Literature for peptidase C19.060: ubiquitin-specific peptidase 30

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Gao,X., Liu,J., Jia,B. and Guo,J.
   USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40
   J Biochem Mol Toxicol39, e70258-e70258. PubMed  Europe PubMed DOI  K
2. Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.
   Recent advances in small molecule inhibitors of deubiquitinating enzymes
   Eur J Med Chem287, 117324-117324. PubMed  Europe PubMed DOI  V
3. O'Brien,D.P., Jones,H.B.L., Shi,Y., Guenther,F., Vendrell,I., Viner,R., Brennan,P.E., Mead,E., Zarganes-Tzitzikas,T., Davis,J.B., Pinto-Fernandez,A., England,K.S., Murphy,E.J., Turnbull,A.P. and Kessler,B.M.
   Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
   J Proteome Res PubMed  Europe PubMed DOI
4. Siwach,A., Patel,H., Khairnar,A. and Parekh,P.
   Molecular Symphony of Mitophagy: Ubiquitin-Specific Protease-30 as a Maestro for Precision Management of Neurodegenerative Diseases
   CNS Neurosci Ther31, e70192-e70192. PubMed  Europe PubMed DOI  V
2024
5. Chi,C., Tang,X., Liu,W., Zhou,Y., Jiang,R., Chen,Y. and Li,M.
   Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30
   Biotechnol J19, e2300653-e2300653. PubMed  Europe PubMed DOI  K
6. Jiang,F., Li,X., Lin,L., Li,M. and Zheng,J.
   NPRC promotes hepatic steatosis via USP30-mediated deubiquitination of C/EBPbeta
   Metabolism162, 156050-156050. PubMed  Europe PubMed DOI
7. Mondal,M., Cao,F., Conole,D., Auner,H.W. and Tate,E.W.
   Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30
   RSC Chem Biol5, 439-446. PubMed  Europe PubMed DOI
8. Okarmus,J., Agergaard,J.B., Stummann,T.C., Haukedal,H., Ambjorn,M., Freude,K.K., Fog,K. and Meyer,M.
   USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
   Cell Death Dis15, 52-52. PubMed  Europe PubMed DOI
9. Soung,A.L., Kyauk,R.V., Pandey,S., Shen,Y.A., Reichelt,M., Lin,H., Jiang,Z., Kirshnamoorthy,P., Foreman,O., Lauffer,B.E. and Yuen,T.J.
   Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation
   Glia PubMed  Europe PubMed DOI
10. Sun,K., Liao,S., Yao,X. and Yao,F.
    USP30 promotes the progression of breast cancer by stabilising Snail
    Cancer Gene Ther31, 472-483. PubMed  Europe PubMed DOI
11. Xu,X., Gong,C., Wang,Y., Yin,Z., Wang,X., Wu,X., Fang,Z. and Wei,S.
    FOXF1 promotes ovarian cancer metastasis by facilitating HMGA2-mediated USP30-dependent S100A6 deubiquitination
    Biochim Biophys Acta Mol Basis Dis1871, 167633-167633. PubMed  Europe PubMed DOI
12. Zhang,R., Jiang,W., Wang,G., Zhang,Y., Liu,W., Li,M., Yu,J., Yan,X., Zhou,F., Du,W., Qian,K., Xiao,Y., Liu,T., Ju,L. and Wang,X.
    Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase
    Commun Biol7, 245-245. PubMed  Europe PubMed DOI  K
2023
13. Alshehri,M.M., Danazumi,A.U., Alshammari,M.K., Bello,R.O., Alghazwni,M.K., Alshehri,A.M., Alshlali,O.M. and Umar,H.I.
    Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies
    J Biomol Struct Dyn1-12. PubMed  Europe PubMed DOI
14. Liu,Y., Yao,C., Sheng,B., Zhi,S., Chen,X., Ding,P., Zhang,J., Tao,Z., Li,W., Zhuang,Z., Mao,J., Peng,Z., Yan,H. and Jin,W.
    Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH
    Transl Stroke Res PubMed  Europe PubMed DOI
15. O'Brien,D.P., Jones,H.B.L., Guenther,F., Murphy,E.J., England,K.S., Vendrell,I., Anderson,M., Brennan,P.E., Davis,J.B., Pinto-Fernandez,A., Turnbull,A.P. and Kessler,B.M.
    Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
    Mol Cell Proteomics22, 100609-100609. PubMed  Europe PubMed DOI
16. Sanchez-Martinez,A., Martinez,A. and Whitworth,A.J.
    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo
    PLoS Biol21, e3002244-e3002244. PubMed  Europe PubMed DOI
17. Wang,H., Huang,S., Meng,Q., Zhang,J. and Wei,L.
    [Bioinformatics analysis of the association between long non-coding RNA ubiquitin-specific peptidase 30 antisense RNA 1 (lncRNA USP30-AS1) and immune cell infiltration in ovarian serous cystadenocarcinoma]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi39, 834-840. PubMed  Europe PubMed  K
18. Wu,Y., Hu,Q., Cheng,H., Yu,J., Gao,L. and Gao,G.
    USP30 impairs mitochondrial quality control and aggravates oxidative damage after traumatic brain injury
    Biochem Biophys Res Commun671, 58-66. PubMed  Europe PubMed DOI
2022
19. Mandal,S., Kumar Br,P., Alam,M.T., Tripathi,P.P. and Channappa,B.
    Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays
    ACS Chem Neurosci13, 1433-1445. PubMed  Europe PubMed DOI  I
20. Qin,X., Wang,R., Xu,H., Tu,L., Chen,H., Li,H., Liu,N., Wang,J., Li,S., Yin,F., Xu,N. and Li,Z.
    Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30
    Autophagy1-20. PubMed  Europe PubMed DOI
21. Wang,F., Gao,Y., Zhou,L., Chen,J., Xie,Z., Ye,Z. and Wang,Y.
    USP30: Structure, Emerging Physiological Role, and Target Inhibition
    Front Pharmacol13, 851654-851654. PubMed  Europe PubMed DOI  V
22. Zhang,R., Ozgen,S., Luo,H., Krigman,J., Zhao,Y., Xin,G. and Sun,N.
    The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling
    Front Pharmacol13, 816551-816551. PubMed  Europe PubMed DOI
23. Zhuang,D., Zhang,R., Liu,H. and Dai,Y.
    A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity
    Molecules27, PubMed  Europe PubMed DOI  K
2021
24. Cabrera,S.F., Muratore,M.E. and Buijnsters,P.
    The intriguing role of USP30 inhibitors as deubiquitinating enzymes from the patent literature since 2013
    Expert Opin Ther Pat PubMed  Europe PubMed DOI
25. Chen,C., Qin,H., Tang,J., Hu,Z., Tan,J. and Zeng,L.
    USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2
    Aging (Albany NY)13, 6194-6204. PubMed  Europe PubMed DOI
26. Yan,D., Li,X., Yang,Q., Huang,Q., Yao,L., Zhang,P., Sun,W., Lin,S., Dou,Q.P., Liu,J. and Chen,X.
    Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
    Cell Death Discov7, 211-211. PubMed  Europe PubMed DOI  I
2019
27. Miller,S. and Muqit,M.M.K.
    Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease
    Neurosci Lett705, 7-13. PubMed  Europe PubMed DOI  T  I
28. Riccio,V., McQuibban,G.A. and Kim,P.K.
    USP30: protector of peroxisomes and mitochondria
    Mol Cell Oncol6, 1600350-1600350. PubMed  Europe PubMed DOI
29. Riccio,V., Demers,N., Hua,R., Vissa,M., Cheng,D.T., Strilchuk,A.W., Wang,Y., McQuibban,G.A. and Kim,P.K.
    Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy
    J Cell Biol218, 798-807. PubMed  Europe PubMed DOI
2017
30. Gersch,M., Gladkova,C., Schubert,A.F., Michel,M.A., Maslen,S. and Komander,D.
    Mechanism and regulation of the Lys6-selective deubiquitinase USP30
    Nat Struct Mol Biol24, 920-930. PubMed  Europe PubMed DOI
31. Hou,J., Eldeeb,M. and Wang,X.
    Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis
    Adv Exp Med Biol1038, 133-148. PubMed  Europe PubMed DOI
32. Sato,Y., Okatsu,K., Saeki,Y., Yamano,K., Matsuda,N., Kaiho,A., Yamagata,A., Goto-Ito,S., Ishikawa,M., Hashimoto,Y., Tanaka,K. and Fukai,S.
    Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
    Nat Struct Mol Biol24, 911-919. PubMed  Europe PubMed DOI  S
2015
33. Cunningham,C.N., Baughman,J.M., Phu,L., Tea,J.S., Yu,C., Coons,M., Kirkpatrick,D.S., Bingol,B. and Corn,J.E.
    USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
    Nat Cell Biol17, 160-169. PubMed  Europe PubMed DOI  P
34. Liang,J.R., Martinez,A., Lane,J.D., Mayor,U., Clague,M.J. and Urbe,S.
    USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death
    EMBO Rep16, 618-627. PubMed  Europe PubMed DOI
35. Thobois,S.
    USP30: a new promising target for Parkinson's disease?
    Mov Disord30, 340-340. PubMed  Europe PubMed DOI
36. Wang,Y., Serricchio,M., Jauregui,M., Shanbhag,R., Stoltz,T., Di Paolo,C.T., Kim,P.K. and McQuibban,G.A.
    Deubiquitinating enzymes regulate PARK2-mediated mitophagy
    Autophagy11, 595-606. PubMed  Europe PubMed DOI
2014
37. Bingol,B., Tea,J.S., Phu,L., Reichelt,M., Bakalarski,C.E., Song,Q., Foreman,O., Kirkpatrick,D.S. and Sheng,M.
    The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
    Nature510, 370-375. PubMed  Europe PubMed DOI  T
38. Krishnmurthy,R.G. and Shradgan,F.M.
    Commentary-1 (Research Highlights: USP30 regulates the mitophagy-mediated neuroprotection in Parkinson's disease)
    CNS Neurol Disord Drug Targets13, 1633-1634. PubMed  Europe PubMed
39. Yue,W., Chen,Z., Liu,H., Yan,C., Chen,M., Feng,D., Yan,C., Wu,H., Du,L., Wang,Y., Liu,J., Huang,X., Xia,L., Liu,L., Wang,X., Jin,H., Wang,J., Song,Z., Hao,X. and Chen,Q.
    A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
    Cell Res24, 482-496. PubMed  Europe PubMed DOI  I
2011
40. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol18, 1550-1561. PubMed  Europe PubMed DOI
2008
41. Nakamura,N. and Hirose,S.
    Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane
    Mol Biol Cell19, 1903-1911. PubMed  Europe PubMed DOI
2004
42. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun314, 54-62. PubMed  Europe PubMed DOI
2003
43. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet4, 544-558. PubMed  Europe PubMed DOI