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Literature for peptidase C47.001: staphopain A

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bauernfried,S., Komar,T., Sterle,K., Tanzer,M.C., Horswill,A.R., Mann,M. and Hornung,V.
    Inflammasome-independent IL-1beta activation via staphopain A protease of Staphylococcus aureus
    J Biol Chem (2025) , 110574-110574. PubMed  Europe PubMed DOI
  2. LaRock,D.L., Sherman,J.D., Qu,C., Ngai,W., Read,T.D., McGavin,M.J. and LaRock,C.N.
    Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis
    Nat Commun (2025) 16, 10570-10570. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Dehbashi,S., Tahmasebi,H., Alikhani,M.Y., Shahbazi,M.A. and Arabestani,M.R.
    Staphopain mediated virulence and antibiotic resistance alteration in co-infection of Staphylococcus aureus and Pseudomonas aeruginosa: an animal model
    BMC Biotechnol (2024) 24, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Gimza,B.D., Jackson,J.K., Frey,A.M., Budny,B.G., Chaput,D., Rizzo,D.N. and Shaw,L.N.
    Unraveling the Impact of Secreted Proteases on Hypervirulence in Staphylococcus aureus
    MBio (2021) 12 PubMed  Europe PubMed DOI
    5. 2020
  5. Hume,E.B., Cole,N., Khan,S., Walsh,B.J. and Willcox,M.D.
    The role of staphopain a in Staphylococcus aureus keratitis
    Exp Eye Res (2020) 193, 107994-107994. PubMed  Europe PubMed DOI
  6. Williams,M.R., Cau,L., Wang,Y., Kaul,D., Sanford,J.A., Zaramela,L.S., Khalil,S., Butcher,A.M., Zengler,K., Horswill,A.R., Dupont,C.L., Hovnanian,A. and Gallo,R.L.
    Interplay of staphylococcal and host proteases promotes skin barrier disruption in Netherton syndrome
    Cell Rep (2020) 30, 2923-2933. PubMed  Europe PubMed DOI
    7. 2019
  7. Gimza,B.D., Larias,M.I., Budny,B.G. and Shaw,L.N.
    Mapping the global network of extracellular protease regulation in Staphylococcus aureus
    mSphere (2019) 4 PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2017
  8. Sonesson,A., Przybyszewska,K., Eriksson,S., Morgelin,M., Kjellstrom,S., Davies,J., Potempa,J. and Schmidtchen,A.
    Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Sci Rep (2017) 7, 8689-8689. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2014
  9. Hewit,K.D., Fraser,A., Nibbs,R.J. and Graham,G.J.
    The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding
    J Biol Chem (2014) 289, 12330-12342. PubMed  Europe PubMed DOI
  10. Jusko,M., Potempa,J., Kantyka,T., Bielecka,E., Miller,H.K., Kalinska,M., Dubin,G., Garred,P., Shaw,L.N. and Blom,A.M.
    Staphylococcal proteases aid in evasion of the human complement system
    J Innate Immun (2014) 6, 31-46. PubMed  Europe PubMed DOI
    11. 2013
  11. Kantyka,T., Pyrc,K., Gruca,M., Smagur,J., Plaza,K., Guzik,K., Zeglen,S., Ochman,M. and Potempa,J.
    Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung
    J Innate Immun (2013) 5, 251-260. PubMed  Europe PubMed DOI
  12. Mootz,J.M., Malone,C.L., Shaw,L.N. and Horswill,A.R.
    Staphopains modulate Staphylococcus aureus biofilm integrity
    Infect Immun (2013) 81, 3227-3238. PubMed  Europe PubMed DOI
  13. Yokoi,K.J., Kuzuwa,S., Kondo,M., Yamakawa,A., Taketo,A. and Kodaira,K.
    Inactivation of the serine proteinase operon (proMCD) of Staphylococcus warneri M: serine proteinase and cysteine proteases are involved in the autolysis
    Gene (2013) 512, 240-246. PubMed  Europe PubMed DOI
    14. 2012
  14. Kantyka,T., Shaw,L.N. and Potempa,J.
    Staphopain A
    [ISSN:978-0-12-407743-0] (2012) 3, 2150-2157. DOI
  15. Laarman,A.J., Mijnheer,G., Mootz,J.M., van Rooijen,W.J., Ruyken,M., Malone,C.L., Heezius,E.C., Ward,R., Milligan,G., van Strijp,J.A., de Haas,C.J., Horswill,A.R., Van Kessel,K.P. and Rooijakkers,S.H.
    Staphylococcus aureus staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis
    EMBO J (2012) 31, 3607-3619. PubMed  Europe PubMed DOI
    16. 2011
  16. Kantyka,T., Plaza,K., Koziel,J., Florczyk,D., Stennicke,H.R., Thogersen,I.B., Enghild,J.J., Silverman,G.A., Pak,S.C. and Potempa,J.
    Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence
    Biol Chem (2011) 392, 483-489. PubMed  Europe PubMed DOI
  17. Kantyka,T., Shaw,L.N. and Potempa,J.
    Papain-like proteases of Staphylococcus aureus
    Adv Exp Med Biol (2011) 712, 1-14. PubMed  Europe PubMed DOI  V
  18. Kantyka,T. and Potempa,J.
    Human SCCA serpins inhibit staphylococcal cysteine proteases by forming classic "serpin-like" covalent complexes
    Methods Enzymol (2011) 499, 331-345. PubMed  Europe PubMed DOI
  19. Ohbayashi,T., Irie,A., Murakami,Y., Nowak,M., Potempa,J., Nishimura,Y., Shinohara,M. and Imamura,T.
    Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus
    Microbiology (Reading) (2011) 157, 786-792. PubMed  Europe PubMed DOI
    20. 2010
  20. Nickerson,N., Ip,J., Passos,D.T. and McGavin,M.J.
    Comparison of staphopain A (ScpA) and B (SspB) precursor activation mechanisms reveals unique secretion kinetics of proSspB (staphopain B), and a different interaction with its cognate staphostatin, SspC
    Mol Microbiol (2010) 75, 161-177. PubMed  Europe PubMed DOI
    21. 2007
  21. Dubin,G., Wladyka,B., Stec-Niemczyk,J., Chmiel,D., Zdzalik,M., Dubin,A. and Potempa,J.
    The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity
    Biol Chem (2007) 388, 227-235. PubMed  Europe PubMed DOI
    22. 2006
  22. Potempa,J., Travis,J., Golonka,E. and Shaw,L.
    Poison-antidote systems in bacteria: the co-evolution of functional counterparts
    Cell Mol Biol (Noisy-le-grand) (2006) 52, 18-22. PubMed  Europe PubMed DOI  V
    23. 2005
  23. [YEAR:16-5-2005]Imamura,T., Tanase,S., Szmyd,G., Kozik,A., Travis,J. and Potempa,J.
    Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus
    J Exp Med (16-5-2005) 201, 1669-1676. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Potempa,J., Golonka,E., Filipek,R. and Shaw,L.N.
    Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases
    Mol Microbiol (2005) 57, 605-610. PubMed  Europe PubMed DOI
  25. [YEAR:23-8-2005]Wladyka,B., Puzia,K. and Dubin,A.
    Efficient co-expression of a recombinant staphopain A and its inhibitor staphostatin A in Escherichia coli
    Biochem J (23-8-2005) 385, 181-187. PubMed  Europe PubMed DOI  PMC  EPMC  E
    26. 2004
  26. Calander,A.M., Jonsson,I.M., Kanth,A., Arvidsson,S., Shaw,L., Foster,S.J. and Tarkowski,A.
    Impact of staphylococcal protease expression on the outcome of infectious arthritis
    Microbes Infect (2004) 6, 202-206. PubMed  Europe PubMed DOI
  27. Golonka,E., Filipek,R., Sabat,A., Sinczak,A. and Potempa,J.
    Genetic characterization of staphopain genes in Staphylococcus aureus
    Biol Chem (2004) 385, 1059-1067. PubMed  Europe PubMed DOI
  28. Imamura,T., Potempa,J. and Travis,J.
    Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
    Biol Chem (2004) 385, 989-996. PubMed  Europe PubMed DOI  V
  29. Potempa,J. and Travis,J.
    Staphopains
    [ISSN:0-12-079610-4] (2004) 2, 1249-1253.  V
  30. Shaw,L., Golonka,E., Potempa,J. and Foster,S.J.
    The role and regulation of the extracellular proteases of Staphylococcus aureus
    Microbiology (Reading, Engl.) (2004) 150, 217-228. PubMed  Europe PubMed
    31. 2003
  31. Dubin,G.
    Defense against own arms: staphylococcal cysteine proteases and their inhibitors
    Acta Biochim Pol (2003) 50, 715-724. PubMed  Europe PubMed DOI
  32. Rzychon,M., Sabat,A., Kosowska,K., Potempa,J. and Dubin,A.
    Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases
    Mol Microbiol (2003) 49, 1051-1066. PubMed  Europe PubMed DOI
    33. 2001
  33. Karlsson,A., Saravia-Otten,P., Tegmark,K., Morfeldt,E. and Arvidson,S.
    Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases
    Infect Immun (2001) 69, 4742-4748. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 1993
  34. Hofmann,B., Hecht,H.J., Kiess,M. and Schomburg,D.
    Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex
    Acta Crystallogr A (1993) 49 Suppl, 102-102.  S  I
    35. 1988
  35. Potempa,J., Dubin,A., Korzus,G. and Travis,J.
    Degradation of elastin by a cysteine proteinase from Staphylococcus aureus
    J Biol Chem (1988) 263, 2664-2667. PubMed  Europe PubMed
    36. 1974
  36. Bjorklind,A. and Jornvall,H.
    Substrate specificity of three different extracellular proteolytic enzymes from Staphylococcus aureus
    Biochim Biophys Acta (1974) 370, 524-529. PubMed  Europe PubMed  P
    37. 1973
  37. Arvidson,S., Holme,T. and Lindholm,B.
    Studies on extracellular proteolytic enzymes from Staphylococcus aureus. I. Purification and characterization of one neutral and one alkaline protease
    Biochim Biophys Acta (1973) 302, 135-148. PubMed  Europe PubMed
  38. Arvidson,S.
    Hydrolysis of casein by three extracellular proteolytic enzymes from Staphylococcus aureus, strain V8
    Acta Pathol Microbiol Scand [B] Microbiol Immunol (1973) 81, 538-544. PubMed  Europe PubMed

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