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Literature for peptidase C19.057: ubiquitin-specific peptidase 44

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Wu,P., Xiao,W., Ni,J., Lou,Y. and Xu,C.<br>USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability<br>Cancer Biol Ther (2025) 26, 2529652-2529652. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.<br>Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation<br>World J Surg Oncol (2025) 23, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC  V
  3. Zeng,L., Li,Y.Q., He,S.W., Xu,H., Zhang,R., Chen,K., Qin,L.J., Zhu,X.H., Li,Y.L., Li,L., Liu,N. and Wang,H.Y.<br>The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma<br>Neuro Oncol (2025) 27, 492-507. PubMed  Europe PubMed DOI
    4. 2024
  4. Chen,S., Wu,K., Zong,Y., Hou,Z., Deng,Z. and Xia,Z.<br>USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma<br>Biol Direct (2024) 19, 143-143. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Ekstrom,T.L., Hussain,S., Bedekovics,T., Ali,A., Paolini,L., Mahmood,H., Rosok,R.M., Koster,J., Johnsen,S.A. and Galardy,P.J.<br>USP44 overexpression drives a MYC-like gene expression program in neuroblastoma through epigenetic reprogramming<br>Mol Cancer Res (2024) 22, 812-825. PubMed  Europe PubMed DOI
  6. Liu,Y., Yuan,M., Xu,X., Yang,H., Yao,Y., Hou,P., Yu,W. and Ji,M.<br>USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21<br>Int J Biol Sci (2024) 20, 5223-5238. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wang,J., Liang,Y., Wang,K., Lin,L., Peng,X., Li,W., Li,Y., Liao,H., Li,J., Qiao,L. and Li,L.<br>Effect of subcutaneous adipose tissue-associated CSRP2 on the progression of prostate cancer via the WDR5/USP44 pathway<br>Am J Cancer Res (2024) 14, 5321-5337. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Zhang,B., Sun,R., Gu,M., Jiang,Z., Wang,Y., Zhang,L., Liu,X. and Chi,Z.<br>RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA<br>Biochem Cell Biol (2024) 102, 60-72. PubMed  Europe PubMed DOI  K
    9. 2022
  9. Chen,Y., Zhao,Y., Yang,X., Ren,X., Huang,S., Gong,S., Tan,X., Li,J., He,S., Li,Y., Hong,X., Li,Q., Ding,C., Fang,X., Ma,J. and Liu,N.<br>USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma<br>Nat Commun (2022) 13, 501-501. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Lou,Y., Ye,M., Xu,C. and Tao,F.<br>Insight into the physiological and pathological roles of USP44, a potential tumor target (Review)<br>Oncol Lett (2022) 24, 455-455. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Zhang,Y., Mandemaker,I.K., Matsumoto,S., Foreman,O., Holland,C.P., Lloyd,W.R., Sugasawa,K., Vermeulen,W., Marteijn,J.A. and Galardy,P.J.<br>USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors<br>Front Cell Dev Biol (2021) 9, 663411-663411. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2020
  12. Huang,T., Zhang,Q., Ren,W., Yan,B., Yi,L., Tang,T., Lin,H. and Zhang,Y.<br>USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination<br>Cell Biol Int (2020) PubMed  Europe PubMed DOI
  13. Marsh,D.J., Ma,Y. and Dickson,K.A.<br>Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Yang,J., Wei,P., Barbi,J., Huang,Q., Yang,E., Bai,Y., Nie,J., Gao,Y., Tao,J., Lu,Y., Xie,C., Hou,X., Ren,J., Wu,X., Meng,J., Zhang,Y., Fu,J., Kou,W., Gao,Y., Chen,Z., Liang,R., Tsun,A., Li,D., Guo,W., Zhang,S., Zheng,S.G., Niu,J., Galardy,P., Tong,X., Shi,G., Li,H., Pan,F. and Li,B.<br>The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation<br>EMBO Rep (2020) , e50308-e50308. PubMed  Europe PubMed DOI
  15. Zhang,H.Y., Liao,B.W., Xu,Z.S., Ran,Y., Wang,D.P., Yang,Y., Luo,W.W. and Wang,Y.Y.<br>USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA<br>PLoS Pathog (2020) 16, e1008178-e1008178. PubMed  Europe PubMed DOI
