Literature for peptidase C19.059: ubiquitin-specific peptidase 35

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

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2026

Huang,H. and Ouyang,J. Ribosome-binding protein 1: A multidimensional regulator of cancer progression and a novel target for precision therapy (Review) Oncol Lett (2026) 31, 5-5. PubMed Europe PubMed DOI PMC EPMC

2025

Cao,J., Wu,T., Zhou,T., Jiang,Z., Ren,Y., Yu,J., Wang,J., Qian,C., Wu,G., He,L., Li,H., Lin,R., Liu,M. and Gu,H. USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis Commun Biol (2025) 8, 64-64. PubMed Europe PubMed DOI PMC EPMC
Chen,G., Shi,Y., Zhang,S., Zhang,X., Li,G. and Jiang,C. USP35 promotes hepatocellular carcinoma proliferation through GASC1-mediated ROCK2 upregulation Transl Oncol (2025) 58, 102430-102430. PubMed Europe PubMed DOI
Feng,L., Hong,L., Chen,Y. and Cai,X. [Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes] Beijing Da Xue Xue Bao Yi Xue Ban (2025) 57, 919-925. PubMed Europe PubMed DOI PMC EPMC
Guo,Y., Lin,Z., Zhou,Z., Zhang,W., Mao,S., Shan,Z., Wu,P. and Yao,X. Oncogenic and immunological functions of USP35 in pan-cancer and its potential as a biomarker in kidney clear cell carcinoma BMC Cancer (2025) 25, 617-617. PubMed Europe PubMed DOI PMC EPMC K
Zhang,H., Zhu,J., He,R., Xu,L., Chen,Y., Yu,H., Sun,X., Wan,S., Yin,X., Liu,Y., Gao,J., Li,Y., Li,Z., Lu,Y. and Xu,Q. Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity Cell Death Dis (2025) 16, 138-138. PubMed Europe PubMed DOI PMC EPMC

2024

Dai,D.L., Xie,C., Zhong,L.Y., Liu,S.X., Zhang,L.L., Zhang,H., Wu,X.P., Wu,Z.M., Kang,K., Li,Y., Sun,Y.M., Xia,T.L., Zhang,C.S., Zhang,A., Shi,M., Sun,C., Chen,M.L., Zhao,G.X., Bu,G.L., Liu,Y.T., Huang,K.Y., Zhao,Z., Li,S.X., Zhang,X.Y., Yuan,Y.F., Wen,S.J., Zhang,L., Li,B.K., Zhong,Q. and Zeng,M.S. AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation Signal Transduct Target Ther (2024) 9, 281-281. PubMed Europe PubMed DOI PMC EPMC
Li,W., Li,J., Li,W., Li,J., Zheng,W., Cheng,J., Zhang,X., Yang,B., Dong,J. and Sun,X. FUS-stabilized USP35 promotes growth, invasion and angiogenesis in NSCLC through deubiquitinating VEGFA Gen Physiol Biophys (2024) 43, 301-312. PubMed Europe PubMed DOI K
Lian,W., Hong,C., Chen,D. and Wang,C. USP35 promotes breast cancer progression by regulating PFK-1 ubiquitination to mediate glycolysis Am J Physiol Cell Physiol (2024) PubMed Europe PubMed DOI K
Ma,C., Tian,Z., Wang,D., Gao,W., Qian,L., Zang,Y., Xu,X., Jia,J. and Liu,Z. Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1 Int J Biol Sci (2024) 20, 953-967. PubMed Europe PubMed DOI PMC EPMC K
Wang,S., Li,X., Wang,T., Sun,Z., Feng,E. and Jin,Y. Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1 Commun Biol (2024) 7, 1330-1330. PubMed Europe PubMed DOI PMC EPMC
Zhang,D., Li,J., Zhang,C., Xue,J., Li,P., Shang,K., Zhang,X. and Lang,B. The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein Open Life Sci (2024) 19, 20220935-20220935. PubMed Europe PubMed DOI PMC EPMC

