D., Goodnow,C.C. and Grey,S.T.
    Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
    Nat Immunol (2019) 20, 1299-1310. PubMed  Europe PubMed DOI  M
    55. 2018
  55. Bombassaro,B., Ignacio-Souza,L.M., Nunez,C.E., Razolli,D.S., Pedro,R.M., Coope,A., Araujo,E.P., Chaim,E.A. and Velloso,L.A.
    A20 deubiquitinase controls PGC-1alpha expression in the adipose tissue
    Lipids Health Dis (2018) 17, 90-90. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Hyeon,J., Lee,B., Shin,S.H., Yoo,H.Y., Kim,S.J., Kim,W.S., Park,W.Y. and Ko,Y.H.
    Targeted deep sequencing of gastric marginal zone lymphoma identified alterations of TRAF3 and TNFAIP3 that were mutually exclusive for MALT1 rearrangement
    Mod Pathol (2018) 31, 1418-1428. PubMed  Europe PubMed DOI  M
  57. Nakamura,B.N., Glazier,A., Kattah,M.G., Duong,B., Jia,Y., Campo,D. and Shao,L.
    A20 regulates canonical wnt-signaling through an interaction with RIPK4
    PLoS ONE (2018) 13, e0195893-e0195893. PubMed  Europe PubMed DOI  K
  58. Soni,D., Wang,D.M., Regmi,S.C., Mittal,M., Vogel,S.M., Schluter,D. and Tiruppathi,C.
    Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury
    Cell Death Discov (2018) 4, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Van Quickelberghe,E., Martens,A., Goeminne,L.J.E., Clement,L., Van Loo,G. and Gevaert,K.
    Identification of Immune-Responsive Gene 1 (IRG1) as a target of A20
    J Proteome Res (2018) 17, 2182-2191. PubMed  Europe PubMed DOI  K
    60. 2017
  60. Lork,M., Verhelst,K. and Beyaert,R.
    CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
    Cell Death Differ (2017) 24, 1172-1183. PubMed  Europe PubMed DOI
    61. 2016
  61. Catrysse,L., Farhang Ghahremani,M., Vereecke,L., Youssef,S.A., Mc Guire,C., Sze,M., Weber,A., Heikenwalder,M., de Bruin,A., Beyaert,R. and Van Loo,G.
    A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
    Cell Death Dis (2016) 7, e2250-e2250. PubMed  Europe PubMed DOI  K
  62. Chang,Y.C., Chang,Y.S., Chang,C.C., Liu,T.C., Ko,Y.C., Lee,C.C., Chang,S.J. and Chang,J.G.
    Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations
    Oncol Rep (2016) 35, 2936-2942. PubMed  Europe PubMed DOI  M
    63. 2015
  63. Abbasi,A., Forsberg,K. and Bischof,F.
    The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes
    Front Mol Neurosci (2015) 8, 21-21. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Duong,B.H., Onizawa,M., Oses-Prieto,J.A., Advincula,R., Burlingame,A., Malynn,B.A. and Ma,A.
    A20 restricts ubiquitination of pro-interleukin-1beta protein complexes and suppresses NLRP3 inflammasome activity
    Immunity (2015) 42, 55-67. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Enesa,K., Moll,H.P., Luong,L., Ferran,C. and Evans,P.C.
    A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes
    FASEB J (2015) 29, 1869-1878. PubMed  Europe PubMed DOI
  66. Nakagawa,M.M., Thummar,K., Mandelbaum,J., Pasqualucci,L. and Rathinam,C.V.
    Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence
    J Exp Med (2015) 212, 203-216. PubMed  Europe PubMed DOI  K
  67. Onizawa,M., Oshima,S., Schulze-Topphoff,U., Oses-Prieto,J.A., Lu,T., Tavares,R., Prodhomme,T., Duong,B., Whang,M.I., Advincula,R., Agelidis,A., Barrera,J., Wu,H., Burlingame,A., Malynn,B.A., Zamvil,S.S. and Ma,A.
    The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
    Nat Immunol (2015) 16, 618-627. PubMed  Europe PubMed DOI
  68. Pfoh,R., Lacdao,I.K. and Saridakis,V.
    Deubiquitinases and the new therapeutic opportunities offered to cancer
    Endocr Relat Cancer (2015) 22, T35-T54. PubMed  Europe PubMed DOI  V  T
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