Literature for peptidase C19.052: ubiquitin-specific peptidase 46

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Cerullo,M.S., Canevari,C., Marte,A., Bacq,A., De Fusco,A., Maletic,M., Baulac,S. and Benfenati,F. DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46 Neurobiol Dis (2025) 212, 106985-106985. PubMed Europe PubMed DOI PMC EPMC K
Hu,L. and Chen,C. USP46 sensitizes BeWo trophoblasts to ferroptosis by stabilizing CIRBP Integr Biol (Camb) (2025) 17 PubMed Europe PubMed DOI K
Yang,H., Wang,Z., Xiong,W., Zhou,L. and Yu,S. Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis Exp Neurol (2025) 386, 115175-115175. PubMed Europe PubMed DOI K
Yang,Y., Cao,H., Sun,P., Feng,Y., Chen,L. and Gao,R. The Deubiquitinating Enzyme USP46 Abolishes Cell Survival of Prostate Cancer via Enhancing BECN1-Dependent Autophagy Biotechnol Appl Biochem (2025) PubMed Europe PubMed DOI K

2024

Gao,S., Wang,Y., Xu,Y., Liu,L. and Liu,S. USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167011-167011. PubMed Europe PubMed DOI
Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J., Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B. and Cao,J. WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc Proc Natl Acad Sci U S A (2024) 121, e2407904121-e2407904121. PubMed Europe PubMed DOI K
Shu,J., Yang,C., Miao,Y., Li,J., Zheng,T., Xiao,J., Kong,W., Xu,Z. and Feng,H. USP46 promotes the interferon antiviral signaling in black carp by deubiquitinating TBK1 Dev Comp Immunol (2024) 156, 105170-105170. PubMed Europe PubMed DOI K
Thi Pham,K.H., Tran,M.H., Nam,L.B., Pham,P.T.V. and Nguyen,T.K. Structure, Inhibitors, and Biological Function in Nervous System and Cancer of Ubiquitin-Specific Protease 46 Bioinform Biol Insights (2024) 18, 11779322241285982-11779322241285982. PubMed Europe PubMed DOI PMC EPMC V
Xu,L., Zhang,B. and Li,W. [Retracted] Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2 Mol Med Rep (2024) 30 PubMed Europe PubMed DOI PMC EPMC
Yoshioka,K., Nakagawa,R., Nguyen,C.L.K., Suzuki,H., Ishigaki,K., Mizuno,S., Okiyoneda,T., Ebihara,S. and Murata,K. Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins FEBS Open Bio (2024) PubMed Europe PubMed DOI
Yu,K., Wang,G.M., Guo,S.S., Bassermann,F. and Fassler,R. The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation EMBO Rep (2024) PubMed Europe PubMed DOI

2023

Ke,L., Jia,Z., Gao,W. and Luo,L. Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis Cell Biol Int (2023) 47, 41-51. PubMed Europe PubMed DOI K
Liu,N., Lin,M.M. and Wang,Y. The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases Mol Neurobiol (2023) 60, 247-263. PubMed Europe PubMed DOI PMC EPMC V
Ng,V.H., Spencer,Z., Neitzel,L.R., Nayak,A., Loberg,M.A., Shen,C., Kassel,S.N., Kroh,H.K., An,Z., Anthony,C.C., Bryant,J.M., Lawson,A., Goldsmith,L., Benchabane,H., Hansen,A.G., Li,J., D'Souza,S., Lebensohn,A.M., Rohatgi,R., Weiss,W.A., Weiss,V.L., Williams,C., Hong,C.C., Robbins,D.J., Ahmed,Y. and Lee,E. The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling Nat Commun (2023) 14, 6173-6173. PubMed Europe PubMed DOI PMC EPMC

2022

Wen,M., Xu,H., Peng,H., Sheng,Y., Yang,W. and Yan,J. MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma Chem Biol Drug Des (2022) 100, 280-289. PubMed Europe PubMed DOI

2021

Kiran,S., Wilson,B., Saha,S., Graff,J.A. and Dutta,A. HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes Cancers (Basel) (2021) 14 PubMed Europe PubMed DOI PMC EPMC K
Qiu,Y., Huang,D., Sheng,Y., Huang,J., Li,N., Zhang,S., Hong,Z., Yin,X. and Yan,J. Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1 Exp Cell Res (2021) 405, 112646-112646. PubMed Europe PubMed DOI K
Seo,J.H., Kim,T.Y., Kim,S.J., Choi,J.H., So,H.S. and Kang,J.I. Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene With Post-traumatic Stress Disorder Front Psychiatry (2021) 12, 663647-663647. PubMed Europe PubMed DOI PMC EPMC

