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Literature for peptidase C47.001: staphopain A

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bauernfried,S., Komar,T., Sterle,K., Tanzer,M.C., Horswill,A.R., Mann,M. and Hornung,V.<br>Inflammasome-independent IL-1beta activation via staphopain A protease of Staphylococcus aureus<br>J Biol Chem (2025) , 110574-110574. PubMed  Europe PubMed DOI
  2. LaRock,D.L., Sherman,J.D., Qu,C., Ngai,W., Read,T.D., McGavin,M.J. and LaRock,C.N.<br>Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis<br>Nat Commun (2025) 16, 10570-10570. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Dehbashi,S., Tahmasebi,H., Alikhani,M.Y., Shahbazi,M.A. and Arabestani,M.R.<br>Staphopain mediated virulence and antibiotic resistance alteration in co-infection of Staphylococcus aureus and Pseudomonas aeruginosa: an animal model<br>BMC Biotechnol (2024) 24, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Gimza,B.D., Jackson,J.K., Frey,A.M., Budny,B.G., Chaput,D., Rizzo,D.N. and Shaw,L.N.<br>Unraveling the Impact of Secreted Proteases on Hypervirulence in Staphylococcus aureus<br>MBio (2021) 12 PubMed  Europe PubMed DOI
    5. 2020
  5. Hume,E.B., Cole,N., Khan,S., Walsh,B.J. and Willcox,M.D.<br>The role of staphopain a in Staphylococcus aureus keratitis<br>Exp Eye Res (2020) 193, 107994-107994. PubMed  Europe PubMed DOI
  6. Williams,M.R., Cau,L., Wang,Y., Kaul,D., Sanford,J.A., Zaramela,L.S., Khalil,S., Butcher,A.M., Zengler,K., Horswill,A.R., Dupont,C.L., Hovnanian,A. and Gallo,R.L.<br>Interplay of staphylococcal and host proteases promotes skin barrier disruption in Netherton syndrome<br>Cell Rep (2020) 30, 2923-2933. PubMed  Europe PubMed DOI
    7. 2019
  7. Gimza,B.D., Larias,M.I., Budny,B.G. and Shaw,L.N.<br>Mapping the global network of extracellular protease regulation in Staphylococcus aureus<br>mSphere (2019) 4 PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2017
  8. Sonesson,A., Przybyszewska,K., Eriksson,S., Morgelin,M., Kjellstrom,S., Davies,J., Potempa,J. and Schmidtchen,A.<br>Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis<br>Sci Rep (2017) 7, 8689-8689. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2014
  9. Hewit,K.D., Fraser,A., Nibbs,R.J. and Graham,G.J.<br>The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding<br>J Biol Chem (2014) 289, 12330-12342. PubMed  Europe PubMed DOI
  10. Jusko,M., Potempa,J., Kantyka,T., Bielecka,E., Miller,H.K., Kalinska,M., Dubin,G., Garred,P., Shaw,L.N. and Blom,A.M.<br>Staphylococcal proteases aid in evasion of the human complement system<br>J Innate Immun (2014) 6, 31-46. PubMed  Europe PubMed DOI
    11. 2013
  11. Kantyka,T., Pyrc,K., Gruca,M., Smagur,J., Plaza,K., Guzik,K., Zeglen,S., Ochman,M. and Potempa,J.<br>Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung<br>J Innate Immun (2013) 5, 251-260. PubMed  Europe PubMed DOI
  12. Mootz,J.M., Malone,C.L., Shaw,L.N. and Horswill,A.R.<br>Staphopains modulate Staphylococcus aureus biofilm integrity<br>Infect Immun (2013) 81, 3227-3238. PubMed  Europe PubMed DOI
  13. Yokoi,K.J., Kuzuwa,S., Kondo,M., Yamakawa,A., Taketo,A. and Kodaira,K.<br>Inactivation of the serine proteinase operon (proMCD) of Staphylococcus warneri M: serine proteinase and cysteine proteases are involved in the autolysis<br>Gene (2013) 512, 240-246. PubMed  Europe PubMed DOI
    14. 2012
  14. Kantyka,T., Shaw,L.N. and Potempa,J.<br>Staphopain A<br>[ISSN:978-0-12-407743-0] (2012) 3, 2150-2157. DOI
  15. Laarman,A.J., Mijnheer,G., Mootz,J.M., van Rooijen,W.J., Ruyken,M., Malone,C.L., Heezius,E.C., Ward,R., Milligan,G., van Strijp,J.A., de Haas,C.J., Horswill,A.R., Van Kessel,K.P. and Rooijakkers,S.H.<br>Staphylococcus aureus staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis<br>EMBO J (2012) 31, 3607-3619. PubMed  Europe PubMed DOI
    16. 2011
  16. Kantyka,T., Plaza,K., Koziel,J., Florczyk,D., Stennicke,H.R., Thogersen,I.B., Enghild,J.J., Silverman,G.A., Pak,S.C. and Potempa,J.<br>Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence<br>Biol Chem (2011) 392, 483-489. PubMed  Europe PubMed DOI
  17. Kantyka,T., Shaw,L.N. and Potempa,J.<br>Papain-like proteases of Staphylococcus aureus<br>Adv Exp Med Biol (2011) 712, 1-14. PubMed  Europe PubMed DOI  V
  18. Kantyka,T. and Potempa,J.<br>Human SCCA serpins inhibit staphylococcal cysteine proteases by forming classic "serpin-like" covalent complexes<br>Methods Enzymol (2011) 499, 331-345. PubMed  Europe PubMed DOI