2023

Lv,T., Zhang,B., Jiang,C., Zeng,Q., Yang,J. and Zhou,Y. USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitinationƒ_'mediated degradation Int J Oncol (2023) 63 PubMed Europe PubMed DOI PMC EPMC
Park,J., Shin,S.C., Jin,K.S., Lim,M.J., Kim,Y., Kim,E.E. and Song,E.J. USP35 dimer prevents its degradation by E3 ligase CHIP through auto-deubiquitinating activity Cell Mol Life Sci (2023) 80, 112-112. PubMed Europe PubMed DOI
Wang,L., Wang,J., Ma,X., Ju,G., Shi,C., Wang,W. and Wu,J. USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway Cell Death Discov (2023) 9, 421-421. PubMed Europe PubMed DOI PMC EPMC K
Wang,S., Wang,T., Zhang,X., Cheng,S., Chen,C., Yang,G., Wang,F., Wang,R., Zhang,Q., Yang,D., Zhang,Y., Liu,S., Qin,H., Liu,Q. and Liu,H. The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma Cell Death Differ (2023) 30, 1757-1770. PubMed Europe PubMed DOI PMC EPMC K

2022

Lin,G., Huang,T., Zhang,X. and Wang,G. Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis Cell Death Discov (2022) 8, 453-453. PubMed Europe PubMed DOI PMC EPMC
Liu,C., Chen,Z., Ding,X., Qiao,Y. and Li,B. Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer Lab Invest (2022) 102, 524-533. PubMed Europe PubMed DOI K
Wang,W., Wang,M., Xiao,Y., Wang,Y., Ma,L., Guo,L., Wu,X., Lin,X. and Zhang,P. USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer Mol Oncol (2022) 16, 1572-1590. PubMed Europe PubMed DOI
Zhang,Q., Liu,Y.J., Li,J.P., Zeng,S.H., Shen,H., Han,M., Guo,S., Liu,S.L. and Zou,X. USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma J Inflamm Res (2022) 15, 3065-3082. PubMed Europe PubMed DOI PMC EPMC

2021

Cao,J., Wu,D., Wu,G., Wang,Y., Ren,T., Wang,Y., Lv,Y., Sun,W., Wang,J., Qian,C., He,L., Yang,K., Li,H. and Gu,H. USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor alpha Cell Death Dis (2021) 12, 619-619. PubMed Europe PubMed DOI PMC EPMC
Tang,Z., Jiang,W., Mao,M., Zhao,J., Chen,J. and Cheng,N. Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin Clin Transl Med (2021) 11, e390-e390. PubMed Europe PubMed DOI PMC EPMC
Wang,W., Lin,H., Zheng,E., Hou,Z., Liu,Y., Huang,W., Chen,D., Feng,J., Li,J. and Li,L. Regulation of survivin protein stability by USP35 is evolutionarily conserved Biochem Biophys Res Commun (2021) 574, 48-55. PubMed Europe PubMed DOI
Zhang,J., Chen,Y., Chen,X., Zhang,W., Zhao,L., Weng,L., Tian,H., Wu,Z., Tan,X., Ge,X., Wang,P. and Fang,L. Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer Cell Death Differ (2021) 28, 139-155. PubMed Europe PubMed DOI K

2018

Leznicki,P., Natarajan,J., Bader,G., Spevak,W., Schlattl,A., Rehman,S.A.A., Pathak,D., Weidlich,S., Zoephel,A., Bordone,M.C., Barbosa-Morais,N.L., Boehmelt,G. and Kulathu,Y. Expansion of DUB functionality by alternative isoforms: USP35, a case study J Cell Sci (2018) 131, jcs212753-jcs212753. PubMed Europe PubMed DOI
Park,J., Kwon,M.S., Kim,E.E., Lee,H. and Song,E.J. USP35 regulates mitotic progression by modulating the stability of Aurora B Nat Commun (2018) 9, 688-688. PubMed Europe PubMed DOI PMC EPMC
Park,J. and Song,E.J. Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability BMB Rep (2018) 51, 261-262. PubMed Europe PubMed DOI

2015

Liu,C., Wang,L., Chen,W., Zhao,S., Yin,C., Lin,Y., Jiang,A. and Zhang,P. USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2 Oncotarget (2015) 6, 27891-27906. PubMed Europe PubMed DOI
Wang,Y., Serricchio,M., Jauregui,M., Shanbhag,R., Stoltz,T., Di Paolo,C.T., Kim,P.K. and McQuibban,G.A. Deubiquitinating enzymes regulate PARK2-mediated mitophagy Autophagy (2015) 11, 595-606. PubMed Europe PubMed DOI

2004

[YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed Europe PubMed DOI

2003

Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C. Human and mouse proteases: a comparative genomic approach Nat Rev Genet (2003) 4, 544-558. PubMed Europe PubMed DOI