Literature for peptidase C19.054: ubiquitin-specific peptidase 28
(Topics flags: S Structure, T Target, R Splicing, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)
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Belal,H., Ng,E.F.Y., Ohta,M. and Meitinger,F.
Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization
Nat Commun (2025) 16, 10310-10310. PubMed Europe PubMed DOI PMC EPMC -
Bratt,A.S., Kilgas,S., Tarazona Guzman,M.I., Magin,R.S., Jaen Maisonet,I., Starnbach,C.A., Teh,W.P., Varca,A.C., Hu,B., Tarazona Guzman,E., Seo,H.S., Dhe-Paganon,S., Girardi,N.M., Adelmant,G., Marto,J.A., Chowdhury,D. and Buhrlage,S.J.
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Cell Chem Biol (2025) 32, 1166-1182. PubMed Europe PubMed DOI I -
Cai,C., Luo,H., Peng,J., Zhen,X., Shen,X., Xi,X., Zhu,J., Fang,Y., Chen,X., Wang,J., Yu,C., Zhang,P. and Xu,C.
The Deubiquitinase USP28 Maintains the Expression of PPARgamma and Its Inactivation Protects Mice from Diet-Induced MASH and Hepatocarcinoma
Mol Ther (2025) PubMed Europe PubMed DOI -
Han,F., Qi,G., Li,R., Peng,J., Yan,S., Yuan,C., Kong,B. and Ma,H.
USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer
Cell Death Dis (2025) 16, 305-305. PubMed Europe PubMed DOI PMC EPMC -
Li,X., He,N., Lv,Y., Wang,H., Zhang,M., Zhai,H., Yang,Z., Yang,Y., Guo,D., Cao,Z. and Chen,Y.
Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers
Sci Rep (2025) 15, 11054-11054. PubMed Europe PubMed DOI PMC EPMC I -
Li,Z., Wang,Y., Hu,J., Du,J., Nie,H., Xi,Y., Huang,Y., Wang,K., Zhang,K., Xu,Q., Cheng,L., Huang,D. and Tu,L.
USP28 knockdown and small molecule inhibitors promote KRT1 destabilization and sensitize hepatocellular carcinoma cells to sorafenib
Exp Cell Res (2025) 448, 114558-114558. PubMed Europe PubMed DOI -
Meng,Y., Xu,Y., Qiu,A., Lin,M., Yang,L. and Huang,Y.
USP28-mediated deubiquitination of FOXK1 activates the Hippo signaling pathway to regulate cell proliferation and radiosensitivity in lung cancer
Life Sci (2025) , 123483-123483. PubMed Europe PubMed DOI -
Mennerich,D., Ashok,Y., Vela-Rodriguez,C., Hentila,H.I., Rall-Scharpf,M., Wiesmuller,L., Prunskaite-Hyyrylainen,R., Lehtio,L. and Kietzmann,T.
The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels
iScience (2025) 28, 112990-112990. PubMed Europe PubMed DOI PMC EPMC K -
Wang,Z., Qian,C., Xiong,Y., Zhang,D., Inuzuka,H., Zhong,Y., Xie,L., Chen,X., Jin,J. and Wei,W.
USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment
J Am Chem Soc (2025) PubMed Europe PubMed DOI -
Wen,W., Zhou,Z., Chen,C. and Chen,M.
Deubiquitinase USP28 promotes the malignant progression and radio-resistance of hepatocellular carcinoma by stabilizing WDHD1
Naunyn Schmiedebergs Arch Pharmacol (2025) PubMed Europe PubMed DOI K -
Xiong,M., He,Z., Wen,L. and Zhao,A.
Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3p/USP28
BMC Biol (2025) 23, 222-222. PubMed Europe PubMed DOI PMC EPMC -
Han,J., Lin,L., Fang,Z., Ye,B., Han,X., Xu,J., Han,B., Min,J., Qian,J., Wu,G., Wang,Y. and Liang,G.
Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21
Theranostics (2024) 14, 6236-6248. PubMed Europe PubMed DOI PMC EPMC -
Jin,C., Einig,E., Xu,W., Kollampally,R.B., Schlosser,A., Flentje,M. and Popov,N.
