Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase homologue C19.972: ubiquitin-specific endopeptidase 39 [misleading]

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cheng,S., Qiu,Z., Zhang,Z., Li,Y., Zhu,Y., Zhou,Y., Yang,Y., Zhang,Y., Yang,D., Zhang,Y., Liu,H., Dai,Z., Sun,S.L. and Liu,S.
    USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression
    Cell Commun Signal (2025) 23, 56-56. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Li,X., Xu,H., Chen,R., Huang,X., Lin,Z., Wang,S., Han,L., Li,J., Lin,L., Qi,Y., Song,G. and Song,C.
    Astaxanthin inhibits hepatocellular carcinoma by targeting USP39-mediated beta-catenin stabilization through deubiquitination
    Sci Rep (2025) 15, 40034-40034. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Schafer,D., Prieto-Garcia,C., Wang,J., Heinz,M., Matkovic,V., Kielkowski,P., Hasselbeck,S., Shah,V.J., Knapp,S., Hummer,G., Dikic,I. and Cheng,X.
    Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation
    Angew Chem Int Ed Engl (2025) , e16809-e16809. PubMed  Europe PubMed DOI
  4. Shen,S., Xue,G., Zeng,Z., Peng,L., Nie,W. and Zeng,X.
    Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination
    Naunyn Schmiedebergs Arch Pharmacol (2025) PubMed  Europe PubMed DOI  K
  5. Wang,X., Zhang,P., Xie,J. and Zuo,X.
    USP39 promotes retinal pathological angiogenesis in retinopathy of prematurity by stabilizing SIRT2 expression through deubiquitination
    Int Ophthalmol (2025) 45, 39-39. PubMed  Europe PubMed DOI
    6. 2024
  6. Becirovic,T., Zhang,B., Vakifahmetoglu-Norberg,H., Kaminskyy,V.O., Kochetkova,E. and Norberg,E.
    USP39 regulates pyruvate handling in non-small cell lung cancer
    Cell Death Discov (2024) 10, 502-502. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Hu,Y., Wang,Y., Hu,W., Hu,C., Wang,B., Liu,C., Deng,A., Shen,B., Wu,K. and Liu,Y.
    USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1
    Technol Cancer Res Treat (2024) 23, 15330338241250298-15330338241250298. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Lu,C., Cai,Y., Wu,S., Wang,Y., Li,J.B., Xu,G. and Ma,J.
    Deubiquitinating enzyme USP39 promotes the growth and metastasis of gastric cancer cells by modulating the degradation of RNA-binding protein RBM39
    J Biol Chem (2024) , 107751-107751. PubMed  Europe PubMed DOI  K
  9. Prieto-Garcia,C., Matkovic,V., Mosler,T., Li,C., Liang,J., Oo,J.A., Haidle,F., Macinkovic,I., Cabrera-Orefice,A., Berkane,R., Giuliani,G., Xu,F., Jacomin,A.C., Tomaskovic,I., Basoglu,M., Hoffmann,M.E., Rathore,R., Cetin,R., Boutguetait,D., Bozkurt,S., Hernandez Canas,M.C., Keller,M., Busam,J., Shah,V.J., Wittig,I., Kaulich,M., Beli,P., Galej,W.P., Ebersberger,I., Wang,L., Munch,C., Stolz,A., Brandes,R.P., Tse,W.K.F., Eimer,S., Stainier,D.Y.R., Legewie,S., Zarnack,K., Muller-McNicoll,M. and Dikic,I.
    Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
    Science (2024) 386, 768-776. PubMed  Europe PubMed DOI
  10. Sirera,J., Sarlak,S., Teisseire,M., Carminati,A., Nicolini,V.J., Savy,C., Brest,P., Juel,T., Bontoux,C., Deckert,M., Ohanna,M., Giuliano,S., Dufies,M., Pages,G. and Luciano,F.
    Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation
    J Exp Clin Cancer Res (2024) 43, 335-335. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2023
  11. Choi,Y., Lee,Y., Kim,J.S., Zhang,P. and Kim,J.
    USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity
    Biomolecules (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Wang,J., Wang,X., Cao,M., Zhang,L. and Lin,J.
    CircUSP39/miR-362-3p/TRAF3 Axis Mediates Hypoxia/Reoxygenation-Induced Cardiomyocyte Oxidative Stress, Inflammation, and Apoptosis
    Int Heart J (2023) 64, 263-273. PubMed  Europe PubMed DOI
  13. Wang,W., Lei,Y., Zhang,G., Li,X., Yuan,J., Li,T., Zhong,W., Zhang,Y., Tan,X. and Song,G.
    USP39 stabilizes beta-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression
    Cell Death Dis (2023) 14, 63-63. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Xiao,Y., Chen,X., Hu,W., Ma,W., Di,Q., Tang,H., Zhao,X., Huang,G. and Chen,W.
    USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression
    Transl Oncol (2023) 34, 101713-101713. PubMed  Europe PubMed DOI  PMC  EPMC  K
  15. Yu,J., Yuan,S., Song,J. and Yu,S.
    USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1
    J Transl Med (2023) 21, 807-807. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Zheng,J., Wu,S., Tang,M., Xi,S., Wang,Y., Ren,J., Luo,H., Hu,P., Sun,L., Du,Y., Yang,H., Wang,F., Gao,H., Dai,Z., Ou,X. and Li,Y.
    USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC
    Cell Death Dis (2023) 14, 670-670. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2022
  17. Cui,F., Luo,P., Wu,R. and Meng,J.
    miR-381 Inhibits Proliferation and Invasion of Non-Small-Cell Cancer Cells by Targeting USP39
    Dis Markers (2022) 2022, 2195393-2195393. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Kimura-Yoshida,C., Mochida,K., Kanno,S.I. and Matsuo,I.
    USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components
    Commun Biol (2022) 5, 378-378. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Liu,Y., Wu,Q., Sun,T., Huang,J., Han,G. and Han,H.
    DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability
    Front Oncol (2022) 12, 1032579-1032579. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Ruan,G.X., Li,Y., Chen,W., Huang,H., Zhang,R., Chen,C., Lam,K.P., Xu,S. and Ou,X.
    The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement
    Cell Rep (2022) 38, 110338-110338. PubMed  Europe PubMed DOI
  21. Xiao,Y., Ma,W., Hu,W., Di,Q., Zhao,X., Ma,X., Chen,X., Sun,P., Wu,H., Wu,Z. and Chen,W.
    Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation
    Mol Oncol (2022) 16, 388-404. PubMed  Europe PubMed DOI
  22. Zhang,Z., Liu,W., Bao,X., Sun,T., Wang,J., Li,M. and Liu,C.
    USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1
    Am J Cancer Res (2022) 12, 3644-3661. PubMed  Europe PubMed  PMC  EPMC  K
    23. 2021
  23. Dong,X., Liu,Z., Zhang,E., Zhang,P., Wang,Y., Hang,J. and Li,Q.
    USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma
    Cell Signal (2021) 85, 110068-110068. PubMed  Europe PubMed DOI
  24. Kim,J.J., Lee,S.Y., Hwang,Y., Kim,S., Chung,J.M., Park,S., Yoon,J., Yun,H., Ji,J.H., Chae,S., Cho,H., Kim,C.G., Dawson,T.M., Kim,H., Dawson,V.L. and Kang,H.C.
    USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing
    Nucleic Acids Res (2021) 49, 11083-11102. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Li,X., Yuan,J., Song,C., Lei,Y., Xu,J., Zhang,G., Wang,W. and Song,G.
    Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma
    Cell Death Differ (2021) PubMed  Europe PubMed DOI
  26. Pan,X.W., Xu,D., Chen,W.J., Chen,J.X., Chen,W.J., Ye,J.Q., Gan,S.S., Zhou,W., Song,X., Shi,L. and Cui,X.G.
    USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1
    Cancer Cell Int (2021) 21, 486-486. PubMed  Europe PubMed DOI  PMC  EPMC  K
  27. Yuan,J., Li,X., Zhang,G., Cheng,W., Wang,W., Lei,Y., Ma,Q. and Song,G.
    USP39 mediates p21-dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis
    Mol Carcinog (2021) 60, 265-278. PubMed  Europe PubMed DOI  K
  28. Zhao,Y., Geng,H., Liu,G., Ji,Q., Cheng,X., Li,X., Liu,W., Thorne,R.F., Zhang,R. and Liu,X.
    The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor
    Front Oncol (2021) 11, 667495-667495. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2020
  29. Dong,L., Yu,L., Li,H., Shi,L., Luo,Z., Zhao,H., Liu,Z., Yin,G., Yan,X. and Lin,Z.
    An NAD(+)-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39
    iScience (2020) 23, 101351-101351. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Peng,Y., Guo,J., Sun,T., Fu,Y., Zheng,H., Dong,C. and Xiong,S.
    USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity
    J Immunol (2020) PubMed  Europe PubMed DOI  K
  31. Yuan,J., Zhang,G., Li,X., Ma,Q., Cheng,W., Wang,W., Zhang,B., Hu,T. and Song,G.
    Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  K
    32. 2019
  32. Liu,C., Yao,X., Li,M., Xi,Y. and Zhao,L.
    USP39 regulates the cell cycle, survival, and growth of human leukemia cells
    Biosci Rep (2019) 39, BSR20190040-BSR20190040. PubMed  Europe PubMed DOI
  33. Wang,L., Chen,T., Li,X., Yan,W., Lou,Y., Liu,Z., Chen,H. and Cui,Z.
    USP39 promotes ovarian cancer malignant phenotypes and carboplatin chemoresistance
    Int J Oncol (2019) 55, 277-288. PubMed  Europe PubMed DOI
  34. Wu,J., Chen,Y., Geng,G., Li,L., Yin,P., Nowsheen,S., Li,Y., Wu,C., Liu,J., Zhao,F., Kim,W., Zhou,Q., Huang,J., Guo,G., Zhang,C., Tu,X., Gao,X., Lou,Z., Luo,K., Qiao,H. and Yuan,J.
    USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2
    Cancer Lett (2019) 449, 114-124. PubMed  Europe PubMed DOI
  35. Yan,C., Yuan,J., Xu,J., Zhang,G., Li,X., Zhang,B., Hu,T., Huang,X., Mao,Y. and Song,G.
    Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT
    Med Oncol (2019) 36, 95-95. PubMed  Europe PubMed DOI
    36. 2018
  36. Dong,X., Su,H., Jiang,F., Li,H., Shi,G. and Fan,L.
    miR-133a, directly targeted USP39, suppresses cell proliferation and predicts prognosis of gastric cancer
    Oncol Lett (2018) 15, 8311-8318. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Xing,Z., Sun,F., He,W., Wang,Z., Song,X. and Zhang,F.
    Downregulation of ubiquitin-specific peptidase 39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells
    Oncol Lett (2018) 15, 5443-5450. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2017
  38. Cai,J., Liu,T., Huang,P., Yan,W., Guo,C., Xiong,L. and Liu,A.
    USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway
    Biochem Biophys Res Commun (2017) 486, 184-190. PubMed  Europe PubMed DOI
  39. Fraile,J.M., Manchado,E., Lujambio,A., Quesada,V., Campos-Iglesias,D., Webb,T.R., Lowe,S.W., Lopez-Otin,C. and Freije,J.M.
    USP39 deubiquitinase is essential for KRAS oncogene-driven cancer
    J Biol Chem (2017) 292, 4164-4175. PubMed  Europe PubMed DOI
  40. Gan,Z., Han,K., Lin,S., Hu,H., Shen,Z. and Min,D.
    Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro
    Biol Res (2017) 50, 15-15. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Yuan,X., Sun,X., Shi,X., Wang,H., Wu,G., Jiang,C., Yu,D., Zhang,W., Xue,B. and Ding,Y.
    USP39 promotes colorectal cancer growth and metastasis through the Wnt/beta-catenin pathway
    Oncol Rep (2017) 37, 2398-2404. PubMed  Europe PubMed DOI
  42. Yuan,X., Sun,X., Shi,X., Jiang,C., Yu,D., Zhang,W. and Ding,Y.
    USP39 regulates the growth of SMMC-7721 cells via FoxM1
    Exp Ther Med (2017) 13, 1506-1513. PubMed  Europe PubMed DOI  PMC  EPMC  K
    43. 2016
  43. Li,K.Y., Zhang,J., Jiang,L.C., Zhang,B., Xia,C.P., Xu,K., Chen,H.Y., Yang,Q.Z., Liu,S.W. and Zhu,H.
    Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma
    Cancer Biomark (2016) 16, 137-144. PubMed  Europe PubMed DOI  K
  44. Zhao,Y., Zhang,B., Lei,Y., Sun,J., Zhang,Y., Yang,S. and Zhang,X.
    Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
    Tumour Biol (2016) 37, 13167-13176. PubMed  Europe PubMed DOI  K
    45. 2015
  45. Pan,Z., Pan,H., Zhang,J., Yang,Y., Liu,H., Yang,Y., Huang,G., Ni,J., Huang,J. and Zhou,W.
    Lentivirus mediated silencing of ubiquitin specific peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro
    Biol Res (2015) 48, 18- PubMed  Europe PubMed DOI  PMC  EPMC  K
    46. 2014
  46. Hadjivassiliou,H., Rosenberg,O.S. and Guthrie,C.
    The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing
    RNA (2014) 20, 656-669. PubMed  Europe PubMed DOI  S
    47. 2013
  47. Wang,H., Ji,X., Liu,X., Yao,R., Chi,J., Liu,S., Wang,Y., Cao,W. and Zhou,Q.
    Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro
    Oncol Rep (2013) 30, 2871-2877. PubMed  Europe PubMed DOI
    48. 2011
  48. Rios,Y., Melmed,S., Lin,S. and Liu,N.A.
    Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion
    PLoS Genet (2011) 7, e1001271-e1001271. PubMed  Europe PubMed DOI  PMC  EPMC  M
    49. 2008
  49. van Leuken,R.J., Luna-Vargas,M.P., Sixma,T.K., Wolthuis,R.M. and Medema,R.H.
    Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B
    Cell Cycle (2008) 7, 2710-2719. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use