Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C30.006: MERS coronavirus picornain 3C-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibitors

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Liu,Y., Tang,H., Niu,T. and Wang,J.
    A Comparative Study of Deep Learning and Classical Modeling Approaches for Protein-Ligand Binding Pose and Affinity Prediction in Coronavirus Main Proteases
    J Chem Inf Model (2025) PubMed  Europe PubMed DOI
  2. Martianez-Vendrell,X., van Kasteren,P.B., Myeni,S.K. and Kikkert,M.
    HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Jiang,H., Li,W., Zhou,X., Zhang,J. and Li,J.
    Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77
    Int J Biol Macromol (2024) 276, 133706-133706. PubMed  Europe PubMed DOI  I
  4. Krismer,L., Schoppe,H., Rauch,S., Bante,D., Sprenger,B., Naschberger,A., Costacurta,F., Furst,A., Sauerwein,A., Rupp,B., Kaserer,T., von Laer,D. and Heilmann,E.
    Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
    Npj Viruses (2024) 2, 23-23. PubMed  Europe PubMed DOI  PMC  EPMC  I
  5. Vlachou,A., Nchioua,R., Regensburger,K., Kirchhoff,F. and Kmiec,D.
    A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity
    Sci Rep (2024) 14, 20697-20697. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Pelliccia,S., Cerchia,C., Esposito,F., Cannalire,R., Corona,A., Costanzi,E., Kuzikov,M., Gribbon,P., Zaliani,A., Brindisi,M., Storici,P., Tramontano,E. and Summa,V.
    Easy access to alpha-ketoamides as SARS-CoV-2 and MERS M(pro) inhibitors via the PADAM oxidation route
    Eur J Med Chem (2022) 244, 114853-114853. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2021
  7. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
    Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
    ACS Infect Dis (2021) 7, 586-597. PubMed  Europe PubMed DOI  PMC  EPMC  I
  8. Ragunathan,V. and Chithra,K.
    Extraction and characterization of metabolites from Olea europaea pulp and their molecular docking against SARS-CoV-2 main-protease (M(pro))
    Nat Prod Res (2021) , 1-7. PubMed  Europe PubMed DOI
    9. 2020
  9. Bahadur Gurung,A., Ajmal Ali,M., Lee,J., Abul Farah,M. and Mashay Al-Anazi,K.
    Structure-based virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels lead molecules as potential inhibitors of coronavirus 3C-like protease enzyme
    J King Saud Univ Sci (2020) 32, 2845-2853. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Gurung,A.B., Ali,M.A., Lee,J., Abul Farah,M. and Al-Anazi,K.M.
    In silico screening of FDA approved drugs reveals ergotamine and dihydroergotamine as potential coronavirus main protease enzyme inhibitors
    Saudi J Biol Sci (2020) 27, 2674-2682. PubMed  Europe PubMed DOI  PMC  EPMC  I
  11. Khan,M.T., Ali,A., Wang,Q., Irfan,M., Khan,A., Zeb,M.T., Zhang,Y.J., Chinnasamy,S. and Wei,D.Q.
    Marine natural compounds as potents inhibitors against the main protease of SARS-CoV-2. A molecular dynamic study
    J Biomol Struct Dyn (2020) , 1-14. PubMed  Europe PubMed DOI  I
  12. Wang,H., He,S., Deng,W., Zhang,Y., Li,G., Sun,J., Zhao,W., Guo,Y., Yin,Z., Li,D. and Shang,L.
    Comprehensive insights into the catalytic mechanism of Middle East Respiratory Syndrome 3C-Like protease and Severe Acute Respiratory Syndrome 3C-like protease
    ACS Catal (2020) 10, 5871-5890. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Zhu,W., Xu,M., Chen,C.Z., Guo,H., Shen,M., Hu,X., Shinn,P., Klumpp-Thomas,C., Michael,S.G. and Zheng,W.
    Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening
    ACS Pharmacol Transl Sci (2020) 3, 1008-1016. PubMed  Europe PubMed DOI  PMC  EPMC  I
    14. 2019
  14. Jo,S., Kim,H., Kim,S., Shin,D.H. and Kim,M.S.
    Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors
    Chem Biol Drug Des (2019) 94, 2023-2030. PubMed  Europe PubMed DOI  I
  15. Rahman,M.M., Hosen,M.B., Howlader,M.Z.H. and Kabir,Y.
    Lead molecule prediction and characterization for designing MERS-CoV 3C-like protease inhibitors: an in silico approach
    Curr Comput Aided Drug Des (2019) 15, 82-88. PubMed  Europe PubMed DOI  I
    16. 2018
  16. Galasiti Kankanamalage,A.C., Kim,Y., Damalanka,V.C., Rathnayake,A.D., Fehr,A.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Lushington,G.H., Perlman,S., Chang,K.O. and Groutas,W.C.
    Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
    Eur J Med Chem (2018) 150, 334-346. PubMed  Europe PubMed DOI  I
    17. 2017
  17. Abuhammad,A., Al-Aqtash,R.A., Anson,B.J., Mesecar,A.D. and Taha,M.O.
    Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus
    J Mol Recognit (2017) 30, e2644- PubMed  Europe PubMed DOI  I
  18. Kumar,V., Shin,J.S., Shie,J.J., Ku,K.B., Kim,C., Go,Y.Y., Huang,K.F., Kim,M. and Liang,P.H.
    Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
    Antiviral Res (2017) 141, 101-106. PubMed  Europe PubMed DOI  I
    19. 2016
  19. Kumar,V., Tan,K.P., Wang,Y.M., Lin,S.W. and Liang,P.H.
    Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
    Bioorg Med Chem (2016) 24, 3035-3042. PubMed  Europe PubMed DOI  I
  20. Lin,F., Fu,X.-M., Wang,C., Jiang,S.-Y., Wang,J.-H., Zhang,S.-W., Yang,L. and Li,Y.
    QSAR, molecular docking and molecular dynamics of 3C-like protease inhibitors
    Wuli Huaxue Xuebao Acta Phys Chim Sin (2016) 32, 2693-2708. DOI  I
    21. 2015
  21. Ho,B.L., Cheng,S.C., Shi,L., Wang,T.Y., Ho,K.I. and Chou,C.Y.
    Critical assessment of the important residues involved in the dimerization and catalysis of MERS coronavirus main protease
    PLoS ONE (2015) 10, e0144865-e0144865. PubMed  Europe PubMed DOI
  22. Needle,D., Lountos,G.T. and Waugh,D.S.
    Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity
    Acta Crystallogr D Biol Crystallogr (2015) 71, 1102-1111. PubMed  Europe PubMed DOI  S
  23. Tomar,S., Johnston,M.L., St John,S.E., Osswald,H.L., Nyalapatla,P.R., Paul,L.N., Ghosh,A.K., Denison,M.R. and Mesecar,A.D.
    Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals
    J Biol Chem (2015) 290, 19403-19422. PubMed  Europe PubMed DOI
  24. Wu,A., Wang,Y., Zeng,C., Huang,X., Xu,S., Su,C., Wang,M., Chen,Y. and Guo,D.
    Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
    Virus Res (2015) 208, 56-65. PubMed  Europe PubMed DOI  P
    25. 2014
  25. Hilgenfeld,R.
    From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
    FEBS J (2014) 281, 4085-4096. PubMed  Europe PubMed DOI  V  S
    26. 2013
  26. Kilianski,A., Mielech,A.M., Deng,X. and Baker,S.C.
    Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors
    J Virol (2013) 87, 11955-11962. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use