The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage
Nucleic Acids Res (2024) 52, 3011-3030. PubMed Europe PubMed DOI -
Karapurkar,J.K., Colaco,J.C., Suresh,B., Tyagi,A., Woo,S.H., Jo,W.J., Ko,N., Singh,V., Hong,S.H., Oh,S.J., Kim,K.S. and Ramakrishna,S.
USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells
Cell Mol Life Sci (2024) 81, 145-145. PubMed Europe PubMed DOI PMC EPMC -
Le Menn,G., Pikkarainen,K., Mennerich,D., Miroszewska,D., Kietzmann,T. and Chen,Z.
USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes
Front Immunol (2024) 15, 1401949-1401949. PubMed Europe PubMed DOI PMC EPMC -
Li,Z., Xi,Y., Tu,L., Zhang,X., Huang,Y., Nie,H., Peng,C., Chai,H., Zeng,S., Zheng,X. and Cheng,L.
Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML
Biomed Pharmacother (2024) 173, 116315-116315. PubMed Europe PubMed DOI -
Meitinger,F., Belal,H., Davis,R.L., Martinez,M.B., Shiau,A.K., Oegema,K. and Desai,A.
Control of cell proliferation by memories of mitosis
Science (2024) 383, 1441-1448. PubMed Europe PubMed DOI -
Qiao,Q., Wang,J., Liu,S., Chang,J., Zhou,T., Li,C., Zhang,Y., Jiang,W., Chen,Y., Xu,X., Wu,M. and Li,X.
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-alpha in cholangiocarcinoma
Cell Oncol (Dordr) (2024) 47, 2217-2231. PubMed Europe PubMed DOI -
Song,Y., Wang,L., Zheng,Y., Jia,L., Li,C., Chao,K., Li,L., Sun,S., Wei,Y., Ge,Y., Yang,Y., Zhu,L., Zhang,Y. and Zhao,J.
Deubiquitinating enzyme USP28 inhibitor AZ1 alone and in combination with cisplatin for the treatment of non-small cell lung cancer
Apoptosis (2024) 29, 1793-1809. PubMed Europe PubMed DOI I -
Wen,C., Huang,C., Liao,X., Luo,Z. and Huang,C.
Mitochondria-targeted Catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Calpha axis
Arch Biochem Biophys (2024) , 110047-110047. PubMed Europe PubMed DOI -
Xie,S.Y., Liu,S.Q., Zhang,T., Shi,W.K., Xing,Y., Fang,W.X., Zhang,M., Chen,M.Y., Xu,S.C., Fan,M.Q., Li,L.L., Zhang,H., Zhao,N., Zeng,Z.X., Chen,S., Zeng,X.F., Deng,W. and Tang,Q.Z.
USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart
Circulation (2024) 149, 684-706. PubMed Europe PubMed DOI -
Xu,J., Peng,J., Sun,S., Wang,D., Yuan,W., Yang,X., Shi,T., Wang,R., Liu,H., Zhang,P. and Zhu,H.H.
Preclinical testing of CT1113, a novel USP28 inhibitor, for the treatment of T-cell acute lymphoblastic leukaemia
Br J Haematol (2024) 204, 2301-2318. PubMed Europe PubMed DOI I -
Li,J., Peng,J., Wu,L., Shen,X., Zhen,X., Zhang,Y., Ma,H., Xu,Y., Xiong,Q., Zhu,Q. and Zhang,P.
The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells
J Biol Chem (2023) 299, 104856-104856. PubMed Europe PubMed DOI PMC EPMC -
Liu,Z., Yu,Y., Zhou,S., Zhang,X. and Zhou,Z.
Inhibition of Pard3 promotes breast cancer metastasis via the USP28 mediated deubiquitination of Snail1
Heliyon (2023) 9, e22599-e22599. PubMed Europe PubMed DOI PMC EPMC K -
Maier,C.R., Hartmann,O., Prieto-Garcia,C., Al-Shami,K.M., Schlicker,L., Vogel,F.C.E., Haid,S., Klann,K., Buck,V., Munch,C., Schmitz,W., Einig,E., Krenz,B., Calzado,M.A., Eilers,M., Popov,N., Rosenfeldt,M.T., Diefenbacher,M.E. and Schulze,A.
