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Literature for family C19

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq Architecture

(Topics flags: A Assay, S Structure, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jin,S.K. and Baek,K.H.
    Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers
    Biochim Biophys Acta Rev Cancer (2025) 1880, 189297-189297. PubMed  Europe PubMed DOI  V
  2. Li,J., Deng,S., Yu,W., Ye,Q., Liu,D., Yi,Z., Liu,C., Huang,J., Zhong,J. and Wang,X.
    Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives
    Discov Oncol (2025) PubMed  Europe PubMed DOI
  3. Patchett,S., Moghadasi,S.A., Shukla,A., El Oualid,F., Ueberheide,B.M., Olsen,S.K. and Huang,T.T.
    Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway
    Mol Cell (2025) 85, 4426-4436. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Wu,Y., Deng,Y., Ai,Q., Li,Y., Qin,F., Hammad,M., Meng,Z., Xu,X., Wei,J., Yu,H., Liang,G. and Zhao,X.
    Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential
    Mol Med (2025) 31, 329-329. PubMed  Europe PubMed DOI
    5. 2024
  5. Al-Balushi,E., Al Marzouqi,A., Tavoosi,S., Baghsheikhi,A.H., Sadri,A., Aliabadi,L.S., Salarabedi,M.M., Rahman,S.A., Al-Yateem,N., Jarrahi,A.M., Halimi,A., Ahmadvand,M. and Abdel-Rahman,W.M.
    Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review
    World J Gastrointest Oncol (2024) 16, 197-213. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A.
    The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence
    Biochim Biophys Acta Rev Cancer (2024) 1879, 189119-189119. PubMed  Europe PubMed DOI  V
  7. Chen,R., Zhang,H., Li,L., Li,J., Xie,J., Weng,J., Tan,H., Liu,Y., Guo,T. and Wang,M.
    Roles of ubiquitin-specific proteases in inflammatory diseases
    Front Immunol (2024) 15, 1258740-1258740. PubMed  Europe PubMed DOI  PMC  EPMC  V
  8. Foster,B.M., Wang,Z. and Schmidt,C.K.
    DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability
    Biochem J (2024) 481, 515-545. PubMed  Europe PubMed DOI  V
  9. Fu,W., Fan,D., Liu,S. and Bu,Y.
    Genome-wide identification and expression analysis of Ubiquitin-specific protease gene family in maize (Zea mays L.)
    BMC Plant Biol (2024) 24, 404-404. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.
    Variety in the USP deubiquitinase catalytic mechanism
    Life Sci Alliance (2024) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Kong,L. and Jin,X.
    Dysregulation of deubiquitination in breast cancer
    Gene (2024) 902, 148175-148175. PubMed  Europe PubMed DOI  V
  12. Li,K.Q., Bai,X., Ke,A.T., Ding,S.Q., Zhang,C.D. and Dai,D.Q.
    Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer
    Biomed Pharmacother (2024) 173, 116323-116323. PubMed  Europe PubMed DOI
  13. Liu,Y., Li,D., Zhang,X., Xia,S., Qu,Y., Ling,X., Li,Y., Kong,X., Zhang,L., Cui,C.P. and Li,D.
    A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions
    Nat Commun (2024) 15, 4519-4519. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Lu,L., Jifu,C., Xia,J. and Wang,J.
    E3 ligases and DUBs target ferroptosis: A potential therapeutic strategy for neurodegenerative diseases
    Biomed Pharmacother (2024) 175, 116753-116753. PubMed  Europe PubMed DOI  V
  15. Poirson,J., Cho,H., Dhillon,A., Haider,S., Imrit,A.Z., Lam,M.H.Y., Alerasool,N., Lacoste,J., Mizan,L., Wong,C., Gingras,A.C., Schramek,D. and Taipale,M.
