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Literature for peptidase C19.056: ubiquitin-specific peptidase 38

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,T., Yang,H., Gong,Y., Zhang,J., Huang,H. and Shuai,W.
    USP38 deficiency mitigates arrhythmogenic remodeling in obese mice by inhibiting TLR4/CaMKII signaling
    Biochim Biophys Acta Mol Basis Dis (2025) 1872, 168122-168122. PubMed  Europe PubMed DOI
  2. Chen,Z., Cao,J., Hou,S., Chao,L., Li,J., Jia,Z., Han,S., Chen,J. and Yan,X.
    Inhibition of Lactate Accumulation via USP38-Mediated MCT1 Deubiquitination Activates AKT/mTOR Signaling to Mitigate PM2.5-Induced Lung Injury
    J Clin Lab Anal (2025) , e70028-e70028. PubMed  Europe PubMed DOI
  3. Chu,X. and Wang,W.
    USP38 regulates autophagy-dependent ferroptosis by deubiquitinating CTNNB1 in melanoma
    Int J Biol Macromol (2025) , 149611-149611. PubMed  Europe PubMed DOI  K
  4. Li,J., Zhong,J., Ye,J., Xiang,Y., Yi,Q., Zhu,G., Deng,S. and Wang,X.
    USP38: an important regulatory factor in tumor malignant progression
    Front Immunol (2025) 16, 1612723-1612723. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Meng,H., Qu,Z., Guo,L., Kong,B., Yang,H., Huang,H. and Shuai,W.
    USP38 deletion improved diastolic dysfunction and arrhythmogenesis in heart failure mice with preserved ejection fraction
    Heart Rhythm (2025) PubMed  Europe PubMed DOI
  6. Meng,H., Qu,Z., Xiao,Z., Kong,B., Yang,H., Shuai,W. and Huang,H.
    Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-beta/SMAD signaling
    Mol Med (2025) 31, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Pan,M., Huang,X., Huang,X., Liu,X. and Lin,J.
    USP38 protects intestinal epithelial cells from ischemia/reperfusion injury by stabilizing BIRC5
    Gastroenterol Rep (Oxf) (2025) 13, goaf024-goaf024. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yue,Q., Li,Z., Du,Y., Hao,X., Huang,H., Sun,Z., Wang,J., Tao,Y., Yin,H., Pei,K., Li,M., Yang,X., Ding,K. and Zhao,M.
    Dehydrocostus lactone attenuates ulcerative colitis via USP38-mediated histone H2B Deubiquitination to suppress NF-kappaB-driven inflammation
    Int Immunopharmacol (2025) 164, 115346-115346. PubMed  Europe PubMed DOI
  9. Zhao,S., Liu,X., Luo,R., Jian,Z., Xu,C., Hou,Y., Liu,X. and Zhang,P.
    USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2
    Cell Death Differ (2025) PubMed  Europe PubMed DOI
    10. 2024
  10. Gong,Y., Yang,H., Chen,T., Zhang,J., Kong,B., Shuai,W. and Huang,H.
    USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway
    Int Immunopharmacol (2024) 145, 113727-113727. PubMed  Europe PubMed DOI
  11. Pan,Y., Xiao,Z., Yang,H., Kong,B., Meng,H., Shuai,W. and Huang,H.
    USP38 exacerbates pressure overload-induced left ventricular electrical remodeling
    Mol Med (2024) 30, 97-97. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Wang,R., Cai,X., Li,X., Li,J., Liu,X., Wang,J. and Xiao,W.
    USP38 promotes deubiquitination of K11-linked polyubiquitination of HIF1alpha at Lys769 to enhance hypoxia signaling
    J Biol Chem (2024) 300, 105532-105532. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Xiao,Z., Dai,C., Yu,T., Zhu,J., Pan,Y., Shuai,W., Kong,B. and Huang,H.
    Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1
    Int J Biol Sci (2024) 20, 1815-1832. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Xiao,Z., Yang,H., Pan,Y., Meng,H., Qu,Z., Kong,B., Shuai,W. and Huang,H.
    Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2
    Free Radic Biol Med (2024) 224, 88-102. PubMed  Europe PubMed DOI
  15. Zhang,T., Su,F., Wang,B., Liu,L., Lu,Y., Su,H., Ling,R., Yue,P., Dai,H., Yang,T., Yang,J., Chen,R., Wu,R., Zhu,K., Zhao,D. and Hou,X.
    Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma
    Oncogene (2024) 43, 1190-1202. PubMed  Europe PubMed DOI  K
    16. 2023
  16. Gong,Y., Yu,T., Shuai,W., Chen,T., Zhang,J. and Huang,H.
    USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
    Mol Med (2023) 29, 157-157. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Gong,Y., Kong,B., Shuai,W., Chen,T., Zhang,J.J. and Huang,H.
    USP38 regulates inflammatory cardiac remodeling after myocardial infarction
    Clin Sci (Lond) (2023) 137, 1665-1681. PubMed  Europe PubMed DOI
  18. Xiao,Z., Pan,Y., Kong,B., Meng,H., Shuai,W. and Huang,H.
    Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload
    Europace (2023) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2022
  19. Huang,J., Zhou,W., Hao,C., He,Q. and Tu,X.
    The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer
    PLoS Genet (2022) 18, e1010366-e1010366. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wang,J., Gu,Y., Yan,X., Zhang,J., Wang,J. and Ding,Y.
    USP38 inhibits colorectal cancer cell proliferation and migration via downregulating HMX3 ubiquitylation
    Cell Cycle (2022) , 1-13. PubMed  Europe PubMed DOI  K
  21. Yi,X.M., Li,M., Chen,Y.D., Shu,H.B. and Li,S.
    Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38
    Proc Natl Acad Sci U S A (2022) 119, e2116279119-e2116279119. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2021
  22. Hu,T., Wang,K.N. and LingHu,H.R.
    USP38 might be a new therapeutic target for glioma via regulation of cancer cell metastasis
    Folia Neuropathol (2021) 59, 359-371. PubMed  Europe PubMed DOI  K
  23. Wang,Y., Li,Q., Hu,D., Gao,D., Wang,W., Wu,K. and Wu,J.
    USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination
    Viruses (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Xu,Z., Hu,H., Fang,D., Wang,J. and Zhao,K.
    The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc
    Int J Biochem Cell Biol (2021) 137, 106023-106023. PubMed  Europe PubMed DOI
    25. 2020
  25. Yang,Y., Yang,C., Li,T., Yu,S., Gan,T., Hu,J., Cui,J. and Zheng,X.
    The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults
    Cancer Res (2020) 80, 719-731. PubMed  Europe PubMed DOI
  26. Zhan,W., Liao,X., Liu,J., Tian,T., Yu,L. and Li,R.
    USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3
    Oncogenesis (2020) 9, 48-48. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Zhao,Z., Su,Z., Liang,P., Liu,D., Yang,S., Wu,Y., Ma,L., Feng,J., Zhang,X., Wu,C., Huang,J. and Cui,J.
    USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation
    Adv Sci (Weinh) (2020) 7, 2002680-2002680. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2018
  28. Chen,S., Yun,F., Yao,Y., Cao,M., Zhang,Y., Wang,J., Song,X. and Qian,Y.
    USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein
    J Exp Med (2018) 215, 2850-2867. PubMed  Europe PubMed DOI
  29. Liu,W., Zhang,Q., Fang,Y. and Wang,Y.
    The deubiquitinase USP38 affects cellular functions through interacting with LSD1
    Biol Res (2018) 51, 53-53. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2016
  30. Lin,M., Zhao,Z., Yang,Z., Meng,Q., Tan,P., Xie,W., Qin,Y., Wang,R.F. and Cui,J.
    USP38 Inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome
    Mol Cell (2016) 64, 267-281. PubMed  Europe PubMed DOI
    31. 2012
  31. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem (2012) 13, 1416-1420. PubMed  Europe PubMed DOI  P
    32. 2004
  32. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI
    33. 2003
  33. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI

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