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
Cell Death Differ (2023) 30, 1710-1725. PubMed Europe PubMed DOI PMC EPMC -
Ren,X., Jiang,M., Ding,P., Zhang,X., Zhou,X., Shen,J., Liu,D., Yan,X. and Ma,Z.
Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
Exp Hematol Oncol (2023) 12, 27-27. PubMed Europe PubMed DOI PMC EPMC V -
Ren,Y., Zhu,X., Fu,K., Zhang,H., Zhao,W., Lin,Y., Fang,Q., Wang,J., Chen,Y. and Guo,D.
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease
Biochem Pharmacol (2023) 207, 115355-115355. PubMed Europe PubMed DOI -
Shen,J., Xie,M., Xu,Y., Qian,Q., Qiu,T., Shi,W., Ren,D., Ji,J. and Huang,J.
Identification of the deubiquitinase USP28 as a novel molecular therapeutic target of ovarian cancer
Biochem Biophys Res Commun (2023) 638, 184-191. PubMed Europe PubMed DOI -
Xu,Z., Wang,H., Meng,Q., Ding,Y., Zhu,M., Zhou,H., Zhang,N. and Shi,L.
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines
Biochem Pharmacol (2023) 215, 115746-115746. PubMed Europe PubMed DOI I -
Zhou,D., Xu,Z., Huang,Y., Wang,H., Zhu,X., Zhang,W., Song,W., Gao,T., Liu,T., Wang,M., Shi,L., Zhang,N. and Xiong,B.
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib
Eur J Med Chem (2023) 254, 115369-115369. PubMed Europe PubMed DOI -
Zhou,L., Qin,B., Yassine,D.M., Luo,M., Liu,X., Wang,F. and Wang,Y.
Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles
Biochem Pharmacol (2023) 213, 115624-115624. PubMed Europe PubMed DOI -
Prieto-Garcia,C., Hartmann,O., Reissland,M., Braun,F., Bozkurt,S., Pahor,N., Fuss,C., Schirbel,A., Schulein-Volk,C., Buchberger,A., Calzado Canale,M.A., Rosenfeldt,M., Dikic,I., Munch,C. and Diefenbacher,M.E.
USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K
Mol Oncol (2022) PubMed Europe PubMed DOI -
Sun,X., Cai,M., Wu,L., Zhen,X., Chen,Y., Peng,J., Han,S. and Zhang,P.
Ubiquitin-specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma
Cancer Sci (2022) 113, 3463-3475. PubMed Europe PubMed DOI PMC EPMC -
Toth,R.K., Solomon,R. and Warfel,N.A.
Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC -
Chen,L., Xu,Z., Li,Q., Feng,Q., Zheng,C., Du,Y., Yuan,R. and Peng,X.
USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1
Cell Death Dis (2021) 12, 887-887. PubMed Europe PubMed DOI PMC EPMC K -
Kim,H., Choi,H., Im,J.S., Park,S.Y., Shin,G., Yoo,J.H., Kim,G. and Lee,J.K.
Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
J Biol Chem (2021) , 101148-101148. PubMed Europe PubMed DOI -
Prieto-Garcia,C., Tomaskovic,I., Shah,V.J., Dikic,I. and Diefenbacher,M.
USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma
Cells (2021) 10 PubMed Europe PubMed DOI PMC EPMC -
Ruiz,E.J., Pinto-Fernandez,A., Turnbull,A.P., Lan,L., Charlton,T.M., Scott,H.C., Damianou,A., Vere,G., Riising,E.M., Da Costa,C., Krajewski,W.W., Guerin,D., Kearns,J.D., Ioannidis,S., Katz,M., McKinnon,C., O'Connell,J., Moncaut,N., Rosewell,I., Nye,E., Jones,N., Heride,C., Gersch,M., Wu,M., Dinsmore,C.J., Hammonds,T.R., Kim,S., Komander,D., Urbe,S., Clague,M.J., Kessler,B.M. and Behrens,A.
