Literature for peptidase C64.001: Cezanne peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Ding,C., Cao,L., Wang,R., Wu,Q., Li,M., Zhang,J., Thorne,R.F., Li,J., Ma,J., Wu,M. and Cang,S. OTUD7B is a new deubiquitinase targeting p53 Theranostics (2025) 15, 2121-2138. PubMed Europe PubMed DOI PMC EPMC K
Harit,K., Yi,W., Jeron,A., Schmidt,J., Beckervordersandforth,R., Wyler,E., Manukyan,A., Deckert,M., Radbruch,H., Conrad,T., Altmuller,J., Landthaler,M., Wang,X., Nishanth,G. and Schluter,D. Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation Nat Commun (2025) 16, 9279-9279. PubMed Europe PubMed DOI PMC EPMC
Rao,Y., Li,F., Wan,C., Tong,S., Fu,Y. and Li,Y. OTUD7B controls oxLDL uptake by stabilizing Lox-1 in THP-1 and U937 cells Biochim Biophys Acta Mol Cell Biol Lipids (2025) , 159618-159618. PubMed Europe PubMed DOI
Wang,L., Wu,X., Paul,A., Yao,J. and Wang,B. The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination PLoS Biol (2025) 23, e3003545-e3003545. PubMed Europe PubMed DOI PMC EPMC

2024

Chen,X., He,L., Zhong,H., Yan,C., Ke,B. and Shi,L. The suppression of OTUD7B by miR-491-5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non-small cell lung cancer J Gene Med (2024) 26, e3743-e3743. PubMed Europe PubMed DOI
Guo,Z. and Guo,L. OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession Dig Liver Dis (2024) 56, 352-362. PubMed Europe PubMed DOI K
Kim,Y.J., Lee,H.J., Kim,K.H., Cho,S.P. and Jung,J.Y. OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell Discov Oncol (2024) 15, 247-247. PubMed Europe PubMed DOI PMC EPMC K
Sun,C., Bai,J., Sun,J., Sun,Y., Zhang,F., Li,H., Liu,Y., Meng,L. and Wang,X. OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction Environ Toxicol (2024) 39, 1989-2005. PubMed Europe PubMed DOI
Sun,J., Jin,X. and Li,Y. OTUD7B inhibited hepatic injury from NAFLD by inhibiting K48-linked ubiquitination and degradation of beta-catenin Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167555-167555. PubMed Europe PubMed DOI

2023

Chen,J., Bolhuis,D.L., Laggner,C., Kong,D., Yu,L., Wang,X., Emanuele,M.J., Brown,N.G. and Liu,P. AtomNet-Aided OTUD7B Inhibitor Discovery and Validation Cancers (Basel) (2023) 15 PubMed Europe PubMed DOI PMC EPMC I
Giang,N.H., Lien,N.T.K., Trang,D.T., Huong,P.T., Hoang,N.H. and Xuan,N.T. Associations of A20, CYLD, Cezanne and JAK2 Genes and Immunophenotype with Psoriasis Susceptibility Medicina (Kaunas) (2023) 59 PubMed Europe PubMed DOI PMC EPMC M
Harit,K., Bhattacharjee,R., Matuschewski,K., Becker,J., Kalinke,U., Schluter,D. and Nishanth,G. The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2 Cell Death Dis (2023) 14, 480-480. PubMed Europe PubMed DOI PMC EPMC
Ilter,M., Schulze-Niemand,E., Naumann,M. and Stein,M. Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle J Chem Inf Model (2023) 63, 2084-2094. PubMed Europe PubMed DOI PMC EPMC

2022

Xie,W., Tian,S., Yang,J., Cai,S., Jin,S., Zhou,T., Wu,Y., Chen,Z., Ji,Y. and Cui,J. OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity Autophagy (2022) , 1-15. PubMed Europe PubMed DOI K
Zhang,J., Zha,Y., Jiao,Y., Li,Y., Wang,J. and Zhang,S. OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway Arch Biochem Biophys (2022) 724, 109266-109266. PubMed Europe PubMed DOI K

2021

An,W., Luong,L.A., Bowden,N.P., Yang,M., Wu,W., Zhou,X., Liu,C., Niu,K., Luo,J., Zhang,C., Sun,X., Poston,R., Zhang,L., Evans,P.C. and Xiao,Q. Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling Cardiovasc Res (2021) PubMed Europe PubMed DOI K
Cheng,J., Fan,Y.Q., Jiang,H.X., Chen,S.F., Chen,J., Liao,X.Y., Zou,Y.Y., Lan,H.Y., Cui,Y., Chen,Z.B., Chen,Q.X. and Wan,Q. Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling Exp Neurol (2021) 345, 113818-113818. PubMed Europe PubMed DOI
Gong,Z., Li,A., Ding,J., Li,Q., Zhang,L., Li,Y., Meng,Z., Chen,F., Huang,J., Zhou,D., Hu,R., Ye,J., Liu,W. and You,H. OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis Adv Sci (Weinh) (2021) , e2004504-e2004504. PubMed Europe PubMed DOI
Snyder,N.A. and Silva,G.M. Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response J Biol Chem (2021) 297, 101077-101077. PubMed Europe PubMed DOI V