    Proteome-scale discovery of protein degradation and stabilization effectors
    Nature (2024) 628, 878-886. PubMed  Europe PubMed DOI
  16. Zhang,X., Jin,J., Cong,J., Chen,S., Wang,T., Gao,B., Huang,G., Huang,Z., Zhang,J., Wang,Z. and Yang,J.
    Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis
    Curr Top Med Chem (2024) 24, 179-191. PubMed  Europe PubMed DOI  V
    17. 2023
  17. Gao,H., Yin,J., Ji,C., Yu,X., Xue,J., Guan,X., Zhang,S., Liu,X. and Xing,F.
    Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application
    J Exp Clin Cancer Res (2023) 42, 225-225. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Luo,R., Yang,K. and Xiao,W.
    Plant deubiquitinases: from structure and activity to biological functions
    Plant Cell Rep (2023) 42, 469-486. PubMed  Europe PubMed DOI  V
  19. Luo,W., Zhang,G., Wang,Z., Wu,Y. and Xiong,Y.
    Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases
    Int Immunopharmacol (2023) 118, 110075-110075. PubMed  Europe PubMed DOI  V
  20. Shen,J., Lin,X., Dai,F., Chen,G., Lin,H., Fang,B. and Liu,H.
    Ubiquitin-specific peptidases: Players in bone metabolism
    Cell Prolif (2023) , e13444-e13444. PubMed  Europe PubMed DOI  V
    21. 2022
  21. Chen,R., Pang,X., Li,L., Zeng,Z., Chen,M. and Zhang,S.
    Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation
    Cell Death Dis (2022) 13, 139-139. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Doherty,L.M., Mills,C.E., Boswell,S.A., Liu,X., Hoyt,C.T., Gyori,B., Buhrlage,S.J. and Sorger,P.K.
    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
    elife (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  23. Elu,N., Osinalde,N., Ramirez,J., Presa,N., Rodriguez,J.A., Prieto,G. and Mayor,U.
    Identification of substrates for human deubiquitinating enzymes (DUBs): An up-to-date review and a case study for neurodevelopmental disorders
    Semin Cell Dev Biol (2022) 132, 120-131. PubMed  Europe PubMed DOI
  24. Estavoyer,B., Messmer,C., Echbicheb,M., Rudd,C.E., Milot,E. and Affar,E.B.
    Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
    J Biol Chem (2022) 298, 102198-102198. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Guo,J., Zhao,J., Sun,L. and Yang,C.
    Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction
    Front Oncol (2022) 12, 955718-955718. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Liang,W., Fang,J., Zhou,S., Hu,W., Yang,Z., Li,Z., Dai,L., Tao,Y., Fu,X. and Wang,X.
    The role of ubiquitin-specific peptidases in glioma progression
    Biomed Pharmacother (2022) 146, 112585-112585. PubMed  Europe PubMed DOI  V
  27. Newton,K. and Gitlin,A.D.
    Deubiquitinases in cell death and inflammation
    Biochem J (2022) 479, 1103-1119. PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Sato,Y.
    Structural basis for the linkage specificity of ubiquitin-binding domain and deubiquitinase
    J Biochem (2022) 172, 1-7. PubMed  Europe PubMed DOI  V
    29. 2021
  29. Chen,S., Liu,Y. and Zhou,H.
    Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  30. Snyder,N.A. and Silva,G.M.
    Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
    J Biol Chem (2021) 297, 101077-101077. PubMed  Europe PubMed DOI  V
    31. 2020
  31. Das,S., Chandrasekaran,A.P., Suresh,B., Haq,S., Kang,J.H., Lee,S.J., Kim,J., Kim,J., Lee,S., Kim,H.H., Kim,K.S. and Ramakrishna,S.
    Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer
    Cell Death Differ (2020) PubMed  Europe PubMed DOI
  32. Lai,K.P., Chen,J. and Tse,W.K.F.
    Role of deubiquitinases in human cancers: potential targeted therapy
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  33. Yamanaka,S., Sato,Y., Oikawa,D., Goto,E., Fukai,S., Tokunaga,F., Takahashi,H. and Sawasaki,T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-kappaB signaling
    Biochem Biophys Res Commun (2020) 524, 1-7. PubMed  Europe PubMed DOI  I
    34. 2019
  34. Ma,X., Zhang,J., Han,B., Tang,J., Cui,D. and Han,L.
    FLA, which encodes a homolog of UBP, is required for chlorophyll accumulation and development of lemma and palea in rice
    Plant Cell Rep (2019) 38, 321-331. PubMed  Europe PubMed DOI
    35. 2018
  35. Wang,D.H., Song,W., Wei,S.W., Zheng,Y.F., Chen,Z.S., Han,J.D., Zhang,H.T., Luo,J.C., Qin,Y.M., Xu,Z.H. and Bai,S.N.
    Characterization of the ubiquitin C-terminal hydrolase and ubiquitin-specific protease families in rice (Oryza sativa)
    Front Plant Sci (2018) 9, 1636-1636. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2017
  36. Zhou,H., Zhao,J., Cai,J. and Patil,S.B.
    Ubiquitin-specific proteases function in plant development and stress responses
    Plant Mol Biol (2017) 94, 565-576. PubMed  Europe PubMed DOI
    37. 2016
  37. Tencer,A.H., Liang,Q. and Zhuang,Z.
    Divergence in ubiquitin interaction and catalysis among the ubiquitin-specific protease family deubiquitinating enzymes
    Biochemistry (2016) 55, 4708-4719. PubMed  Europe PubMed DOI
    38. 2015
  38. Vlasschaert,C., Xia,X., Coulombe,J. and Gray,D.A.
    Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11
    BMC Evol Biol (2015) 15, 230-230. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2014
  39. Isono,E. and Nagel,M.K.
    Deubiquitylating enzymes and their emerging role in plant biology
    Front Plant Sci (2014) 5, 56-56. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2012
  40. Faesen,A.C., Luna-Vargas,M.P. and Sixma,T.K.
    The role of UBL domains in ubiquitin-specific proteases
    Biochem Soc Trans (2012) 40, 539-545. PubMed  Europe PubMed DOI
  41. Villamil,M.A., Chen,J., Liang,Q. and Zhuang,Z.
    A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1
    Biochemistry (2012) 51, 2829-2839. PubMed  Europe PubMed DOI
    42. 2011
  42. Luna-Vargas,M.P., Christodoulou,E., Alfieri,A., van Dijk,W.J., Stadnik,M., Hibbert,R.G., Sahtoe,D.D., Clerici,M., Marco,V.D., Littler,D., Celie,P.H., Sixma,T.K. and Perrakis,A.
    Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases
    J Struct Biol (2011) 175, 113-119. PubMed  Europe PubMed DOI  E
  43. Todi,S.V. and Paulson,H.L.
    Balancing act: deubiquitinating enzymes in the nervous system
    Trends Neurosci (2011) 34, 370-382. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Zhang,W., Sulea,T., Tao,L., Cui,Q., Purisima,E.O., Vongsamphanh,R., Lachance,P., Lytvyn,V., Qi,H., Li,Y. and Menard,R.
    Contribution of active site residues to substrate hydrolysis by USP2: insights into catalysis by ubiquitin specific proteases
    Biochemistry (2011) 50, 4775-4785. PubMed  Europe PubMed DOI  S
    45. 2010
  45. Komander,D.
    Mechanism, specificity and structure of the deubiquitinases
    Subcell Biochem (2010) 54, 69-87. PubMed  Europe PubMed DOI
  46. Sacco,J.J., Coulson,J.M., Clague,M.J. and Urbe,S.
    Emerging roles of deubiquitinases in cancer-associated pathways
    IUBMB Life (2010) 62, 140-157. PubMed  Europe PubMed DOI  V
    47. 2009
  47. Reyes-Turcu,F.E., Ventii,K.H. and Wilkinson,K.D.
    Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes
    Annu Rev Biochem (2009) 78, 363-397. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Ye,Y., Scheel,H., Hofmann,K. and Komander,D.
