Literature for peptidase C19.041: ubiquitin-specific peptidase 25

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Xu,Y., Jin,K., Chen,J., Li,Z., Zhu,Z., Su,X., Shen,J., Zhou,B., Cao,Z., Lou,L., Deng,D., Zhang,J., Liu,B., Shentu,Y. and Wang,X.<br>USP25 inhibition ameliorates Parkinson's disease by restoring mitophagy<br>Proc Natl Acad Sci U S A (2026) 123, e2516471123-e2516471123. PubMed  Europe PubMed DOI  PMC  EPMC
  2. 2025
  3. Du,L., Chen,J., Du,C., Chen,J., Wang,Z., Bao,B., Zhonglin,L.V., Xing,C., Liang,M., Wang,L., Xie,S., Li,Y., Wang,Z., Li,G., Zhang,J. and Han,G.<br>Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway<br>Cell Immunol (2025) 409-410, 104930-104930. PubMed  Europe PubMed DOI
  4. Jia,X., Jiang,S., Cheng,H., Wang,Z., Chen,Z., Dong,W., Zhong,H., Zhang,Q., Song,X., Zhang,S. and Xia,R.<br>USP25-Mediated Talin-1 Stabilization in Platelets: A Novel Mechanism of Hyperreactivity and Thrombosis Risk During Aging<br>Blood (2025) PubMed  Europe PubMed DOI
  5. Jin,L., Zhu,W., Hu,X., Ye,L., Lou,S., Zhang,Q., Wang,M., Ye,B., Min,J., Wang,Y., Huang,L., Luo,W. and Liang,G.<br>USP25 directly interacts with and deubiquitinates PPARalpha to increase PPARalpha stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice<br>Cell Death Differ (2025) PubMed  Europe PubMed DOI
  6. Liu,Z., Liu,J., Wei,Y., Li,J., Zhang,J., Yu,R., Yang,Q., Miao,Y. and Dong,W.<br>Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3<br>Cell Death Dis (2025) 16, 5-5. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Ma,H., Guan,H., Sun,X., Wu,L., Cai,M., Zhen,X., Shen,X., Han,S., Liu,G., Peng,J. and Zhang,P.<br>USP25 Maintains KRAS Expression and Inhibiting the Deubiquitinase Suppresses KRAS Signaling in Human Cancer<br>J Biol Chem (2025) , 110337-110337. PubMed  Europe PubMed DOI
  8. Sun,Y., Chen,S., Qi,X., Sun,Y., Jiang,Z., Chang,J., Ma,Y., Huang,J., You,B. and Sun,F.<br>Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy<br>J Nanobiotechnology (2025) 23, 575-575. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Xu,Y., Liu,J., Wang,J., Wang,J., Lan,P. and Wang,T.<br>USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis<br>Int J Biol Sci (2025) 21, 475-489. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Yang,C., Li,H.X., Gan,H., Shuai,X., Dong,C., Wang,W., Lin,D. and Zhong,B.<br>KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31<br>Dev Cell (2025) PubMed  Europe PubMed DOI
  11. Ye,B., Xu,D., Zhong,L., Wang,Y., Wang,W., Xu,H., Han,X., Min,J., Wu,G., Huang,W. and Liang,G.<br>Ubiquitin-specific protease 25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes<br>Clin Transl Med (2025) 15, e70243-e70243. PubMed  Europe PubMed DOI  PMC  EPMC
  12. 2024
  13. Fan,C.X., Liu,X.R., Mei,D.Q., Li,B.M., Li,W.B., Xie,H.C., Wang,J., Shen,N.X., Ye,Z.L., You,Q.L., Li,L.Y., Qu,X.C., Chen,L.Z., Liang,J.J., Zhang,M.R., He,N., Li,J., Gao,J.Y., Deng,W.Y., Liu,W.Z., Wang,W.T., Liao,W.P., Chen,Q. and Shi,Y.W.<br>Heterozygous variants in USP25 cause genetic generalized epilepsy<br>Brain (2024) 147, 3442-3457. PubMed  Europe PubMed DOI
  14. Fu,Y., Yang,X., Ling,Q., Huang,Y., You,X., Nie,D., Sheng,J., Chen,Y., Wen,Q., Zhou,X., Zhou,C., Hu,S. and Ma,L.<br>USP25 Promotes the Antimycobacterial Response of Macrophages Through Stabilizing B-Raf and C-Raf<br>J Infect Dis (2024) PubMed  Europe PubMed DOI
  15. Hu,Q., Zhang,X., Peng,H., Guan,J., Huang,Z., Jiang,B. and Sun,D.<br>A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25<br>Inflammation (2024) 47, 1520-1535. PubMed  Europe PubMed DOI