2020

Chen,X., Pang,Z., Wang,Y., Zhu,L., Liu,J. and Du,J. Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R Am J Cancer Res (2020) 10, 4342-4356. PubMed Europe PubMed PMC EPMC K
Mader,J., Huber,J., Bonn,F., Dotsch,V., Rogov,V.V. and Bremm,A. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding J Biol Chem (2020) 295, 2160-2174. PubMed Europe PubMed DOI

2019

Bonacci,T. and Emanuele,M.J. Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne Cell Cycle (2019) 18, 652-660. PubMed Europe PubMed DOI
Lei,S., He,Z., Chen,T., Guo,X., Zeng,Z., Shen,Y. and Jiang,J. Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway J Exp Clin Cancer Res (2019) 38, 470-470. PubMed Europe PubMed DOI
Wu,X., Liu,S., Sagum,C., Chen,J., Singh,R., Chaturvedi,A., Horton,J.R., Kashyap,T.R., Fushman,D., Cheng,X., Bedford,M.T. and Wang,B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne Genes Dev (2019) 33, 1702-1717. PubMed Europe PubMed DOI
Yin,Z., Yang,L., Wu,F., Fan,J., Xu,J., Jin,Y. and Yang,G. Reactive oxygen specie-mediated Cezanne inactivation by oxidation of its catalytic cysteine residue in hepatocellular carcinoma Oncol Res (2019) 27, 1069-1077. PubMed Europe PubMed DOI

2018

Bonacci,T., Suzuki,A., Grant,G.D., Stanley,N., Cook,J.G., Brown,N.G. and Emanuele,M.J. Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates EMBO J (2018) 37, e98701-e98701. PubMed Europe PubMed DOI
Ji,Y., Cao,L., Zeng,L., Zhang,Z., Xiao,Q., Guan,P., Chen,S., Chen,Y., Wang,M. and Guo,D. The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-kappaB pathway J Cell Biochem (2018) 119, 1979-1991. PubMed Europe PubMed DOI

2017

Wang,J.H., Zhong,X.P., Zhang,Y.F., Wu,X.L., Li,S.H., Jian,P.E., Ling,Y.H., Shi,M., Chen,M.S., Wei,W. and Guo,R.P. Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma Cell Death Dis (2017) 8, e3043-e3043. PubMed Europe PubMed DOI

2016

Mevissen,T.E.T., Kulathu,Y., Mulder,M.P.C., Geurink,P.P., Maslen,S.L., Gersch,M., Elliott,P.R., Burke,J.E., van Tol,B.D.M., Akutsu,M., Oualid,F.E., Kawasaki,M., Freund,S.M.V., Ovaa,H. and Komander,D. Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne Nature (2016) 538, 402-405. PubMed Europe PubMed DOI PMC EPMC

2015

Moniz,S., Bandarra,D., Biddlestone,J., Campbell,K.J., Komander,D., Bremm,A. and Rocha,S. Cezanne regulates E2F1-dependent HIF2alpha expression J Cell Sci (2015) 128, 3082-3093. PubMed Europe PubMed DOI

2014

Bremm,A., Moniz,S., Mader,J., Rocha,S. and Komander,D. Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner EMBO Rep (2014) 15, 1268-1277. PubMed Europe PubMed DOI

2011

McNally,R.S., Davis,B.K., Clements,C.M., Accavitti-Loper,M.A., Mak,T.W. and Ting,J.P. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB J Biol Chem (2011) 286, 4098-4106. PubMed Europe PubMed DOI

2010

Bremm,A., Freund,S.M. and Komander,D. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne Nat Struct Mol Biol (2010) 17, 939-947. PubMed Europe PubMed DOI PMC EPMC P

2009

Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development BMC Genomics (2009) 10, 637-637. PubMed Europe PubMed DOI

2005

Bermudez Moretti,M., Perullini,A.M., Batlle,A. and Correa Garcia,S. Expression of the UGA4 gene encoding the delta-aminolevulinic and gamma-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems Arch Microbiol (2005) 184, 137-140. PubMed Europe PubMed DOI

2003

[YEAR:7-4-2003]Evans,P.C., Smith,T.S., Lai,M.J., Williams,M.G., Burke,D.F., Heyninck,K., Kreike,M.M., Beyaert,R., Blundell,T.L. and Kilshaw,P.J. A novel type of deubiquitinating enzyme J Biol Chem (7-4-2003) 278, 23180-23186. PubMed Europe PubMed DOI

2001

[YEAR:1-8-2001]Evans,P.C., Taylor,E.R., Coadwell,J., Heyninck,K., Beyaert,R. and Kilshaw,P.J. Isolation and characterization of two novel A20-like proteins Biochem J (1-8-2001) 357, 617-623. PubMed Europe PubMed DOI PMC EPMC