  19. Ohbayashi,T., Irie,A., Murakami,Y., Nowak,M., Potempa,J., Nishimura,Y., Shinohara,M. and Imamura,T.<br>Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus<br>Microbiology (Reading) (2011) 157, 786-792. PubMed  Europe PubMed DOI
    20. 2010
  20. Nickerson,N., Ip,J., Passos,D.T. and McGavin,M.J.<br>Comparison of staphopain A (ScpA) and B (SspB) precursor activation mechanisms reveals unique secretion kinetics of proSspB (staphopain B), and a different interaction with its cognate staphostatin, SspC<br>Mol Microbiol (2010) 75, 161-177. PubMed  Europe PubMed DOI
    21. 2007
  21. Dubin,G., Wladyka,B., Stec-Niemczyk,J., Chmiel,D., Zdzalik,M., Dubin,A. and Potempa,J.<br>The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity<br>Biol Chem (2007) 388, 227-235. PubMed  Europe PubMed DOI
    22. 2006
  22. Potempa,J., Travis,J., Golonka,E. and Shaw,L.<br>Poison-antidote systems in bacteria: the co-evolution of functional counterparts<br>Cell Mol Biol (Noisy-le-grand) (2006) 52, 18-22. PubMed  Europe PubMed DOI  V
    23. 2005
  23. [YEAR:16-5-2005]Imamura,T., Tanase,S., Szmyd,G., Kozik,A., Travis,J. and Potempa,J.<br>Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus<br>J Exp Med (16-5-2005) 201, 1669-1676. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Potempa,J., Golonka,E., Filipek,R. and Shaw,L.N.<br>Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases<br>Mol Microbiol (2005) 57, 605-610. PubMed  Europe PubMed DOI
  25. [YEAR:23-8-2005]Wladyka,B., Puzia,K. and Dubin,A.<br>Efficient co-expression of a recombinant staphopain A and its inhibitor staphostatin A in Escherichia coli<br>Biochem J (23-8-2005) 385, 181-187. PubMed  Europe PubMed DOI  PMC  EPMC  E
    26. 2004
  26. Calander,A.M., Jonsson,I.M., Kanth,A., Arvidsson,S., Shaw,L., Foster,S.J. and Tarkowski,A.<br>Impact of staphylococcal protease expression on the outcome of infectious arthritis<br>Microbes Infect (2004) 6, 202-206. PubMed  Europe PubMed DOI
  27. Golonka,E., Filipek,R., Sabat,A., Sinczak,A. and Potempa,J.<br>Genetic characterization of staphopain genes in Staphylococcus aureus<br>Biol Chem (2004) 385, 1059-1067. PubMed  Europe PubMed DOI
  28. Imamura,T., Potempa,J. and Travis,J.<br>Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases<br>Biol Chem (2004) 385, 989-996. PubMed  Europe PubMed DOI  V
  29. Potempa,J. and Travis,J.<br>Staphopains<br>[ISSN:0-12-079610-4] (2004) 2, 1249-1253.  V
  30. Shaw,L., Golonka,E., Potempa,J. and Foster,S.J.<br>The role and regulation of the extracellular proteases of Staphylococcus aureus<br>Microbiology (Reading, Engl.) (2004) 150, 217-228. PubMed  Europe PubMed
    31. 2003
  31. Dubin,G.<br>Defense against own arms: staphylococcal cysteine proteases and their inhibitors<br>Acta Biochim Pol (2003) 50, 715-724. PubMed  Europe PubMed DOI
  32. Rzychon,M., Sabat,A., Kosowska,K., Potempa,J. and Dubin,A.<br>Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases<br>Mol Microbiol (2003) 49, 1051-1066. PubMed  Europe PubMed DOI
    33. 2001
  33. Karlsson,A., Saravia-Otten,P., Tegmark,K., Morfeldt,E. and Arvidson,S.<br>Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases<br>Infect Immun (2001) 69, 4742-4748. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 1993
  34. Hofmann,B., Hecht,H.J., Kiess,M. and Schomburg,D.<br>Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex<br>Acta Crystallogr A (1993) 49 Suppl, 102-102.  S  I
    35. 1988
  35. Potempa,J., Dubin,A., Korzus,G. and Travis,J.<br>Degradation of elastin by a cysteine proteinase from Staphylococcus aureus<br>J Biol Chem (1988) 263, 2664-2667. PubMed  Europe PubMed
    36. 1974
  36. Bjorklind,A. and Jornvall,H.<br>Substrate specificity of three different extracellular proteolytic enzymes from Staphylococcus aureus<br>Biochim Biophys Acta (1974) 370, 524-529. PubMed  Europe PubMed  P
    37. 1973
  37. Arvidson,S., Holme,T. and Lindholm,B.<br>Studies on extracellular proteolytic enzymes from Staphylococcus aureus. I. Purification and characterization of one neutral and one alkaline protease<br>Biochim Biophys Acta (1973) 302, 135-148. PubMed  Europe PubMed
  38. Arvidson,S.<br>Hydrolysis of casein by three extracellular proteolytic enzymes from Staphylococcus aureus, strain V8<br>Acta Pathol Microbiol Scand [B] Microbiol Immunol (1973) 81, 538-544. PubMed  Europe PubMed

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