    Dissection of USP catalytic domains reveals five common insertion points
    Mol Biosyst (2009) 5, 1797-1808. PubMed  Europe PubMed DOI
    49. 2005
  49. Nijman,S.M., Luna-Vargas,M.P., Velds,A., Brummelkamp,T.R., Dirac,A.M., Sixma,T.K. and Bernards,R.
    A genomic and functional inventory of deubiquitinating enzymes
    Cell (2005) 123, 773-786. PubMed  Europe PubMed DOI
  50. Russell,N.S. and Wilkinson,K.D.
    Deubiquitinating enzyme purification, assay inhibitors, and characterization
    Methods Mol Biol (2005) 301, 207-219. PubMed  Europe PubMed DOI  A
    51. 2004
  51. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    52. 2002
  52. [YEAR:20-11-2002]Lacombe,T. and Gabriel,J.M.
    Further characterization of the putative human isopeptidase T catalytic site
    FEBS Lett (20-11-2002) 531, 469-474. PubMed  Europe PubMed DOI
    53. 2001
  53. [YEAR:17-9-2001]Borodovsky,A., Kessler,B.M., Casagrande,R., Overkleeft,H.S., Wilkinson,K.D. and Ploegh,H.L.
    A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
    EMBO J (17-9-2001) 20, 5187-5196. PubMed  Europe PubMed DOI  PMC  EPMC  I
    54. 2000
  54. Amerik,A.Y., Li,S.J. and Hochstrasser,M.
    Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae
    Biol Chem (2000) 381, 981-992. PubMed  Europe PubMed DOI
    55. 1999
  55. [YEAR:1-8-1999]Baker,R.T., Wang,X.W., Woollatt,E., White,J.A. and Sutherland,G.R.
    Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
    Genomics (1-8-1999) 59, 264-274. PubMed  Europe PubMed DOI
  56. [YEAR:29-12-1999]Chung,C.H. and Baek,S.H.
    Deubiquitinating enzymes: their diversity and emerging roles
    Biochem Biophys Res Commun (29-12-1999) 266, 633-640. PubMed  Europe PubMed DOI
    57. 1997
  57. Weissman,A.M.
    Regulating protein degradation by ubiquitination
    Immunol Today (1997) 18, 189-198. PubMed  Europe PubMed DOI
  58. Wilkinson,K.D.
    Regulation of ubiquitin-dependent processes by deubiquitinating enzymes
    FASEB J (1997) 11, 1245-1256. PubMed  Europe PubMed
    59. 1996
  59. Hofmann,K. and Bucher,P.
    The UBA domain: A sequence motif present in multiple enzyme classes of the ubiquitination pathway
    Trends Biochem Sci (1996) 21, 172-173. PubMed  Europe PubMed DOI
    60. 1995
  60. Hochstrasser,M., Papa,F.R., Chen,P., Swaminathan,S., Johnson,P., Stillman,L., Amerik,A.Y. and Li,S.J.
    The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae
    Cold Spring Harb Symp Quant Biol (1995) 60, 503-513. PubMed  Europe PubMed
    61. 1986
  61. Pickart,C.M. and Rose,I.A.
    Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin
    J Biol Chem (1986) 261, 10210-10217. PubMed  Europe PubMed  I
    62. 1982
  62. Matsui,S., Sandberg,A.A., Negoro,S., Seon,B.K. and Goldstein,G.
    Isopeptidase: a novel eukaryotic enzyme that cleaves isopeptide bonds
    Proc Natl Acad Sci U S A (1982) 79, 1535-1539. PubMed  Europe PubMed  PMC  EPMC

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