  16. Li,Y., Li,L., Wang,X., Zhao,F., Yang,Y., Zhou,Y., Zhang,J., Wang,L., Jiang,Z., Zhang,Y., Chen,Y., Wu,C., Li,K., Zhang,T., Wang,P., Mao,Z., Zhu,W., Xu,X., Liang,S., Lou,Z. and Yuan,J.<br>USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer<br>Adv Sci (Weinh) (2024) , e2403485-e2403485. PubMed  Europe PubMed DOI
  17. Liu,P., Song,X., Chen,Q., Cen,L., Tang,C., Yu,C. and Xu,C.<br>Ubiquitin-specific peptidase 25 ameliorates hepatic steatosis by stabilizing peroxisome proliferator activated receptor alpha<br>J Biol Chem (2024) , 107876-107876. PubMed  Europe PubMed DOI
  18. Ye,B., Chen,Y., Chen,X., Xu,D., Jiang,Y., Lin,W., Fang,D., Xu,J., Han,J., Han,X., Long,X., Wang,W., Zhou,H., Wu,G. and Liang,G.<br>Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation<br>JACC Basic Transl Sci (2024) 9, 1287-1304. PubMed  Europe PubMed DOI  PMC  EPMC
  19. 2023
  20. Cai,C., Ma,H., Peng,J., Shen,X., Zhen,X., Yu,C., Zhang,P., Ji,F. and Wang,J.<br>USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice<br>Nat Commun (2023) 14, 3648-3648. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Cai,F., Song,B., Yang,Y., Liao,H., Li,R., Wang,Z., Cao,R., Chen,H., Wang,J., Wu,Y., Zhang,Y. and Song,W.<br>USP25 contributes to defective neurogenesis and cognitive impairments<br>FASEB J (2023) 37, e22971-e22971. PubMed  Europe PubMed DOI
  22. Li,R., Song,B., Xu,L., Zheng,J., Pan,W., Cai,F., Wang,J., Wu,Y. and Song,W.<br>Regulation of USP25 by SP1 Associates with Amyloidogenesis<br>J Alzheimers Dis (2023) 92, 1459-1472. PubMed  Europe PubMed DOI
  23. Li,Z., Liu,B., Lambertsen,K.L., Clausen,B.H., Zhu,Z., Du,X., Xu,Y., Poulsen,F.R., Halle,B., Bonde,C., Chen,M., Wang,X., Schluter,D., Huang,J., Waisman,A., Song,W. and Wang,X.<br>USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2<br>Adv Sci (Weinh) (2023) 10, e2301641-e2301641. PubMed  Europe PubMed DOI  PMC  EPMC  K
  24. Liu,B., Miao,X., Shen,J., Lou,L., Chen,K., Mei,F., Chen,M., Su,X., Du,X., Zhu,Z., Song,W. and Wang,X.<br>USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses<br>Int Immunopharmacol (2023) 124, 110877-110877. PubMed  Europe PubMed DOI
  25. Liu,Y., Ma,J., Lu,S., He,P. and Dong,W.<br>USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/beta-catenin signaling pathway<br>Chin Med J (Engl) (2023) 136, 2229-2242. PubMed  Europe PubMed DOI  PMC  EPMC  K
  26. Sui,J., Dai,F., Shi,J. and Zhou,C.<br>Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation<br>J Orthop Surg Res (2023) 18, 762-762. PubMed  Europe PubMed DOI  PMC  EPMC  K
  27. Yang,H., Liu,Y., Yang,J., Zhang,Q., Wang,H., Chen,Y. and Zhou,K.<br>Upregulation of USP25 promotes progression of human diffuse large B-cell lymphoma through blocking the ubiquitinated degradation of MDM2<br>Biochem Biophys Res Commun (2023) 676, 21-29. PubMed  Europe PubMed DOI
  28. Yang,Y., Zhan,X., Zhang,C., Shi,J., Wu,J., Deng,X., Hong,Y., Li,Q., Ge,S., Xu,G. and He,F.<br>USP25-PKM2-glycolysis axis contributes to ischemia reperfusion-induced acute kidney injury by promoting M1-like macrophage polarization and proinflammatory response<br>Clin Immunol (2023) 251, 109279-109279. PubMed  Europe PubMed DOI
  29. Ye,B., Zhou,H., Chen,Y., Luo,W., Lin,W., Zhao,Y., Han,J., Han,X., Huang,W., Wu,G., Wang,X. and Liang,G.<br>USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes<br>Circ Res (2023) 132, 465-480. PubMed  Europe PubMed DOI
