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Literature for peptidase C19.056: ubiquitin-specific peptidase 38

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,T., Yang,H., Gong,Y., Zhang,J., Huang,H. and Shuai,W.<br>USP38 deficiency mitigates arrhythmogenic remodeling in obese mice by inhibiting TLR4/CaMKII signaling<br>Biochim Biophys Acta Mol Basis Dis (2025) 1872, 168122-168122. PubMed  Europe PubMed DOI
  2. Chen,Z., Cao,J., Hou,S., Chao,L., Li,J., Jia,Z., Han,S., Chen,J. and Yan,X.<br>Inhibition of Lactate Accumulation via USP38-Mediated MCT1 Deubiquitination Activates AKT/mTOR Signaling to Mitigate PM2.5-Induced Lung Injury<br>J Clin Lab Anal (2025) , e70028-e70028. PubMed  Europe PubMed DOI
  3. Chu,X. and Wang,W.<br>USP38 regulates autophagy-dependent ferroptosis by deubiquitinating CTNNB1 in melanoma<br>Int J Biol Macromol (2025) , 149611-149611. PubMed  Europe PubMed DOI  K
  4. Li,J., Zhong,J., Ye,J., Xiang,Y., Yi,Q., Zhu,G., Deng,S. and Wang,X.<br>USP38: an important regulatory factor in tumor malignant progression<br>Front Immunol (2025) 16, 1612723-1612723. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Meng,H., Qu,Z., Guo,L., Kong,B., Yang,H., Huang,H. and Shuai,W.<br>USP38 deletion improved diastolic dysfunction and arrhythmogenesis in heart failure mice with preserved ejection fraction<br>Heart Rhythm (2025) PubMed  Europe PubMed DOI
  6. Meng,H., Qu,Z., Xiao,Z., Kong,B., Yang,H., Shuai,W. and Huang,H.<br>Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-beta/SMAD signaling<br>Mol Med (2025) 31, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Pan,M., Huang,X., Huang,X., Liu,X. and Lin,J.<br>USP38 protects intestinal epithelial cells from ischemia/reperfusion injury by stabilizing BIRC5<br>Gastroenterol Rep (Oxf) (2025) 13, goaf024-goaf024. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yue,Q., Li,Z., Du,Y., Hao,X., Huang,H., Sun,Z., Wang,J., Tao,Y., Yin,H., Pei,K., Li,M., Yang,X., Ding,K. and Zhao,M.<br>Dehydrocostus lactone attenuates ulcerative colitis via USP38-mediated histone H2B Deubiquitination to suppress NF-kappaB-driven inflammation<br>Int Immunopharmacol (2025) 164, 115346-115346. PubMed  Europe PubMed DOI
  9. Zhao,S., Liu,X., Luo,R., Jian,Z., Xu,C., Hou,Y., Liu,X. and Zhang,P.<br>USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2<br>Cell Death Differ (2025) PubMed  Europe PubMed DOI
    10. 2024
  10. Gong,Y., Yang,H., Chen,T., Zhang,J., Kong,B., Shuai,W. and Huang,H.<br>USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway<br>Int Immunopharmacol (2024) 145, 113727-113727. PubMed  Europe PubMed DOI
  11. Pan,Y., Xiao,Z., Yang,H., Kong,B., Meng,H., Shuai,W. and Huang,H.<br>USP38 exacerbates pressure overload-induced left ventricular electrical remodeling<br>Mol Med (2024) 30, 97-97. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Wang,R., Cai,X., Li,X., Li,J., Liu,X., Wang,J. and Xiao,W.<br>USP38 promotes deubiquitination of K11-linked polyubiquitination of HIF1alpha at Lys769 to enhance hypoxia signaling<br>J Biol Chem (2024) 300, 105532-105532. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Xiao,Z., Dai,C., Yu,T., Zhu,J., Pan,Y., Shuai,W., Kong,B. and Huang,H.<br>Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1<br>Int J Biol Sci (2024) 20, 1815-1832. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Xiao,Z., Yang,H., Pan,Y., Meng,H., Qu,Z., Kong,B., Shuai,W. and Huang,H.<br>Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2<br>Free Radic Biol Med (2024) 224, 88-102. PubMed  Europe PubMed DOI
  15. Zhang,T., Su,F., Wang,B., Liu,L., Lu,Y., Su,H., Ling,R., Yue,P., Dai,H., Yang,T., Yang,J., Chen,R., Wu,R., Zhu,K., Zhao,D. and Hou,X.<br>Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma<br>Oncogene (2024) 43, 1190-1202. PubMed  Europe PubMed DOI  K
