Literature for peptidase C48.009: SENP7 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Saad,A.K., Hassan,N.H., Soliman,H.N., Zaki,M.S., Senousy,S.M. and El-Dessouky,S.H. Lethal Phenotype and Expansion of the Clinical Spectrum of Biallelic Loss of Function Variant in SENP7 Gene Unveiled by Whole Exome Sequencing Clin Genet (2025) PubMed Europe PubMed DOI

2024

Pei,J., Zou,D., Li,L., Kang,L., Sun,M., Li,X., Chen,Q., Chen,D., Qu,B., Gao,X. and Lin,Z. Senp7 Deficiency Impairs Lipid Droplets Maturation in White Adipose Tissues via Plin4 DeSUMOylation J Biol Chem (2024) , 107319-107319. PubMed Europe PubMed DOI

2023

Samra,N., Jansen,N.S., Morani,I., Kakun,R.R., Zaid,R., Paperna,T., Garcia-Dominguez,M., Viner,Y., Frankenthal,H., Shinwell,E.S., Portnov,I., Bakry,D., Shalata,A., Shapira Rootman,M., Kidron,D., Claessens,L.A., Wevers,R.A., Mandel,H., Vertegaal,A.C.O. and Weiss,K. Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia J Med Genet (2023) 60, 1133-1141. PubMed Europe PubMed DOI

2022

Amrute-Nayak,M., Gand,L.V., Khan,B., Holler,T., Kefalakes,E., Kosanke,M., Kraft,T. and Nayak,A. SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy Cell Rep (2022) 41, 111702-111702. PubMed Europe PubMed DOI
Li,Y., De Bolos,A., Amador,V. and Reverter,D. Structural Basis for the SUMO2 Isoform Specificity of SENP7 J Mol Biol (2022) 434, 167875-167875. PubMed Europe PubMed DOI
Wu,Z., Huang,H., Han,Q., Hu,Z., Teng,X.L., Ding,R., Ye,Y., Yu,X., Zhao,R., Wang,Z. and Zou,Q. SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells J Clin Invest (2022) 132 PubMed Europe PubMed DOI PMC EPMC

2020

Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T. and Salmona,M. Neuronal Localization of SENP Proteins with Super Resolution Microscopy Brain Sci (2020) 10 PubMed Europe PubMed DOI

2017

Karami,S., Lin,F.M., Kumar,S., Bahnassy,S., Thangavel,H., Quttina,M., Li,Y., Ren,J. and Bawa-Khalfe,T. Novel SUMO-protease SENP7S regulates beta-catenin signaling and mammary epithelial cell transformation Sci Rep (2017) 7, 46477-46477. PubMed Europe PubMed DOI PMC EPMC

2016

Juarez-Vicente,F., Luna-Pelaez,N. and Garcia-Dominguez,M. The Sumo protease Senp7 is required for proper neuronal differentiation Biochim Biophys Acta (2016) 1863, 1490-1498. PubMed Europe PubMed DOI

2015

Romeo,K., Louault,Y., Cantaloube,S., Loiodice,I., Almouzni,G. and Quivy,J.P. The SENP7 SUMO-protease presents a module of two HP1 interaction motifs that locks HP1 protein at pericentric heterochromatin Cell Rep (2015) 10, 771-782. PubMed Europe PubMed DOI

2013

Garvin,A.J., Densham,R.M., Blair-Reid,S.A., Pratt,K.M., Stone,H.R., Weekes,D., Lawrence,K.J. and Morris,J.R. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair EMBO Rep (2013) 14, 975-983. PubMed Europe PubMed DOI

2012

Bawa-Khalfe,T., Lu,L.S., Zuo,Y., Huang,C., Dere,R., Lin,F.M. and Yeh,E.T. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition Proc Natl Acad Sci U S A (2012) 109, 17466-17471. PubMed Europe PubMed DOI M
Maison,C., Romeo,K., Bailly,D., Dubarry,M., Quivy,J.P. and Almouzni,G. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin Nat Struct Mol Biol (2012) 19, 458-460. PubMed Europe PubMed DOI
Reverter,D. SENP6 and SENP7 peptidases [ISSN:978-0-12-407743-0] (2012) 3, 2375-2379. DOI

2011

Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases Chem Biol (2011) 18, 722-732. PubMed Europe PubMed DOI I
Alegre,K.O. and Reverter,D. Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7 J Biol Chem (2011) 286, 36142-36151. PubMed Europe PubMed DOI

2009

Shen,L.N., Geoffroy,M.C., Jaffray,E.G. and Hay,R.T. Characterization of SENP7, a SUMO-2/3-specific isopeptidase Biochem J (2009) 421, 223-230. PubMed Europe PubMed DOI
Wang,Y., Mukhopadhyay,D., Mathew,S., Hasebe,T., Heimeier,R.A., Azuma,Y., Kolli,N., Shi,Y.B., Wilkinson,K.D. and Dasso,M. Identification and developmental expression of Xenopus laevis SUMO proteases PLoS ONE (2009) 4, e8462-e8462. PubMed Europe PubMed DOI

2008

Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family Biochem J (2008) 409, 461-469. PubMed Europe PubMed DOI P
Lima,C.D. and Reverter,D. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7 J Biol Chem (2008) 283, 32045-32055. PubMed Europe PubMed DOI PMC EPMC S

2007

Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and Salvesen,G.S. Small Ubiquitin-related Modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs J Biol Chem (2007) 282, 26217-26224. PubMed Europe PubMed DOI P

2000

Yeh,E.T., Gong,L. and Kamitani,T. Ubiquitin-like proteins: new wines in new bottles Gene (2000) 248, 1-14. PubMed Europe PubMed DOI