Literature for peptidase C19.057: ubiquitin-specific peptidase 44

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol23, 60-60. PubMed  Europe PubMed DOI  V
  2. Zeng,L., Li,Y.Q., He,S.W., Xu,H., Zhang,R., Chen,K., Qin,L.J., Zhu,X.H., Li,Y.L., Li,L., Liu,N. and Wang,H.Y.
    The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma
    Neuro Oncol27, 492-507. PubMed  Europe PubMed DOI
  3. 2024
  4. Chen,S., Wu,K., Zong,Y., Hou,Z., Deng,Z. and Xia,Z.
    USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma
    Biol Direct19, 143-143. PubMed  Europe PubMed DOI  K
  5. Ekstrom,T.L., Hussain,S., Bedekovics,T., Ali,A., Paolini,L., Mahmood,H., Rosok,R.M., Koster,J., Johnsen,S.A. and Galardy,P.J.
    USP44 overexpression drives a MYC-like gene expression program in neuroblastoma through epigenetic reprogramming
    Mol Cancer Res22, 812-825. PubMed  Europe PubMed DOI
  6. Liu,Y., Yuan,M., Xu,X., Yang,H., Yao,Y., Hou,P., Yu,W. and Ji,M.
    USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21
    Int J Biol Sci20, 5223-5238. PubMed  Europe PubMed DOI
  7. Wang,J., Liang,Y., Wang,K., Lin,L., Peng,X., Li,W., Li,Y., Liao,H., Li,J., Qiao,L. and Li,L.
    Effect of subcutaneous adipose tissue-associated CSRP2 on the progression of prostate cancer via the WDR5/USP44 pathway
    Am J Cancer Res14, 5321-5337. PubMed  Europe PubMed DOI
  8. Zhang,B., Sun,R., Gu,M., Jiang,Z., Wang,Y., Zhang,L., Liu,X. and Chi,Z.
    RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA
    Biochem Cell Biol102, 60-72. PubMed  Europe PubMed DOI  K
  9. 2022
  10. Chen,Y., Zhao,Y., Yang,X., Ren,X., Huang,S., Gong,S., Tan,X., Li,J., He,S., Li,Y., Hong,X., Li,Q., Ding,C., Fang,X., Ma,J. and Liu,N.
    USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma
    Nat Commun13, 501-501. PubMed  Europe PubMed DOI
  11. Lou,Y., Ye,M., Xu,C. and Tao,F.
    Insight into the physiological and pathological roles of USP44, a potential tumor target (Review)
    Oncol Lett24, 455-455. PubMed  Europe PubMed DOI
  12. 2021
  13. Zhang,Y., Mandemaker,I.K., Matsumoto,S., Foreman,O., Holland,C.P., Lloyd,W.R., Sugasawa,K., Vermeulen,W., Marteijn,J.A. and Galardy,P.J.
    USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors
    Front Cell Dev Biol9, 663411-663411. PubMed  Europe PubMed DOI
  14. 2020
  15. Huang,T., Zhang,Q., Ren,W., Yan,B., Yi,L., Tang,T., Lin,H. and Zhang,Y.
    USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination
    Cell Biol Int PubMed  Europe PubMed DOI
  16. Marsh,D.J., Ma,Y. and Dickson,K.A.
    Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer
    Cancers (Basel)12, PubMed  Europe PubMed DOI  V
  17. Zhang,H.Y., Liao,B.W., Xu,Z.S., Ran,Y., Wang,D.P., Yang,Y., Luo,W.W. and Wang,Y.Y.
    USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
    PLoS Pathog16, e1008178-e1008178. PubMed  Europe PubMed DOI
  18. Zheng,J., Wang,B., Zheng,R., Zhang,J., Huang,C., Zheng,R., Huang,Z., Qiu,W., Liu,M., Yang,K., Mao,Z., Ji,A. and Yuan,Y.
    Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells
    Cell Death Dis11, 758-758. PubMed  Europe PubMed DOI
  19. 2019
  20. Lin,Y.H., Forster,M., Liang,Y., Yu,M., Wang,H., Robert,F., Langlais,D., Pelletier,J., Clare,S. and Nijnik,A.
    USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model
    Exp Hematol72, 1-8. PubMed  Europe PubMed DOI
  21. Park,J.M., Lee,J.E., Park,C.M. and Kim,J.H.
    USP44 promotes the tumorigenesis of prostate cancer cells through EZH2 protein stabilization
    Mol Cells42, 17-27. PubMed  Europe PubMed DOI
  22. Yang,C., Zhu,S., Yang,H., Deng,S., Fan,P., Li,M. and Jin,X.
    USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1
    Am J Cancer Res9, 1722-1733. PubMed  Europe PubMed
  23. Zhang,Y.K., Tian,W.Z., Zhang,R.S., Zhang,Y.J. and Ma,H.T.
    Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer
    Kaohsiung J Med Sci35, 535-541. PubMed  Europe PubMed DOI
  24. 2017
  25. Zou,Y., Qiu,G., Jiang,L., Cai,Z., Sun,W., Hu,H., Lu,C., Jin,W. and Hu,G.
    Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin
    Oncotarget8, 58231-58246. PubMed  Europe PubMed DOI
  26. 2015
  27. Liu,T., Sun,B., Zhao,X., Li,Y., Zhao,X., Liu,Y., Yao,Z., Gu,Q., Dong,X., Shao,B., Lin,X., Liu,F. and An,J.
    USP44+ cancer stem cell subclones contribute to breast cancer aggressiveness by promoting vasculogenic mimicry
    Mol Cancer Ther14, 2121-2131. PubMed  Europe PubMed DOI
  28. 2013
  29. Anon
    A deubiquitinase protects against aneuploidy and tumor formation
    Cancer Discov3, 11-11. DOI
  30. Mosbech,A., Lukas,C., Bekker-Jensen,S. and Mailand,N.
    The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
    J Biol Chem288, 16579-16587. PubMed  Europe PubMed DOI
  31. 2012
  32. Fuchs,G., Shema,E., Vesterman,R., Kotler,E., Wolchinsky,Z., Wilder,S., Golomb,L., Pribluda,A., Zhang,F., Haj-Yahya,M., Feldmesser,E., Brik,A., Yu,X., Hanna,J., Aberdam,D., Domany,E. and Oren,M.
    RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
    Mol Cell46, 662-673. PubMed  Europe PubMed DOI
  33. Holland,A.J. and Cleveland,D.W.
    The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation
    J Clin Invest122, 4325-4328. PubMed  Europe PubMed DOI
  34. Zhang,Y., Foreman,O., Wigle,D.A., Kosari,F., Vasmatzis,G., Salisbury,J.L., van Deursen,J. and Galardy,P.J.
    USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
    J Clin Invest122, 4362-4374. PubMed  Europe PubMed DOI
  35. 2011
  36. Zhang,Y., van Deursen,J. and Galardy,P.J.
    Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia
    PLoS ONE6, e23389-e23389. PubMed  Europe PubMed DOI
  37. 2010
  38. Suresh,B., Ramakrishna,S., Lee,H.J., Choi,J.H., Kim,J.Y., Ahn,W.S. and Baek,K.H.
    K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44
    Cell Biol Int34, 799-808. PubMed  Europe PubMed DOI
  39. 2007
  40. Stegmeier,F., Rape,M., Draviam,V.M., Nalepa,G., Sowa,M.E., Ang,X.L., McDonald,E.R., III, Li,M.Z., Hannon,G.J., Sorger,P.K., Kirschner,M.W., Harper,J.W. and Elledge,S.J.
    Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
    Nature446, 876-881. PubMed  Europe PubMed DOI
  41. 2004
  42. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun314, 54-62. PubMed  Europe PubMed DOI
  43. 2003
  44. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet4, 544-558. PubMed  Europe PubMed DOI