Literature for peptidase C19.067: ubiquitin-specific peptidase 34

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

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    2026
  1. Jiang,S., Chen,D., Sheng,R., Yuan,Q., Pan,J. and Guo,Y.
    USP34 attenuates cartilage degradation in temporomandibular joint osteoarthritis by ANT1-mediated mitophagy
    JBMR Plus (2026) 10, ziag004-ziag004. PubMed  Europe PubMed DOI  PMC  EPMC
  2. 2025
  3. Fan,M., Liu,J.S., Wei,X.L., Nie,Y. and Liu,H.L.
    Histone Lactylation-Driven Ubiquitin-Specific Protease 34 Promotes Cisplatin Resistance in Hepatocellular Carcinoma
    Gastroenterology Res (2025) 18, 23-30. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. 2024
  5. Cheng,N., Gonzalez Ramirez,M.L., Edwards,C. and Trejo,J.
    USP34 regulates endothelial PAR1 mRNA transcript expression and cellular signaling
    Mol Biol Cell (2024) , mbcE24070294-mbcE24070294. PubMed  Europe PubMed DOI  K
  6. Pan,Y., Yuan,F., Lin,Z. and Li,Y.
    BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
    Histol Histopathol (2024) , 18748-18748. PubMed  Europe PubMed DOI  K
  7. Zhu,Q., Liang,P., Meng,H., Li,F., Miao,W., Chu,C., Wang,W., Li,D., Chen,C., Shi,Y., Yu,X., Ping,Y., Niu,C., Wu,H.B., Zhang,A., Bian,X.W. and Zhou,W.
    Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells
    Nat Commun (2024) 15, 40-40. PubMed  Europe PubMed DOI  PMC  EPMC
  8. 2023
  9. Cheng,N. and Trejo,J.
    An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses
    J Biol Chem (2023) 299, 105370-105370. PubMed  Europe PubMed DOI  PMC  EPMC  K
  10. Li,H., Li,X., Kong,Y. and Sun,W.
    Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice
    Immunobiology (2023) 228, 152383-152383. PubMed  Europe PubMed DOI
  11. 2022
  12. Pahi,Z.G., Kovacs,L., Szucs,D., Borsos,B.N., Deak,P. and Pankotai,T.
    Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster
    Sci Rep (2022) 12, 5870-5870. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Xu,G., Su,H., Lu,L., Liu,X., Zhao,L., Tang,B. and Ming,Z.
    Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34
    J Mol Biol (2022) 434, 167634-167634. PubMed  Europe PubMed DOI
  14. 2021
  15. Jiang,S., Sheng,R., Qi,X., Wang,J., Guo,Y. and Yuan,Q.
    USP34 regulates tooth root morphogenesis by stabilizing NFIC
    Int J Oral Sci (2021) 13, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xu,J., Li,L., Ren,J., Zhong,X., Xie,C., Zheng,A., Abudukadier,A., Tuerxun,M., Zhang,S., Tang,L., Hairoula,D. and Zou,X.
    Whole-Exome Sequencing Implicates the USP34 rs777591A > G Intron Variant in Chronic Obstructive Pulmonary Disease in a Kashi Cohort
    Front Cell Dev Biol (2021) 9, 792027-792027. PubMed  Europe PubMed DOI  PMC  EPMC
  17. 2020
  18. Dai,W.L., Yuan,S.X. and Cao,J.P.
    The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drug resistance in laryngeal squamous cell carcinoma
    Kaohsiung J Med Sci (2020) PubMed  Europe PubMed DOI  K
  19. Guo,Y.C., Wang,M.Y., Zhang,S.W., Wu,Y.S., Zhou,C.C., Zheng,R.X., Shao,B., Wang,Y., Xie,L., Liu,W.Q., Sun,N.Y., Jing,J.J., Ye,L., Chen,Q.M. and Yuan,Q.
    Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling
    EMBO J (2020) 39, e105578-e105578. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Li,Q., Wang,M., Xue,H., Liu,W., Guo,Y., Xu,R., Shao,B. and Yuan,Q.
    Ubiquitin-specific protease 34 inhibits osteoclast differentiation by regulating NF-kappaB signaling
    J Bone Miner Res (2020) PubMed  Europe PubMed DOI
  21. Lin,C., Xia,J., Gu,Z., Meng,Y., Gao,D. and Wei,S.
    Downregulation of USP34 inhibits the growth and migration of pancreatic cancer cells via inhibiting the PRR11
    Onco Targets Ther (2020) 13, 1471-1480. PubMed  Europe PubMed DOI  PMC  EPMC
  22. 2019
  23. Gu,Z., Lin,C., Hu,J., Xia,J., Wei,S. and Gao,D.
    USP34 regulated human pancreatic cancer cell survival via AKT and PKC pathways
    Biol Pharm Bull (2019) 42, 573-579. PubMed  Europe PubMed DOI
  24. 2018
  25. Guo,Y.C., Wang,M.Y., Zhang,S.W., Wu,Y.S., Zhou,C.C., Zheng,R.X., Shao,B., Wang,Y., Xie,L., Liu,W.Q., Sun,N.Y., Jing,J.J., Ye,L., Chen,Q.M. and Yuan,Q.
    Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling
    EMBO J (2018) 37, e99398-e99398. PubMed  Europe PubMed DOI
  26. Wang,H., Ju,D., Kho,D.H., Yang,H., Li,L., Raz,A., Sun,F. and Xie,Y.
    The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation
    Biochem Biophys Res Commun (2018) DOI
  27. 2013
  28. Poalas,K., Hatchi,E.M., Cordeiro,N., Dubois,S.M., Leclair,H.M., Leveau,C., Alexia,C., Gavard,J., Vazquez,A. and Bidere,N.
    Negative regulation of NF-kappaB signaling in T lymphocytes by the ubiquitin-specific protease USP34
    Cell Commun Signal (2013) 11, 25-25. PubMed  Europe PubMed DOI  K
  29. Sy,S.M., Jiang,J., O,W.S., Deng,Y. and Huen,M.S.
    The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks
    Nucleic Acids Res (2013) 41, 8572-8580. PubMed  Europe PubMed DOI
  30. 2011
  31. Lui,T.T., Lacroix,C., Ahmed,S.M., Goldenberg,S.J., Leach,C.A., Daulat,A.M. and Angers,S.
    The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling
    Mol Cell Biol (2011) 31, 2053-2065. PubMed  Europe PubMed DOI
  32. 2004
  33. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI