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Literature for peptidase C19.059: ubiquitin-specific peptidase 35

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Huang,H. and Ouyang,J.
    Ribosome-binding protein 1: A multidimensional regulator of cancer progression and a novel target for precision therapy (Review)
    Oncol Lett (2026) 31, 5-5. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Cao,J., Wu,T., Zhou,T., Jiang,Z., Ren,Y., Yu,J., Wang,J., Qian,C., Wu,G., He,L., Li,H., Lin,R., Liu,M. and Gu,H.
    USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis
    Commun Biol (2025) 8, 64-64. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Chen,G., Shi,Y., Zhang,S., Zhang,X., Li,G. and Jiang,C.
    USP35 promotes hepatocellular carcinoma proliferation through GASC1-mediated ROCK2 upregulation
    Transl Oncol (2025) 58, 102430-102430. PubMed  Europe PubMed DOI
  4. Feng,L., Hong,L., Chen,Y. and Cai,X.
    [Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes]
    Beijing Da Xue Xue Bao Yi Xue Ban (2025) 57, 919-925. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Guo,Y., Lin,Z., Zhou,Z., Zhang,W., Mao,S., Shan,Z., Wu,P. and Yao,X.
    Oncogenic and immunological functions of USP35 in pan-cancer and its potential as a biomarker in kidney clear cell carcinoma
    BMC Cancer (2025) 25, 617-617. PubMed  Europe PubMed DOI  PMC  EPMC  K
  6. Zhang,H., Zhu,J., He,R., Xu,L., Chen,Y., Yu,H., Sun,X., Wan,S., Yin,X., Liu,Y., Gao,J., Li,Y., Li,Z., Lu,Y. and Xu,Q.
    Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity
    Cell Death Dis (2025) 16, 138-138. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2024
  7. Dai,D.L., Xie,C., Zhong,L.Y., Liu,S.X., Zhang,L.L., Zhang,H., Wu,X.P., Wu,Z.M., Kang,K., Li,Y., Sun,Y.M., Xia,T.L., Zhang,C.S., Zhang,A., Shi,M., Sun,C., Chen,M.L., Zhao,G.X., Bu,G.L., Liu,Y.T., Huang,K.Y., Zhao,Z., Li,S.X., Zhang,X.Y., Yuan,Y.F., Wen,S.J., Zhang,L., Li,B.K., Zhong,Q. and Zeng,M.S.
    AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
    Signal Transduct Target Ther (2024) 9, 281-281. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Li,W., Li,J., Li,W., Li,J., Zheng,W., Cheng,J., Zhang,X., Yang,B., Dong,J. and Sun,X.
    FUS-stabilized USP35 promotes growth, invasion and angiogenesis in NSCLC through deubiquitinating VEGFA
    Gen Physiol Biophys (2024) 43, 301-312. PubMed  Europe PubMed DOI  K
  9. Lian,W., Hong,C., Chen,D. and Wang,C.
    USP35 promotes breast cancer progression by regulating PFK-1 ubiquitination to mediate glycolysis
    Am J Physiol Cell Physiol (2024) PubMed  Europe PubMed DOI  K
  10. Ma,C., Tian,Z., Wang,D., Gao,W., Qian,L., Zang,Y., Xu,X., Jia,J. and Liu,Z.
    Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1
    Int J Biol Sci (2024) 20, 953-967. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Wang,S., Li,X., Wang,T., Sun,Z., Feng,E. and Jin,Y.
    Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1
    Commun Biol (2024) 7, 1330-1330. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zhang,D., Li,J., Zhang,C., Xue,J., Li,P., Shang,K., Zhang,X. and Lang,B.
    The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein
    Open Life Sci (2024) 19, 20220935-20220935. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2023
  13. Lv,T., Zhang,B., Jiang,C., Zeng,Q., Yang,J. and Zhou,Y.
    USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitinationƒ_'mediated degradation
    Int J Oncol (2023) 63 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Park,J., Shin,S.C., Jin,K.S., Lim,M.J., Kim,Y., Kim,E.E. and Song,E.J.
