Literature for peptidase C19.041: ubiquitin-specific peptidase 25

(Topics flags: S Structure, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Du,L., Chen,J., Du,C., Chen,J., Wang,Z., Bao,B., Zhonglin,L.V., Xing,C., Liang,M., Wang,L., Xie,S., Li,Y., Wang,Z., Li,G., Zhang,J. and Han,G.
   Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway
   Cell Immunol409-410, 104930-104930. PubMed  Europe PubMed DOI
2. Jin,L., Zhu,W., Hu,X., Ye,L., Lou,S., Zhang,Q., Wang,M., Ye,B., Min,J., Wang,Y., Huang,L., Luo,W. and Liang,G.
   USP25 directly interacts with and deubiquitinates PPARalpha to increase PPARalpha stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice
   Cell Death Differ PubMed  Europe PubMed DOI
3. Liu,Z., Liu,J., Wei,Y., Li,J., Zhang,J., Yu,R., Yang,Q., Miao,Y. and Dong,W.
   Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3
   Cell Death Dis16, 5-5. PubMed  Europe PubMed DOI
4. Xu,Y., Liu,J., Wang,J., Wang,J., Lan,P. and Wang,T.
   USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis
   Int J Biol Sci21, 475-489. PubMed  Europe PubMed DOI
5. Yang,C., Li,H.X., Gan,H., Shuai,X., Dong,C., Wang,W., Lin,D. and Zhong,B.
   KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31
   Dev Cell PubMed  Europe PubMed DOI
6. Ye,B., Xu,D., Zhong,L., Wang,Y., Wang,W., Xu,H., Han,X., Min,J., Wu,G., Huang,W. and Liang,G.
   Ubiquitin-specific protease 25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes
   Clin Transl Med15, e70243-e70243. PubMed  Europe PubMed DOI
2024
7. Fan,C.X., Liu,X.R., Mei,D.Q., Li,B.M., Li,W.B., Xie,H.C., Wang,J., Shen,N.X., Ye,Z.L., You,Q.L., Li,L.Y., Qu,X.C., Chen,L.Z., Liang,J.J., Zhang,M.R., He,N., Li,J., Gao,J.Y., Deng,W.Y., Liu,W.Z., Wang,W.T., Liao,W.P., Chen,Q. and Shi,Y.W.
   Heterozygous variants in USP25 cause genetic generalized epilepsy
   Brain147, 3442-3457. PubMed  Europe PubMed DOI
8. Fu,Y., Yang,X., Ling,Q., Huang,Y., You,X., Nie,D., Sheng,J., Chen,Y., Wen,Q., Zhou,X., Zhou,C., Hu,S. and Ma,L.
   USP25 Promotes the Antimycobacterial Response of Macrophages Through Stabilizing B-Raf and C-Raf
   J Infect Dis PubMed  Europe PubMed DOI
9. Hu,Q., Zhang,X., Peng,H., Guan,J., Huang,Z., Jiang,B. and Sun,D.
   A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25
   Inflammation47, 1520-1535. PubMed  Europe PubMed DOI
10. Li,Y., Li,L., Wang,X., Zhao,F., Yang,Y., Zhou,Y., Zhang,J., Wang,L., Jiang,Z., Zhang,Y., Chen,Y., Wu,C., Li,K., Zhang,T., Wang,P., Mao,Z., Zhu,W., Xu,X., Liang,S., Lou,Z. and Yuan,J.
    USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer
    Adv Sci (Weinh)e2403485-e2403485. PubMed  Europe PubMed DOI
11. Liu,P., Song,X., Chen,Q., Cen,L., Tang,C., Yu,C. and Xu,C.
    Ubiquitin-specific peptidase 25 ameliorates hepatic steatosis by stabilizing peroxisome proliferator activated receptor alpha
    J Biol Chem107876-107876. PubMed  Europe PubMed DOI
12. Ye,B., Chen,Y., Chen,X., Xu,D., Jiang,Y., Lin,W., Fang,D., Xu,J., Han,J., Han,X., Long,X., Wang,W., Zhou,H., Wu,G. and Liang,G.
    Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation
    JACC Basic Transl Sci9, 1287-1304. PubMed  Europe PubMed DOI
2023
13. Cai,C., Ma,H., Peng,J., Shen,X., Zhen,X., Yu,C., Zhang,P., Ji,F. and Wang,J.
    USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice
    Nat Commun14, 3648-3648. PubMed  Europe PubMed DOI
14. Cai,F., Song,B., Yang,Y., Liao,H., Li,R., Wang,Z., Cao,R., Chen,H., Wang,J., Wu,Y., Zhang,Y. and Song,W.
    USP25 contributes to defective neurogenesis and cognitive impairments
    FASEB J37, e22971-e22971. PubMed  Europe PubMed DOI
15. Li,R., Song,B., Xu,L., Zheng,J., Pan,W., Cai,F., Wang,J., Wu,Y. and Song,W.
    Regulation of USP25 by SP1 Associates with Amyloidogenesis
    J Alzheimers Dis92, 1459-1472. PubMed  Europe PubMed DOI
16. Li,Z., Liu,B., Lambertsen,K.L., Clausen,B.H., Zhu,Z., Du,X., Xu,Y., Poulsen,F.R., Halle,B., Bonde,C., Chen,M., Wang,X., Schluter,D., Huang,J., Waisman,A., Song,W. and Wang,X.
    USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2
    Adv Sci (Weinh)10, e2301641-e2301641. PubMed  Europe PubMed DOI  K
17. Liu,B., Miao,X., Shen,J., Lou,L., Chen,K., Mei,F., Chen,M., Su,X., Du,X., Zhu,Z., Song,W. and Wang,X.
    USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses
    Int Immunopharmacol124, 110877-110877. PubMed  Europe PubMed DOI
18. Liu,Y., Ma,J., Lu,S., He,P. and Dong,W.
    USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/beta-catenin signaling pathway
    Chin Med J (Engl)136, 2229-2242. PubMed  Europe PubMed DOI  K
19. Sui,J., Dai,F., Shi,J. and Zhou,C.
    Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation
    J Orthop Surg Res18, 762-762. PubMed  Europe PubMed DOI  K
20. Yang,H., Liu,Y., Yang,J., Zhang,Q., Wang,H., Chen,Y. and Zhou,K.
    Upregulation of USP25 promotes progression of human diffuse large B-cell lymphoma through blocking the ubiquitinated degradation of MDM2
    Biochem Biophys Res Commun676, 21-29. PubMed  Europe PubMed DOI
21. Yang,Y., Zhan,X., Zhang,C., Shi,J., Wu,J., Deng,X., Hong,Y., Li,Q., Ge,S., Xu,G. and He,F.
    USP25-PKM2-glycolysis axis contributes to ischemia reperfusion-induced acute kidney injury by promoting M1-like macrophage polarization and proinflammatory response
    Clin Immunol251, 109279-109279. PubMed  Europe PubMed DOI
22. Ye,B., Zhou,H., Chen,Y., Luo,W., Lin,W., Zhao,Y., Han,J., Han,X., Huang,W., Wu,G., Wang,X. and Liang,G.
    USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes
    Circ Res132, 465-480. PubMed  Europe PubMed DOI
23. Zhao,Y., Chen,X., Lin,Y., Li,Z., Su,X., Fan,S., Chen,Y., Wang,X. and Liang,G.
    USP25 inhibits renal fibrosis by regulating TGFbeta-SMAD signaling pathway in Ang II-induced hypertensive mice
    Biochim Biophys Acta Mol Basis Dis1869, 166713-166713. PubMed  Europe PubMed DOI
24. Zhou,L., Qin,B., Yassine,D.M., Luo,M., Liu,X., Wang,F. and Wang,Y.
    Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles
    Biochem Pharmacol213, 115624-115624. PubMed  Europe PubMed DOI
2022
25. Bogan,J.S.
    Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle
    Front Endocrinol (Lausanne)13, 1019405-1019405. PubMed  Europe PubMed DOI
26. Liu,X., Luo,W., Chen,J., Hu,C., Mutsinze,R.N., Wang,X., Zhang,Y., Huang,L., Zuo,W., Liang,G. and Wang,Y.
    USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-kappaB Signaling in Macrophages
    Cell Mol Gastroenterol Hepatol14, 1103-1122. PubMed  Europe PubMed DOI
27. Nelson,J.K., Thin,M.Z., Evan,T., Howell,S., Wu,M., Almeida,B., Legrave,N., Koenis,D.S., Koifman,G., Sugimoto,Y., Llorian Sopena,M., MacRae,J., Nye,E., Howell,M., Snijders,A.P., Prachalias,A., Zen,Y., Sarker,D. and Behrens,A.
    USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
    Nat Commun13, 2070-2070. PubMed  Europe PubMed DOI
28. Tang,B., Luo,H., Xie,S., Pan,C. and Fu,J.
    Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma
    Dis Markers2022, 9087190-9087190. PubMed  Europe PubMed DOI
29. Xu,Z., Peng,Q., Wang,Y., Chen,X. and Zhang,J.
    Ubiquitin specific peptidase 25 alleviates acute lung injury and suppresses the inflammatory response in lung epithelial cells
    Gen Physiol Biophys41, 569-577. PubMed  Europe PubMed DOI
30. Zheng,Q., Song,B., Li,G., Cai,F., Wu,M., Zhao,Y., Jiang,L., Guo,T., Shen,M., Hou,H., Zhou,Y., Zhao,Y., Di,A., Zhang,L., Zeng,F., Zhang,X.F., Luo,H., Zhang,X., Zhang,H., Zeng,Z., Huang,T.Y., Dong,C., Qing,H., Zhang,Y., Zhang,Q., Wang,X., Wu,Y., Xu,H., Song,W. and Wang,X.
    USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Abeta generation
    J Clin Invest132, PubMed  Europe PubMed DOI
2021
31. Gao,Y., Chen,J., Ji,R., Ding,J., Zhang,Y. and Yang,J.
    USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN
    Front Cell Dev Biol9, 779718-779718. PubMed  Europe PubMed DOI  K
32. Liu,Z., Qi,M., Tian,S., Yang,Q., Liu,J., Wang,S., Ji,M., Yu,R., Zeng,S., Li,J., Wei,Y. and Dong,W.
    Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway
    Front Cell Dev Biol9, 806850-806850. PubMed  Europe PubMed DOI
33. Shen,J., Fu,B., Wu,Y., Yang,Y., Lin,X., Lin,H., Liu,H. and Huang,W.
    USP25 Expression in Peripheral Blood Mononuclear Cells Is Associated With Bone Mineral Density in Women
    Front Cell Dev Biol9, 811611-811611. PubMed  Europe PubMed DOI
34. Zheng,Q., Li,G., Wang,S., Zhou,Y., Liu,K., Gao,Y., Zhou,Y., Zheng,L., Zhu,L., Deng,Q., Wu,M., Di,A., Zhang,L., Zhao,Y., Zhang,H., Sun,H., Dong,C., Xu,H. and Wang,X.
    Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25
    Sci Adv7, PubMed  Europe PubMed DOI
2020
35. Nino,C.A., Wollscheid,N., Giangreco,G., Maspero,E. and Polo,S.
    USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics
    Biomolecules10, PubMed  Europe PubMed DOI
36. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
37. Shibata,N., Ohoka,N., Tsuji,G., Demizu,Y., Miyawaza,K., Ui-Tei,K., Akiyama,T. and Naito,M.
    Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells
    Oncogene39, 3867-3878. PubMed  Europe PubMed DOI
2019
38. Cheng,H., Li,X., Wang,C., Chen,Y., Li,S., Tan,J., Tan,B. and He,Y.
    Inhibition of tankyrase by a novel small molecule significantly attenuates prostate cancer cell proliferation
    Cancer Lett443, 80-90. PubMed  Europe PubMed DOI
39. Gersch,M., Wagstaff,J.L., Toms,A.V., Graves,B., Freund,S.M.V. and Komander,D.
    Distinct USP25 and USP28 oligomerization states regulate deubiquitinating activity
    Mol Cell74, 436-451. PubMed  Europe PubMed DOI
40. Sadler,J.B.A., Lamb,C.A., Welburn,C.R., Adamson,I.S., Kioumourtzoglou,D., Chi,N.W., Gould,G.W. and Bryant,N.J.
    The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
    Sci Rep9, 4710-4710. PubMed  Europe PubMed DOI
41. Sauer,F., Klemm,T., Kollampally,R.B., Tessmer,I., Nair,R.K., Popov,N. and Kisker,C.
    Differential oligomerization of the deubiquitinases USP25 and USP28 regulates their activities
    Mol Cell74, 421-435. PubMed  Europe PubMed DOI  S
42. Wen,J., Bai,H., Chen,N., Zhang,W., Zhu,X., Li,P. and Gong,J.
    USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells
    Mol Immunol106, 53-62. PubMed  Europe PubMed DOI
2018
43. Habtemichael,E.N., Li,D.T., Alcazar-Roman,A., Westergaard,X.O., Li,M., Petersen,M.C., Li,H., DeVries,S.G., Li,E., Julca-Zevallos,O., Wolenski,J.S. and Bogan,J.S.
    Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes
    J Biol Chem293, 10466-10486. PubMed  Europe PubMed DOI
44. Liu,B., Sureda-Gomez,M., Zhen,Y., Amador,V. and Reverter,D.
    A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
    Nat Commun9, 4973-4973. PubMed  Europe PubMed DOI
45. Qian,G., Hu,X., Li,G., Ding,Y., Zhu,L., Zheng,H., Li,M., Li,Z., Pan,J., Li,Y., Li,G., Yang,C., Liu,Y., Xie,Y. and Lv,H.
    Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation
    Biochem Biophys Res Commun498, 537-543. PubMed  Europe PubMed DOI
2017
46. Kargbo,R.B.
    Ubiquitin-specific inhibitors for the treatment of cancers, autoimmune, and infectious diseases
    ACS Med Chem Lett8, 1211-1212. PubMed  Europe PubMed DOI  I
47. Kawaguchi,K., Uo,K., Tanaka,T. and Komada,M.
    Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25
    Sci Rep7, 45037-45037. PubMed  Europe PubMed DOI
48. Wrigley,J.D., Gavory,G., Simpson,I., Preston,M., Plant,H., Bradley,J., Goeppert,A.U., Rozycka,E., Davies,G., Walsh,J., Valentine,A., McClelland,K., Odrzywol,K.E., Renshaw,J., Boros,J., Tart,J., Leach,L., Nowak,T., Ward,R.A., Harrison,T. and Andrews,D.M.
    Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily
    ACS Chem Biol12, 3113-3125. PubMed  Europe PubMed DOI  I
49. Yang,Y., Shi,L., Ding,Y., Shi,Y., Hu,H.Y., Wen,Y. and Zhang,N.
    Structural and functional investigations of the N-terminal ubiquitin binding region of Usp25
    Biophys J112, 2099-2108. PubMed  Europe PubMed DOI
2015
50. Kim,S., Lee,D., Lee,J., Song,H., Kim,H.J. and Kim,K.T.
    Vaccinia-related kinase 2 controls the stability of the eukaryotic chaperonin TRiC/CCT by inhibiting the deubiquitinating enzyme USP25
    Mol Cell Biol35, 1754-1762. PubMed  Europe PubMed DOI
51. Lin,D., Zhang,M., Zhang,M.X., Ren,Y., Zhao,Q., Jin,J., Pan,Z., Wu,M., Shu,H.B., Dong,C. and Zhong,B.
    Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6
    Proc Natl Acad Sci U S A112, 11324-11329. PubMed  Europe PubMed DOI
2014
52. Shi,L., Wen,Y. and Zhang,N.
    1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25
    Biomol NMR Assign8, 255-258. PubMed  Europe PubMed DOI
2013
53. Zhong,B., Liu,X., Wang,X., Liu,X., Li,H., Darnay,B.G., Lin,X., Sun,S.C. and Dong,C.
    Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3
    Sci Signal6, ra35-ra35. PubMed  Europe PubMed DOI
54. Zhong,H., Wang,D., Fang,L., Zhang,H., Luo,R., Shang,M., Ouyang,C., Ouyang,H., Chen,H. and Xiao,S.
    Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling
    PLoS ONE8, e80976-e80976. PubMed  Europe PubMed DOI
2012
55. Blount,J.R., Burr,A.A., Denuc,A., Marfany,G. and Todi,S.V.
    Ubiquitin-specific protease 25 functions in endoplasmic reticulum-associated degradation
    PLoS ONE7, e36542-e36542. PubMed  Europe PubMed DOI
56. Marfany,G.
    Ubiquitin-specific peptidase 25
    [ISSN:978-0-12-407743-0]3, 2095-2098. DOI
57. Zhong,B., Liu,X., Wang,X., Chang,S.H., Liu,X., Wang,A., Reynolds,J.M. and Dong,C.
    Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25
    Nat Immunol13, 1110-1117. PubMed  Europe PubMed DOI
2011
58. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol18, 1550-1561. PubMed  Europe PubMed DOI
2010
59. Cholay,M., Reverdy,C., Benarous,R., Colland,F. and Daviet,L.
    Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase
    Exp Cell Res316, 667-675. PubMed  Europe PubMed DOI
2009
60. Denuc,A., Bosch-Comas,A., Gonzalez-Duarte,R. and Marfany,G.
    The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition
    PLoS ONE4, e5571-e5571. PubMed  Europe PubMed DOI
61. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics10, 637-637. PubMed  Europe PubMed DOI
2008
62. Meulmeester,E., Kunze,M., Hsiao,H.H., Urlaub,H. and Melchior,F.
    Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25
    Mol Cell30, 610-619. PubMed  Europe PubMed DOI
63. Mohideen,F. and Lima,C.D.
    SUMO takes control of a ubiquitin-specific protease
    Mol Cell30, 539-540. PubMed  Europe PubMed DOI
2006
64. [YEAR:23-2-2006]Bosch-Comas,A., Lindsten,K., Gonzalez-Duarte,R., Masucci,M.G. and Marfany,G.
    The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins
    Cell Mol Life Sci63, 723-734. PubMed  Europe PubMed DOI
2001
65. Valero,R., Bayes,M., Francisca Sanchez-Font,M., Gonzalez-Angulo,O., Gonzalez-Duarte,R. and Marfany,G.
    Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
    Genome Biol2, RESEARCH0043-RESEARCH0043. PubMed  Europe PubMed  R
1999
66. [YEAR:15-12-1999]Valero,R., Marfany,G., Gonzalez-Angulo,O., Gonzalez-Gonzalez,G., Puelles,L. and Gonzalez-Duarte,R.
    USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2
    Genomics62, 395-405. PubMed  Europe PubMed DOI