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Literature for peptidase C19.054: ubiquitin-specific peptidase 28

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cai,C., Luo,H., Peng,J., Zhen,X., Shen,X., Xi,X., Zhu,J., Fang,Y., Chen,X., Wang,J., Yu,C., Zhang,P. and Xu,C.
    The Deubiquitinase USP28 Maintains the Expression of PPARgamma and Its Inactivation Protects Mice from Diet-Induced MASH and Hepatocarcinoma
    Mol Ther PubMed  Europe PubMed DOI
  2. Han,F., Qi,G., Li,R., Peng,J., Yan,S., Yuan,C., Kong,B. and Ma,H.
    USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer
    Cell Death Dis16, 305-305. PubMed  Europe PubMed DOI
  3. Li,Z., Wang,Y., Hu,J., Du,J., Nie,H., Xi,Y., Huang,Y., Wang,K., Zhang,K., Xu,Q., Cheng,L., Huang,D. and Tu,L.
    USP28 knockdown and small molecule inhibitors promote KRT1 destabilization and sensitize hepatocellular carcinoma cells to sorafenib
    Exp Cell Res448, 114558-114558. PubMed  Europe PubMed DOI
  4. Meng,Y., Xu,Y., Qiu,A., Lin,M., Yang,L. and Huang,Y.
    USP28-mediated deubiquitination of FOXK1 activates the Hippo signaling pathway to regulate cell proliferation and radiosensitivity in lung cancer
    Life Sci123483-123483. PubMed  Europe PubMed DOI
  5. Wang,Z., Qian,C., Xiong,Y., Zhang,D., Inuzuka,H., Zhong,Y., Xie,L., Chen,X., Jin,J. and Wei,W.
    USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment
    J Am Chem Soc PubMed  Europe PubMed DOI
  6. Wen,W., Zhou,Z., Chen,C. and Chen,M.
    Deubiquitinase USP28 promotes the malignant progression and radio-resistance of hepatocellular carcinoma by stabilizing WDHD1
    Naunyn Schmiedebergs Arch Pharmacol PubMed  Europe PubMed DOI  K
    7. 2024
  7. Han,J., Lin,L., Fang,Z., Ye,B., Han,X., Xu,J., Han,B., Min,J., Qian,J., Wu,G., Wang,Y. and Liang,G.
    Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21
    Theranostics14, 6236-6248. PubMed  Europe PubMed DOI
  8. Jin,C., Einig,E., Xu,W., Kollampally,R.B., Schlosser,A., Flentje,M. and Popov,N.
    The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage
    Nucleic Acids Res52, 3011-3030. PubMed  Europe PubMed DOI
  9. Karapurkar,J.K., Colaco,J.C., Suresh,B., Tyagi,A., Woo,S.H., Jo,W.J., Ko,N., Singh,V., Hong,S.H., Oh,S.J., Kim,K.S. and Ramakrishna,S.
    USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells
    Cell Mol Life Sci81, 145-145. PubMed  Europe PubMed DOI
  10. Le Menn,G., Pikkarainen,K., Mennerich,D., Miroszewska,D., Kietzmann,T. and Chen,Z.
    USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes
    Front Immunol15, 1401949-1401949. PubMed  Europe PubMed DOI
  11. Li,Z., Xi,Y., Tu,L., Zhang,X., Huang,Y., Nie,H., Peng,C., Chai,H., Zeng,S., Zheng,X. and Cheng,L.
    Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML
    Biomed Pharmacother173, 116315-116315. PubMed  Europe PubMed DOI
  12. Meitinger,F., Belal,H., Davis,R.L., Martinez,M.B., Shiau,A.K., Oegema,K. and Desai,A.
    Control of cell proliferation by memories of mitosis
    Science383, 1441-1448. PubMed  Europe PubMed DOI
  13. Qiao,Q., Wang,J., Liu,S., Chang,J., Zhou,T., Li,C., Zhang,Y., Jiang,W., Chen,Y., Xu,X., Wu,M. and Li,X.
    USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-alpha in cholangiocarcinoma
    Cell Oncol (Dordr)47, 2217-2231. PubMed  Europe PubMed DOI
  14. Song,Y., Wang,L., Zheng,Y., Jia,L., Li,C., Chao,K., Li,L., Sun,S., Wei,Y., Ge,Y., Yang,Y., Zhu,L., Zhang,Y. and Zhao,J.
    Deubiquitinating enzyme USP28 inhibitor AZ1 alone and in combination with cisplatin for the treatment of non-small cell lung cancer
    Apoptosis29, 1793-1809. PubMed  Europe PubMed DOI  I
  15. Wen,C., Huang,C., Liao,X., Luo,Z. and Huang,C.
    Mitochondria-targeted Catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Calpha axis
    Arch Biochem Biophys110047-110047. PubMed  Europe PubMed DOI
  16. Xie,S.Y., Liu,S.Q., Zhang,T., Shi,W.K., Xing,Y., Fang,W.X., Zhang,M., Chen,M.Y., Xu,S.C., Fan,M.Q., Li,L.L., Zhang,H., Zhao,N., Zeng,Z.X., Chen,S., Zeng,X.F., Deng,W. and Tang,Q.Z.
    USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart
    Circulation149, 684-706. PubMed  Europe PubMed DOI
  17. Xu,J., Peng,J., Sun,S., Wang,D., Yuan,W., Yang,X., Shi,T., Wang,R., Liu,H., Zhang,P. and Zhu,H.H.
    Preclinical testing of CT1113, a novel USP28 inhibitor, for the treatment of T-cell acute lymphoblastic leukaemia
    Br J Haematol204, 2301-2318. PubMed  Europe PubMed DOI  I
    18. 2023
  18. Li,J., Peng,J., Wu,L., Shen,X., Zhen,X., Zhang,Y., Ma,H., Xu,Y., Xiong,Q., Zhu,Q. and Zhang,P.
    The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells
    J Biol Chem299, 104856-104856. PubMed  Europe PubMed DOI
  19. Liu,Z., Yu,Y., Zhou,S., Zhang,X. and Zhou,Z.
    Inhibition of Pard3 promotes breast cancer metastasis via the USP28 mediated deubiquitination of Snail1
    Heliyon9, e22599-e22599. PubMed  Europe PubMed DOI  K
  20. Maier,C.R., Hartmann,O., Prieto-Garcia,C., Al-Shami,K.M., Schlicker,L., Vogel,F.C.E., Haid,S., Klann,K., Buck,V., Munch,C., Schmitz,W., Einig,E., Krenz,B., Calzado,M.A., Eilers,M., Popov,N., Rosenfeldt,M.T., Diefenbacher,M.E. and Schulze,A.
    USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
    Cell Death Differ30, 1710-1725. PubMed  Europe PubMed DOI
  21. Ren,X., Jiang,M., Ding,P., Zhang,X., Zhou,X., Shen,J., Liu,D., Yan,X. and Ma,Z.
    Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
    Exp Hematol Oncol12, 27-27. PubMed  Europe PubMed DOI  V
  22. Ren,Y., Zhu,X., Fu,K., Zhang,H., Zhao,W., Lin,Y., Fang,Q., Wang,J., Chen,Y. and Guo,D.
    Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease
    Biochem Pharmacol207, 115355-115355. PubMed  Europe PubMed DOI
  23. Shen,J., Xie,M., Xu,Y., Qian,Q., Qiu,T., Shi,W., Ren,D., Ji,J. and Huang,J.
    Identification of the deubiquitinase USP28 as a novel molecular therapeutic target of ovarian cancer
    Biochem Biophys Res Commun638, 184-191. PubMed  Europe PubMed DOI
  24. Xu,Z., Wang,H., Meng,Q., Ding,Y., Zhu,M., Zhou,H., Zhang,N. and Shi,L.
    Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines
    Biochem Pharmacol215, 115746-115746. PubMed  Europe PubMed DOI  I
  25. Zhou,D., Xu,Z., Huang,Y., Wang,H., Zhu,X., Zhang,W., Song,W., Gao,T., Liu,T., Wang,M., Shi,L., Zhang,N. and Xiong,B.
    Structure-based discovery of potent USP28 inhibitors derived from Vismodegib
    Eur J Med Chem254, 115369-115369. PubMed  Europe PubMed DOI
  26. Zhou,L., Qin,B., Yassine,D.M., Luo,M., Liu,X., Wang,F. and Wang,Y.
    Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles
    Biochem Pharmacol213, 115624-115624. PubMed  Europe PubMed DOI
    27. 2022
  27. Prieto-Garcia,C., Hartmann,O., Reissland,M., Braun,F., Bozkurt,S., Pahor,N., Fuss,C., Schirbel,A., Schulein-Volk,C., Buchberger,A., Calzado Canale,M.A., Rosenfeldt,M., Dikic,I., Munch,C. and Diefenbacher,M.E.
    USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K
    Mol Oncol PubMed  Europe PubMed DOI
  28. Sun,X., Cai,M., Wu,L., Zhen,X., Chen,Y., Peng,J., Han,S. and Zhang,P.
    Ubiquitin-specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma
    Cancer Sci113, 3463-3475. PubMed  Europe PubMed DOI
  29. Toth,R.K., Solomon,R. and Warfel,N.A.
    Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
    Cells11, PubMed  Europe PubMed DOI
    30. 2021
  30. Chen,L., Xu,Z., Li,Q., Feng,Q., Zheng,C., Du,Y., Yuan,R. and Peng,X.
    USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1
    Cell Death Dis12, 887-887. PubMed  Europe PubMed DOI  K
  31. Kim,H., Choi,H., Im,J.S., Park,S.Y., Shin,G., Yoo,J.H., Kim,G. and Lee,J.K.
    Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
    J Biol Chem101148-101148. PubMed  Europe PubMed DOI
  32. Prieto-Garcia,C., Tomaskovic,I., Shah,V.J., Dikic,I. and Diefenbacher,M.
    USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma
    Cells10, PubMed  Europe PubMed DOI
  33. Ruiz,E.J., Pinto-Fernandez,A., Turnbull,A.P., Lan,L., Charlton,T.M., Scott,H.C., Damianou,A., Vere,G., Riising,E.M., Da Costa,C., Krajewski,W.W., Guerin,D., Kearns,J.D., Ioannidis,S., Katz,M., McKinnon,C., O'Connell,J., Moncaut,N., Rosewell,I., Nye,E., Jones,N., Heride,C., Gersch,M., Wu,M., Dinsmore,C.J., Hammonds,T.R., Kim,S., Komander,D., Urbe,S., Clague,M.J., Kessler,B.M. and Behrens,A.
    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
    elife10, PubMed  Europe PubMed DOI
  34. Wang,J., Dong,Y., Ma,H., Wu,L., Zhen,X., Tang,L., Jin,J., Han,S., Zhang,P. and Peng,J.
    The Deubiquitinase USP28 Stabilizes Expression of RecQ Family Helicases and Maintains the Viability of Triple Negative Breast Cancer Cells
    J Biol Chem101443-101443. PubMed  Europe PubMed DOI  K
    35. 2019
  35. Gersch,M., Wagstaff,J.L., Toms,A.V., Graves,B., Freund,S.M.V. and Komander,D.
    Distinct USP25 and USP28 oligomerization states regulate deubiquitinating activity
    Mol Cell74, 436-451. PubMed  Europe PubMed DOI
  36. Haq,S., Das,S., Kim,D.H., Chandrasekaran,A.P., Hong,S.H., Kim,K.S. and Ramakrishna,S.
    The stability and oncogenic function of LIN28A are regulated by USP28
    Biochim Biophys Acta Mol Basis Dis1865, 599-610. PubMed  Europe PubMed DOI
  37. Li,F., Han,H., Sun,Q., Liu,K., Lin,N., Xu,C., Zhao,Z. and Zhao,W.
    USP28 regulates deubiquitination of histone H2A and cell proliferation
    Exp Cell Res379, 11-18. PubMed  Europe PubMed DOI  K
  38. Li,P., Huang,Z., Wang,J., Chen,W. and Huang,J.
    Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer
    Onco Targets Ther12, 1603-1611. PubMed  Europe PubMed DOI
  39. Sauer,F., Klemm,T., Kollampally,R.B., Tessmer,I., Nair,R.K., Popov,N. and Kisker,C.
    Differential oligomerization of the deubiquitinases USP25 and USP28 regulates their activities
    Mol Cell74, 421-435. PubMed  Europe PubMed DOI  S
    40. 2018
  40. Richter,K., Paakkola,T., Mennerich,D., Kubaichuk,K., Konzack,A., Kippari,H.A., Kozlova,N., Koivunen,P., Haapasaari,K.M., Jukkola-Vuorinen,A., Teppo,H.R., Dimova,E.Y., Bloigu,R., Szabo,Z., Kerkela,R. and Kietzmann,T.
    USP28 deficiency promotes breast and liver carcinogenesis as well as tumor angiogenesis in a HIF-independent manner
    Mol Cancer Res16, 1000-1012. PubMed  Europe PubMed DOI  K
  41. Wang,X., Liu,Z., Zhang,L., Yang,Z., Chen,X., Luo,J., Zhou,Z., Mei,X., Yu,X., Shao,Z., Feng,Y., Fu,S., Zhang,Z., Wei,D., Jia,L., Ma,J. and Guo,X.
    Targeting deubiquitinase USP28 for cancer therapy
    Cell Death Dis9, 186-186. PubMed  Europe PubMed DOI  T
  42. Zhao,L.J., Zhang,T., Feng,X.J., Chang,J., Suo,F.Z., Ma,J.L., Liu,Y.J., Liu,Y., Zheng,Y.C. and Liu,H.M.
    USP28 contributes to the proliferation and metastasis of gastric cancer
    J Cell Biochem120, 7657-7666. PubMed  Europe PubMed DOI
    43. 2017
  43. Kargbo,R.B.
    Ubiquitin-specific inhibitors for the treatment of cancers, autoimmune, and infectious diseases
    ACS Med Chem Lett8, 1211-1212. PubMed  Europe PubMed DOI  I
  44. Ren,K., Li,Y., Lu,H., Li,Z. and Han,X.
    miR-3940-5p functions as a tumor suppressor in non-small cell lung cancer cells by targeting cyclin D1 and ubiquitin specific peptidase-28
    Transl Oncol10, 80-89. PubMed  Europe PubMed DOI
  45. Wrigley,J.D., Gavory,G., Simpson,I., Preston,M., Plant,H., Bradley,J., Goeppert,A.U., Rozycka,E., Davies,G., Walsh,J., Valentine,A., McClelland,K., Odrzywol,K.E., Renshaw,J., Boros,J., Tart,J., Leach,L., Nowak,T., Ward,R.A., Harrison,T. and Andrews,D.M.
    Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily
    ACS Chem Biol12, 3113-3125. PubMed  Europe PubMed DOI  I
    46. 2015
  46. Diefenbacher,M.E., Chakraborty,A., Blake,S.M., Mitter,R., Popov,N., Eilers,M. and Behrens,A.
    Usp28 counteracts Fbw7 in intestinal homeostasis and cancer
    Cancer Res75, 1181-1186. PubMed  Europe PubMed DOI
  47. Sun,X.X., Sears,R.C. and Dai,M.S.
    Deubiquitinating c-Myc: USP36 steps up in the nucleolus
    Cell Cycle14, 3786-3793. PubMed  Europe PubMed DOI
  48. Taranets,L., Zhu,J., Xu,W. and Popov,N.
    Fbw7 and Usp28 - enemies and allies
    Mol Cell Oncol2, e995041-e995041. PubMed  Europe PubMed DOI
  49. Wen,Y., Shi,L., Ding,Y., Cui,R., He,W.T., Hu,H.Y. and Zhang,N.
    The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights
    Biochem J471, 155-165. PubMed  Europe PubMed DOI  S
    50. 2014
  50. Diefenbacher,M.E., Popov,N., Blake,S.M., Schulein-Volk,C., Nye,E., Spencer-Dene,B., Jaenicke,L.A., Eilers,M. and Behrens,A.
    The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
    J Clin Invest124, 3407-3418. PubMed  Europe PubMed DOI
  51. Schulein-Volk,C., Wolf,E., Zhu,J., Xu,W., Taranets,L., Hellmann,A., Janicke,L.A., Diefenbacher,M.E., Behrens,A., Eilers,M. and Popov,N.
    Dual regulation of Fbw7 function and oncogenic transformation by Usp28
    Cell Rep9, 1099-1109. PubMed  Europe PubMed DOI
  52. Wen,Y., Cui,R., Zhang,H. and Zhang,N.
    1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of the human deubiquitinase Usp28
    Biomol NMR Assign8, 251-254. PubMed  Europe PubMed DOI
  53. Zhen,Y., Knobel,P.A., Stracker,T.H. and Reverter,D.
    Regulation of USP28 deubiquitinating activity by SUMO conjugation
    J Biol Chem289, 34838-34850. PubMed  Europe PubMed DOI
    54. 2013
  54. Bohgaki,M., Hakem,A., Halaby,M.J., Bohgaki,T., Li,Q., Bissey,P.A., Shloush,J., Kislinger,T., Sanchez,O., Sheng,Y. and Hakem,R.
    The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover
    Cell Death Differ20, 812-822. PubMed  Europe PubMed DOI
  55. Wu,Y., Wang,Y., Yang,X.H., Kang,T., Zhao,Y., Wang,C., Evers,B.M. and Zhou,B.P.
    The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells
    Cell Rep5, 224-236. PubMed  Europe PubMed DOI
    56. 2012
  56. Flugel,D., Gorlach,A. and Kietzmann,T.
    GSK-3beta regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1alpha
    Blood119, 1292-1301. PubMed  Europe PubMed DOI
    57. 2010
  57. Sacco,J.J., Coulson,J.M., Clague,M.J. and Urbe,S.
    Emerging roles of deubiquitinases in cancer-associated pathways
    IUBMB Life62, 140-157. PubMed  Europe PubMed DOI  V
    58. 2007
  58. Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
    Fbw7 and Usp28 regulate Myc protein stability in response to DNA damage
    Cell Cycle6, 2327-2331. PubMed  Europe PubMed
  59. Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R., Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
    The ubiquitin-specific protease USP28 is required for MYC stability
    Nat Cell Biol9, 765-774. PubMed  Europe PubMed DOI
    60. 2006
  60. [YEAR:4-8-2006]Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
    A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
    Cell126, 529-542. PubMed  Europe PubMed DOI
    61. 2001
  61. Valero,R., Bayes,M., Francisca Sanchez-Font,M., Gonzalez-Angulo,O., Gonzalez-Duarte,R. and Marfany,G.
    Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
    Genome Biol2, RESEARCH0043-RESEARCH0043. PubMed  Europe PubMed  R

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