  16. Zheng,J., Wang,B., Zheng,R., Zhang,J., Huang,C., Zheng,R., Huang,Z., Qiu,W., Liu,M., Yang,K., Mao,Z., Ji,A. and Yuan,Y.<br>Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells<br>Cell Death Dis (2020) 11, 758-758. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2019
  17. Lin,Y.H., Forster,M., Liang,Y., Yu,M., Wang,H., Robert,F., Langlais,D., Pelletier,J., Clare,S. and Nijnik,A.<br>USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model<br>Exp Hematol (2019) 72, 1-8. PubMed  Europe PubMed DOI
  18. Park,J.M., Lee,J.E., Park,C.M. and Kim,J.H.<br>USP44 promotes the tumorigenesis of prostate cancer cells through EZH2 protein stabilization<br>Mol Cells (2019) 42, 17-27. PubMed  Europe PubMed DOI
  19. Yang,C., Zhu,S., Yang,H., Deng,S., Fan,P., Li,M. and Jin,X.<br>USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1<br>Am J Cancer Res (2019) 9, 1722-1733. PubMed  Europe PubMed  PMC  EPMC
  20. Zhang,Y.K., Tian,W.Z., Zhang,R.S., Zhang,Y.J. and Ma,H.T.<br>Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer<br>Kaohsiung J Med Sci (2019) 35, 535-541. PubMed  Europe PubMed DOI
    21. 2017
  21. Zou,Y., Qiu,G., Jiang,L., Cai,Z., Sun,W., Hu,H., Lu,C., Jin,W. and Hu,G.<br>Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin<br>Oncotarget (2017) 8, 58231-58246. PubMed  Europe PubMed DOI
    22. 2015
  22. Liu,T., Sun,B., Zhao,X., Li,Y., Zhao,X., Liu,Y., Yao,Z., Gu,Q., Dong,X., Shao,B., Lin,X., Liu,F. and An,J.<br>USP44+ cancer stem cell subclones contribute to breast cancer aggressiveness by promoting vasculogenic mimicry<br>Mol Cancer Ther (2015) 14, 2121-2131. PubMed  Europe PubMed DOI
    23. 2013
  23. Anon<br>A deubiquitinase protects against aneuploidy and tumor formation<br>Cancer Discov (2013) 3, 11-11. DOI
  24. Mosbech,A., Lukas,C., Bekker-Jensen,S. and Mailand,N.<br>The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases<br>J Biol Chem (2013) 288, 16579-16587. PubMed  Europe PubMed DOI
    25. 2012
  25. Fuchs,G., Shema,E., Vesterman,R., Kotler,E., Wolchinsky,Z., Wilder,S., Golomb,L., Pribluda,A., Zhang,F., Haj-Yahya,M., Feldmesser,E., Brik,A., Yu,X., Hanna,J., Aberdam,D., Domany,E. and Oren,M.<br>RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation<br>Mol Cell (2012) 46, 662-673. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Holland,A.J. and Cleveland,D.W.<br>The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation<br>J Clin Invest (2012) 122, 4325-4328. PubMed  Europe PubMed DOI
  27. Zhang,Y., Foreman,O., Wigle,D.A., Kosari,F., Vasmatzis,G., Salisbury,J.L., van Deursen,J. and Galardy,P.J.<br>USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis<br>J Clin Invest (2012) 122, 4362-4374. PubMed  Europe PubMed DOI
    28. 2011
  28. Zhang,Y., van Deursen,J. and Galardy,P.J.<br>Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia<br>PLoS ONE (2011) 6, e23389-e23389. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2010
  29. Suresh,B., Ramakrishna,S., Lee,H.J., Choi,J.H., Kim,J.Y., Ahn,W.S. and Baek,K.H.<br>K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44<br>Cell Biol Int (2010) 34, 799-808. PubMed  Europe PubMed DOI
    30. 2007
  30. Stegmeier,F., Rape,M., Draviam,V.M., Nalepa,G., Sowa,M.E., Ang,X.L., McDonald,E.R., III, Li,M.Z., Hannon,G.J., Sorger,P.K., Kirschner,M.W., Harper,J.W. and Elledge,S.J.<br>Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities<br>Nature (2007) 446, 876-881. PubMed  Europe PubMed DOI
    31. 2004
  31. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.<br>Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases<br>Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    32. 2003
  32. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.<br>Human and mouse proteases: a comparative genomic approach<br>Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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