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
elife (2021) 10 PubMed Europe PubMed DOI PMC EPMC -
Wang,J., Dong,Y., Ma,H., Wu,L., Zhen,X., Tang,L., Jin,J., Han,S., Zhang,P. and Peng,J.
The Deubiquitinase USP28 Stabilizes Expression of RecQ Family Helicases and Maintains the Viability of Triple Negative Breast Cancer Cells
J Biol Chem (2021) , 101443-101443. PubMed Europe PubMed DOI K -
Gersch,M., Wagstaff,J.L., Toms,A.V., Graves,B., Freund,S.M.V. and Komander,D.
Distinct USP25 and USP28 oligomerization states regulate deubiquitinating activity
Mol Cell (2019) 74, 436-451. PubMed Europe PubMed DOI -
Haq,S., Das,S., Kim,D.H., Chandrasekaran,A.P., Hong,S.H., Kim,K.S. and Ramakrishna,S.
The stability and oncogenic function of LIN28A are regulated by USP28
Biochim Biophys Acta Mol Basis Dis (2019) 1865, 599-610. PubMed Europe PubMed DOI -
Li,F., Han,H., Sun,Q., Liu,K., Lin,N., Xu,C., Zhao,Z. and Zhao,W.
USP28 regulates deubiquitination of histone H2A and cell proliferation
Exp Cell Res (2019) 379, 11-18. PubMed Europe PubMed DOI K -
Li,P., Huang,Z., Wang,J., Chen,W. and Huang,J.
Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer
Onco Targets Ther (2019) 12, 1603-1611. PubMed Europe PubMed DOI PMC EPMC -
Sauer,F., Klemm,T., Kollampally,R.B., Tessmer,I., Nair,R.K., Popov,N. and Kisker,C.
Differential oligomerization of the deubiquitinases USP25 and USP28 regulates their activities
Mol Cell (2019) 74, 421-435. PubMed Europe PubMed DOI S -
Richter,K., Paakkola,T., Mennerich,D., Kubaichuk,K., Konzack,A., Kippari,H.A., Kozlova,N., Koivunen,P., Haapasaari,K.M., Jukkola-Vuorinen,A., Teppo,H.R., Dimova,E.Y., Bloigu,R., Szabo,Z., Kerkela,R. and Kietzmann,T.
USP28 deficiency promotes breast and liver carcinogenesis as well as tumor angiogenesis in a HIF-independent manner
Mol Cancer Res (2018) 16, 1000-1012. PubMed Europe PubMed DOI K -
Wang,X., Liu,Z., Zhang,L., Yang,Z., Chen,X., Luo,J., Zhou,Z., Mei,X., Yu,X., Shao,Z., Feng,Y., Fu,S., Zhang,Z., Wei,D., Jia,L., Ma,J. and Guo,X.
Targeting deubiquitinase USP28 for cancer therapy
Cell Death Dis (2018) 9, 186-186. PubMed Europe PubMed DOI T -
Zhao,L.J., Zhang,T., Feng,X.J., Chang,J., Suo,F.Z., Ma,J.L., Liu,Y.J., Liu,Y., Zheng,Y.C. and Liu,H.M.
USP28 contributes to the proliferation and metastasis of gastric cancer
J Cell Biochem (2018) 120, 7657-7666. PubMed Europe PubMed DOI -
Kargbo,R.B.
Ubiquitin-specific inhibitors for the treatment of cancers, autoimmune, and infectious diseases
ACS Med Chem Lett (2017) 8, 1211-1212. PubMed Europe PubMed DOI PMC EPMC I -
Ren,K., Li,Y., Lu,H., Li,Z. and Han,X.
miR-3940-5p functions as a tumor suppressor in non-small cell lung cancer cells by targeting cyclin D1 and ubiquitin specific peptidase-28
Transl Oncol (2017) 10, 80-89. PubMed Europe PubMed DOI PMC EPMC -
Wrigley,J.D., Gavory,G., Simpson,I., Preston,M., Plant,H., Bradley,J., Goeppert,A.U., Rozycka,E., Davies,G., Walsh,J., Valentine,A., McClelland,K., Odrzywol,K.E., Renshaw,J., Boros,J., Tart,J., Leach,L., Nowak,T., Ward,R.A., Harrison,T. and Andrews,D.M.
Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily
ACS Chem Biol (2017) 12, 3113-3125. PubMed Europe PubMed DOI I -
Diefenbacher,M.E., Chakraborty,A., Blake,S.M., Mitter,R., Popov,N., Eilers,M. and Behrens,A.
Usp28 counteracts Fbw7 in intestinal homeostasis and cancer
Cancer Res (2015) 75, 1181-1186. PubMed Europe PubMed DOI -
Sun,X.X., Sears,R.C. and Dai,M.S.
Deubiquitinating c-Myc: USP36 steps up in the nucleolus
Cell Cycle (2015) 14, 3786-3793. PubMed Europe PubMed DOI -
Taranets,L., Zhu,J., Xu,W. and Popov,N.
Fbw7 and Usp28 - enemies and allies
Mol Cell Oncol (2015) 2, e995041-e995041. PubMed Europe PubMed DOI PMC EPMC -
Wen,Y., Shi,L., Ding,Y., Cui,R., He,W.T., Hu,H.Y. and Zhang,N.
The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights
Biochem J (2015) 471, 155-165. PubMed Europe PubMed DOI S -
Diefenbacher,M.E., Popov,N., Blake,S.M., Schulein-Volk,C., Nye,E., Spencer-Dene,B., Jaenicke,L.A., Eilers,M. and Behrens,A.
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
J Clin Invest (2014) 124, 3407-3418. PubMed Europe PubMed DOI -
Schulein-Volk,C., Wolf,E., Zhu,J., Xu,W., Taranets,L., Hellmann,A., Janicke,L.A., Diefenbacher,M.E., Behrens,A., Eilers,M. and Popov,N.
Dual regulation of Fbw7 function and oncogenic transformation by Usp28
Cell Rep (2014) 9, 1099-1109. PubMed Europe PubMed DOI -
Wen,Y., Cui,R., Zhang,H. and Zhang,N.
1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of the human deubiquitinase Usp28
Biomol NMR Assign (2014) 8, 251-254. PubMed Europe PubMed DOI -
Zhen,Y., Knobel,P.A., Stracker,T.H. and Reverter,D.
Regulation of USP28 deubiquitinating activity by SUMO conjugation
J Biol Chem (2014) 289, 34838-34850. PubMed Europe PubMed DOI -
Bohgaki,M., Hakem,A., Halaby,M.J., Bohgaki,T., Li,Q., Bissey,P.A., Shloush,J., Kislinger,T., Sanchez,O., Sheng,Y. and Hakem,R.
The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover
Cell Death Differ (2013) 20, 812-822. PubMed Europe PubMed DOI -
Wu,Y., Wang,Y., Yang,X.H., Kang,T., Zhao,Y., Wang,C., Evers,B.M. and Zhou,B.P.
The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells
Cell Rep (2013) 5, 224-236. PubMed Europe PubMed DOI -
Flugel,D., Gorlach,A. and Kietzmann,T.
GSK-3beta regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1alpha
Blood (2012) 119, 1292-1301. PubMed Europe PubMed DOI -
Sacco,J.J., Coulson,J.M., Clague,M.J. and Urbe,S.
Emerging roles of deubiquitinases in cancer-associated pathways
IUBMB Life (2010) 62, 140-157. PubMed Europe PubMed DOI V -
Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R., Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
The ubiquitin-specific protease USP28 is required for MYC stability
Nat Cell Biol (2007) 9, 765-774. PubMed Europe PubMed DOI -
Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
Fbw7 and Usp28 regulate Myc protein stability in response to DNA damage
Cell Cycle (2007) 6, 2327-2331. PubMed Europe PubMed -
[YEAR:4-8-2006]Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
Cell (4-8-2006) 126, 529-542. PubMed Europe PubMed DOI -
Valero,R., Bayes,M., Francisca Sanchez-Font,M., Gonzalez-Angulo,O., Gonzalez-Duarte,R. and Marfany,G.
Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
Genome Biol (2001) 2, RESEARCH0043-RESEARCH0043. PubMed Europe PubMed PMC EPMC R
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