Literature for peptidase C30.006: MERS coronavirus picornain 3C-like peptidase

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Martianez-Vendrell,X., van Kasteren,P.B., Myeni,S.K. and Kikkert,M.
   HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms
   Int J Mol Sci26, PubMed  Europe PubMed DOI
2024
2. Jiang,H., Li,W., Zhou,X., Zhang,J. and Li,J.
   Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77
   Int J Biol Macromol276, 133706-133706. PubMed  Europe PubMed DOI  I
3. Krismer,L., Schoppe,H., Rauch,S., Bante,D., Sprenger,B., Naschberger,A., Costacurta,F., Furst,A., Sauerwein,A., Rupp,B., Kaserer,T., von Laer,D. and Heilmann,E.
   Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
   Npj Viruses2, 23-23. PubMed  Europe PubMed DOI  I
4. Vlachou,A., Nchioua,R., Regensburger,K., Kirchhoff,F. and Kmiec,D.
   A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity
   Sci Rep14, 20697-20697. PubMed  Europe PubMed DOI
2022
5. Pelliccia,S., Cerchia,C., Esposito,F., Cannalire,R., Corona,A., Costanzi,E., Kuzikov,M., Gribbon,P., Zaliani,A., Brindisi,M., Storici,P., Tramontano,E. and Summa,V.
   Easy access to alpha-ketoamides as SARS-CoV-2 and MERS M(pro) inhibitors via the PADAM oxidation route
   Eur J Med Chem244, 114853-114853. PubMed  Europe PubMed DOI
2021
6. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
   Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
   ACS Infect Dis7, 586-597. PubMed  Europe PubMed DOI  I
7. Ragunathan,V. and Chithra,K.
   Extraction and characterization of metabolites from Olea europaea pulp and their molecular docking against SARS-CoV-2 main-protease (M(pro))
   Nat Prod Res1-7. PubMed  Europe PubMed DOI
2020
8. Bahadur Gurung,A., Ajmal Ali,M., Lee,J., Abul Farah,M. and Mashay Al-Anazi,K.
   Structure-based virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels lead molecules as potential inhibitors of coronavirus 3C-like protease enzyme
   J King Saud Univ Sci32, 2845-2853. PubMed  Europe PubMed DOI
9. Gurung,A.B., Ali,M.A., Lee,J., Abul Farah,M. and Al-Anazi,K.M.
   In silico screening of FDA approved drugs reveals ergotamine and dihydroergotamine as potential coronavirus main protease enzyme inhibitors
   Saudi J Biol Sci27, 2674-2682. PubMed  Europe PubMed DOI  I
10. Khan,M.T., Ali,A., Wang,Q., Irfan,M., Khan,A., Zeb,M.T., Zhang,Y.J., Chinnasamy,S. and Wei,D.Q.
    Marine natural compounds as potents inhibitors against the main protease of SARS-CoV-2. A molecular dynamic study
    J Biomol Struct Dyn1-14. PubMed  Europe PubMed DOI  I
11. Wang,H., He,S., Deng,W., Zhang,Y., Li,G., Sun,J., Zhao,W., Guo,Y., Yin,Z., Li,D. and Shang,L.
    Comprehensive insights into the catalytic mechanism of Middle East Respiratory Syndrome 3C-Like protease and Severe Acute Respiratory Syndrome 3C-like protease
    ACS Catal10, 5871-5890. PubMed  Europe PubMed DOI
12. Zhu,W., Xu,M., Chen,C.Z., Guo,H., Shen,M., Hu,X., Shinn,P., Klumpp-Thomas,C., Michael,S.G. and Zheng,W.
    Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening
    ACS Pharmacol Transl Sci3, 1008-1016. PubMed  Europe PubMed DOI  I
2019
13. Jo,S., Kim,H., Kim,S., Shin,D.H. and Kim,M.S.
    Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors
    Chem Biol Drug Des94, 2023-2030. PubMed  Europe PubMed DOI  I
14. Rahman,M.M., Hosen,M.B., Howlader,M.Z.H. and Kabir,Y.
    Lead molecule prediction and characterization for designing MERS-CoV 3C-like protease inhibitors: an in silico approach
    Curr Comput Aided Drug Des15, 82-88. PubMed  Europe PubMed DOI  I
2018
15. Galasiti Kankanamalage,A.C., Kim,Y., Damalanka,V.C., Rathnayake,A.D., Fehr,A.R., Mehzabeen,N., Battaile,K.P., Lovell,S., Lushington,G.H., Perlman,S., Chang,K.O. and Groutas,W.C.
    Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
    Eur J Med Chem150, 334-346. PubMed  Europe PubMed DOI  I
2017
16. Abuhammad,A., Al-Aqtash,R.A., Anson,B.J., Mesecar,A.D. and Taha,M.O.
    Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus
    J Mol Recognit30, e2644- PubMed  Europe PubMed DOI  I
17. Kumar,V., Shin,J.S., Shie,J.J., Ku,K.B., Kim,C., Go,Y.Y., Huang,K.F., Kim,M. and Liang,P.H.
    Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
    Antiviral Res141, 101-106. PubMed  Europe PubMed DOI  I
2016
18. Kumar,V., Tan,K.P., Wang,Y.M., Lin,S.W. and Liang,P.H.
    Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
    Bioorg Med Chem24, 3035-3042. PubMed  Europe PubMed DOI  I
19. Lin,F., Fu,X.-M., Wang,C., Jiang,S.-Y., Wang,J.-H., Zhang,S.-W., Yang,L. and Li,Y.
    QSAR, molecular docking and molecular dynamics of 3C-like protease inhibitors
    Wuli Huaxue Xuebao Acta Phys Chim Sin32, 2693-2708. DOI  I
2015
20. Ho,B.L., Cheng,S.C., Shi,L., Wang,T.Y., Ho,K.I. and Chou,C.Y.
    Critical assessment of the important residues involved in the dimerization and catalysis of MERS coronavirus main protease
    PLoS ONE10, e0144865-e0144865. PubMed  Europe PubMed DOI
21. Needle,D., Lountos,G.T. and Waugh,D.S.
    Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity
    Acta Crystallogr D Biol Crystallogr71, 1102-1111. PubMed  Europe PubMed DOI  S
22. Tomar,S., Johnston,M.L., St John,S.E., Osswald,H.L., Nyalapatla,P.R., Paul,L.N., Ghosh,A.K., Denison,M.R. and Mesecar,A.D.
    Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals
    J Biol Chem290, 19403-19422. PubMed  Europe PubMed DOI
23. Wu,A., Wang,Y., Zeng,C., Huang,X., Xu,S., Su,C., Wang,M., Chen,Y. and Guo,D.
    Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
    Virus Res208, 56-65. PubMed  Europe PubMed DOI  P
2014
24. Hilgenfeld,R.
    From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
    FEBS J281, 4085-4096. PubMed  Europe PubMed DOI  V  S
2013
25. Kilianski,A., Mielech,A.M., Deng,X. and Baker,S.C.
    Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors
    J Virol87, 11955-11962. PubMed  Europe PubMed DOI