Literature for peptidase C19.065: ubiquitin-specific peptidase 51

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ou,Y., Zhang,K., Shuai,Q., Wang,C., Hu,H., Cao,L., Qi,C., Guo,M., Li,Z., Shi,J., Liu,Y., Zuo,S., Chen,X., Wang,Y., Feng,M., Wang,H., Sun,P., Shi,Y., Yang,G. and Yang,S.
    USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells
    Acta Pharm Sin B (2025) 15, 2593-2611. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Sakamoto,Y., Takahashi,M., Nishimura,H., Watanabe,K. and Suzuki,H.
    Regulation of divergent epithelial-to-mesenchymal transition responses via the CDK4/6-USP51 pathway through ZEB1 protein stabilization
    Sci Rep (2025) 15, 31802-31802. PubMed  Europe PubMed DOI  PMC  EPMC
  3. 2023
  4. Chen,J., Wu,Z., Deng,W., Tang,M., Wu,L., Lin,N., Chen,L., Fu,Y., Zhao,M., Chen,C. and Li,W.
    USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1
    J Transl Med (2023) 21, 453-453. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Li,J., Xiao,X., Ou,Y., Cao,L., Guo,M., Qi,C., Wang,Z., Liu,Y., Shuai,Q., Wang,H., Sun,P., Shi,Y., Yang,G. and Yang,S.
    USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer
    Cancer Commun (Lond) (2023) 43, 765-787. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Liu,Y.J., Zeng,S.H., Zhang,W., Li,J.P., Yin,Y., Zhuang,Y.W., Zhou,J.Y., Liu,S.L. and Zou,X.
    USP51/ZEB1/ACTA2 axis promotes mesenchymal phenotype in gastric cancer and is associated with low cohesion characteristics
    Pharmacol Res (2023) 188, 106644-106644. PubMed  Europe PubMed DOI
  7. Mu,M., Zhang,Q., Li,J., Zhao,C., Li,X., Chen,Z., Sun,X. and Yu,J.
    USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A
    Cell Death Differ (2023) 30, 2393-2407. PubMed  Europe PubMed DOI  PMC  EPMC
  8. 2020
  9. Zhang,Z., Li,J., Ou,Y., Yang,G., Deng,K., Wang,Q., Wang,Z., Wang,W., Zhang,Q., Wang,H., Sun,W., Sun,P. and Yang,S.
    CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism
    Signal Transduct Target Ther (2020) 5, 25-25. PubMed  Europe PubMed DOI  PMC  EPMC
  10. 2019
  11. Ai,H., Guo,Y., Sun,D., Liu,S., Qi,Y., Guo,J., Qu,Q., Gong,Q., Zhao,S., Li,J. and Liu,L.
    Examination of the deubiquitylation site selectivity of USP51 by using chemically synthesized ubiquitylated histones
    Chembiochem (2019) 20, 221-229. PubMed  Europe PubMed DOI  P
  12. 2016
  13. Wang,Z., Zhang,H., Liu,J., Cheruiyot,A., Lee,J.H., Ordog,T., Lou,Z., You,Z. and Zhang,Z.
    USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response
    Genes Dev (2016) 30, 946-959. PubMed  Europe PubMed DOI
  14. 2004
  15. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI