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Literature for peptidase C19.060: ubiquitin-specific peptidase 30

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Baoyinna,B., He,J., Miao,J., Shaheen,N., Xia,B., Wang,C., Ma,Q., Bernier,M.C., Whitson,B.A., Sun,N., Zhao,J. and Zhao,Y.<br>Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle<br>Adv Sci (Weinh) (2025) , e12807-e12807. PubMed  Europe PubMed DOI
  2. Cheng,X.G., Liu,Y.C., Chen,F., Li,J.W., Yao,X.Z. and Chen,Q.Y.<br>GNPAT/USP30 Stabilizes DRP1 Protein to Promote Mitochondrial Fission and Functional Damage in COPD Progression<br>Kaohsiung J Med Sci (2025) , e70080-e70080. PubMed  Europe PubMed DOI
  3. Frison,M., Lockey,B.S., Nie,Y., Golder,Z., Theiaspra,E., Ryall,C.D., Lyons,C., Burr,S.P., Prater,M., Bozhilova,L.V., Glynos,A., Stewart,J.B., Jones,N.S., Chiaratti,M.R. and Chinnery,P.F.<br>Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations<br>Science (2025) 390, 156-163. PubMed  Europe PubMed DOI
  4. Gao,X., Liu,J., Jia,B. and Guo,J.<br>USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40<br>J Biochem Mol Toxicol (2025) 39, e70258-e70258. PubMed  Europe PubMed DOI  K
  5. Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.<br>Recent advances in small molecule inhibitors of deubiquitinating enzymes<br>Eur J Med Chem (2025) 287, 117324-117324. PubMed  Europe PubMed DOI  V
  6. O'Brien,D.P., Jones,H.B.L., Shi,Y., Guenther,F., Vendrell,I., Viner,R., Brennan,P.E., Mead,E., Zarganes-Tzitzikas,T., Davis,J.B., Pinto-Fernandez,A., England,K.S., Murphy,E.J., Turnbull,A.P. and Kessler,B.M.<br>Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor<br>J Proteome Res (2025) PubMed  Europe PubMed DOI
  7. Okatsu,K. and Fukai,S.<br>Ubiquitin signaling in PINK1/Parkin-dependent mitophagy<br>J Biochem (2025) PubMed  Europe PubMed DOI
  8. Siwach,A., Patel,H., Khairnar,A. and Parekh,P.<br>Molecular Symphony of Mitophagy: Ubiquitin-Specific Protease-30 as a Maestro for Precision Management of Neurodegenerative Diseases<br>CNS Neurosci Ther (2025) 31, e70192-e70192. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Sun,N., Barta,H., Chaudhuri,S., Chen,K., Jin,J., Luo,H., Yang,M., Krigman,J., Zhang,R., Sanghvi,S., Sekine,S., Sanders,H., Kolonay,D., Patel,M., Baskin,K., Singh,H., Zhang,P., Xin,G. and Finkel,T.<br>Mitophagy mitigates mitochondrial fatty acid beta-oxidation deficient cardiomyopathy<br>Nat Commun (2025) 16, 5465-5465. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zhang,G. and Xu,W.<br>Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway<br>Neuroreport (2025) 36, 719-727. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2024
  11. Chi,C., Tang,X., Liu,W., Zhou,Y., Jiang,R., Chen,Y. and Li,M.<br>Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30<br>Biotechnol J (2024) 19, e2300653-e2300653. PubMed  Europe PubMed DOI  K
  12. Jiang,F., Li,X., Lin,L., Li,M. and Zheng,J.<br>NPRC promotes hepatic steatosis via USP30-mediated deubiquitination of C/EBPbeta<br>Metabolism (2024) 162, 156050-156050. PubMed  Europe PubMed DOI
  13. Mondal,M., Cao,F., Conole,D., Auner,H.W. and Tate,E.W.<br>Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30<br>RSC Chem Biol (2024) 5, 439-446. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Okarmus,J., Agergaard,J.B., Stummann,T.C., Haukedal,H., Ambjorn,M., Freude,K.K., Fog,K. and Meyer,M.<br>USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons<br>Cell Death Dis (2024) 15, 52-52. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Soung,A.L., Kyauk,R.V., Pandey,S., Shen,Y.A., Reichelt,M., Lin,H., Jiang,Z., Kirshnamoorthy,P., Foreman,O., Lauffer,B.E. and Yuen,T.J.<br>Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation<br>Glia (2024) PubMed  Europe PubMed DOI
  16. Sun,K., Liao,S., Yao,X. and Yao,F.<br>USP30 promotes the progression of breast cancer by stabilising Snail<br>Cancer Gene Ther (2024) 31, 472-483. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Xu,X., Gong,C., Wang,Y., Yin,Z., Wang,X., Wu,X., Fang,Z. and Wei,S.<br>FOXF1 promotes ovarian cancer metastasis by facilitating HMGA2-mediated USP30-dependent S100A6 deubiquitination<br>Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167633-167633. PubMed  Europe PubMed DOI
  18. Zhang,R., Jiang,W., Wang,G., Zhang,Y., Liu,W., Li,M., Yu,J., Yan,X., Zhou,F., Du,W., Qian,K., Xiao,Y., Liu,T., Ju,L. and Wang,X.<br>Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase<br>Commun Biol (2024) 7, 245-245. PubMed  Europe PubMed DOI  PMC  EPMC  K
    19. 2023
  19. Alshehri,M.M., Danazumi,A.U., Alshammari,M.K., Bello,R.O., Alghazwni,M.K., Alshehri,A.M., Alshlali,O.M. and Umar,H.I.<br>Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies<br>J Biomol Struct Dyn (2023) , 1-12. PubMed  Europe PubMed DOI
  20. Liu,Y., Yao,C., Sheng,B., Zhi,S., Chen,X., Ding,P., Zhang,J., Tao,Z., Li,W., Zhuang,Z., Mao,J., Peng,Z., Yan,H. and Jin,W.<br>Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH<br>Transl Stroke Res (2023) PubMed  Europe PubMed DOI
  21. O'Brien,D.P., Jones,H.B.L., Guenther,F., Murphy,E.J., England,K.S., Vendrell,I., Anderson,M., Brennan,P.E., Davis,J.B., Pinto-Fernandez,A., Turnbull,A.P. and Kessler,B.M.<br>Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides<br>Mol Cell Proteomics (2023) 22, 100609-100609. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Sanchez-Martinez,A., Martinez,A. and Whitworth,A.J.<br>FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo<br>PLoS Biol (2023) 21, e3002244-e3002244. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Wang,H., Huang,S., Meng,Q., Zhang,J. and Wei,L.<br>[Bioinformatics analysis of the association between long non-coding RNA ubiquitin-specific peptidase 30 antisense RNA 1 (lncRNA USP30-AS1) and immune cell infiltration in ovarian serous cystadenocarcinoma]<br>Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2023) 39, 834-840. PubMed  Europe PubMed  K
  24. Wu,Y., Hu,Q., Cheng,H., Yu,J., Gao,L. and Gao,G.<br>USP30 impairs mitochondrial quality control and aggravates oxidative damage after traumatic brain injury<br>Biochem Biophys Res Commun (2023) 671, 58-66. PubMed  Europe PubMed DOI
    25. 2022
  25. Mandal,S., Kumar Br,P., Alam,M.T., Tripathi,P.P. and Channappa,B.<br>Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays<br>ACS Chem Neurosci (2022) 13, 1433-1445. PubMed  Europe PubMed DOI  I
  26. Qin,X., Wang,R., Xu,H., Tu,L., Chen,H., Li,H., Liu,N., Wang,J., Li,S., Yin,F., Xu,N. and Li,Z.<br>Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30<br>Autophagy (2022) , 1-20. PubMed  Europe PubMed DOI
  27. Wang,F., Gao,Y., Zhou,L., Chen,J., Xie,Z., Ye,Z. and Wang,Y.<br>USP30: Structure, Emerging Physiological Role, and Target Inhibition<br>Front Pharmacol (2022) 13, 851654-851654. PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Zhang,R., Ozgen,S., Luo,H., Krigman,J., Zhao,Y., Xin,G. and Sun,N.<br>The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling<br>Front Pharmacol (2022) 13, 816551-816551. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Zhuang,D., Zhang,R., Liu,H. and Dai,Y.<br>A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity<br>Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC  K
    30. 2021
  30. Cabrera,S.F., Muratore,M.E. and Buijnsters,P.<br>The intriguing role of USP30 inhibitors as deubiquitinating enzymes from the patent literature since 2013<br>Expert Opin Ther Pat (2021) PubMed  Europe PubMed DOI
  31. Chen,C., Qin,H., Tang,J., Hu,Z., Tan,J. and Zeng,L.<br>USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2<br>Aging (Albany NY) (2021) 13, 6194-6204. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Yan,D., Li,X., Yang,Q., Huang,Q., Yao,L., Zhang,P., Sun,W., Lin,S., Dou,Q.P., Liu,J. and Chen,X.<br>Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30<br>Cell Death Discov (2021) 7, 211-211. PubMed  Europe PubMed DOI  PMC  EPMC  I
