Literature for peptidase C19.055: ubiquitin-specific peptidase 47

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Chen,W., Wang,H., Sun,H., Zuo,J., Jiang,P., Feng,W. and Huang,Z. USP47 enhances NRP1-mediated angiogenesis to promote gastric cancer progression Biochim Biophys Acta Mol Cell Res (2025) , 120004-120004. PubMed Europe PubMed DOI
Jiang,Y., Cai,W., Lei,G., Cai,G., Wu,Q. and Lu,P. Deubiquitinase USP47 ameliorates cardiac hypertrophy through reducing protein O-GlcNAcylation J Cardiovasc Pharmacol (2025) 85, 54-62. PubMed Europe PubMed DOI
Shin,H., Hwang,S., Jeong,J.H., Shin,S.C., Oh,Y., Kim,J., Hwang,I., Kim,E.E., Choo,H. and Song,E.J. Targeting USP47 enhances the efficacy of KRAS inhibitor in KRAS(G12C) mutated non-small cell lung cancer by controlling deubiquitination of c-Myc Pharmacol Res (2025) 215, 107722-107722. PubMed Europe PubMed DOI K I
Tao,B., Wang,Z., Wang,X., Song,A., Liu,J., Wang,J., Zhang,Q., Chen,Z., Wang,Z., Xu,W., Sun,M., Wang,Y., Zhang,P., Xu,T., Wei,G.H., Chen,F.X. and Wang,M. An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling J Clin Invest (2025) PubMed Europe PubMed DOI K

2024

Wang,W.P., Shi,D., Yun,D., Hu,J., Wang,J.F., Liu,J., Yang,Y.P., Li,M.R., Wang,J.F. and Kong,D.L. Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma World J Gastroenterol (2024) 30, 565-578. PubMed Europe PubMed DOI PMC EPMC K
Wu,Z., Li,W., Wang,S. and Zheng,Z. Role of deubiquitinase USP47 in cardiac function alleviation and anti-inflammatory immunity after myocardial infarction by regulating NLRP3 inflammasome-mediated pyroptotic signal pathways Int Immunopharmacol (2024) 136, 112346-112346. PubMed Europe PubMed DOI

2023

Chen,H.Y., Tang,R.C., Liang,J.W., Zhao,W., Yu,S.S., Yao,R.R., Xu,R., Zhang,A., Geng,S., Sun,X.Y., Ge,Q. and Zhang,J. Deubiquitinase USP47 attenuates virus-induced type I interferon signaling Int Immunopharmacol (2023) 118, 110040-110040. PubMed Europe PubMed DOI
Li,X., Qian,K., Zhang,Y., Zhang,Y., Liu,Y., Sun,C., Jiao,Y., Yu,D., Geng,F., Cao,J. and Zhang,S. Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT) Toxicol Appl Pharmacol (2023) 480, 116734-116734. PubMed Europe PubMed DOI
Luo,G., Zhang,L., Wu,W., Zhang,L., Lin,J., Shi,H., Wu,X., Yu,Y., Qiu,W., Chen,J., Ding,H. and Chen,X. Upregulation of ubiquitin carboxyƒ_'terminal hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro Oncol Lett (2023) 26, 370-370. PubMed Europe PubMed DOI PMC EPMC
Shin,S.C., Park,J., Kim,K.H., Yoon,J.M., Cho,J., Ha,B.H., Oh,Y., Choo,H., Song,E.J. and Kim,E.E. Structural and functional characterization of USP47 reveals a hot spot for inhibitor design Commun Biol (2023) 6, 970-970. PubMed Europe PubMed DOI PMC EPMC K
Wang,A., Huang,H., Shi,J.H., Yu,X., Ding,R., Zhang,Y., Han,Q., Ni,Z.Y., Li,X., Zhao,R. and Zou,Q. USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis J Clin Invest (2023) 133 PubMed Europe PubMed DOI PMC EPMC
Zhu,Y., Guo,Y., Liu,H., Zhou,A., Fan,Z., Zhu,X. and Miao,X. Ubiquitin specific peptidase 47 contributes to liver regeneration Life Sci (2023) 329, 121967-121967. PubMed Europe PubMed DOI K

2022

Gong,L., Han,Y., Chen,R., Yang,P. and Zhang,C. LncRNA ZNF883-Mediated NLRP3 Inflammasome Activation and Epilepsy Development Involve USP47 Upregulation Mol Neurobiol (2022) 59, 5207-5221. PubMed Europe PubMed DOI
Lei,H., Yang,L., Xu,H., Wang,Z., Li,X., Liu,M. and Wu,Y. Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells Sci China Life Sci (2022) 65, 1624-1635. PubMed Europe PubMed DOI
Nie,L., Wang,C., Liu,X., Teng,H., Li,S., Huang,M., Feng,X., Pei,G., Hang,Q., Zhao,Z., Gan,B., Ma,L. and Chen,J. USP7 substrates identified by proteomics analysis reveal the specificity of USP7 Genes Dev (2022) 36, 1016-1030. PubMed Europe PubMed DOI PMC EPMC
Park,J., Cho,M., Cho,J., Kim,E.E. and Song,E.J. MicroRNA-101-3p Suppresses Cancer Cell Growth by Inhibiting the USP47-Induced Deubiquitination of RPL11 Cancers (Basel) (2022) 14 PubMed Europe PubMed DOI PMC EPMC
Peng,J., Li,W., Tan,N., Lai,X., Jiang,W. and Chen,G. USP47 stabilizes BACH1 to promote the Warburg effect and non-small cell lung cancer development via stimulating Hk2 and Gapdh transcription Am J Cancer Res (2022) 12, 91-107. PubMed Europe PubMed PMC EPMC
Xiao,Q., Tang,Y., Xia,J., Luo,H., Yu,M., Chen,S., Wang,W., Pu,L., Wang,L., Li,G. and Li,Y. Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells Ren Fail (2022) 44, 752-766. PubMed Europe PubMed DOI PMC EPMC K
Yang,J., Weisberg,E.L., Qi,S., Ni,W., Mei,H., Wang,Z., Meng,C., Zhang,S., Hou,M., Qi,Z., Wang,A., Jiang,Y., Jiang,Z., Huang,T., Liu,Q., Magin,R.S., Doherty,L., Wang,W., Liu,J., Buhrlage,S.J., Liu,Q. and Griffin,J.D. Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 Leukemia (2022) PubMed Europe PubMed DOI
Yu,L., Fu,J. and Shen,C. Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma Genes Genomics (2022) 44, 721-731. PubMed Europe PubMed DOI

2021

Hou,X., Xia,J., Feng,Y., Cui,L., Yang,Y., Yang,P. and Xu,X. USP47-Mediated Deubiquitination and Stabilization of TCEA3 Attenuates Pyroptosis and Apoptosis of Colorectal Cancer Cells Induced by Chemotherapeutic Doxorubicin Front Pharmacol (2021) 12, 713322-713322. PubMed Europe PubMed DOI PMC EPMC K
Lei,H., Xu,H.Z., Shan,H.Z., Liu,M., Lu,Y., Fang,Z.X., Jin,J., Jing,B., Xiao,X.H., Gao,S.M., Gao,F.H., Xia,L., Yang,L., Liu,L.G., Wang,W.W., Liu,C.X., Tong,Y., Wu,Y.Z., Zheng,J.K., Chen,G.Q., Zhou,L. and Wu,Y.L. Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia Nat Commun (2021) 12, 51-51. PubMed Europe PubMed DOI PMC EPMC K I
Pan,K., Fu,J. and Xu,W. Role of Ubiquitin-Specific Peptidase 47 in Cancers and Other Diseases Front Cell Dev Biol (2021) 9, 726632-726632. PubMed Europe PubMed DOI PMC EPMC
Zhang,S., Ju,X., Yang,Q., Zhu,Y., Fan,D., Su,G., Kong,L. and Li,Y. USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide Biochem Biophys Res Commun (2021) 562, 21-28. PubMed Europe PubMed DOI I

2020

Cho,J., Park,J., Shin,S.C., Jang,M., Kim,J.H., Kim,E.E. and Song,E.J. USP47 Promotes tumorigenesis by negative regulation of p53 through deubiquitinating ribosomal protein S2 Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI
Hu,Y., Ma,Z., Chen,Z. and Chen,B. USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF-kappaB activation Biotechnol Appl Biochem (2020) PubMed Europe PubMed DOI K
Ka,H.I., Lee,S., Han,S., Jeong,A.L., Park,J.Y., Joo,H.J., Soh,S.J., Park,D. and Yang,Y. Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA Cell Death Discov (2020) 6, 34-34. PubMed Europe PubMed DOI PMC EPMC
Pan,B., Yang,Y., Li,J., Wang,Y., Fang,C., Yu,F.X. and Xu,Y. USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer Protein Cell (2020) 11, 138-143. PubMed Europe PubMed DOI
Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H. Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Silvestrini,V.C., Thome,C.H., Albuquerque,D., de Souza Palma,C., Ferreira,G.A., Lanfredi,G.P., Masson,A.P., Delsin,L.E.A., Ferreira,F.U., de Souza,F.C., de Godoy,L.M.F., Aquino,A., Carrilho,E., Panepucci,R.A., Covas,D.T. and Faca,V.M. Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in Epithelial to Mesenchymal Transition (EMT) induced by TGFbeta2 in breast cells J Proteomics (2020) 219, 103734-103734. PubMed Europe PubMed DOI

2019

Hu,L., Kolibaba,H., Zhang,S., Cao,M., Niu,H., Mei,H., Hao,Y., Xu,Y. and Yin,Q. MicroRNA-204-5p Inhibits ovarian cancer cell proliferation by down-regulating USP47 Cell Transplant (2019) 28, 51S-58S. PubMed Europe PubMed DOI
Yu,L., Dong,L., Wang,Y., Liu,L., Long,H., Li,H., Li,J., Yang,X., Liu,Z., Duan,G., Dai,X. and Lin,Z. Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression Cancer Lett (2019) 448, 40-51. PubMed Europe PubMed DOI

2018

Palazon-Riquelme,P., Worboys,J.D., Green,J., Valera,A., Martin-Sanchez,F., Pellegrini,C., Brough,D. and Lopez-Castejon,G. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation EMBO Rep (2018) 19, e44766-e44766. PubMed Europe PubMed DOI

2017

Choi,B.J., Park,S.A., Lee,S.Y., Cha,Y.N. and Surh,Y.J. Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9 Sci Rep (2017) 7, 15918-15918. PubMed Europe PubMed DOI PMC EPMC

2015

Piao,J., Tashiro,A., Nishikawa,M., Aoki,Y., Moriyoshi,E., Hattori,A. and Kakeya,H. Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47 J Biochem (2015) 158, 477-484. PubMed Europe PubMed DOI E
Shi,J., Liu,Y., Xu,X., Zhang,W., Yu,T., Jia,J. and Liu,C. Deubiquitinase USP47/UBP64E regulates beta-catenin ubiquitination and degradation and plays a positive role in Wnt signaling Mol Cell Biol (2015) 35, 3301-3311. PubMed Europe PubMed DOI

2013

Yang,S.W., Oh,K.H., Park,E., Chang,H.M., Park,J.M., Seong,M.W., Ka,S.H., Song,W.K., Park,D.E., Baas,P.W., Jeon,Y.J. and Chung,C.H. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth J Neurosci (2013) 33, 12728-12738. PubMed Europe PubMed DOI

2012

Weinstock,J., Wu,J., Cao,P., Kingsbury,W.D., McDermott,J.L., Kodrasov,M.P., McKelvey,D.M., Suresh Kumar,K.G., Goldenberg,S.J., Mattern,M.R. and Nicholson,B. Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47 ACS Med Chem Lett (2012) 3, 789-792. PubMed Europe PubMed DOI I

2011

Parsons,J.L., Dianova,I.I., Khoronenkova,S.V., Edelmann,M.J., Kessler,B.M. and Dianov,G.L. USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta Mol Cell (2011) 41, 609-615. PubMed Europe PubMed DOI

2010

Peschiaroli,A., Skaar,J.R., Pagano,M. and Melino,G. The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival Oncogene (2010) 29, 1384-1393. PubMed Europe PubMed DOI

2004

[YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed Europe PubMed DOI

2003

Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C. Human and mouse proteases: a comparative genomic approach Nat Rev Genet (2003) 4, 544-558. PubMed Europe PubMed DOI