    USP35 dimer prevents its degradation by E3 ligase CHIP through auto-deubiquitinating activity
    Cell Mol Life Sci (2023) 80, 112-112. PubMed  Europe PubMed DOI
  15. Wang,L., Wang,J., Ma,X., Ju,G., Shi,C., Wang,W. and Wu,J.
    USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway
    Cell Death Discov (2023) 9, 421-421. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Wang,S., Wang,T., Zhang,X., Cheng,S., Chen,C., Yang,G., Wang,F., Wang,R., Zhang,Q., Yang,D., Zhang,Y., Liu,S., Qin,H., Liu,Q. and Liu,H.
    The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma
    Cell Death Differ (2023) 30, 1757-1770. PubMed  Europe PubMed DOI  PMC  EPMC  K
    17. 2022
  17. Lin,G., Huang,T., Zhang,X. and Wang,G.
    Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis
    Cell Death Discov (2022) 8, 453-453. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Liu,C., Chen,Z., Ding,X., Qiao,Y. and Li,B.
    Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer
    Lab Invest (2022) 102, 524-533. PubMed  Europe PubMed DOI  K
  19. Wang,W., Wang,M., Xiao,Y., Wang,Y., Ma,L., Guo,L., Wu,X., Lin,X. and Zhang,P.
    USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer
    Mol Oncol (2022) 16, 1572-1590. PubMed  Europe PubMed DOI
  20. Zhang,Q., Liu,Y.J., Li,J.P., Zeng,S.H., Shen,H., Han,M., Guo,S., Liu,S.L. and Zou,X.
    USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma
    J Inflamm Res (2022) 15, 3065-3082. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2021
  21. Cao,J., Wu,D., Wu,G., Wang,Y., Ren,T., Wang,Y., Lv,Y., Sun,W., Wang,J., Qian,C., He,L., Yang,K., Li,H. and Gu,H.
    USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor alpha
    Cell Death Dis (2021) 12, 619-619. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Tang,Z., Jiang,W., Mao,M., Zhao,J., Chen,J. and Cheng,N.
    Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin
    Clin Transl Med (2021) 11, e390-e390. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Wang,W., Lin,H., Zheng,E., Hou,Z., Liu,Y., Huang,W., Chen,D., Feng,J., Li,J. and Li,L.
    Regulation of survivin protein stability by USP35 is evolutionarily conserved
    Biochem Biophys Res Commun (2021) 574, 48-55. PubMed  Europe PubMed DOI
  24. Zhang,J., Chen,Y., Chen,X., Zhang,W., Zhao,L., Weng,L., Tian,H., Wu,Z., Tan,X., Ge,X., Wang,P. and Fang,L.
    Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer
    Cell Death Differ (2021) 28, 139-155. PubMed  Europe PubMed DOI  K
    25. 2018
  25. Leznicki,P., Natarajan,J., Bader,G., Spevak,W., Schlattl,A., Rehman,S.A.A., Pathak,D., Weidlich,S., Zoephel,A., Bordone,M.C., Barbosa-Morais,N.L., Boehmelt,G. and Kulathu,Y.
    Expansion of DUB functionality by alternative isoforms: USP35, a case study
    J Cell Sci (2018) 131, jcs212753-jcs212753. PubMed  Europe PubMed DOI
  26. Park,J., Kwon,M.S., Kim,E.E., Lee,H. and Song,E.J.
    USP35 regulates mitotic progression by modulating the stability of Aurora B
    Nat Commun (2018) 9, 688-688. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Park,J. and Song,E.J.
    Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability
    BMB Rep (2018) 51, 261-262. PubMed  Europe PubMed DOI
    28. 2015
  28. Liu,C., Wang,L., Chen,W., Zhao,S., Yin,C., Lin,Y., Jiang,A. and Zhang,P.
    USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2
    Oncotarget (2015) 6, 27891-27906. PubMed  Europe PubMed DOI
  29. Wang,Y., Serricchio,M., Jauregui,M., Shanbhag,R., Stoltz,T., Di Paolo,C.T., Kim,P.K. and McQuibban,G.A.
    Deubiquitinating enzymes regulate PARK2-mediated mitophagy
    Autophagy (2015) 11, 595-606. PubMed  Europe PubMed DOI
    30. 2004
  30. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    31. 2003
  31. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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