    33. 2019
  33. Miller,S. and Muqit,M.M.K.<br>Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease<br>Neurosci Lett (2019) 705, 7-13. PubMed  Europe PubMed DOI  T  I
  34. Riccio,V., Demers,N., Hua,R., Vissa,M., Cheng,D.T., Strilchuk,A.W., Wang,Y., McQuibban,G.A. and Kim,P.K.<br>Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy<br>J Cell Biol (2019) 218, 798-807. PubMed  Europe PubMed DOI
  35. Riccio,V., McQuibban,G.A. and Kim,P.K.<br>USP30: protector of peroxisomes and mitochondria<br>Mol Cell Oncol (2019) 6, 1600350-1600350. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2017
  36. Gersch,M., Gladkova,C., Schubert,A.F., Michel,M.A., Maslen,S. and Komander,D.<br>Mechanism and regulation of the Lys6-selective deubiquitinase USP30<br>Nat Struct Mol Biol (2017) 24, 920-930. PubMed  Europe PubMed DOI
  37. Hou,J., Eldeeb,M. and Wang,X.<br>Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis<br>Adv Exp Med Biol (2017) 1038, 133-148. PubMed  Europe PubMed DOI
  38. Sato,Y., Okatsu,K., Saeki,Y., Yamano,K., Matsuda,N., Kaiho,A., Yamagata,A., Goto-Ito,S., Ishikawa,M., Hashimoto,Y., Tanaka,K. and Fukai,S.<br>Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30<br>Nat Struct Mol Biol (2017) 24, 911-919. PubMed  Europe PubMed DOI  S
    39. 2015
  39. Cunningham,C.N., Baughman,J.M., Phu,L., Tea,J.S., Yu,C., Coons,M., Kirkpatrick,D.S., Bingol,B. and Corn,J.E.<br>USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria<br>Nat Cell Biol (2015) 17, 160-169. PubMed  Europe PubMed DOI  P
  40. Liang,J.R., Martinez,A., Lane,J.D., Mayor,U., Clague,M.J. and Urbe,S.<br>USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death<br>EMBO Rep (2015) 16, 618-627. PubMed  Europe PubMed DOI
  41. Thobois,S.<br>USP30: a new promising target for Parkinson's disease?<br>Mov Disord (2015) 30, 340-340. PubMed  Europe PubMed DOI
  42. Wang,Y., Serricchio,M., Jauregui,M., Shanbhag,R., Stoltz,T., Di Paolo,C.T., Kim,P.K. and McQuibban,G.A.<br>Deubiquitinating enzymes regulate PARK2-mediated mitophagy<br>Autophagy (2015) 11, 595-606. PubMed  Europe PubMed DOI
    43. 2014
  43. Bingol,B., Tea,J.S., Phu,L., Reichelt,M., Bakalarski,C.E., Song,Q., Foreman,O., Kirkpatrick,D.S. and Sheng,M.<br>The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy<br>Nature (2014) 510, 370-375. PubMed  Europe PubMed DOI  T
  44. Krishnmurthy,R.G. and Shradgan,F.M.<br>Commentary-1 (Research Highlights: USP30 regulates the mitophagy-mediated neuroprotection in Parkinson's disease)<br>CNS Neurol Disord Drug Targets (2014) 13, 1633-1634. PubMed  Europe PubMed
  45. Yue,W., Chen,Z., Liu,H., Yan,C., Chen,M., Feng,D., Yan,C., Wu,H., Du,L., Wang,Y., Liu,J., Huang,X., Xia,L., Liu,L., Wang,X., Jin,H., Wang,J., Song,Z., Hao,X. and Chen,Q.<br>A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30<br>Cell Res (2014) 24, 482-496. PubMed  Europe PubMed DOI  I
    46. 2011
  46. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.<br>The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types<br>Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
    47. 2008
  47. Nakamura,N. and Hirose,S.<br>Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane<br>Mol Biol Cell (2008) 19, 1903-1911. PubMed  Europe PubMed DOI  PMC  EPMC
    48. 2004
  48. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.<br>Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases<br>Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    49. 2003
  49. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.<br>Human and mouse proteases: a comparative genomic approach<br>Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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