Literature for peptidase C48.011: SENP8 peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, I Inhibitor, P Specificity. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jimenez-Lasheras,B., Velasco-Beltran,P., Egia-Mendikute,L., Perez-Gutierrez,L., Lee,S.Y., de Blas,A., Garcia Del Rio,A., Zanetti,S.R., Antonana-Vildosola,A., Barreira-Manrique,A., Bosch,A., Etxaniz Diaz de Durana,J., Prieto-Fernandez,E., Serrano-Macia,M., Goikoetxea-Usandizaga,N., Azkargorta,M., Elortza,F., Gruber,T., Peer,S., Baier,G., Woodhoo,A., Martinez-Chantar,M.L. and Palazon,A.
    NEDDylation regulates CD8+ T cell metabolism and anti-tumor immunity
    Cancer Immunol Res PubMed  Europe PubMed DOI
  2. 2021
  3. Chen,D.V., Suzuki,T., Itoh,Y., Maeda,Y., Hirano,J., Haga,S., Zhang,H., Ito,D., Matsuura,Y. and Okamoto,T.
    Deneddylation by SENP8 Restricts Hepatitis B Virus Propagation
    Microbiol Immunol[PMID:i] DOI
  4. 2020
  5. Dubiel,W., Chaithongyot,S., Dubiel,D. and Naumann,M.
    The COP9 Signalosome: A Multi-DUB Complex
    Biomolecules10, 1082-1082. PubMed  Europe PubMed DOI
  6. 2017
  7. Coleman,K.E., Bekes,M., Chapman,J.R., Crist,S.B., Jones,M.J., Ueberheide,B.M. and Huang,T.T.
    SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
    elife6, PubMed  Europe PubMed DOI
  8. Mergner,J., Kuster,B. and Schwechheimer,C.
    DENEDDYLASE1 protein counters automodification of neddylating enzymes to maintain NEDD8 protein homeostasis in Arabidopsis
    J Biol Chem292, 3854-3865. PubMed  Europe PubMed DOI
  9. 2012
  10. Drag,M.
    SENP8 peptidase
    [ISSN:978-0-12-407743-0]3, 2379-2381. DOI
  11. 2011
  12. Shin,Y.C., Tang,S.J., Chen,J.H., Liao,P.H. and Chang,S.C.
    The molecular determinants of NEDD8 specific recognition by human SENP8
    PLoS ONE6, e27742-e27742. PubMed  Europe PubMed DOI
  13. 2010
  14. Watson,I.R., Li,B.K., Roche,O., Blanch,A., Ohh,M. and Irwin,M.S.
    Chemotherapy induces NEDP1-mediated destabilization of MDM2
    Oncogene29, 297-304. PubMed  Europe PubMed DOI
  15. 2008
  16. Chan,Y., Yoon,J., Wu,J.T., Kim,H.J., Pan,K.T., Yim,J. and Chien,C.T.
    DEN1 deneddylates non-cullin proteins in vivo
    J Cell Sci121, 3218-3223. PubMed  Europe PubMed DOI
  17. Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S.
    Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Biochem J409, 461-469. PubMed  Europe PubMed DOI  P
  18. 2006
  19. Watson,I.R., Blanch,A., Lin,D.C., Ohh,M. and Irwin,M.S.
    Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
    J Biol Chem281, 34096-34103. PubMed  Europe PubMed DOI
  20. 2005
  21. [YEAR:7-1-2005]Reverter,D., Wu,K., Erdene,T.G., Pan,Z.Q., Wilkinson,K.D. and Lima,C.D.
    Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1
    J Mol Biol345, 141-151. PubMed  Europe PubMed DOI  S
  22. [YEAR:17-3-2005]Shen,L.N., Liu,H., Dong,C., Xirodimas,D., Naismith,J.H. and Hay,R.T.
    Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1
    EMBO J24, 1341-1351. PubMed  Europe PubMed DOI  S
  23. Yamoah,K., Wu,K. and Pan,Z.Q.
    In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1
    Methods Enzymol398, 509-522. PubMed  Europe PubMed DOI
  24. 2004
  25. Hemelaar,J., Borodovsky,A., Kessler,B.M., Reverter,D., Cook,J., Kolli,N., Gan-Erdene,T., Wilkinson,K.D., Gill,G., Lima,C.D., Ploegh,H.L. and Ovaa,H.
    Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
    Mol Cell Biol24, 84-95. PubMed  Europe PubMed DOI  I
  26. 2003
  27. [YEAR:1-8-2003]Gan-Erdene,T., Nagamalleswari,K., Yin,L., Wu,K., Pan,Z.Q. and Wilkinson,K.D.
    Identification and characterization of DEN1, a deneddylase of the ULP family
    J Biol Chem278, 28892-28900. PubMed  Europe PubMed DOI
  28. [YEAR:11-7-2003]Mendoza,H.M., Shen,L.N., Botting,C., Lewis,A., Chen,J., Ink,B. and Hay,R.T.
    NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins
    J Biol Chem278, 25637-25643. PubMed  Europe PubMed DOI
  29. [YEAR:1-8-2003]Wu,K., Yamoah,K., Dolios,G., Gan-Erdene,T., Tan,P., Chen,A., Lee,C.G., Wei,N., Wilkinson,K.D., Wang,R. and Pan,Z.Q.
    DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1
    J Biol Chem278, 28882-28891. PubMed  Europe PubMed DOI
  30. 2000
  31. Yeh,E.T., Gong,L. and Kamitani,T.
    Ubiquitin-like proteins: new wines in new bottles
    Gene248, 1-14. PubMed  Europe PubMed DOI
  32. 1999
  33. Gong,L. and Yeh,E.T.
    Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
    J Biol Chem274, 12036-12042. PubMed  Europe PubMed DOI