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Literature for peptidase C19.060: ubiquitin-specific peptidase 30

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Baoyinna,B., He,J., Miao,J., Shaheen,N., Xia,B., Wang,C., Ma,Q., Bernier,M.C., Whitson,B.A., Sun,N., Zhao,J. and Zhao,Y.
    Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle
    Adv Sci (Weinh) (2025) , e12807-e12807. PubMed  Europe PubMed DOI
  2. Cheng,X.G., Liu,Y.C., Chen,F., Li,J.W., Yao,X.Z. and Chen,Q.Y.
    GNPAT/USP30 Stabilizes DRP1 Protein to Promote Mitochondrial Fission and Functional Damage in COPD Progression
    Kaohsiung J Med Sci (2025) , e70080-e70080. PubMed  Europe PubMed DOI
  3. Frison,M., Lockey,B.S., Nie,Y., Golder,Z., Theiaspra,E., Ryall,C.D., Lyons,C., Burr,S.P., Prater,M., Bozhilova,L.V., Glynos,A., Stewart,J.B., Jones,N.S., Chiaratti,M.R. and Chinnery,P.F.
    Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
    Science (2025) 390, 156-163. PubMed  Europe PubMed DOI
  4. Gao,X., Liu,J., Jia,B. and Guo,J.
    USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40
    J Biochem Mol Toxicol (2025) 39, e70258-e70258. PubMed  Europe PubMed DOI  K
  5. Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.
    Recent advances in small molecule inhibitors of deubiquitinating enzymes
    Eur J Med Chem (2025) 287, 117324-117324. PubMed  Europe PubMed DOI  V
  6. O'Brien,D.P., Jones,H.B.L., Shi,Y., Guenther,F., Vendrell,I., Viner,R., Brennan,P.E., Mead,E., Zarganes-Tzitzikas,T., Davis,J.B., Pinto-Fernandez,A., England,K.S., Murphy,E.J., Turnbull,A.P. and Kessler,B.M.
    Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
    J Proteome Res (2025) PubMed  Europe PubMed DOI
  7. Okatsu,K. and Fukai,S.
    Ubiquitin signaling in PINK1/Parkin-dependent mitophagy
    J Biochem (2025) PubMed  Europe PubMed DOI
  8. Siwach,A., Patel,H., Khairnar,A. and Parekh,P.
    Molecular Symphony of Mitophagy: Ubiquitin-Specific Protease-30 as a Maestro for Precision Management of Neurodegenerative Diseases
    CNS Neurosci Ther (2025) 31, e70192-e70192. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Sun,N., Barta,H., Chaudhuri,S., Chen,K., Jin,J., Luo,H., Yang,M., Krigman,J., Zhang,R., Sanghvi,S., Sekine,S., Sanders,H., Kolonay,D., Patel,M., Baskin,K., Singh,H., Zhang,P., Xin,G. and Finkel,T.
    Mitophagy mitigates mitochondrial fatty acid beta-oxidation deficient cardiomyopathy
    Nat Commun (2025) 16, 5465-5465. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zhang,G. and Xu,W.
    Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway
    Neuroreport (2025) 36, 719-727. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2024
  11. Chi,C., Tang,X., Liu,W., Zhou,Y., Jiang,R., Chen,Y. and Li,M.
    Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30
    Biotechnol J (2024) 19, e2300653-e2300653. PubMed  Europe PubMed DOI  K
  12. Jiang,F., Li,X., Lin,L., Li,M. and Zheng,J.
    NPRC promotes hepatic steatosis via USP30-mediated deubiquitination of C/EBPbeta
    Metabolism (2024) 162, 156050-156050. PubMed  Europe PubMed DOI
  13. Mondal,M., Cao,F., Conole,D., Auner,H.W. and Tate,E.W.
    Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30
    RSC Chem Biol (2024) 5, 439-446. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Okarmus,J., Agergaard,J.B., Stummann,T.C., Haukedal,H., Ambjorn,M., Freude,K.K., Fog,K. and Meyer,M.
    USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
    Cell Death Dis (2024) 15, 52-52. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Soung,A.L., Kyauk,R.V., Pandey,S., Shen,Y.A., Reichelt,M., Lin,H., Jiang,Z., Kirshnamoorthy,P., Foreman,O., Lauffer,B.E. and Yuen,T.J.
    Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation
    Glia (2024) PubMed  Europe PubMed DOI
  16. Sun,K., Liao,S., Yao,X. and Yao,F.
    USP30 promotes the progression of breast cancer by stabilising Snail
    Cancer Gene Ther (2024) 31, 472-483. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Xu,X., Gong,C., Wang,Y., Yin,Z., Wang,X., Wu,X., Fang,Z. and Wei,S.
    FOXF1 promotes ovarian cancer metastasis by facilitating HMGA2-mediated USP30-dependent S100A6 deubiquitination
    Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167633-167633. PubMed  Europe PubMed DOI
  18. Zhang,R., Jiang,W., Wang,G., Zhang,Y., Liu,W., Li,M., Yu,J., Yan,X., Zhou,F., Du,W., Qian,K., Xiao,Y., Liu,T., Ju,L. and Wang,X.
    Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase
    Commun Biol (2024) 7, 245-245. PubMed  Europe PubMed DOI  PMC  EPMC  K
    19. 2023
  19. Alshehri,M.M., Danazumi,A.U., Alshammari,M.K., Bello,R.O., Alghazwni,M.K., Alshehri,A.M., Alshlali,O.M. and Umar,H.I.
    Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies
    J Biomol Struct Dyn (2023) , 1-12. PubMed  Europe PubMed DOI
  20. Liu,Y., Yao,C., Sheng,B., Zhi,S., Chen,X., Ding,P., Zhang,J., Tao,Z., Li,W., Zhuang,Z., Mao,J., Peng,Z., Yan,H. and Jin,W.
    Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH
    Transl Stroke Res (2023) PubMed  Europe PubMed DOI
  21. O'Brien,D.P., Jones,H.B.L., Guenther,F., Murphy,E.J., England,K.S., Vendrell,I., Anderson,M., Brennan,P.E., Davis,J.B., Pinto-Fernandez,A., Turnbull,A.P. and Kessler,B.M.
    Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
    Mol Cell Proteomics (2023) 22, 100609-100609. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Sanchez-Martinez,A., Martinez,A. and Whitworth,A.J.
    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo
    PLoS Biol (2023) 21, e3002244-e3002244. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Wang,H., Huang,S., Meng,Q., Zhang,J. and Wei,L.
    [Bioinformatics analysis of the association between long non-coding RNA ubiquitin-specific peptidase 30 antisense RNA 1 (lncRNA USP30-AS1) and immune cell infiltration in ovarian serous cystadenocarcinoma]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2023) 39, 834-840. PubMed  Europe PubMed  K
  24. Wu,Y., Hu,Q., Cheng,H., Yu,J., Gao,L. and Gao,G.
    USP30 impairs mitochondrial quality control and aggravates oxidative damage after traumatic brain injury
    Biochem Biophys Res Commun (2023) 671, 58-66. PubMed  Europe PubMed DOI
    25. 2022
  25. Mandal,S., Kumar Br,P., Alam,M.T., Tripathi,P.P. and Channappa,B.
    Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays
    ACS Chem Neurosci (2022) 13, 1433-1445. PubMed  Europe PubMed DOI  I
  26. Qin,X., Wang,R., Xu,H., Tu,L., Chen,H., Li,H., Liu,N., Wang,J., Li,S., Yin,F., Xu,N. and Li,Z.
    Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30
    Autophagy (2022) , 1-20. PubMed  Europe PubMed DOI
  27. Wang,F., Gao,Y., Zhou,L., Chen,J., Xie,Z., Ye,Z. and Wang,Y.
    USP30: Structure, Emerging Physiological Role, and Target Inhibition
    Front Pharmacol (2022) 13, 851654-851654. PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Zhang,R., Ozgen,S., Luo,H., Krigman,J., Zhao,Y., Xin,G. and Sun,N.
    The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling
    Front Pharmacol (2022) 13, 816551-816551. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Zhuang,D., Zhang,R., Liu,H. and Dai,Y.
    A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity
    Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC  K
    30. 2021
  30. Cabrera,S.F., Muratore,M.E. and Buijnsters,P.
    The intriguing role of USP30 inhibitors as deubiquitinating enzymes from the patent literature since 2013
    Expert Opin Ther Pat (2021) PubMed  Europe PubMed DOI
  31. Chen,C., Qin,H., Tang,J., Hu,Z., Tan,J. and Zeng,L.
    USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2
    Aging (Albany NY) (2021) 13, 6194-6204. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Yan,D., Li,X., Yang,Q., Huang,Q., Yao,L., Zhang,P., Sun,W., Lin,S., Dou,Q.P., Liu,J. and Chen,X.
    Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
    Cell Death Discov (2021) 7, 211-211. PubMed  Europe PubMed DOI  PMC  EPMC  I
    33. 2019
  33. Miller,S. and Muqit,M.M.K.
    Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease
    Neurosci Lett (2019) 705, 7-13. PubMed  Europe PubMed DOI  T  I
  34. Riccio,V., Demers,N., Hua,R., Vissa,M., Cheng,D.T., Strilchuk,A.W., Wang,Y., McQuibban,G.A. and Kim,P.K.
    Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy
    J Cell Biol (2019) 218, 798-807. PubMed  Europe PubMed DOI
  35. Riccio,V., McQuibban,G.A. and Kim,P.K.
    USP30: protector of peroxisomes and mitochondria
    Mol Cell Oncol (2019) 6, 1600350-1600350. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2017
  36. Gersch,M., Gladkova,C., Schubert,A.F., Michel,M.A., Maslen,S. and Komander,D.
    Mechanism and regulation of the Lys6-selective deubiquitinase USP30
    Nat Struct Mol Biol (2017) 24, 920-930. PubMed  Europe PubMed DOI
  37. Hou,J., Eldeeb,M. and Wang,X.
    Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis
    Adv Exp Med Biol (2017) 1038, 133-148. PubMed  Europe PubMed DOI
  38. Sato,Y., Okatsu,K., Saeki,Y., Yamano,K., Matsuda,N., Kaiho,A., Yamagata,A., Goto-Ito,S., Ishikawa,M., Hashimoto,Y., Tanaka,K. and Fukai,S.
    Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
    Nat Struct Mol Biol (2017) 24, 911-919. PubMed  Europe PubMed DOI  S
    39. 2015
  39. Cunningham,C.N., Baughman,J.M., Phu,L., Tea,J.S., Yu,C., Coons,M., Kirkpatrick,D.S., Bingol,B. and Corn,J.E.
    USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
    Nat Cell Biol (2015) 17, 160-169. PubMed  Europe PubMed DOI  P
  40. Liang,J.R., Martinez,A., Lane,J.D., Mayor,U., Clague,M.J. and Urbe,S.
    USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death
    EMBO Rep (2015) 16, 618-627. PubMed  Europe PubMed DOI
  41. Thobois,S.
    USP30: a new promising target for Parkinson's disease?
    Mov Disord (2015) 30, 340-340. PubMed  Europe PubMed DOI
  42. Wang,Y., Serricchio,M., Jauregui,M., Shanbhag,R., Stoltz,T., Di Paolo,C.T., Kim,P.K. and McQuibban,G.A.
    Deubiquitinating enzymes regulate PARK2-mediated mitophagy
    Autophagy (2015) 11, 595-606. PubMed  Europe PubMed DOI
    43. 2014
  43. Bingol,B., Tea,J.S., Phu,L., Reichelt,M., Bakalarski,C.E., Song,Q., Foreman,O., Kirkpatrick,D.S. and Sheng,M.
    The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
    Nature (2014) 510, 370-375. PubMed  Europe PubMed DOI  T
  44. Krishnmurthy,R.G. and Shradgan,F.M.
    Commentary-1 (Research Highlights: USP30 regulates the mitophagy-mediated neuroprotection in Parkinson's disease)
    CNS Neurol Disord Drug Targets (2014) 13, 1633-1634. PubMed  Europe PubMed
  45. Yue,W., Chen,Z., Liu,H., Yan,C., Chen,M., Feng,D., Yan,C., Wu,H., Du,L., Wang,Y., Liu,J., Huang,X., Xia,L., Liu,L., Wang,X., Jin,H., Wang,J., Song,Z., Hao,X. and Chen,Q.
    A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
    Cell Res (2014) 24, 482-496. PubMed  Europe PubMed DOI  I
    46. 2011
  46. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
    47. 2008
  47. Nakamura,N. and Hirose,S.
    Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane
    Mol Biol Cell (2008) 19, 1903-1911. PubMed  Europe PubMed DOI  PMC  EPMC
    48. 2004
  48. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    49. 2003
  49. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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