Literature for peptidase C19.052: ubiquitin-specific peptidase 46

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Cerullo,M.S., Canevari,C., Marte,A., Bacq,A., De Fusco,A., Maletic,M., Baulac,S. and Benfenati,F.
   DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46
   Neurobiol Dis (2025) 212, 106985-106985. PubMed  Europe PubMed DOI  PMC  EPMC  K
2. Hu,L. and Chen,C.
   USP46 sensitizes BeWo trophoblasts to ferroptosis by stabilizing CIRBP
   Integr Biol (Camb) (2025) 17 PubMed  Europe PubMed DOI  K
3. Yang,H., Wang,Z., Xiong,W., Zhou,L. and Yu,S.
   Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis
   Exp Neurol (2025) 386, 115175-115175. PubMed  Europe PubMed DOI  K
4. Yang,Y., Cao,H., Sun,P., Feng,Y., Chen,L. and Gao,R.
   The Deubiquitinating Enzyme USP46 Abolishes Cell Survival of Prostate Cancer via Enhancing BECN1-Dependent Autophagy
   Biotechnol Appl Biochem (2025) PubMed  Europe PubMed DOI  K
2024
5. Gao,S., Wang,Y., Xu,Y., Liu,L. and Liu,S.
   USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis
   Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167011-167011. PubMed  Europe PubMed DOI
6. Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J., Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B. and Cao,J.
   WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc
   Proc Natl Acad Sci U S A (2024) 121, e2407904121-e2407904121. PubMed  Europe PubMed DOI  K
7. Shu,J., Yang,C., Miao,Y., Li,J., Zheng,T., Xiao,J., Kong,W., Xu,Z. and Feng,H.
   USP46 promotes the interferon antiviral signaling in black carp by deubiquitinating TBK1
   Dev Comp Immunol (2024) 156, 105170-105170. PubMed  Europe PubMed DOI  K
8. Thi Pham,K.H., Tran,M.H., Nam,L.B., Pham,P.T.V. and Nguyen,T.K.
   Structure, Inhibitors, and Biological Function in Nervous System and Cancer of Ubiquitin-Specific Protease 46
   Bioinform Biol Insights (2024) 18, 11779322241285982-11779322241285982. PubMed  Europe PubMed DOI  PMC  EPMC  V
9. Xu,L., Zhang,B. and Li,W.
   [Retracted] Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2
   Mol Med Rep (2024) 30 PubMed  Europe PubMed DOI  PMC  EPMC
10. Yoshioka,K., Nakagawa,R., Nguyen,C.L.K., Suzuki,H., Ishigaki,K., Mizuno,S., Okiyoneda,T., Ebihara,S. and Murata,K.
    Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins
    FEBS Open Bio (2024) PubMed  Europe PubMed DOI
11. Yu,K., Wang,G.M., Guo,S.S., Bassermann,F. and Fassler,R.
    The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation
    EMBO Rep (2024) PubMed  Europe PubMed DOI
2023
12. Ke,L., Jia,Z., Gao,W. and Luo,L.
    Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis
    Cell Biol Int (2023) 47, 41-51. PubMed  Europe PubMed DOI  K
13. Liu,N., Lin,M.M. and Wang,Y.
    The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
    Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
14. Ng,V.H., Spencer,Z., Neitzel,L.R., Nayak,A., Loberg,M.A., Shen,C., Kassel,S.N., Kroh,H.K., An,Z., Anthony,C.C., Bryant,J.M., Lawson,A., Goldsmith,L., Benchabane,H., Hansen,A.G., Li,J., D'Souza,S., Lebensohn,A.M., Rohatgi,R., Weiss,W.A., Weiss,V.L., Williams,C., Hong,C.C., Robbins,D.J., Ahmed,Y. and Lee,E.
    The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling
    Nat Commun (2023) 14, 6173-6173. PubMed  Europe PubMed DOI  PMC  EPMC
2022
15. Wen,M., Xu,H., Peng,H., Sheng,Y., Yang,W. and Yan,J.
    MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma
    Chem Biol Drug Des (2022) 100, 280-289. PubMed  Europe PubMed DOI
2021
16. Kiran,S., Wilson,B., Saha,S., Graff,J.A. and Dutta,A.
    HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
    Cancers (Basel) (2021) 14 PubMed  Europe PubMed DOI  PMC  EPMC  K
17. Qiu,Y., Huang,D., Sheng,Y., Huang,J., Li,N., Zhang,S., Hong,Z., Yin,X. and Yan,J.
    Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1
    Exp Cell Res (2021) 405, 112646-112646. PubMed  Europe PubMed DOI  K
18. Seo,J.H., Kim,T.Y., Kim,S.J., Choi,J.H., So,H.S. and Kang,J.I.
    Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene With Post-traumatic Stress Disorder