  30. Zhao,Y., Chen,X., Lin,Y., Li,Z., Su,X., Fan,S., Chen,Y., Wang,X. and Liang,G.<br>USP25 inhibits renal fibrosis by regulating TGFbeta-SMAD signaling pathway in Ang II-induced hypertensive mice<br>Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166713-166713. PubMed  Europe PubMed DOI
  31. Zhou,L., Qin,B., Yassine,D.M., Luo,M., Liu,X., Wang,F. and Wang,Y.<br>Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles<br>Biochem Pharmacol (2023) 213, 115624-115624. PubMed  Europe PubMed DOI
  32. 2022
  33. Bogan,J.S.<br>Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle<br>Front Endocrinol (Lausanne) (2022) 13, 1019405-1019405. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Liu,X., Luo,W., Chen,J., Hu,C., Mutsinze,R.N., Wang,X., Zhang,Y., Huang,L., Zuo,W., Liang,G. and Wang,Y.<br>USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-kappaB Signaling in Macrophages<br>Cell Mol Gastroenterol Hepatol (2022) 14, 1103-1122. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Nelson,J.K., Thin,M.Z., Evan,T., Howell,S., Wu,M., Almeida,B., Legrave,N., Koenis,D.S., Koifman,G., Sugimoto,Y., Llorian Sopena,M., MacRae,J., Nye,E., Howell,M., Snijders,A.P., Prachalias,A., Zen,Y., Sarker,D. and Behrens,A.<br>USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer<br>Nat Commun (2022) 13, 2070-2070. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Tang,B., Luo,H., Xie,S., Pan,C. and Fu,J.<br>Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma<br>Dis Markers (2022) 2022, 9087190-9087190. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Xu,Z., Peng,Q., Wang,Y., Chen,X. and Zhang,J.<br>Ubiquitin specific peptidase 25 alleviates acute lung injury and suppresses the inflammatory response in lung epithelial cells<br>Gen Physiol Biophys (2022) 41, 569-577. PubMed  Europe PubMed DOI
  38. Zheng,Q., Song,B., Li,G., Cai,F., Wu,M., Zhao,Y., Jiang,L., Guo,T., Shen,M., Hou,H., Zhou,Y., Zhao,Y., Di,A., Zhang,L., Zeng,F., Zhang,X.F., Luo,H., Zhang,X., Zhang,H., Zeng,Z., Huang,T.Y., Dong,C., Qing,H., Zhang,Y., Zhang,Q., Wang,X., Wu,Y., Xu,H., Song,W. and Wang,X.<br>USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Abeta generation<br>J Clin Invest (2022) 132 PubMed  Europe PubMed DOI  PMC  EPMC
  39. 2021
  40. Gao,Y., Chen,J., Ji,R., Ding,J., Zhang,Y. and Yang,J.<br>USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN<br>Front Cell Dev Biol (2021) 9, 779718-779718. PubMed  Europe PubMed DOI  PMC  EPMC  K
  41. Liu,Z., Qi,M., Tian,S., Yang,Q., Liu,J., Wang,S., Ji,M., Yu,R., Zeng,S., Li,J., Wei,Y. and Dong,W.<br>Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway<br>Front Cell Dev Biol (2021) 9, 806850-806850. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Shen,J., Fu,B., Wu,Y., Yang,Y., Lin,X., Lin,H., Liu,H. and Huang,W.<br>USP25 Expression in Peripheral Blood Mononuclear Cells Is Associated With Bone Mineral Density in Women<br>Front Cell Dev Biol (2021) 9, 811611-811611. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Zheng,Q., Li,G., Wang,S., Zhou,Y., Liu,K., Gao,Y., Zhou,Y., Zheng,L., Zhu,L., Deng,Q., Wu,M., Di,A., Zhang,L., Zhao,Y., Zhang,H., Sun,H., Dong,C., Xu,H. and Wang,X.<br>Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25<br>Sci Adv (2021) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  44. 2020
  45. Nino,C.A., Wollscheid,N., Giangreco,G., Maspero,E. and Polo,S.<br>USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics<br>Biomolecules (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  46. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  47. Shibata,N., Ohoka,N., Tsuji,G., Demizu,Y., Miyawaza,K., Ui-Tei,K., Akiyama,T. and Naito,M.<br>Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells<br>Oncogene (2020) 39, 3867-3878. PubMed  Europe PubMed DOI
  48. 2019
  49. Cheng,H., Li,X., Wang,C., Chen,Y., Li,S., Tan,J., Tan,B. and He,Y.<br>Inhibition of tankyrase by a novel small molecule significantly attenuates prostate cancer cell proliferation<br>Cancer Lett (2019) 443, 80-90. PubMed  Europe PubMed DOI
  50. Gersch,M., Wagstaff,J.L., Toms,A.V., Graves,B., Freund,S.M.V. and Komander,D.<br>Distinct USP25 and USP28 oligomerization states regulate deubiquitinating activity<br>Mol Cell (2019) 74, 436-451. PubMed  Europe PubMed DOI
  51. Sadler,J.B.A., Lamb,C.A., Welburn,C.R., Adamson,I.S., Kioumourtzoglou,D., Chi,N.W., Gould,G.W. and Bryant,N.J.<br>The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes<br>Sci Rep (2019) 9, 4710-4710. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Sauer,F., Klemm,T., Kollampally,R.B., Tessmer,I., Nair,R.K., Popov,N. and Kisker,C.<br>Differential oligomerization of the deubiquitinases USP25 and USP28 regulates their activities<br>Mol Cell (2019) 74, 421-435. PubMed  Europe PubMed DOI  S
  53. Wen,J., Bai,H., Chen,N., Zhang,W., Zhu,X., Li,P. and Gong,J.<br>USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells<br>Mol Immunol (2019) 106, 53-62. PubMed  Europe PubMed DOI
  54. 2018
  55. Habtemichael,E.N., Li,D.T., Alcazar-Roman,A., Westergaard,X.O., Li,M., Petersen,M.C., Li,H., DeVries,S.G., Li,E., Julca-Zevallos,O., Wolenski,J.S. and Bogan,J.S.<br>Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes<br>J Biol Chem (2018) 293, 10466-10486. PubMed  Europe PubMed DOI
  56. Liu,B., Sureda-Gomez,M., Zhen,Y., Amador,V. and Reverter,D.<br>A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25<br>Nat Commun (2018) 9, 4973-4973. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Qian,G., Hu,X., Li,G., Ding,Y., Zhu,L., Zheng,H., Li,M., Li,Z., Pan,J., Li,Y., Li,G., Yang,C., Liu,Y., Xie,Y. and Lv,H.<br>Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation<br>Biochem Biophys Res Commun (2018) 498, 537-543. PubMed  Europe PubMed DOI
  58. 2017
  59. Kargbo,R.B.<br>Ubiquitin-specific inhibitors for the treatment of cancers, autoimmune, and infectious diseases<br>ACS Med Chem Lett (2017) 8, 1211-1212. PubMed  Europe PubMed DOI  PMC  EPMC  I
  60. Kawaguchi,K., Uo,K., Tanaka,T. and Komada,M.<br>Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25<br>Sci Rep (2017) 7, 45037-45037. PubMed  Europe PubMed DOI
  61. Wrigley,J.D., Gavory,G., Simpson,I., Preston,M., Plant,H., Bradley,J., Goeppert,A.U., Rozycka,E., Davies,G., Walsh,J., Valentine,A., McClelland,K., Odrzywol,K.E., Renshaw,J., Boros,J., Tart,J., Leach,L., Nowak,T., Ward,R.A., Harrison,T. and Andrews,D.M.<br>Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily<br>ACS Chem Biol (2017) 12, 3113-3125. PubMed  Europe PubMed DOI  I
  62. Yang,Y., Shi,L., Ding,Y., Shi,Y., Hu,H.Y., Wen,Y. and Zhang,N.<br>Structural and functional investigations of the N-terminal ubiquitin binding region of Usp25<br>Biophys J (2017) 112, 2099-2108. PubMed  Europe PubMed DOI  PMC  EPMC
  63. 2015
  64. Kim,S., Lee,D., Lee,J., Song,H., Kim,H.J. and Kim,K.T.<br>Vaccinia-related kinase 2 controls the stability of the eukaryotic chaperonin TRiC/CCT by inhibiting the deubiquitinating enzyme USP25<br>Mol Cell Biol (2015) 35, 1754-1762. PubMed  Europe PubMed DOI
  65. Lin,D., Zhang,M., Zhang,M.X., Ren,Y., Zhao,Q., Jin,J., Pan,Z., Wu,M., Shu,H.B., Dong,C. and Zhong,B.<br>Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6<br>Proc Natl Acad Sci U S A (2015) 112, 11324-11329. PubMed  Europe PubMed DOI
  66. 2014
  67. Shi,L., Wen,Y. and Zhang,N.<br>1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25<br>Biomol NMR Assign (2014) 8, 255-258. PubMed  Europe PubMed DOI
  68. 2013
  69. Zhong,B., Liu,X., Wang,X., Liu,X., Li,H., Darnay,B.G., Lin,X., Sun,S.C. and Dong,C.<br>Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3<br>Sci Signal (2013) 6, ra35-ra35. PubMed  Europe PubMed DOI
  70. Zhong,H., Wang,D., Fang,L., Zhang,H., Luo,R., Shang,M., Ouyang,C., Ouyang,H., Chen,H. and Xiao,S.<br>Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling<br>PLoS ONE (2013) 8, e80976-e80976. PubMed  Europe PubMed DOI  PMC  EPMC
  71. 2012
  72. Blount,J.R., Burr,A.A., Denuc,A., Marfany,G. and Todi,S.V.<br>Ubiquitin-specific protease 25 functions in endoplasmic reticulum-associated degradation<br>PLoS ONE (2012) 7, e36542-e36542. PubMed  Europe PubMed DOI  PMC  EPMC
  73. Marfany,G.<br>Ubiquitin-specific peptidase 25<br>[ISSN:978-0-12-407743-0] (2012) 3, 2095-2098. DOI
  74. Zhong,B., Liu,X., Wang,X., Chang,S.H., Liu,X., Wang,A., Reynolds,J.M. and Dong,C.<br>Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25<br>Nat Immunol (2012) 13, 1110-1117. PubMed  Europe PubMed DOI
  75. 2011
  76. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.<br>The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types<br>Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
  77. 2010
  78. Cholay,M., Reverdy,C., Benarous,R., Colland,F. and Daviet,L.<br>Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase<br>Exp Cell Res (2010) 316, 667-675. PubMed  Europe PubMed DOI
  79. 2009
  80. Denuc,A., Bosch-Comas,A., Gonzalez-Duarte,R. and Marfany,G.<br>The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition<br>PLoS ONE (2009) 4, e5571-e5571. PubMed  Europe PubMed DOI  PMC  EPMC
  81. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.<br>Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development<br>BMC Genomics (2009) 10, 637-637. PubMed  Europe PubMed DOI
  82. 2008
  83. Meulmeester,E., Kunze,M., Hsiao,H.H., Urlaub,H. and Melchior,F.<br>Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25<br>Mol Cell (2008) 30, 610-619. PubMed  Europe PubMed DOI
  84. Mohideen,F. and Lima,C.D.<br>SUMO takes control of a ubiquitin-specific protease<br>Mol Cell (2008) 30, 539-540. PubMed  Europe PubMed DOI  PMC  EPMC
  85. 2006
  86. [YEAR:23-2-2006]Bosch-Comas,A., Lindsten,K., Gonzalez-Duarte,R., Masucci,M.G. and Marfany,G.<br>The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins<br>Cell Mol Life Sci (23-2-2006) 63, 723-734. PubMed  Europe PubMed DOI
  87. 2001
  88. Valero,R., Bayes,M., Francisca Sanchez-Font,M., Gonzalez-Angulo,O., Gonzalez-Duarte,R. and Marfany,G.<br>Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25<br>Genome Biol (2001) 2, RESEARCH0043-RESEARCH0043. PubMed  Europe PubMed  PMC  EPMC  R
  89. 1999
  90. [YEAR:15-12-1999]Valero,R., Marfany,G., Gonzalez-Angulo,O., Gonzalez-Gonzalez,G., Puelles,L. and Gonzalez-Duarte,R.<br>USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2<br>Genomics (15-12-1999) 62, 395-405. PubMed  Europe PubMed DOI