    16. 2023
  16. Gong,Y., Yu,T., Shuai,W., Chen,T., Zhang,J. and Huang,H.<br>USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice<br>Mol Med (2023) 29, 157-157. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Gong,Y., Kong,B., Shuai,W., Chen,T., Zhang,J.J. and Huang,H.<br>USP38 regulates inflammatory cardiac remodeling after myocardial infarction<br>Clin Sci (Lond) (2023) 137, 1665-1681. PubMed  Europe PubMed DOI
  18. Xiao,Z., Pan,Y., Kong,B., Meng,H., Shuai,W. and Huang,H.<br>Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload<br>Europace (2023) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2022
  19. Huang,J., Zhou,W., Hao,C., He,Q. and Tu,X.<br>The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer<br>PLoS Genet (2022) 18, e1010366-e1010366. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wang,J., Gu,Y., Yan,X., Zhang,J., Wang,J. and Ding,Y.<br>USP38 inhibits colorectal cancer cell proliferation and migration via downregulating HMX3 ubiquitylation<br>Cell Cycle (2022) , 1-13. PubMed  Europe PubMed DOI  K
  21. Yi,X.M., Li,M., Chen,Y.D., Shu,H.B. and Li,S.<br>Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38<br>Proc Natl Acad Sci U S A (2022) 119, e2116279119-e2116279119. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2021
  22. Hu,T., Wang,K.N. and LingHu,H.R.<br>USP38 might be a new therapeutic target for glioma via regulation of cancer cell metastasis<br>Folia Neuropathol (2021) 59, 359-371. PubMed  Europe PubMed DOI  K
  23. Wang,Y., Li,Q., Hu,D., Gao,D., Wang,W., Wu,K. and Wu,J.<br>USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination<br>Viruses (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Xu,Z., Hu,H., Fang,D., Wang,J. and Zhao,K.<br>The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc<br>Int J Biochem Cell Biol (2021) 137, 106023-106023. PubMed  Europe PubMed DOI
    25. 2020
  25. Yang,Y., Yang,C., Li,T., Yu,S., Gan,T., Hu,J., Cui,J. and Zheng,X.<br>The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults<br>Cancer Res (2020) 80, 719-731. PubMed  Europe PubMed DOI
  26. Zhan,W., Liao,X., Liu,J., Tian,T., Yu,L. and Li,R.<br>USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3<br>Oncogenesis (2020) 9, 48-48. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Zhao,Z., Su,Z., Liang,P., Liu,D., Yang,S., Wu,Y., Ma,L., Feng,J., Zhang,X., Wu,C., Huang,J. and Cui,J.<br>USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation<br>Adv Sci (Weinh) (2020) 7, 2002680-2002680. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2018
  28. Chen,S., Yun,F., Yao,Y., Cao,M., Zhang,Y., Wang,J., Song,X. and Qian,Y.<br>USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein<br>J Exp Med (2018) 215, 2850-2867. PubMed  Europe PubMed DOI
  29. Liu,W., Zhang,Q., Fang,Y. and Wang,Y.<br>The deubiquitinase USP38 affects cellular functions through interacting with LSD1<br>Biol Res (2018) 51, 53-53. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2016
  30. Lin,M., Zhao,Z., Yang,Z., Meng,Q., Tan,P., Xie,W., Qin,Y., Wang,R.F. and Cui,J.<br>USP38 Inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome<br>Mol Cell (2016) 64, 267-281. PubMed  Europe PubMed DOI
    31. 2012
  31. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.<br>Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes<br>Chembiochem (2012) 13, 1416-1420. PubMed  Europe PubMed DOI  P
    32. 2004
  32. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.<br>Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases<br>Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    33. 2003
  33. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.<br>Human and mouse proteases: a comparative genomic approach<br>Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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