    Front Psychiatry (2021) 12, 663647-663647. PubMed  Europe PubMed DOI  PMC  EPMC
2020
19. Tian,M., Zhu,R., Ding,F. and Liu,Z.
    Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma
    Exp Cell Res (2020) , 112188-112188. PubMed  Europe PubMed DOI
20. Wang,W., Chen,M., Xu,H., Lv,D., Zhou,S. and Yang,H.
    USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway
    Biomed Res Int (2020) 2020, 2509529-2509529. PubMed  Europe PubMed DOI  PMC  EPMC  K
2019
21. Gui,D., Peng,W., Jiang,W., Huang,G., Liu,G., Ye,Z., Wang,Y., Xu,Z., Fu,J., Luo,S. and Zhao,Y.
    Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation
    Biochem Biophys Res Commun (2019) 519, 689-696. PubMed  Europe PubMed DOI
2018
22. Kiran,S., Dar,A., Singh,S.K., Lee,K.Y. and Dutta,A.
    The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers
    Mol Cell (2018) 72, 823-835. PubMed  Europe PubMed DOI
2017
23. Hodul,M., Dahlberg,C.L. and Juo,P.
    Function of the deubiquitinating enzyme USP46 in the nervous system and its regulation by WD40-repeat proteins
    Front Synaptic Neurosci (2017) 9, 16-16. PubMed  Europe PubMed DOI  PMC  EPMC  V
2015
24. Huo,Y., Khatri,N., Hou,Q., Gilbert,J., Wang,G. and Man,H.Y.
    The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking
    J Neurochem (2015) 134, 1067-1080. PubMed  Europe PubMed DOI
25. Ribeiro,F.C., Santos,L.E. and Ferreira,S.T.
    USP46: a new piece of the memory puzzle?
    J Neurochem (2015) 134, 979-981. PubMed  Europe PubMed DOI
26. Umemura,S., Imai,S., Mimura,A., Fujiwara,M. and Ebihara,S.
    Impaired maternal behavior in Usp46 mutant mice: a model for trans-generational transmission of maternal care
    PLoS ONE (2015) 10, e0136016-e0136016. PubMed  Europe PubMed DOI  PMC  EPMC  M
27. Yin,J., Schoeffler,A.J., Wickliffe,K., Newton,K., Starovasnik,M.A., Dueber,E.C. and Harris,S.F.
    Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46
    Structure (2015) 23, 2043-2054. PubMed  Europe PubMed DOI  S
2013
28. Imai,S., Kano,M., Nonoyama,K. and Ebihara,S.
    Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice
    PLoS ONE (2013) 8, e58566-e58566. PubMed  Europe PubMed DOI  PMC  EPMC  M
2012
29. Imai,S., Mamiya,T., Tsukada,A., Sakai,Y., Mouri,A., Nabeshima,T. and Ebihara,S.
    Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system
    PLoS ONE (2012) 7, e39084-e39084. PubMed  Europe PubMed DOI  PMC  EPMC
2011
30. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
31. Fukuo,Y., Kishi,T., Kushima,I., Yoshimura,R., Okochi,T., Kitajima,T., Matsunaga,S., Kawashima,K., Umene-Nakano,W., Naitoh,H., Inada,T., Nakamura,J., Ozaki,N. and Iwata,N.
    Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population
    J Affect Disord (2011) 133, 150-157. PubMed  Europe PubMed DOI  M
32. Joo,H.Y., Jones,A., Yang,C., Zhai,L., Smith,A.D., Zhang,Z., Chandrasekharan,M.B., Sun,Z.W., Renfrow,M.B., Wang,Y., Chang,C. and Wang,H.
    Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46
    J Biol Chem (2011) 286, 7190-7201. PubMed  Europe PubMed DOI
33. Zhang,W., Tian,Q.B., Li,Q.K., Wang,J.M., Wang,C.N., Liu,T., Liu,D.W. and Wang,M.W.
    Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity
    PLoS ONE (2011) 6, e26297-e26297. PubMed  Europe PubMed DOI  PMC  EPMC  M
2010
34. Ebihara,S. and Tomida,S.
    [Identification of a gene regulating "behavioral despair" in mice]
    Nihon Shinkei Seishin Yakurigaku Zasshi (2010) 30, 19-22. PubMed  Europe PubMed  M
35. Kushima,I., Aleksic,B., Ito,Y., Nakamura,Y., Nakamura,K., Mori,N., Kikuchi,M., Inada,T., Kunugi,H., Nanko,S., Kato,T., Yoshikawa,T., Ujike,H., Suzuki,M., Iwata,N. and Ozaki,N.
    Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population
    J Hum Genet (2010) 55, 133-136. PubMed  Europe PubMed DOI  M
2009
36. Tomida,S., Mamiya,T., Sakamaki,H., Miura,M., Aosaki,T., Masuda,M., Niwa,M., Kameyama,T., Kobayashi,J., Iwaki,Y., Imai,S., Ishikawa,A., Abe,K., Yoshimura,T., Nabeshima,T. and Ebihara,S.
    Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests
    Nat Genet (2009) 41, 688-695. PubMed  Europe PubMed DOI  M
2004
37. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C.
    Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI