Literature for peptidase C64.001: Cezanne peptidase

(Topics flags: M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Ding,C., Cao,L., Wang,R., Wu,Q., Li,M., Zhang,J., Thorne,R.F., Li,J., Ma,J., Wu,M. and Cang,S.
   OTUD7B is a new deubiquitinase targeting p53
   Theranostics (2025) 15, 2121-2138. PubMed  Europe PubMed DOI  PMC  EPMC  K
2. Harit,K., Yi,W., Jeron,A., Schmidt,J., Beckervordersandforth,R., Wyler,E., Manukyan,A., Deckert,M., Radbruch,H., Conrad,T., Altmuller,J., Landthaler,M., Wang,X., Nishanth,G. and Schluter,D.
   Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation
   Nat Commun (2025) 16, 9279-9279. PubMed  Europe PubMed DOI  PMC  EPMC
3. Rao,Y., Li,F., Wan,C., Tong,S., Fu,Y. and Li,Y.
   OTUD7B controls oxLDL uptake by stabilizing Lox-1 in THP-1 and U937 cells
   Biochim Biophys Acta Mol Cell Biol Lipids (2025) , 159618-159618. PubMed  Europe PubMed DOI
4. Wang,L., Wu,X., Paul,A., Yao,J. and Wang,B.
   The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination
   PLoS Biol (2025) 23, e3003545-e3003545. PubMed  Europe PubMed DOI  PMC  EPMC
2024
5. Chen,X., He,L., Zhong,H., Yan,C., Ke,B. and Shi,L.
   The suppression of OTUD7B by miR-491-5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non-small cell lung cancer
   J Gene Med (2024) 26, e3743-e3743. PubMed  Europe PubMed DOI
6. Guo,Z. and Guo,L.
   OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession
   Dig Liver Dis (2024) 56, 352-362. PubMed  Europe PubMed DOI  K
7. Kim,Y.J., Lee,H.J., Kim,K.H., Cho,S.P. and Jung,J.Y.
   OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell
   Discov Oncol (2024) 15, 247-247. PubMed  Europe PubMed DOI  PMC  EPMC  K
8. Sun,C., Bai,J., Sun,J., Sun,Y., Zhang,F., Li,H., Liu,Y., Meng,L. and Wang,X.
   OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction
   Environ Toxicol (2024) 39, 1989-2005. PubMed  Europe PubMed DOI
9. Sun,J., Jin,X. and Li,Y.
   OTUD7B inhibited hepatic injury from NAFLD by inhibiting K48-linked ubiquitination and degradation of beta-catenin
   Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167555-167555. PubMed  Europe PubMed DOI
2023
10. Chen,J., Bolhuis,D.L., Laggner,C., Kong,D., Yu,L., Wang,X., Emanuele,M.J., Brown,N.G. and Liu,P.
    AtomNet-Aided OTUD7B Inhibitor Discovery and Validation
    Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC  I
11. Giang,N.H., Lien,N.T.K., Trang,D.T., Huong,P.T., Hoang,N.H. and Xuan,N.T.
    Associations of A20, CYLD, Cezanne and JAK2 Genes and Immunophenotype with Psoriasis Susceptibility
    Medicina (Kaunas) (2023) 59 PubMed  Europe PubMed DOI  PMC  EPMC  M
12. Harit,K., Bhattacharjee,R., Matuschewski,K., Becker,J., Kalinke,U., Schluter,D. and Nishanth,G.
    The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
    Cell Death Dis (2023) 14, 480-480. PubMed  Europe PubMed DOI  PMC  EPMC
13. Ilter,M., Schulze-Niemand,E., Naumann,M. and Stein,M.
    Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle
    J Chem Inf Model (2023) 63, 2084-2094. PubMed  Europe PubMed DOI  PMC  EPMC
2022
14. Xie,W., Tian,S., Yang,J., Cai,S., Jin,S., Zhou,T., Wu,Y., Chen,Z., Ji,Y. and Cui,J.
    OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity
    Autophagy (2022) , 1-15. PubMed  Europe PubMed DOI  K
15. Zhang,J., Zha,Y., Jiao,Y., Li,Y., Wang,J. and Zhang,S.
    OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway
    Arch Biochem Biophys (2022) 724, 109266-109266. PubMed  Europe PubMed DOI  K
2021
16. An,W., Luong,L.A., Bowden,N.P., Yang,M., Wu,W., Zhou,X., Liu,C., Niu,K., Luo,J., Zhang,C., Sun,X., Poston,R., Zhang,L., Evans,P.C. and Xiao,Q.
    Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling
    Cardiovasc Res (2021) PubMed  Europe PubMed DOI  K
17. Cheng,J., Fan,Y.Q., Jiang,H.X., Chen,S.F., Chen,J., Liao,X.Y., Zou,Y.Y., Lan,H.Y., Cui,Y., Chen,Z.B., Chen,Q.X. and Wan,Q.
    Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling
    Exp Neurol (2021) 345, 113818-113818. PubMed  Europe PubMed DOI
18. Gong,Z., Li,A., Ding,J., Li,Q., Zhang,L., Li,Y., Meng,Z., Chen,F., Huang,J., Zhou,D., Hu,R., Ye,J., Liu,W. and You,H.
    OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis
    Adv Sci (Weinh) (2021) , e2004504-e2004504. PubMed  Europe PubMed DOI
19. Snyder,N.A. and Silva,G.M.
    Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
    J Biol Chem (2021) 297, 101077-101077. PubMed  Europe PubMed DOI  V
2020
20. Chen,X., Pang,Z., Wang,Y., Zhu,L., Liu,J. and Du,J.
    Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R
    Am J Cancer Res (2020) 10, 4342-4356. PubMed  Europe PubMed  PMC  EPMC  K
21. Mader,J., Huber,J., Bonn,F., Dotsch,V., Rogov,V.V. and Bremm,A.
    Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding
    J Biol Chem (2020) 295, 2160-2174. PubMed  Europe PubMed DOI
2019
22. Bonacci,T. and Emanuele,M.J.
    Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne
    Cell Cycle (2019) 18, 652-660. PubMed  Europe PubMed DOI
23. Lei,S., He,Z., Chen,T., Guo,X., Zeng,Z., Shen,Y. and Jiang,J.
    Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway
    J Exp Clin Cancer Res (2019) 38, 470-470. PubMed  Europe PubMed DOI
24. Wu,X., Liu,S., Sagum,C., Chen,J., Singh,R., Chaturvedi,A., Horton,J.R., Kashyap,T.R., Fushman,D., Cheng,X., Bedford,M.T. and Wang,B.
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
    Genes Dev (2019) 33, 1702-1717. PubMed  Europe PubMed DOI
25. Yin,Z., Yang,L., Wu,F., Fan,J., Xu,J., Jin,Y. and Yang,G.
    Reactive oxygen specie-mediated Cezanne inactivation by oxidation of its catalytic cysteine residue in hepatocellular carcinoma
    Oncol Res (2019) 27, 1069-1077. PubMed  Europe PubMed DOI
2018
26. Bonacci,T., Suzuki,A., Grant,G.D., Stanley,N., Cook,J.G., Brown,N.G. and Emanuele,M.J.
    Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates
    EMBO J (2018) 37, e98701-e98701. PubMed  Europe PubMed DOI
27. Ji,Y., Cao,L., Zeng,L., Zhang,Z., Xiao,Q., Guan,P., Chen,S., Chen,Y., Wang,M. and Guo,D.
    The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-kappaB pathway
    J Cell Biochem (2018) 119, 1979-1991. PubMed  Europe PubMed DOI
2017
28. Wang,J.H., Zhong,X.P., Zhang,Y.F., Wu,X.L., Li,S.H., Jian,P.E., Ling,Y.H., Shi,M., Chen,M.S., Wei,W. and Guo,R.P.
    Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma
    Cell Death Dis (2017) 8, e3043-e3043. PubMed  Europe PubMed DOI
2016
29. Mevissen,T.E.T., Kulathu,Y., Mulder,M.P.C., Geurink,P.P., Maslen,S.L., Gersch,M., Elliott,P.R., Burke,J.E., van Tol,B.D.M., Akutsu,M., Oualid,F.E., Kawasaki,M., Freund,S.M.V., Ovaa,H. and Komander,D.
    Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
    Nature (2016) 538, 402-405. PubMed  Europe PubMed DOI  PMC  EPMC
2015
30. Moniz,S., Bandarra,D., Biddlestone,J., Campbell,K.J., Komander,D., Bremm,A. and Rocha,S.
    Cezanne regulates E2F1-dependent HIF2alpha expression
    J Cell Sci (2015) 128, 3082-3093. PubMed  Europe PubMed DOI
2014
31. Bremm,A., Moniz,S., Mader,J., Rocha,S. and Komander,D.
    Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner
    EMBO Rep (2014) 15, 1268-1277. PubMed  Europe PubMed DOI
2011
32. McNally,R.S., Davis,B.K., Clements,C.M., Accavitti-Loper,M.A., Mak,T.W. and Ting,J.P.
    DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    J Biol Chem (2011) 286, 4098-4106. PubMed  Europe PubMed DOI
2010
33. Bremm,A., Freund,S.M. and Komander,D.
    Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
    Nat Struct Mol Biol (2010) 17, 939-947. PubMed  Europe PubMed DOI  PMC  EPMC  P
2009
34. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics (2009) 10, 637-637. PubMed  Europe PubMed DOI
2005
35. Bermudez Moretti,M., Perullini,A.M., Batlle,A. and Correa Garcia,S.
    Expression of the UGA4 gene encoding the delta-aminolevulinic and gamma-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems
    Arch Microbiol (2005) 184, 137-140. PubMed  Europe PubMed DOI
2003
36. [YEAR:7-4-2003]Evans,P.C., Smith,T.S., Lai,M.J., Williams,M.G., Burke,D.F., Heyninck,K., Kreike,M.M., Beyaert,R., Blundell,T.L. and Kilshaw,P.J.
    A novel type of deubiquitinating enzyme
    J Biol Chem (7-4-2003) 278, 23180-23186. PubMed  Europe PubMed DOI
2001
37. [YEAR:1-8-2001]Evans,P.C., Taylor,E.R., Coadwell,J., Heyninck,K., Beyaert,R. and Kilshaw,P.J.
    Isolation and characterization of two novel A20-like proteins
    Biochem J (1-8-2001) 357, 617-623. PubMed  Europe PubMed DOI  PMC  EPMC