2020

Tian,M., Zhu,R., Ding,F. and Liu,Z. Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma Exp Cell Res (2020) , 112188-112188. PubMed Europe PubMed DOI
Wang,W., Chen,M., Xu,H., Lv,D., Zhou,S. and Yang,H. USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway Biomed Res Int (2020) 2020, 2509529-2509529. PubMed Europe PubMed DOI PMC EPMC K

2019

Gui,D., Peng,W., Jiang,W., Huang,G., Liu,G., Ye,Z., Wang,Y., Xu,Z., Fu,J., Luo,S. and Zhao,Y. Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation Biochem Biophys Res Commun (2019) 519, 689-696. PubMed Europe PubMed DOI

2018

Kiran,S., Dar,A., Singh,S.K., Lee,K.Y. and Dutta,A. The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers Mol Cell (2018) 72, 823-835. PubMed Europe PubMed DOI

2017

Hodul,M., Dahlberg,C.L. and Juo,P. Function of the deubiquitinating enzyme USP46 in the nervous system and its regulation by WD40-repeat proteins Front Synaptic Neurosci (2017) 9, 16-16. PubMed Europe PubMed DOI PMC EPMC V

2015

Huo,Y., Khatri,N., Hou,Q., Gilbert,J., Wang,G. and Man,H.Y. The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking J Neurochem (2015) 134, 1067-1080. PubMed Europe PubMed DOI
Ribeiro,F.C., Santos,L.E. and Ferreira,S.T. USP46: a new piece of the memory puzzle? J Neurochem (2015) 134, 979-981. PubMed Europe PubMed DOI
Umemura,S., Imai,S., Mimura,A., Fujiwara,M. and Ebihara,S. Impaired maternal behavior in Usp46 mutant mice: a model for trans-generational transmission of maternal care PLoS ONE (2015) 10, e0136016-e0136016. PubMed Europe PubMed DOI PMC EPMC M
Yin,J., Schoeffler,A.J., Wickliffe,K., Newton,K., Starovasnik,M.A., Dueber,E.C. and Harris,S.F. Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46 Structure (2015) 23, 2043-2054. PubMed Europe PubMed DOI S

2013

Imai,S., Kano,M., Nonoyama,K. and Ebihara,S. Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice PLoS ONE (2013) 8, e58566-e58566. PubMed Europe PubMed DOI PMC EPMC M

2012

Imai,S., Mamiya,T., Tsukada,A., Sakai,Y., Mouri,A., Nabeshima,T. and Ebihara,S. Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system PLoS ONE (2012) 7, e39084-e39084. PubMed Europe PubMed DOI PMC EPMC

2011

Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types Chem Biol (2011) 18, 1550-1561. PubMed Europe PubMed DOI
Fukuo,Y., Kishi,T., Kushima,I., Yoshimura,R., Okochi,T., Kitajima,T., Matsunaga,S., Kawashima,K., Umene-Nakano,W., Naitoh,H., Inada,T., Nakamura,J., Ozaki,N. and Iwata,N. Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population J Affect Disord (2011) 133, 150-157. PubMed Europe PubMed DOI M
Joo,H.Y., Jones,A., Yang,C., Zhai,L., Smith,A.D., Zhang,Z., Chandrasekharan,M.B., Sun,Z.W., Renfrow,M.B., Wang,Y., Chang,C. and Wang,H. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46 J Biol Chem (2011) 286, 7190-7201. PubMed Europe PubMed DOI
Zhang,W., Tian,Q.B., Li,Q.K., Wang,J.M., Wang,C.N., Liu,T., Liu,D.W. and Wang,M.W. Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity PLoS ONE (2011) 6, e26297-e26297. PubMed Europe PubMed DOI PMC EPMC M

2010

Ebihara,S. and Tomida,S. [Identification of a gene regulating "behavioral despair" in mice] Nihon Shinkei Seishin Yakurigaku Zasshi (2010) 30, 19-22. PubMed Europe PubMed M
Kushima,I., Aleksic,B., Ito,Y., Nakamura,Y., Nakamura,K., Mori,N., Kikuchi,M., Inada,T., Kunugi,H., Nanko,S., Kato,T., Yoshikawa,T., Ujike,H., Suzuki,M., Iwata,N. and Ozaki,N. Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population J Hum Genet (2010) 55, 133-136. PubMed Europe PubMed DOI M

2009

Tomida,S., Mamiya,T., Sakamaki,H., Miura,M., Aosaki,T., Masuda,M., Niwa,M., Kameyama,T., Kobayashi,J., Iwaki,Y., Imai,S., Ishikawa,A., Abe,K., Yoshimura,T., Nabeshima,T. and Ebihara,S. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests Nat Genet (2009) 41, 688-695. PubMed Europe PubMed DOI M

2004

[YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed Europe PubMed DOI