Literature for peptidase C19.073: ubiquitin-specific peptidase 49

(Topics flags: K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Chen,J., Fu,X., Gao,X., Sun,Y., Xiao,J., Chen,W., Wang,H., Yang,B., Zhang,M., Chen,Y., Wen,Y., Deng,H., Chen,C. and Luo,H.
   USP49 promotes the malignancy of triple-negative breast cancer cells by regulating PKMYT1 ubiquitination and stability
   Biochem Biophys Res Commun (2026) 797, 153163-153163. PubMed  Europe PubMed DOI  K
2. Xu,W., Shan,J., Wang,J., Zhou,Y., Ouyang,Y., Chen,Y. and Zhou,Q.
   USP49 regulates lipid metabolism in hepatocellular carcinoma by stabilizing RACK1 to promote tumor proliferation and migration
   Biochim Biophys Acta Mol Cell Res (2026) 1873, 120107-120107. PubMed  Europe PubMed DOI
2025
3. Cao,X., Yan,Z., Ma,C., Xie,P., Sun,W., Ge,Y., Zong,D. and He,X.
   USP49 undergoes liquid-liquid phase separation and stabilizes RPA70 to induce radioresistance through homologous recombination repair in esophageal squamous cell carcinoma
   Int J Biol Macromol (2025) 318, 144834-144834. PubMed  Europe PubMed DOI
4. Hang,S., Wang,Q., Zhang,J., Dong,Y., Hu,B., Wang,P. and Xu,L.
   FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation
   Front Immunol (2025) 16, 1660034-1660034. PubMed  Europe PubMed DOI  PMC  EPMC  K
5. Xia,Q., Dong,S., Xu,W., Lai,Q., Song,H. and Zhang,W.
   Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy
   Biochim Biophys Acta Mol Basis Dis (2025) 1872, 168128-168128. PubMed  Europe PubMed DOI
2024
6. Ding,Y., Liu,Z., Dai,X., Ruan,R., Zhong,H., Wu,Z., Yao,Y., Chen,J., Deng,J. and Xiong,J.
   USP49 promotes adenocarcinoma of the esophagogastric junction malignant progression via activating SHCBP1-beta-catenin-GPX4 axis
   Carcinogenesis (2024) PubMed  Europe PubMed DOI  K
7. Geng,H., Qi,L., You,L., Feng,W., Yang,X. and Lei,M.
   miR-361-3p overexpression promotes apoptosis and inflammation by regulating the USP49/IkappaBalpha/NF-kappaB pathway to aggravate sepsis-induced myocardial injury
   Toxicol Res (Camb) (2024) 13, tfae190-tfae190. PubMed  Europe PubMed DOI  PMC  EPMC
8. Li,L., Yang,N., Sun,J.H., Wei,L.J. and Gao,Y.
   IGF2BP3-dependent N6-methyladenosine modification of USP49 promotes carboplatin resistance in retinoblastoma by enhancing autophagy via regulating the stabilization of SIRT1
   Kaohsiung J Med Sci (2024) PubMed  Europe PubMed DOI
2023
9. Campos-Iglesias,D., Fraile,J.M., Bretones,G., Montero,A.A., Bonzon-Kulichenko,E., Vazquez,J., Lopez-Otin,C. and Freije,J.M.P.
   USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
   Cell Death Dis (2023) 14, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC
2022
10. Liu,Z., Li,J., Ding,Y., Ma,M., Chen,J., Lei,W., Li,L., Yao,Y., Yu,X., Zhong,M., Liao,Q., Fang,W., Fan,L., Huang,C., Zhong,H., Wen,Q., Fang,Z., Chen,J., Huang,S., Xiong,J., Xiang,X. and Deng,J.
    USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer
    Oncogene (2022) 41, 2555-2570. PubMed  Europe PubMed DOI  K
11. Shi,L., Shen,X. and Shen,Y.
    USP49-mediated histone H2B deubiquitination regulates HCT116 cell proliferation through MDM2-p53 axis
    Mol Cell Biol (2022) , MCB0043421-MCB0043421. PubMed  Europe PubMed DOI
12. Tu,R., Kang,W., Kang,Y., Chen,Z., Zhang,P., Xiong,X., Ma,J., Du,R.L. and Zhang,C.
    c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro
    Biochem Biophys Res Commun (2022) 607, 117-123. PubMed  Europe PubMed DOI
2021
13. Zhuang,Y.Y., Zhong,W., Xia,Z.S., Lin,S.Z., Chan,M.C., Jiang,K., Li,W.F. and Xu,X.Y.
    miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer
    Cell Death Discov (2021) 7, 129-129. PubMed  Europe PubMed DOI  PMC  EPMC
2019
14. Pan,T., Song,Z., Wu,L., Liu,G., Ma,X., Peng,Z., Zhou,M., Liang,L., Liu,B., Liu,J., Zhang,J., Zhang,X., Huang,R., Zhao,J., Li,Y., Ling,X., Luo,Y., Tang,X., Cai,W., Deng,K., Li,L. and Zhang,H.
    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
    elife (2019) 8 PubMed  Europe PubMed DOI  PMC  EPMC
15. Shen,W.M., Yin,J.N., Xu,R.J., Xu,D.F. and Zheng,S.Y.
    Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling
    Kaohsiung J Med Sci (2019) 35, 401-407. PubMed  Europe PubMed DOI
16. Ye,L., Zhang,Q., Liuyu,T., Xu,Z., Zhang,M.X., Luo,M.H., Zeng,W.B., Zhu,Q., Lin,D. and Zhong,B.
    USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
    PLoS Pathog (2019) 15, e1007680-e1007680. PubMed  Europe PubMed DOI
2018
17. Tu,R., Kang,W., Yang,X., Zhang,Q., Xie,X., Liu,W., Zhang,J., Zhang,X.D., Wang,H. and Du,R.L.
    USP49 participates in the DNA damage response by forming a positive feedback loop with p53
    Cell Death Dis (2018) 9, 553-553. PubMed  Europe PubMed DOI  PMC  EPMC
2017
18. Luo,K., Li,Y., Yin,Y., Li,L., Wu,C., Chen,Y., Nowsheen,S., Hu,Q., Zhang,L., Lou,Z. and Yuan,J.
    USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling
    EMBO J (2017) 36, 1434-1446. PubMed  Europe PubMed DOI
2004
19. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI